Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor von Cumming, Jared N., Smith, Elizabeth M., Wang, Lingyan, Misiaszek, Jeffrey, Durkin, James, Pan, Jianping, Iserloh, Ulrich, Wu, Yusheng, Zhu, Zhaoning, Strickland, Corey, Voigt, Johannes, Chen, Xia, Kennedy, Matthew E., Kuvelkar, Reshma, Hyde, Lynn A., Cox, Kathleen, Favreau, Leonard, Czarniecki, Michael F., Greenlee, William J., McKittrick, Brian A., Parker, Eric M., Stamford, Andrew W.

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An orally available small molecule that targets soluble TNF to deliver anti-TNF biologic-like efficacy in rheumatoid arthritis von Vugler, Alexander, O'Connell, James, Nguyen, Mai Anh, Weitz, Dietmar, Leeuw, Thomas, Hickford, Elizabeth, Verbitsky, Alexander, Ying, Xiaoyou, Rehberg, Markus, Carrington, Bruce, Merriman, Mark, Moss, Andrew, Nicholas, Jean-Marie, Stanley, Phil, Wright, Sara, Bourne, Tim, Foricher, Yann, Zhu, Zhaoning, Brookings, Daniel, Horsley, Helen, Heer, Jag, Schio, Laurent, Herrmann, Matthias, Rao, Srinivas, Kohlmann, Markus, Florian, Peter

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Discovery of Cyclic Acylguanidines as Highly Potent and Selective β-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part IInhibitor Design and Validation von Zhu, Zhaoning, Sun, Zhong-Yue, Ye, Yuanzan, Voigt, Johannes, Strickland, Corey, Smith, Elizabeth M, Cumming, Jared, Wang, Lingyan, Wong, Jesse, Wang, Yu-Sen, Wyss, Daniel F, Chen, Xia, Kuvelkar, Reshma, Kennedy, Matthew E, Favreau, Leonard, Parker, Eric, McKittrick, Brian A, Stamford, Andrew, Czarniecki, Michael, Greenlee, William, Hunter, John C

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Corrigendum: An orally available small molecule that targets soluble TNF to deliver anti-TNF biologic-like efficacy in rheumatoid arthritis von Vugler, Alexander, O'connell, James, Nguyen, Mai Anh, Weitz, Dietmar, Leeuw, Thomas, Hickford, Elizabeth, Verbitsky, Alexander, Ying, Xiaoyou, Rehberg, Markus, Carrington, Bruce, Merriman, Mark, Moss, Andrew, Nicolas, Jean-Marie, Stanley, Phil, Wright, Sara, Bourne, Tim, Foricher, Yann, Zhu, Zhaoning, Brookings, Daniel, Horsley, Helen, Heer, Jag, Schio, Laurent, Herrmann, Matthias, Rao, Srinivas, Kohlmann, Markus, Florian, Peter

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Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme‑1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation von Mandal, Mihirbaran, Zhu, Zhaoning, Cumming, Jared N, Liu, Xiaoxiang, Strickland, Corey, Mazzola, Robert D, Caldwell, John P, Leach, Prescott, Grzelak, Michael, Hyde, Lynn, Zhang, Qi, Terracina, Giuseppe, Zhang, Lili, Chen, Xia, Kuvelkar, Reshma, Kennedy, Matthew E, Favreau, Leonard, Cox, Kathleen, Orth, Peter, Buevich, Alexei, Voigt, Johannes, Wang, Hongwu, Kazakevich, Irina, McKittrick, Brian A, Greenlee, William, Parker, Eric M, Stamford, Andrew W

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Iminoheterocycle as a druggable motif: BACE1 inhibitors and beyond von Zhu, Zhaoning

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Iminoheterocycles as γ-secretase modulators von Caldwell, John P., Bennett, Chad E., McCracken, Troy M., Mazzola, Robert D., Bara, Thomas, Buevich, Alexei, Burnett, Duane A., Chu, Inhou, Cohen-Williams, Mary, Josein, Hubert, Hyde, Lynn, Lee, Julie, McKittrick, Brian, Song, Lixin, Terracina, Giuseppe, Voigt, Johannes, Zhang, Lili, Zhu, Zhaoning

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Discovery of Novel Hydroxamates as Highly Potent Tumor Necrosis Factor-α Converting Enzyme Inhibitors: Part IDiscovery of Two Binding Modes von Zhu, Zhaoning, Mazzola, Robert, Sinning, Lisa, McKittrick, Brian, Niu, Xiaoda, Lundell, Daniel, Sun, Jing, Orth, Peter, Guo, Zhuyan, Madison, Vincent, Ingram, Richard, Beyer, Brian M

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Discovery of fused 5,6-bicyclic heterocycles as γ-secretase modulators von Qin, Jun, Dhondi, Pawan, Huang, Xianhai, Mandal, Mihirbaran, Zhao, Zhiqiang, Pissarnitski, Dmitri, Zhou, Wei, Aslanian, Robert, Zhu, Zhaoning, Greenlee, William, Clader, John, Zhang, Lili, Cohen-Williams, Mary, Jones, Nicholas, Hyde, Lynn, Palani, Anandan

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Design and discovery of 1,3-benzodiazepines as novel dopamine antagonists von Zhu, Zhaoning, Sun, Zhong-Yue, Ye, Yuanzan, McKittrick, Brian, Greenlee, William, Czarniecki, Michael, Fawzi, Ahmad, Zhang, Hongtao, Lachowicz, Jean E.

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Discovery and SAR of cyclic isothioureas as novel NPY Y1 receptor antagonists von SUN, Zhong-Yue, ZHAONING ZHU, YUANZAN YE, MCKITTRICK, Brian, CZARNIECKI, Michael, GREENLEE, William, MULLINS, Deborra, GUZZI, Mario

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Structure and activity relationships of tartrate-based TACE inhibitors von Li, Dansu, Popovici-Muller, Janeta, Belanger, David B., Caldwell, John, Dai, Chaoyang, David, Maria, Girijavallabhan, Vinay M., Lavey, Brian J., Lee, Joe F., Liu, Zhidan, Mazzola, Rob, Rizvi, Razia, Rosner, Kristin E., Shankar, Bandarpalle, Spitler, Jim, Ting, Pauline C., Vaccaro, Henry, Yu, Wensheng, Zhou, Guowei, Zhu, Zhaoning, Niu, Xiaoda, Sun, Jing, Guo, Zhuyan, Orth, Peter, Chen, Shiying, Kozlowski, Joseph A., Lundell, Daniel J., Madison, Vincent, McKittrick, Brian, Piwinski, John J., Shih, Neng-Yang, Shipps, Gerald W., Siddiqui, M. Arshad, Strickland, Corey O.

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Generation of Leads for γ‑Secretase Modulation von Mandal, Mihirbaran, Buevich, Alexei, Caldwell, John P, Hyde, Lynn, Huang, Xianhai, Liu, Xiaoxiang, McKittrick, Brian, Mazzola, Robert D, Pissarnitski, Dmitri, Palani, Anandan, Zhang, Lili, Parker, Eric, Xiao, Li, Rindgen, Diane, Zhu, Zhaoning

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Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362 von Lowe, Martin A., Cardenas, Alvaro, Valentin, Jean-Pierre, Zhu, Zhaoning, Abendroth, Jan, Castro, Jose L., Class, Reiner, Delaunois, Annie, Fleurance, Renaud, Gerets, Helga, Gryshkova, Vitalina, King, Lloyd, Lorimer, Donald D., MacCoss, Malcolm, Rowley, Julian H., Rosseels, Marie-Luce, Royer, Leandro, Taylor, Richard D., Wong, Melanie, Zaccheo, Oliver, Chavan, Vishal P., Ghule, Gokul A., Tapkir, Bapusaheb K., Burrows, Jeremy N., Duffey, Maëlle, Rottmann, Matthias, Wittlin, Sergio, Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Striepen, Josefine, Fairhurst, Kate J., Yeo, Tomas, Fidock, David A., Cowman, Alan F., Favuzza, Paola, Crespo-Fernandez, Benigno, Gamo, Francisco Javier, Goldberg, Daniel E., Soldati-Favre, Dominique, Laleu, Benoît, de Haro, Teresa

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Unprecedented Reversal of Regioselectivity during Methanolysis and an Interception of Curtius Rearrangement von Mandal, Mihirbaran, Buevich, Alexei V., Wang, Hongwu, Brunskill, Andrew, Orth, Peter, Caldwell, John P., Liu, Xiaoxiang, Mazzola, Robert, Cumming, Jared, McKittrick, Brian, Zhu, Zhaoning, Stamford, Andrew

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Quantitative Antihydrophobic Effects as Probes for Transition State Structures. 2. Diels-Alder Reactions von Breslow, Ronald, Zhu, Zhaoning

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Lead Optimization to Advance Protease-Activated Receptor‑1 Antagonists in Early Discovery von Mandal, Mihirbaran, Madeira, Maria, Amin, Rupesh P, Buevich, Alexei V, Cheng, Alan, Labroli, Marc, Liu, Xiaoxiang, Acton, John, Pio, Barbara, Basso, Andrea, Chobanian, Harry, Dong, Grace, Dropinski, Jamie, Guo, Yan, Guo, Zhuyan, Kurowski, Stan, Korfmacher, Walter, Lee, Sandra, Meng, Dongfang, Ondeyka, Debra, Yang, Zhiqiang, Zhang, Rumin, Wei, Huijun, Wu, Zhicai, Zhang, Fengqi, Wollenberg, Gordon, Biftu, Tesfaye, Greenlee, William J, Chintala, Madhu, Maletic, Milana, Zhu, Zhaoning

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Structure-Based Design of an Iminoheterocyclic β‑Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates von Mandal, Mihirbaran, Wu, Yusheng, Misiaszek, Jeffrey, Li, Guoqing, Buevich, Alexei, Caldwell, John P, Liu, Xiaoxiang, Mazzola, Robert D, Orth, Peter, Strickland, Corey, Voigt, Johannes, Wang, Hongwu, Zhu, Zhaoning, Chen, Xia, Grzelak, Michael, Hyde, Lynn A, Kuvelkar, Reshma, Leach, Prescott T, Terracina, Giuseppe, Zhang, Lili, Zhang, Qi, Michener, Maria S, Smith, Brad, Cox, Kathleen, Grotz, Diane, Favreau, Leonard, Mitra, Kaushik, Kazakevich, Irina, McKittrick, Brian A, Greenlee, William, Kennedy, Matthew E, Parker, Eric M, Cumming, Jared N, Stamford, Andrew W

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Overcoming Time-Dependent Inhibition (TDI) of Cytochrome P450 3A4 (CYP3A4) Resulting from Bioactivation of a Fluoropyrimidine Moiety von Mandal, Mihirbaran, Mitra, Kaushik, Grotz, Diane, Lin, Xinjie, Palamanda, Jairam, Kumari, Pramila, Buevich, Alexei, Caldwell, John P, Chen, Xia, Cox, Kathleen, Favreau, Leonard, Hyde, Lynn, Kennedy, Matthew E, Kuvelkar, Reshma, Liu, Xiaoxiang, Mazzola, Robert D, Parker, Eric, Rindgen, Diane, Sherer, Edward, Wang, Hongwu, Zhu, Zhaoning, Stamford, Andrew W, Cumming, Jared N

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Cyclic Hydroxyamidines as Amide Isosteres: Discovery of Oxadiazolines and Oxadiazines as Potent and Highly Efficacious γ-Secretase Modulators in Vivo von Sun, Zhong-Yue, Asberom, Theodros, Bara, Thomas, Bennett, Chad, Burnett, Duane, Chu, Inhou, Clader, John, Cohen-Williams, Mary, Cole, David, Czarniecki, Michael, Durkin, James, Gallo, Gioconda, Greenlee, William, Josien, Hubert, Huang, Xianhai, Hyde, Lynn, Jones, Nicholas, Kazakevich, Irina, Li, Hongmei, Liu, Xiaoxiang, Lee, Julie, MacCoss, Malcolm, Mandal, Mihir B, McCracken, Troy, Nomeir, Amin, Mazzola, Robert, Palani, Anandan, Parker, Eric M, Pissarnitski, Dmitri A, Qin, Jun, Song, Lixin, Terracina, Giuseppe, Vicarel, Monica, Voigt, Johannes, Xu, Ruo, Zhang, Lili, Zhang, Qi, Zhao, Zhiqiang, Zhu, Xiaohong, Zhu, Zhaoning

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