FGF21 Analogs of Sustained Action Enabled by Orthogonal Biosynthesis Demonstrate Enhanced Antidiabetic Pharmacology in Rodents von MU, James, PINKSTAFF, Jason, WU, Margaret, NORMAN, Thea C, RODRIGUEZ, Carlos G, KIMMEL, Bruce, METZGER, Joseph M, MANIBUSAN, Anthony, LEE, Darin, ZALLER, Dennis M, ZHANG, Bei B, DIMARCHI, Richard D, ZHIHUA LI, BERGER, Joel P, AXELROD, Douglas W, SKIDMORE, Lillian, NINA LI, MYLER, Heather, DALLAS-YANG, Qing, PUTNAM, Anna-Maria, JUN YAO, BUSSELL, Stuart

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Subcellular location of L1 retrotransposon-encoded ORF1p, reverse transcription products, and DNA sensors in lupus granulocytes von Moadab, Fatemeh, Sohrabi, Sepideh, Wang, Xiaoxing, Najjar, Rayan, Wolters, Justina C, Jiang, Hua, Miao, Wenyan, Romero, Donna, Zaller, Dennis M, Tran, Megan, Bays, Alison, Taylor, Martin S, Kapeller, Rosana, LaCava, John, Mustelin, Tomas

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TLR7 Protein Expression in Mild and Severe Lupus-Prone Models Is Regulated in a Leukocyte, Genetic, and IRAK4 Dependent Manner von Celhar, Teja, Lu, Hao Kim, Benso, Lia, Rakhilina, Larissa, Lee, Hui Yin, Tripathi, Shubhita, Zharkova, Olga, Ong, Wei Yee, Yasuga, Hiroko, Au, Bijin, Marlier, Damien, Lim, Lina Hsiu Kim, Thamboo, Thomas Paulraj, Mudgett, John S, Mackey, Matthew F, Zaller, Dennis M, Connolly, John E, Fairhurst, Anna-Marie

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A human tissue-based functional assay platform to evaluate the immune function impact of small molecule inhibitors that target the immune system von St Pierre, Cristina, Guo, Jane, Shin, John D, Engstrom, Laura W, Lee, Hyun-Hee, Herbert, Alan, Surdi, Laura, Baker, James, Salmon, Michael, Shah, Sanjiv, Ellis, J Michael, Houshyar, Hani, Crackower, Michael A, Kleinschek, Melanie A, Jones, Dallas C, Hicks, Alexandra, Zaller, Dennis M, Alves, Stephen E, Ramadas, Ravisankar A

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Pharmacological Inhibition of O-GlcNAcase Does Not Increase Sensitivity of Glucocorticoid Receptor-Mediated Transrepression von Stivers, Peter J, Harmonay, Lauren, Hicks, Alexandra, Mehmet, Huseyin, Morris, Melody, Robinson, Gain M, Strack, Peter R, Savage, Mary J, Zaller, Dennis M, Zwierzynski, Izabela, Brandish, Philip E

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Mediation by HLA-DM of dissociation of peptides from HLA-DR von Sloan, Victor S, Cameron, Patricia, Porter, Gene, Gammon, Maureen, Amaya, Miguel, Mellins, Elizabeth, Zaller, Dennis M

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Structures, functions and adaptations of the human LINE-1 ORF2 protein von Baldwin, Eric T., van Eeuwen, Trevor, Hoyos, David, Zalevsky, Arthur, Tchesnokov, Egor P., Sánchez, Roberto, Miller, Bryant D., Di Stefano, Luciano H., Ruiz, Francesc Xavier, Hancock, Matthew, Işik, Esin, Mendez-Dorantes, Carlos, Walpole, Thomas, Nichols, Charles, Wan, Paul, Riento, Kirsi, Halls-Kass, Rowan, Augustin, Martin, Lammens, Alfred, Jestel, Anja, Upla, Paula, Xibinaku, Kera, Congreve, Samantha, Hennink, Maximiliaan, Rogala, Kacper B., Schneider, Anna M., Fairman, Jennifer E., Christensen, Shawn M., Desrosiers, Brian, Bisacchi, Gregory S., Saunders, Oliver L., Hafeez, Nafeeza, Miao, Wenyan, Kapeller, Rosana, Zaller, Dennis M., Sali, Andrej, Weichenrieder, Oliver, Burns, Kathleen H., Götte, Matthias, Rout, Michael P., Arnold, Eddy, Greenbaum, Benjamin D., Romero, Donna L., LaCava, John, Taylor, Martin S.

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Production of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor α1 von Redpath, Nicholas T, Xu, Yibin, Wilson, Nicholas J, Fabri, Louis J, Baca, Manuel, Andrews, Arna E, Braley, Hal, Lu, Ping, Ireland, Cheryl, Ernst, Robin E, Woods, Andrea, Forrest, Gail, An, Zhiqiang, Zaller, Dennis M, Strohl, William R, Luo, Cindy S, Czabotar, Peter E, Garrett, Thomas P J, Hilton, Douglas J, Nash, Andrew D, Zhang, Jian-Guo, Nicola, Nicos A

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Genetic ablation or pharmacological blockade of dipeptidyl peptidase IV does not impact T cell-dependent immune responses von Vora, Kalpit A, Porter, Gene, Peng, Roche, Cui, Yan, Pryor, Kellyann, Eiermann, George, Zaller, Dennis M

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HLA-DR1 (DRB10101) and DR4 (DRB10401) Use the Same Anchor Residues for Binding an Immunodominant Peptide Derived from Human Type II Collagen von Rosloniec, Edward F, Whittington, Karen B, Zaller, Dennis M, Kang, Andrew H

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Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase von Stelmach, John E., Liu, Luping, Patel, Sangita B., Pivnichny, James V., Scapin, Giovanna, Singh, Suresh, Hop, Cornelis E.C.A., Wang, Zhen, Strauss, John R., Cameron, Patricia M., Nichols, Elizabeth A., O'Keefe, Stephen J., O'Neill, Edward A., Schmatz, Dennis M., Schwartz, Cheryl D., Thompson, Chris M., Zaller, Dennis M., Doherty, James B.

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Staging and resetting T cell activation in SMACs von Kupfer, Abraham, Freiberg, Benjamin A, Kupfer, Hannah, Maslanik, William, Delli, Joe, Kappler, John, Zaller, Dennis M

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Inhibition of spleen tyrosine kinase attenuates IgE‐mediated airway contraction and mediator release in human precision cut lung slices von Koziol‐White, Cynthia J, Jia, Yanlin, Baltus, Gretchen A, Cooper, Philip R, Zaller, Dennis M, Crackower, Michael A, Sirkowski, Erich E, Smock, Steven, Northrup, Alan B, Himes, Blanca E, Alves, Stephen E, Panettieri, Reynold A

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Evidence for cyclic diguanylate as a vaccine adjuvant with novel immunostimulatory activities von Gray, Peter M., Forrest, Gail, Wisniewski, Thomas, Porter, Gene, Freed, Daniel C., DeMartino, Julie A., Zaller, Dennis M., Guo, Zhiqiang, Leone, Joseph, Fu, Tong-Ming, Vora, Kalpit A.

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Chemical Genetics Define the Roles of p38α and p38β in Acute and Chronic Inflammation von O'Keefe, Stephen J., Mudgett, John S., Cupo, Susan, Parsons, Janey N., Chartrain, Nicole A., Fitzgerald, Catherine, Chen, Shiow-Ling, Lowitz, Karen, Rasa, Cordelia, Visco, Denise, Luell, Silvi, Carballo-Jane, Ester, Owens, Karen, Zaller, Dennis M.

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Synthesis and biological activity of quinolinone and dihydroquinolinone p38 MAP kinase inhibitors von Chen, Meng-Hsin, Fitzgerald, Patricia, Singh, Suresh B., O’Neill, Edward A., Schwartz, Cheryl D., Thompson, Chris M., O’Keefe, Stephen J., Zaller, Dennis M., Doherty, James B.

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The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection von Xiong, Yusheng, Wiltsie, Judyann, Woods, Andrea, Guo, Jian, Pivnichny, James V., Tang, Wei, Bansal, Alka, Cummings, Richard T., Cunningham, Barry R., Friedlander, Arthur M., Douglas, Cameron M., Salowe, Scott P., Zaller, Dennis M., Scolnick, Edward M., Schmatz, Dennis M., Bartizal, Kenneth, Hermes, Jeffrey D., MacCoss, Malcolm, Chapman, Kevin T.

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Novel N-Arylpyrazolo[3,2-c]-Based Ligands for the Glucocorticoid Receptor:  Receptor Binding and in Vivo Activity von Ali, Amjad, Thompson, Christopher F, Balkovec, James M, Graham, Donald W, Hammond, Milton L, Quraishi, Nazia, Tata, James R, Einstein, Monica, Ge, Lan, Harris, Georgianna, Kelly, Terri M, Mazur, Paul, Pandit, Shilpa, Santoro, Joseph, Sitlani, Ayesha, Wang, Chuanlin, Williamson, Joanne, Miller, Douglas K, Thompson, Chris M, Zaller, Dennis M, Forrest, Michael J, Carballo-Jane, Ester, Luell, Silvi

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Identification of the lateral interaction surfaces of human histocompatibility leukocyte antigen (HLA)-DM with HLA-DR1 by formation of tethered complexes that present enhanced HLA-... von Stratikos, Efstratios, Mosyak, Lidia, Zaller, Dennis M, Wiley, Don C

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Induction of Autoimmune Arthritis in HLA-DR4 (DRB10401) Transgenic Mice by Immunization with Human and Bovine Type II Collagen von Rosloniec1, Edward F, Brand, David D, Myers, Linda K, Esaki, Yukio, Whittington, Karen B, Zaller, Dennis M, Woods, Andrea, Stuart, John M, Kang, Andrew H

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