Aggregation risk prediction for antibodies and its application to biotherapeutic development von Obrezanova, Olga, Arnell, Andreas, de la Cuesta, Ramón Gómez, Berthelot, Maud E, Gallagher, Thomas RA, Zurdo, Jesús, Stallwood, Yvette

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Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases von Bucciantini, Monica, Giannoni, Elisa, Chiti, Fabrizio, Baroni, Fabiana, Formigli, Lucia, Zurdo, Jesús, Taddei, Niccolò, Ramponi, Giampietro, Dobson, Christopher M., Stefani, Massimo

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De novo Designed Peptide-Based Amyloid Fibrils von de la Paz, Manuela López, Goldie, Kenneth, Zurdo, Jesús, Lacroix, Emmanuel, Dobson, Christopher M., Hoenger, Andreas, Serrano, Luis

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Molecular recycling within amyloid fibrils von Carulla, Natàlia, Caddy, Gemma L., Hall, Damien R., Zurdo, Jesús, Gairí, Margarida, Feliz, Miguel, Giralt, Ernest, Robinson, Carol V., Dobson, Christopher M.

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Toward a two-tier process-development paradigm: prototype versus commercial biomanufacturing von Zurdo, Jesús

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Short Amino Acid Stretches Can Mediate Amyloid Formation in Globular Proteins: The Src Homology 3 (SH3) Case von Ventura, Salvador, Zurdo, Jesús, Narayanan, Saravanakumar, Parreño, Matilde, Mangues, Ramón, Reif, Bernd, Chiti, Fabrizio, Giannoni, Elisa, Dobson, Christopher M., Aviles, Francesc X., Serrano, Luis, Fersht, Alan

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Prediction of the Absolute Aggregation Rates of Amyloidogenic Polypeptide Chains von DuBay, Kateri F., Pawar, Amol P., Chiti, Fabrizio, Zurdo, Jesús, Dobson, Christopher M., Vendruscolo, Michele

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Rational Design of Aggregation-Resistant Bioactive Peptides: Reengineering Human Calcitonin von Fowler, Susan B., Poon, Stephen, Muff, Roman, Chiti, Fabrizio, Dobson, Christopher M., Zurdo, Jesús, Wells, James A.

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Exploring Amyloid Formation by a de novo Design von Kammerer, Richard A., Kostrewa, Dirk, Zurdo, Jesús, Detken, Andreas, García-Echeverría, Carlos, Green, Janelle D., Müller, Shirley A., Meier, Beat H., Winkler, Fritz K., Dobson, Christopher M., Steinmetz, Michel O., Pollard, Thomas D.

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Cryo-electron microscopy structure of an SH3 amyloid fibril and model of the molecular packing von Jiménez, José L., Guijarro, J.Iñaki, Orlova, Elena, Zurdo, Jesús, Dobson, Christopher M., Sunde, Margaret, Saibil, Helen R.

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Early Implementation of QbD in Biopharmaceutical Development: A Practical Example von Abrahmsén, Lars, Höidén-Guthenberg, Ingmarie, Ekblad, Caroline, Michael, Rebecca, Gallagher, Thomas R. A., Gómez de la Cuesta, Ramón, Smith, Noel, Obrezanova, Olga, Arnell, Andreas, Zurdo, Jesús, Stallwood, Yvette

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Transition from Natively Unfolded to Folded State Induced by Desiccation in an Anhydrobiotic Nematode Protein von Goyal, Kshamata, Tisi, Laurence, Basran, Amrik, Browne, John, Burnell, Ann, Zurdo, Jesus, Tunnacliffe, Alan

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Probing the Mechanism of Amyloidogenesis through a Tandem Repeat of the PI3-SH3 Domain Suggests a Generic Model for Protein Aggregation and Fibril Formation von Bader, Reto, Bamford, Richard, Zurdo, Jesús, Luisi, Ben F., Dobson, Christopher M.

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Dependence on solution conditions of aggregation and amyloid formation by an SH3 domain von Zurdo, Jesús, Guijarro, J.I, Jiménez, Jose L, Saibil, Helen R, Dobson, Christopher M

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Protein folding and misfolding: a paradigm of self–assembly and regulation in complex biological systems von Vendruscolo, Michele, Zurdo, Jesús, MacPhee, Cait E., Dobson, Christopher M.

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Amyloid Fibril Formation and Seeding by Wild-Type Human Lysozyme and Its Disease-Related Mutational Variants von Morozova-Roche, Ludmilla A., Zurdo, Jesús, Spencer, Andrew, Noppe, Wim, Receveur, Veronique, Archer, David B., Joniau, Marcel, Dobson, Christopher M.

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Protein Aggregation and Amyloid Fibril Formation by an SH3 Domain Probed by Limited Proteolysis von Polverino de Laureto, Patrizia, Taddei, Niccolò, Frare, Erica, Capanni, Cristina, Costantini, Silvia, Zurdo, Jesús, Chiti, Fabrizio, Dobson, Christopher M., Fontana, Angelo

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Ultrastructural organization of amyloid fibrils by atomic force microscopy von Chamberlain, A K, MacPhee, C E, Zurdo, J, Morozova-Roche, L A, Hill, H A, Dobson, C M, Davis, J J

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Developability assessment as an early de-risking tool for biopharmaceutical development von Zurdo, Jesús

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Protein engineering as a strategy to avoid formation of amyloid fibrils von VILLEGAS, VIRTUDES, ZURDO, JESÚS, FILIMONOV, VLADIMIR V., AVILÉS, FRANCESC X., DOBSON, CHRISTOPHER M., SERRANO, LUIS

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