Properties and Functions of GAF Domains in Cyclic Nucleotide Phosphodiesterases and Other Proteins von Zoraghi, Roya, Corbin, Jackie D., Francis, Sharron H.

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Binding of Tritiated Sildenafil, Tadalafil, or Vardenafil to the Phosphodiesterase-5 Catalytic Site Displays Potency, Specificity, Heterogeneity, and cGMP Stimulation von Blount, Mitsi A, Beasley, Alfreda, Zoraghi, Roya, Sekhar, Konjeti R, Bessay, Emmanuel P, Francis, Sharron H, Corbin, Jackie D

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Structural and Functional Features in Human PDE5A1 Regulatory Domain That Provide for Allosteric cGMP Binding, Dimerization, and Regulation von Zoraghi, Roya, Bessay, Emmanuel P., Corbin, Jackie D., Francis, Sharron H.

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Identification of Pyruvate Kinase in Methicillin-Resistant Staphylococcus aureus as a Novel Antimicrobial Drug Target von ZORAGHI, Roya, SEE, Raymond H, AMANDORON, Emily, TIAN LIAN, JACKSON, Linda, JIHONG JIANG, THORSON, Lisa, LABRIERE, Christophe, FOSTER, Leonard, BRUNHAM, Robert C, MCMASTER, William R, FINLAY, B. Brett, AXERIO-CILIES, Peter, STRYNADKA, Natalie C, CHERKASOV, Artem, YOUNG, Robert N, REINER, Neil E, KUMAR, Nag S, HUANSHENG GONG, MOREAU, Anne, HSING, Michael, KAUR, Sukhbir, SWAYZE, Richard D, WORRALL, Liam

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Mapping the Protein Interaction Network in Methicillin-Resistant Staphylococcus aureus von Cherkasov, Artem, Hsing, Michael, Zoraghi, Roya, Foster, Leonard J, See, Raymond H, Stoynov, Nikolay, Jiang, Jihong, Kaur, Sukhbir, Lian, Tian, Jackson, Linda, Gong, Huansheng, Swayze, Rick, Amandoron, Emily, Hormozdiari, Farhad, Dao, Phuong, Sahinalp, Cenk, Santos-Filho, Osvaldo, Axerio-Cilies, Peter, Byler, Kendall, McMaster, William R, Brunham, Robert C, Finlay, B. Brett, Reiner, Neil E

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The cAMP-Specific Phosphodiesterase TbPDE2C is an Essential Enzyme in Bloodstream Form Trypanosoma brucei von Zoraghi, Roya, Seebeck, Thomas

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A 46-Amino Acid Segment in Phosphodiesterase-5 GAF-B Domain Provides for High Vardenafil Potency over Sildenafil and Tadalafil and Is Involved in Phosphodiesterase-5 Dimerization von Blount, Mitsi A, Zoraghi, Roya, Ke, Hengming, Bessay, Emmanuel P, Corbin, Jackie D, Francis, Sharron H

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Protein interaction networks as starting points to identify novel antimicrobial drug targets von Zoraghi, Roya, Reiner, Neil E

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Phosphodiesterase-5 Gln817 Is Critical for cGMP, Vardenafil, or Sildenafil Affinity von Zoraghi, Roya, Corbin, Jackie D., Francis, Sharron H.

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Characterization of TbPDE2A, a Novel Cyclic Nucleotide-specific Phosphodiesterase from the Protozoan Parasite Trypanosoma brucei von Zoraghi, Roya, Kunz, Stefan, Gong, Kewei, Seebeck, Thomas

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Methicillin-resistant Staphylococcus aureus (MRSA) Pyruvate Kinase as a Target for Bis-indole Alkaloids with Antibacterial Activities von Zoraghi, Roya, Worrall, Liam, See, Raymond H., Strangman, Wendy, Popplewell, Wendy L., Gong, Huansheng, Samaai, Toufiek, Swayze, Richard D., Kaur, Sukhbir, Vuckovic, Marija, Finlay, B. Brett, Brunham, Robert C., McMaster, William R., Davies-Coleman, Michael T., Strynadka, Natalie C., Andersen, Raymond J., Reiner, Neil E.

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Multiple Conformations of Phosphodiesterase-5 von Wang, Huanchen, Liu, Yudong, Huai, Qing, Cai, Jiwen, Zoraghi, Roya, Francis, Sharron H., Corbin, Jackie D., Robinson, Howard, Xin, Zhongcheng, Lin, Guiting, Ke, Hengming

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Novel inhibitors of the methicillin-resistant Staphylococcus aureus (MRSA)-pyruvate kinase von El-Sayed, Mardia Telep, Zoraghi, Roya, Reiner, Neil, Suzen, Sibel, Ohlsen, Knut, Lalk, Michael, Altanlar, Nurten, Hilgeroth, Andreas

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Synthesis and MRSA PK inhibitory activity of thiazole containing deoxytopsentin analogues von Veale, Clinton G.L., Lobb, Kevin A., Zoraghi, Roya, Morrison, James P., Reiner, Neil E., Andersen, Raymond J., Davies-Coleman, Michael T.

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Multiple Conformations of Phosphodiesterase-5: IMPLICATIONS FOR ENZYME FUNCTION AND DRUG DEVELOPMENT von Wang, Huanchen, Liu, Yudong, Huai, Qing, Cai, Jiwen, Zoraghi, Roya, Francis, Sharron H, Corbin, Jackie D, Robinson, Howard, Xin, Zhongcheng, Lin, Guiting, Ke, Hengming

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Synthetic Analogues of the Marine Bisindole Deoxytopsentin: Potent Selective Inhibitors of MRSA Pyruvate Kinase von Veale, Clinton G. L, Zoraghi, Roya, Young, Ryan M, Morrison, James P, Pretheeban, Manoja, Lobb, Kevin A, Reiner, Neil E, Andersen, Raymond J, Davies-Coleman, Michael T

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Functional Analysis, Overexpression, and Kinetic Characterization of Pyruvate Kinase from Methicillin-Resistant Staphylococcus aureus von Zoraghi, Roya, See, Raymond H, Gong, Huansheng, Lian, Tian, Swayze, Rick, Finlay, B. Brett, Brunham, Robert C, McMaster, William R, Reiner, Neil E

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Discovery and optimization of a new class of pyruvate kinase inhibitors as potential therapeutics for the treatment of methicillin-resistant Staphylococcus aureus infections von Kumar, Nag S., Dullaghan, Edie M., Finlay, B. Brett, Gong, Huansheng, Reiner, Neil E., Jon Paul Selvam, J., Thorson, Lisa M., Campbell, Sara, Vitko, Nicholas, Richardson, Anthony R., Zoraghi, Roya, Young, Robert N.

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Discovery of a 1,2-bis(3-indolyl)ethane that selectively inhibits the pyruvate kinase of methicillin-resistant Staphylococcus aureus over human isoforms von Zoraghi, Roya, Campbell, Sara, Kim, Catrina, Dullaghan, Edie M., Blair, Lachlan M., Gillard, Rachel M., Reiner, Neil E., Sperry, Jonathan

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Critical Amino Acids in Phosphodiesterase-5 Catalytic Site That Provide for High-Affinity Interaction with Cyclic Guanosine Monophosphate and Inhibitors von Zoraghi, Roya, Francis, Sharron H, Corbin, Jackie D

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