Site-Specific Dolasynthen Antibody-Drug Conjugates Exhibit Consistent Pharmacokinetic Profiles across a Wide Range of Drug-to-Antibody Ratios von Clardy, Susan M, Uttard, Alex, Du, Bingfan, Catcott, Kalli C, Lancaster, Kelly L, Ditty, Elizabeth, Sadowsky, Jack, Zurita, Jeffrey, Malli, Naniye, Qin, LiuLiang, Bradley, Stephen P, Avocetien, Kenneth, Carter, Tyler, Kim, Dokyong, Nazzaro, Mark, Xu, Ling, Pillow, Thomas H, Zacharias, Neelie T, Lewis, Gail D, Rowntree, Rebecca K, Iyengar, Radha, Lee, David H, Damelin, Marc, Toader, Dorin, Lowinger, Timothy B

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Site-Specific Conjugation to Cys-Engineered THIOMAB™ Antibodies von Adhikari, Pragya, Zacharias, Neelie, Ohri, Rachana, Sadowsky, Jack

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LRRC15+ myofibroblasts dictate the stromal setpoint to suppress tumour immunity von Krishnamurty, Akshay T., Shyer, Justin A., Thai, Minh, Gandham, Vineela, Buechler, Matthew B., Yang, Yeqing Angela, Pradhan, Rachana N., Wang, Amber W., Sanchez, Patricia L., Qu, Yan, Breart, Beatrice, Chalouni, Cécile, Dunlap, Debra, Ziai, James, Elstrott, Justin, Zacharias, Neelie, Mao, Weiguang, Rowntree, Rebecca K., Sadowsky, Jack, Lewis, Gail D., Pillow, Thomas H., Nabet, Barzin Y., Banchereau, Romain, Tam, Lucinda, Caothien, Roger, Bacarro, Natasha, Roose-Girma, Merone, Modrusan, Zora, Mariathasan, Sanjeev, Müller, Sören, Turley, Shannon J.

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Development, Optimization, and Structural Characterization of an Efficient Peptide-Based Photoaffinity Cross-Linking Reaction for Generation of Homogeneous Conjugates from Wild-Typ... von Vance, Nicholas, Zacharias, Neelie, Ultsch, Mark, Li, Guangmin, Fourie, Aimee, Liu, Peter, LaFrance-Vanasse, Julien, Ernst, James A, Sandoval, Wendy, Kozak, Katherine R, Phillips, Gail, Wang, Weiru, Sadowsky, Jack

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A homogeneous high-DAR antibody-drug conjugate platform combining THIOMAB antibodies and XTEN polypeptides von Zacharias, Neelie, Podust, Vladimir N, Kajihara, Kimberly K, Leipold, Douglas, Del Rosario, Geoffrey, Thayer, Desiree, Dong, Emily, Paluch, Maciej, Fischer, David, Zheng, Kai, Lei, Corinna, He, Jintang, Ng, Carl, Su, Dian, Liu, Luna, Masih, Shabkhaiz, Sawyer, William, Tinianow, Jeff, Marik, Jan, Yip, Victor, Li, Guangmin, Chuh, Josefa, Morisaki, J Hiroshi, Park, Summer, Zheng, Bing, Hernandez-Barry, Hilda, Loyet, Kelly M, Xu, Min, Kozak, Katherine R, Phillips, Gail Lewis, Shen, Ben-Quan, Wu, Cong, Xu, Keyang, Yu, Shang-Fan, Kamath, Amrita, Rowntree, Rebecca K, Reilly, Dorothea, Pillow, Thomas, Polson, Andrew, Schellenberger, Volker, Hazenbos, Wouter L W, Sadowsky, Jack

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Development of a Cysteine-Conjugatable Disulfide FRET Probe: Influence of Charge on Linker Cleavage and Payload Trafficking for an Anti-HER2 Antibody Conjugate von Scales, Suzie J, Tsai, Siao Ping, Zacharias, Neelie, Cruz-Chuh, Josefa dela, Bullen, Gordy, Velasquez, Erick, Chang, Julie, Bruguera, Elise, Kozak, Katherine R, Sadowsky, Jack

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PHOTOCROSSLINKING PEPTIDES FOR SITE SPECIFIC CONJUGATION TO FC-CONTAINING PROTEINS von SADOWSKY JACK, ZACHARIAS NEELIE TYANA

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Abstract P167: Site-specific Dolasynthen ADCs demonstrate consistent exposure across a wide range of drug-to-antibody ratios von Catcott, Kalli C., Clardy, Susan, Sadowsky, Jack, Rowntree, Rebecca K., Centibas, Naniye Malli, Xu, Ling, Polson, Andy, Avocetien, Kenneth, Carter, Tyler, Nazzaro, Mark, Kim, Dokyong "DK", Pillow, Thomas H., Zacharias, Neelie, Wu, Cong, Zurita, Jeffrey, Ditty, Elizabeth, Bradley, Stephen, Uttard, Alex, Du, Bingfan, Sawyer, William S., Leipold, Doug, Phillips, Gail Lewis, Qin, LiuLiang, Slocum, Kelly, Rosario, Geoffrey Del, Li, Ginny, Yu, Shang-Fan, Lee, David, Iyengar, Radha, Damelin, Marc, Toader, Dorin, Lowinger, Timothy B.

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PHOTOCROSSLINKING PEPTIDES FOR SITE SPECIFIC CONJUGATION TO FC-CONTAINING PROTEINS von ZACHARIAS, Neelie Tyana, SADOWSKY, Jack

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PHOTOCROSSLINKING PEPTIDES FOR SITE SPECIFIC CONJUGATION TO FC-CONTAINING PROTEINS von ZACHARIAS, Neelie Tyana, SADOWSKY, Jack

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PHOTOCROSSLINKING PEPTIDES FOR SITE SPECIFIC CONJUGATION TO FC-CONTAINING PROTEINS von ZACHARIAS, Neelie Tyana, SADOWSKY, Jack

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