The influence of an enamine usnic acid derivative (a tyrosyl-DNA phosphodiesterase 1 inhibitor) on the therapeutic effect of topotecan against transplanted tumors in vivo von Nikolin, V. P., Popova, N. A., Kaledin, V. I., Luzina, O. A., Zakharenko, A. L., Salakhutdinov, N. F., Lavrik, O. I.

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Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topoteсan on in vivo tumor models von Zakharenko, A.L., Luzina, O.A., Sokolov, D.N., Kaledin, V.I., Nikolin, V.P., Popova, N.A., Patel, J., Zakharova, O.D., Chepanova, A.A., Zafar, A., Reynisson, J., Leung, E., Leung, I.K.H., Volcho, K.P., Salakhutdinov, N.F., Lavrik, O.I.

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Identification of novel inhibitors for the tyrosyl-DNA-phosphodiesterase 1 (Tdp1) mutant SCAN1 using virtual screening von Mamontova, E.M., Zakharenko, A.L., Zakharova, O.D., Dyrkheeva, N.S., Volcho, K.P., Reynisson, J., Arabshahi, H.J., Salakhutdinov, N.F., Lavrik, O.I.

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A two-phase solution procedure using mixtures of algorithms in the structure–property problem von Prokhorov, E. I., Svitan’ko, I. V., Zakharenko, A. L., Sukhanova, M. V., Bekker, A. V., Perevoznikov, A. V., Kumskov, M. I.

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PARP1 Gene Knockout Suppresses Expression of DNA Base Excision Repair Genes von Zakharenko, A. L., Malakhova, A. A., Dyrkheeva, N. S., Okorokova, L. S., Medvedev, S. P., Zakian, S. M., Kabilov, M. R., Tupikin, A. A., Lavrik, O. I.

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Influence of Tyrosyl-DNA Phosphodiesterase 1 Inhibitor on the Proapoptotic and Genotoxic Effects of Anticancer Agent Topotecan von Chepanova, A. A., Zakharenko, A. L., Dyrkheeva, N. S., Chernyshova, I. A., Zakharova, O. D., Ilina, E. S., Luzina, O. A., Salakhutdinov, N. F., Lavrik, O. I.

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2,5-Diketopiperazines: A New Class of Poly(ADP-ribose)polymerase Inhibitors von Nilov, D. K., Yashina, K. I., Gushchina, I. V., Zakharenko, A. L., Sukhanova, M. V., Lavrik, O. I., Švedas, V. K.

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Antimetastatic Activity of Combined Topotecan and Tyrosyl-DNA Phosphodiesterase-1 Inhibitor on Modeled Lewis Lung Carcinoma von Koldysheva, E. V., Men’shchikova, A. P., Lushnikova, E. L., Popova, N. A., Kaledin, V. I., Nikolin, V. P., Zakharenko, A. L., Luzina, O. A., Salakhutdinov, N. F., Lavrik, O. I.

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Effect of Usnic Acid-Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitor Used as Monotherapy or in Combination with Olaparib on Transplanted Tumors In Vivo von Kornienko, T. E., Zakharenko, A. L., Ilina, E. S., Chepanova, A. A., Zakharova, O. D., Dyrkheeva, N. S., Popova, N. A., Nikolin, V. P., Filimonov, A. S., Luzina, O. A., Salakhutdinov, N. F., Lavrik, O. I.

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DNA Repair Enzymes as Promising Targets in Oncotherapy von Zakharenko, A. L., Lebedeva, N. A., Lavrik, O. I.

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Antitumor Activity of the Combination of Topotecan and Tyrosyl-DNA-Phosphodiesterase 1 Inhibitor on Model Krebs-2 Mouse Ascite Carcinoma von Dyrkheeva, N. S., Zakharenko, A. L., Novoselova, E. S., Chepanova, A. A., Popova, N. A., Nikolin, V. P., Luzina, O. A., Salakhutdinov, N. F., Ryabchikova, E. I., Lavrik, O. I.

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Effective Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 Based on Monoterpenoids as Potential Agents for Antitumor Therapy von Chepanova, A. A., Li-Zhulanov, N. S., Sukhikh, A. S., Zafar, A., Reynisson, J., Zakharenko, A. L., Zakharova, O. D., Korchagina, D. V., Volcho, K. P., Salakhutdinov, N. F., Lavrik, O. I.

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Synthesis and Inhibitory Properties of Imines Containing Monoterpenoid and Adamantane Fragments Against DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) von Zakharenko, A. L., Mozhaitsev, E. S., Suslov, E. V., Korchagina, D. V., Volcho, K. P., Salakhutdinov, N. F., Lavrik, O. I.

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Usnic acid derivatives are effective inhibitors of tyrosyl-DNA phosphodiesterase 1 von Zakharenko, A. L., Luzina, O. A., Sokolov, D. N., Zakharova, O. D., Rakhmanova, M. E., Chepanova, A. A., Dyrkheeva, N. S., Lavrik, O. I., Salakhutdinov, N. F.

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Structure Modeling of Human Tyrosyl-DNA Phosphodiesterase 1 and Screening for Its Inhibitors von Gushchina, I V, Nilov, D K, Zakharenko, A L, Lavrik, O I, Švedas, V K

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Inhibition of Poly(ADP-Ribose) Polymerase by Nucleic Acid Metabolite 7-Methylguanine von Nilov, D K, Tararov, V I, Kulikov, A V, Zakharenko, A L, Gushchina, I V, Mikhailov, S N, Lavrik, O I, Švedas, V K

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Synthesis of a series of NAD+ analogues, potential inhibitors of PARP 1, using ADP conjugates functionalized at the terminal phosphate group von Sherstyuk, Yu. V., Zakharenko, A. L., Kutuzov, M. M., Sukhanova, M. V., Lavrik, O. I., Silnikov, V. N., Abramova, T. V.

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Inhibitory properties of nitrogen-containing adamantane derivatives with monoterpenoid fragments against tyrosyl-DNA phosphodiesterase 1 von Zakharenko, A. L., Ponomarev, K. U., Suslov, E. V., Korchagina, D. V., Volcho, K. P., Vasil’eva, I. A., Salakhutdinov, N. F., Lavrik, O. I.

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Improved procedure of the search for poly(ADP-Ribose) polymerase-1 potential inhibitors with the use of the molecular docking approach von Zakharenko, A. L., Sukhanova, M. V., Khodyreva, S. N., Novikov, F. N., Stroylov, V. S., Nilov, D. K., Chilov, G. G., Svedas, V. K., Lavrik, O. I.

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Investigation of the dNTP-binding site of HIV-1 reverse transcriptase using photoreactive analogs of dNTP von Zakharenko, A L, Kolpashchikov, D M, Khodyreva, S N, Lavrik, O I, Menéndez-Arias, L

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