Results of a phase 1, randomized, placebo-controlled first-in-human trial of griffithsin formulated in a carrageenan vaginal gel von Teleshova, Natalia, Keller, Marla J, Fernández Romero, José A, Friedland, Barbara A, Creasy, George W, Plagianos, Marlena G, Ray, Laurie, Barnable, Patrick, Kizima, Larisa, Rodriguez, Aixa, Cornejal, Nadjet, Melo, Claudia, Cruz Rodriguez, Gearoff, Mukhopadhyay, Sampurna, Calenda, Giulia, Sinkar, Shweta U, Bonnaire, Thierry, Wesenberg, Asa, Zhang, Shimin, Kleinbeck, Kyle, Palmer, Kenneth, Alami, Mohcine, O'Keefe, Barry R, Gillevet, Patrick, Hur, Hong, Liang, Yupu, Santone, Gabriela, Fichorova, Raina N, Kalir, Tamara, Zydowsky, Thomas M

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Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo von Derby, Nina, Lal, Manjari, Aravantinou, Meropi, Kizima, Larisa, Barnable, Patrick, Rodriguez, Aixa, Lai, Manshun, Wesenberg, Asa, Ugaonkar, Shweta, Levendosky, Keith, Mizenina, Olga, Kleinbeck, Kyle, Lifson, Jeffrey D., Peet, M. Melissa, Lloyd, Zachary, Benson, Michael, Heneine, Walid, O’Keefe, Barry R, Robbiani, Melissa, Martinelli, Elena, Grasperge, Brooke, Blanchard, James, Gettie, Agegnehu, Teleshova, Natalia, Fernández-Romero, José A., Zydowsky, Thomas M.

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Griffithsin and Carrageenan Combination To Target Herpes Simplex Virus 2 and Human Papillomavirus von Levendosky, Keith, Mizenina, Olga, Martinelli, Elena, Jean-Pierre, Ninochka, Kizima, Larisa, Rodriguez, Aixa, Kleinbeck, Kyle, Bonnaire, Thierry, Robbiani, Melissa, Zydowsky, Thomas M, O'Keefe, Barry R, Fernández-Romero, José A

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Taking the daily grind out of HIV prevention von Zydowsky, Thomas M.

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Griffithsin and Carrageenan Combination Results in Antiviral Synergy against SARS-CoV-1 and 2 in a Pseudoviral Model von Alsaidi, Sahar, Cornejal, Nadjet, Mahoney, Oneil, Melo, Claudia, Verma, Neeharika, Bonnaire, Thierry, Chang, Theresa, O’Keefe, Barry R., Sailer, James, Zydowsky, Thomas M., Teleshova, Natalia, Romero, José A. Fernández

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A potent combination microbicide that targets SHIV-RT, HSV-2 and HPV von Kizima, Larisa, Rodríguez, Aixa, Kenney, Jessica, Derby, Nina, Mizenina, Olga, Menon, Radhika, Seidor, Samantha, Zhang, Shimin, Levendosky, Keith, Jean-Pierre, Ninochka, Pugach, Pavel, Villegas, Guillermo, Ford, Brian E, Gettie, Agegnehu, Blanchard, James, Piatak, Jr, Michael, Lifson, Jeffrey D, Paglini, Gabriela, Teleshova, Natalia, Zydowsky, Thomas M, Robbiani, Melissa, Fernández-Romero, José A

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An antiretroviral/zinc combination gel provides 24 hours of complete protection against vaginal SHIV infection in macaques von Kenney, Jessica, Aravantinou, Meropi, Singer, Rachel, Hsu, Mayla, Rodriguez, Aixa, Kizima, Larisa, Abraham, Ciby J, Menon, Radhika, Seidor, Samantha, Chudolij, Anne, Gettie, Agegnehu, Blanchard, James, Lifson, Jeffrey D, Piatak, Jr, Michael, Fernández-Romero, Jose A, Zydowsky, Thomas M, Robbiani, Melissa

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Zinc Acetate/Carrageenan Gels Exhibit Potent Activity In Vivo against High-Dose Herpes Simplex Virus 2 Vaginal and Rectal Challenge von Fernández-Romero, José A, Abraham, Ciby J, Rodriguez, Aixa, Kizima, Larisa, Jean-Pierre, Ninochka, Menon, Radhika, Begay, Othell, Seidor, Samantha, Ford, Brian E, Gil, Pedro I, Peters, Jennifer, Katz, David, Robbiani, Melissa, Zydowsky, Thomas M

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A Novel Microbicide/Contraceptive Intravaginal Ring Protects Macaque Genital Mucosa against SHIV-RT Infection Ex Vivo von Villegas, Guillermo, Calenda, Giulia, Ugaonkar, Shweta, Zhang, Shimin, Kizima, Larisa, Mizenina, Olga, Gettie, Agegnehu, Blanchard, James, Cooney, Michael L, Robbiani, Melissa, Fernández-Romero, José A, Zydowsky, Thomas M, Teleshova, Natalia

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A macaque model to study vaginal HSV-2/immunodeficiency virus co-infection and the impact of HSV-2 on microbicide efficacy von Crostarosa, Federica, Aravantinou, Meropi, Akpogheneta, Onome J, Jasny, Edith, Shaw, Andrew, Kenney, Jessica, Piatak, Michael, Lifson, Jeffrey D, Teitelbaum, Aaron, Hu, Lieyu, Chudolij, Anne, Zydowsky, Thomas M, Blanchard, James, Gettie, Agegnehu, Robbiani, Melissa

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A Modified Zinc Acetate Gel, a Potential Nonantiretroviral Microbicide, Is Safe and Effective against Simian-Human Immunodeficiency Virus and Herpes Simplex Virus 2 Infection In Vi... von KENNEY, Jessica, RODRIGUEZ, Aixa, BLANCHARD, James, PIATAK, Michael, LIFSON, Jeffrey D, PAGLINI, Gabriela, ZYDOWSKY, Thomas M, ROBBIANI, Melissa, FERNANDEZ ROMERO, José A, KIZIMA, Larisa, SEIDOR, Samantha, MENON, Radhika, JEAN-PIERRE, Ninochka, PUGACH, Pavel, LEVENDOSKY, Keith, DERBY, Nina, GETTIE, Agegnehu

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A fresh look at an old problem von Zydowsky, Thomas M

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Exposure to MIV-150 from a high-dose intravaginal ring results in limited emergence of drug resistance mutations in SHIV-RT infected rhesus macaques von Hsu, Mayla, Keele, Brandon F, Aravantinou, Meropi, Krawczyk, Noa, Seidor, Samantha, Abraham, Ciby J, Zhang, Shimin, Rodriguez, Aixa, Kizima, Larisa, Derby, Nina, Jean-Pierre, Ninochka, Mizenina, Olga, Gettie, Agegnehu, Grasperge, Brooke, Blanchard, James, Piatak, Jr, Michael J, Lifson, Jeffrey D, Fernández-Romero, José A, Zydowsky, Thomas M, Robbiani, Melissa

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A MIV-150/zinc acetate gel inhibits SHIV-RT infection in macaque vaginal explants von Barnable, Patrick, Calenda, Giulia, Ouattara, Louise, Gettie, Agegnehu, Blanchard, James, Jean-Pierre, Ninochka, Kizima, Larisa, Rodríguez, Aixa, Abraham, Ciby, Menon, Radhika, Seidor, Samantha, Cooney, Michael L, Roberts, Kevin D, Sperling, Rhoda, Piatak, Jr, Michael, Lifson, Jeffrey D, Fernandez-Romero, Jose A, Zydowsky, Thomas M, Robbiani, Melissa, Teleshova, Natalia

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A novel intravaginal ring to prevent HIV-1, HSV-2, HPV, and unintended pregnancy von Ugaonkar, Shweta R., Wesenberg, Asa, Wilk, Jolanta, Seidor, Samantha, Mizenina, Olga, Kizima, Larisa, Rodriguez, Aixa, Zhang, Shimin, Levendosky, Keith, Kenney, Jessica, Aravantinou, Meropi, Derby, Nina, Grasperge, Brooke, Gettie, Agegnehu, Blanchard, James, Kumar, Narender, Roberts, Kevin, Robbiani, Melissa, Fernández-Romero, José A., Zydowsky, Thomas M.

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Preclinical assessments of vaginal microbicide candidate safety and efficacy von Fernández-Romero, José A., Teleshova, Natalia, Zydowsky, Thomas M., Robbiani, Melissa

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First-in-Human Trial of MIV-150 and Zinc Acetate Coformulated in a Carrageenan Gel: Safety, Pharmacokinetics, Acceptability, Adherence, and Pharmacodynamics von Friedland, Barbara A, Hoesley, Craig J, Plagianos, Marlena, Hoskin, Elena, Zhang, Shimin, Teleshova, Natalia, Alami, Mohcine, Novak, Lea, Kleinbeck, Kyle R, Katzen, Lauren L, Zydowsky, Thomas M, Fernández-Romero, José A, Creasy, George W

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Antiviral activity of aframomum melegueta against severe acute respiratory syndrome coronaviruses type 1 and 2 von Mahoney, Oneil, Melo, Claudia, Lockhart, Anthony, Cornejal, Nadjet, Alsaidi, Sahar, Wu, Qingli, Simon, Jim, Juliani, Rodolfo, Zydowsky, Thomas M., Priano, Christine, Koroch, Adolfina, Fernández Romero, José A.

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MZC Gel Inhibits SHIV-RT and HSV-2 in Macaque Vaginal Mucosa and SHIV-RT in Rectal Mucosa von Calenda, Giulia, Villegas, Guillermo, Barnable, Patrick, Litterst, Claudia, Levendosky, Keith, Gettie, Agegnehu, Cooney, Michael L, Blanchard, James, Fernández-Romero, José A, Zydowsky, Thomas M, Teleshova, Natalia

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In Vitro Exposure to PC-1005 and Cervicovaginal Lavage Fluid from Women Vaginally Administered PC-1005 Inhibits HIV-1 and HSV-2 Infection in Human Cervical Mucosa von Villegas, Guillermo, Calenda, Giulia, Zhang, Shimin, Mizenina, Olga, Kleinbeck, Kyle, Cooney, Michael L, Hoesley, Craig J, Creasy, George W, Friedland, Barbara, Fernández-Romero, José A, Zydowsky, Thomas M, Teleshova, Natalia

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