Inhibition of inositol kinase B controls acute and chronic graft-versus-host disease von Thangavelu, Govindarajan, Du, Jing, Paz, Katelyn G., Loschi, Michael, Zaiken, Michael C., Flynn, Ryan, Taylor, Patricia A., Kirchmeier, Andrew Kemal, Panoskaltsis-Mortari, Angela, Luznik, Leo, MacDonald, Kelli P., Hill, Geoffrey R., Maillard, Ivan, Munn, David H., Serody, Jonathan S., Murphy, William J., Miklos, David, Cutler, Corey S., Koreth, John, Antin, Joseph H., Soiffer, Robert J., Ritz, Jerome, Dahlberg, Carol, Miller, Andrew T., Blazar, Bruce R.

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Targeting the Retinoid X Receptor Pathway Prevents and Ameliorates Murine Chronic Graft-Versus-Host Disease von Thangavelu, Govindarajan, Zaiken, Michael C, Mohamed, Fathima A, Flynn, Ryan, Du, Jing, Rhee, Stephanie Y, Riddle, Megan J, Aguilar, Ethan G, Panoskaltsis-Mortari, Angela, Sanders, Martin E, Blazar, Bruce R

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Enforced gut homing of murine regulatory T cells reduces early graft-versus-host disease severity von Larson, Jemma H., Jin, Sujeong, Loschi, Michael, Bolivar Wagers, Sara, Thangavelu, Govindarajan, Zaiken, Michael C., McDonald-Hyman, Cameron, Saha, Asim, Aguilar, Ethan G., Koehn, Brent, Osborn, Mark J., Panoskaltsis-Mortari, Angela, Macdonald, Kelli P.A., Hill, Geoffrey R., Murphy, William J., Serody, Jonathan S., Maillard, Ivan, Kean, Leslie S., Kim, Sangwon V., Littman, Dan R., Blazar, Bruce R.

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BET-bromodomain and EZH2 inhibitor–treated chronic GVHD mice have blunted germinal centers with distinct transcriptomes von Zaiken, Michael C., Flynn, Ryan, Paz, Katelyn G., Rhee, Stephanie Y., Jin, Sujeong, Mohamed, Fathima A., Saha, Asim, Thangavelu, Govindarajan, Park, Paul M.C., Hemming, Matthew L., Sage, Peter T., Sharpe, Arlene H., DuPage, Michel, Bluestone, Jeffrey A., Panoskaltsis-Mortari, Angela, Cutler, Corey S., Koreth, John, Antin, Joseph H., Soiffer, Robert J., Ritz, Jerome, Luznik, Leo, Maillard, Ivan, Hill, Geoffrey R., MacDonald, Kelli P.A., Munn, David H., Serody, Jonathan S., Murphy, William J., Kean, Leslie S., Zhang, Yi, Bradner, James E., Qi, Jun, Blazar, Bruce R.

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Retinoic acid signaling acts as a rheostat to balance Treg function von Thangavelu, Govindarajan, Andrejeva, Gabriela, Bolivar-Wagers, Sara, Jin, Sujeong, Zaiken, Michael C., Loschi, Michael, Aguilar, Ethan G., Furlan, Scott N., Brown, Chrysothemis C., Lee, Yu-Chi, Hyman, Cameron McDonald, Feser, Colby J., Panoskaltsis-Mortari, Angela, Hippen, Keli L., MacDonald, Kelli P., Murphy, William J., Maillard, Ivan, Hill, Geoffrey R., Munn, David H., Zeiser, Robert, Kean, Leslie S., Rathmell, Jeffrey C., Chi, Hongbo, Noelle, Randolph J., Blazar, Bruce R.

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Mitochondrial Pyruvate Carrier Inhibition Mitigates Murine Chronic Graft Versus Host Disease By Attenuating the Germinal Center Reaction von Mohamed, Fathima A, Rhee, Stephanie Y, Ly, Joanna, Aguilar, Ethan G, Melin, Haley, Sage, Peter T, Schumacher, Tanner, Thangavelu, Govindarajan, Zaiken, Michael C, Liu, Juan, Mereddy, Venkatram, Locasale, Jason W, Blazar, Bruce R

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Targeting temporal metabolic needs of T follicular helper cells to treat cGVHD utilizing a mitochondrial pyruvate carrier inhibitor von Mohamed, Fathima A, Rhee, Stephanie Y, Ly, Joanna, Aguilar, Ethan G, Sage, Peter T, Schumacher, Tanner, Thangavelu, Govindarajan, Zaiken, Michael C, Liu, Juan, Mereddy, Venkatram, Locasale, Jason W, Blazar, Bruce R

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Targeted gastrointestinal tract homing of regulatory T-cells reduces acute graft-versus-host disease severity by simulating an increase in Treg dose in vivo von Nicholls, Jemma H, Loschi, Michael, Jin, Sujeong, Wagers, Sara Bolivar, Thangavelu, Govindarajan, Zaiken, Michael C, McDonald-Hyman, Cameron, Saha, Asim, Aguliar, Ethan G, Koehn, Brent, Osborn, Mark J, MacDonald, Kelli P.A., Kim, Sangwon V, Littman, Dan R, Blazar, Bruce R

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Divergent roles of retinoic acid signaling in T regulatory cell function von Thangavelu, Govindarajan, Andrejeva, Gabriela, Loschi, Michael, Aguilar, Ethan G, Lee, Yu-Chi, Furlan, Scott N, McDonald-Hyman, Cameron, Zaiken, Michael C, Feser, Colby J, Panoskaltsis-Mortari, Angela, Kean, Leslie S, Rathmell, Jeffrey C, Chi, Hongbo, Noelle, Randolph J, Blazar, Bruce R

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Inhibiting EZH2 function prevents and treats chronic graft vs host disease (cGVHD) by disrupting germinal center formation and plasma cell maturation von Zaiken, Michael C, Flynn, Ryan, Paz, Katelyn, Rhee, Stephanie, Park, Paul, Hemming, Matthew, Sage, Peter, Sharpe, Arlene, Luznik, Leonard, Mailard, Ivan, Hill, Geoffrey R., MacDonald, Kelli, Serody, Jonathon, Cutler, Corey, Koreth, John, Miklos, David, Antin, Joseph, Soiffer, Robert, Ritz, Jerome, Bradner, Jay, Qi, Jun, Blazar, Bruce R.

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Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD von Koehn, Brent H., Saha, Asim, McDonald-Hyman, Cameron, Loschi, Michael, Thangavelu, Govindarajan, Ma, Lie, Zaiken, Michael, Dysthe, Josh, Krepps, Walker, Panthera, Jamie, Hippen, Keli, Jameson, Stephen C., Miller, Jeffrey S., Cooper, Matthew A., Farady, Christopher J., Iwawaki, Takao, Ting, Jenny P.-Y., Serody, Jonathan S., Murphy, William J., Hill, Geoffrey R., Murray, Peter J., Bronte, Vincenzo, Munn, David H., Zeiser, Robert, Blazar, Bruce R.

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Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease von Paz, Katelyn, Flynn, Ryan, Du, Jing, Tannheimer, Stacey, Johnson, Amy J., Dong, Shuai, Stark, Anne-Katrien, Okkenhaug, Klaus, Panoskaltsis-Mortari, Angela, Sage, Peter T., Sharpe, Arlene H., Luznik, Leo, Ritz, Jerome, Soiffer, Robert J., Cutler, Corey S., Koreth, John, Antin, Joseph H., Miklos, David B., MacDonald, Kelli P., Hill, Geoffrey R., Maillard, Ivan, Serody, Jonathan S., Murphy, William J., Munn, David H., Feser, Colby, Zaiken, Michael, Vanhaesebroeck, Bart, Turka, Laurence A., Byrd, John C., Blazar, Bruce R.

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A Critical Role for Donor-Derived IL-22 in Cutaneous Chronic Gvhd von Gartlan, Kate H, Bommiasamy, Hemamalini, Paz, Katelyn, Wilkinson, Andrew, Owen, Mary, Reichenbach, Dawn, Banovic, Tatjana, Wehner, Kimberly, Buchanan, Faith, Varelias, Antiopi, Kuns, Rachel, Chang, Karshing, Fedoriw, Yuri, Shea, Thomas C., Coghill, James M., Zaiken, Michael, Plank, Maximilian, Foster, Paul, Clouston, Andrew, Blazar, Bruce, Serody, Jonathan S, Hill, Geoffrey R

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Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease von Paz, Katelyn, Flynn, Ryan, Du, Jing, Tannheimer, Stacey, Johnson, Amy J, Dong, Shuai, Stark, Anne-Katrien, Okkenhaug, Klaus, Panoskaltsis-Mortari, Angela, Sage, Peter T, Sharpe, Arlene H, Luznik, Leo, Ritz, Jerome, Soiffer, Robert J, Cutler, Corey S, Koreth, John, Antin, Joseph H, Miklos, David B, MacDonald, Kelli P, Hill, Geoffrey R, Maillard, Ivan, Serody, Jonathan S, Murphy, William J, Munn, David H, Feser, Colby, Zaiken, Michael, Vanhaesebroeck, Bart, Turka, Laurence A, Byrd, John C, Blazar, Bruce R

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