BMS-345541 Is a Highly Selective Inhibitor of IκB Kinase That Binds at an Allosteric Site of the Enzyme and Blocks NF-κB-dependent Transcription in Mice von Burke, James R., Pattoli, Mark A., Gregor, Kurt R., Brassil, Patrick J., MacMaster, John F., McIntyre, Kim W., Yang, Xiaoxia, Iotzova, Violetta S., Clarke, Wendy, Strnad, Joann, Qiu, Yuping, Zusi, F. Christopher

Volltext

Design and Synthesis of a New Series of 4‑Heteroarylamino-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octanes as α7 Nicotinic Receptor Agonists. 1. Development of Pharmacophore and Earl... von Cook, James, Zusi, F. Christopher, McDonald, Ivar M, King, Dalton, Hill, Matthew D, Iwuagwu, Christiana, Mate, Robert A, Fang, Haiquan, Zhao, Rulin, Wang, Bei, Cutrone, Jingfang, Ma, Baoqing, Gao, Qi, Knox, Ronald J, Matchett, Michele, Gallagher, Lizbeth, Ferrante, Meredith, Post-Munson, Debra, Molski, Thaddeus, Easton, Amy, Miller, Regina, Jones, Kelli, Digavalli, Siva, Healy, Francine, Lentz, Kimberley, Benitex, Yulia, Clarke, Wendy, Natale, Joanne, Siuciak, Judith A, Lodge, Nicholas, Zaczek, Robert, Denton, Rex, Morgan, Daniel, Bristow, Linda J, Macor, John E, Olson, Richard E

Volltext

Design and synthesis of a novel series of 4-heteroarylamino-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octanes as α7 nicotinic receptor agonists 2. Development of 4-heteroaryl SAR von Iwuagwu, Christiana, King, Dalton, McDonald, Ivar M., Cook, James, Zusi, F. Christopher, Hill, Matthew D., Mate, Robert A., Fang, Haiquan, Knox, Ronald, Gallagher, Lizbeth, Post-Munson Amy Easton, Debra, Miller, Regina, Benitex, Yulia, Siuciak, Judy, Lodge, Nicholas, Zaczek, Robert, Morgan, Daniel, Bristow, Linda, Macor, John E., Olson, Richard E.

Volltext

Design and synthesis of a novel series of (1′S,2R,4′S)-3H-4′-azaspiro[benzo[4,5]imidazo[2,1-b]oxazole-2,2′-bicyclo[2.2.2]octanes] with high affinity for the α7 neuronal nicotinic r... von Cook, James, Zusi, F. Christopher, Hill, Matthew D., Fang, Haiquan, Pearce, Bradley, Park, Hyunsoo, Gallagher, Lizbeth, McDonald, Ivar M., Bristow, Linda, Macor, John E., Olson, Richard E.

Volltext

Triazolopyridine ethers as potent, orally active mGlu2 positive allosteric modulators for treating schizophrenia von Higgins, Mendi A., Marcin, Lawrence R., Christopher Zusi, F., Gentles, Robert, Ding, Min, Pearce, Bradley C., Easton, Amy, Kostich, Walter A., Seager, Matthew A., Bourin, Clotilde, Bristow, Linda J., Johnson, Kim A., Miller, Regina, Hogan, John, Whiterock, Valerie, Gulianello, Michael, Ferrante, Meredith, Huang, Yanling, Hendricson, Adam, Alt, Andrew, Macor, John E., Bronson, Joanne J.

Volltext

Development of 4‑Heteroarylamino-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octanes] as α7 Nicotinic Receptor Agonists von Hill, Matthew D, Fang, Haiquan, King, H. Dalton, Iwuagwu, Christiana I, McDonald, Ivar M, Cook, James, Zusi, F. Christopher, Mate, Robert A, Knox, Ronald J, Post-Munson, Debra, Easton, Amy, Miller, Regina, Lentz, Kimberley, Clarke, Wendy, Benitex, Yulia, Lodge, Nicholas, Zaczek, Robert, Denton, Rex, Morgan, Daniel, Bristow, Linda, Macor, John E, Olson, Richard

Volltext

BMS-933043, a Selective α7 nAChR Partial Agonist for the Treatment of Cognitive Deficits Associated with Schizophrenia von King, Dalton, Iwuagwu, Christiana, Cook, Jim, McDonald, Ivar M, Mate, Robert, Zusi, F. Christopher, Hill, Matthew D, Fang, Haiquan, Zhao, Rulin, Wang, Bei, Easton, Amy E, Miller, Regina, Post-Munson, Debra, Knox, Ronald J, Gallagher, Lizbeth, Westphal, Ryan, Molski, Thaddeus, Fan, Jingsong, Clarke, Wendy, Benitex, Yulia, Lentz, Kimberley A, Denton, Rex, Morgan, Daniel, Zaczek, Robert, Lodge, Nicholas J, Bristow, Linda J, Macor, John E, Olson, Richard E

Volltext

Discovery of a novel series of quinolone α7 nicotinic acetylcholine receptor agonists von McDonald, Ivar M., Mate, Robert A., Zusi, F. Christopher, Huang, Hong, Post-Munson, Debra J., Ferrante, Meredith A., Gallagher, Lizbeth, Bertekap, Robert L., Knox, Ronald J., Robertson, Barbara J., Harden, David G., Morgan, Daniel G., Lodge, Nicholas J., Dworetzky, Steven I., Olson, Richard E., Macor, John E.

Volltext

Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1 von Marcin, Lawrence R., Higgins, Mendi A., Zusi, F. Christopher, Zhang, Yunhui, Dee, Michael F., Parker, Michael F., Muckelbauer, Jodi K., Camac, Daniel M., Morin, Paul E., Ramamurthy, Vidhyashankar, Tebben, Andrew J., Lentz, Kimberley A., Grace, James E., Marcinkeviciene, Jovita A., Kopcho, Lisa M., Burton, Catherine R., Barten, Donna M., Toyn, Jeremy H., Meredith, Jere E., Albright, Charles F., Bronson, Joanne J., Macor, John E., Thompson, Lorin A.

Volltext

Rational design of RAR-selective ligands revealed by RARβ crystal stucture von Germain, Pierre, Kammerer, Sabrina, Pérez, Efrén, Peluso-Iltis, Carole, Tortolani, David, Zusi, F Christopher, Starrett, John, Lapointe, Philippe, Daris, Jean-Paul, Marinier, Anne, de Lera, Angel R, Rochel, Natacha, Gronemeyer, Hinrich

Volltext

Synthesis and biological evaluation of 4-amino derivatives of benzimidazoquinoxaline, benzimidazoquinoline, and benzopyrazoloquinazoline as potent IKK inhibitors von Beaulieu, Francis, Ouellet, Carl, Ruediger, Edward H., Belema, Makonen, Qiu, Yuping, Yang, Xuejie, Banville, Jacques, Burke, James R., Gregor, Kurt R., MacMaster, John F., Martel, Alain, McIntyre, Kim W., Pattoli, Mark A., Zusi, F. Christopher, Vyas, Dolatrai

Volltext

Selective retinoids and rexinoids in cancer therapy and chemoprevention von Zusi, F.Christopher, Lorenzi, Matthew V, Vivat-Hannah, Valerie

Volltext

Synthesis of 1,1-diarylethylenes from an α-stannyl β-silylstyrene von Belema, Makonen, Nguyen, Van N., Christopher Zusi, F.

Volltext

Design and synthesis of a novel series of (1′ S ,2 R ,4′ S )-3 H -4′-azaspiro[benzo[4,5]imidazo[2,1- b ]oxazole-2,2′-bicyclo[2.2.2]octanes] with high affinity for the α7 neuronal n... von Cook, James, Zusi, F. Christopher, Hill, Matthew D., Fang, Haiquan, Pearce, Bradley, Park, Hyunsoo, Gallagher, Lizbeth, McDonald, Ivar M., Bristow, Linda, Macor, John E., Olson, Richard E.

Volltext

Rational design of RAR-selective ligands revealed by RARbeta crystal stucture von Germain, Pierre, Kammerer, Sabrina, Pérez, Efrén, Peluso-Iltis, Carole, Tortolani, David, Zusi, F Christopher, Starrett, John, Lapointe, Philippe, Daris, Jean-Paul, Marinier, Anne, de Lera, Angel R, Rochel, Natacha, Gronemeyer, Hinrich

Volltext

Competitive, Reversible Inhibition of Cytosolic Phospholipase A2 at the Lipid-Water Interface by Choline Derivatives That Partially Partition into the Phospholipid Bilayer von Burke, J R, Witmer, M R, Zusi, F C, Gregor, K R, Davern, L B, Padmanabha, R, Swann, R T, Smith, D, Tredup, J A, Micanovic, R, Manly, S P, Villafranca, J J, Tramposch, K M

Volltext

A highly selective inhibitor of IκB kinase, BMS‐345541, blocks both joint inflammation and destruction in collagen‐induced arthritis in mice von McIntyre, Kim W., Shuster, David J., Gillooly, Kathleen M., Dambach, Donna M., Pattoli, Mark A., Lu, Pin, Zhou, Xia‐Di, Qiu, Yuping, Zusi, F. Christopher, Burke, James R.

Volltext

Development of 4-Heteroarylamino-1'-azaspirooxazole-5,3'-bicyclo2.2.2octanes as α7 Nicotinic Receptor Agonists von Hill, Matthew D, Fang, Haiquan, King, H Dalton, Iwuagwu, Christiana I, McDonald, Ivar M, Cook, James, Zusi, F Christopher, Mate, Robert A, Knox, Ronald J, Post-Munson, Debra, Easton, Amy, Miller, Regina, Lentz, Kimberley, Clarke, Wendy, Benitex, Yulia, Lodge, Nicholas, Zaczek, Robert, Denton, Rex, Morgan, Daniel, Bristow, Linda, Macor, John E, Olson, Richard

Volltext

Triazolopyridine ethers as potent, orally active mGlu 2 positive allosteric modulators for treating schizophrenia von Higgins, Mendi A, Marcin, Lawrence R, Christopher Zusi, F, Gentles, Robert, Ding, Min, Pearce, Bradley C, Easton, Amy, Kostich, Walter A, Seager, Matthew A, Bourin, Clotilde, Bristow, Linda J, Johnson, Kim A, Miller, Regina, Hogan, John, Whiterock, Valerie, Gulianello, Michael, Ferrante, Meredith, Huang, Yanling, Hendricson, Adam, Alt, Andrew, Macor, John E, Bronson, Joanne J

Volltext

Synergistic cytotoxicity exhibited by combination treatment of selective retinoid ligands with Taxol (paclitaxel) von VIVAT-HANNAH, Valerie, DAN YOU, RIZZO, Cheryl, DARIS, Jean-Paul, LAPOINTE, Philippe, ZUSI, F. Christopher, MARINIER, Anne, LORENZI, Matthew V, GOTTARDIS, Marco M

Volltext