Discovery and Optimization of Potent GPR40 Full Agonists Containing Tricyclic Spirocycles von Wang, Yingcai, Liu, Jiwen (Jim), Dransfield, Paul J, Zhu, Liusheng, Wang, Zhongyu, Du, Xiaohui, Jiao, Xianyun, Su, Yongli, Li, An-rong, Brown, Sean P, Kasparian, Annie, Vimolratana, Marc, Yu, Ming, Pattaropong, Vatee, Houze, Jonathan B, Swaminath, Gayathri, Tran, Thanhvien, Nguyen, Khanh, Guo, Qi, Zhang, Jane, Zhuang, Run, Li, Frank, Miao, Lynn, Bartberger, Michael D, Correll, Tiffany L, Chow, David, Wong, Simon, Luo, Jian, Lin, Daniel C.-H, Medina, Julio C

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Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3 von Johnson, Michael, Li, An-Rong, Liu, Jiwen, Fu, Zice, Zhu, Liusheng, Miao, Shichang, Wang, Xuemei, Xu, Qingge, Huang, Alan, Marcus, Andrew, Xu, Feng, Ebsworth, Karen, Sablan, Emmanuel, Danao, Jay, Kumer, Jeff, Dairaghi, Dan, Lawrence, Chris, Sullivan, Tim, Tonn, George, Schall, Thomas, Collins, Tassie, Medina, Julio

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AMG 837: A potent, orally bioavailable GPR40 agonist von Houze, Jonathan B., Zhu, Liusheng, Sun, Ying, Akerman, Michelle, Qiu, Wei, Zhang, Alex J., Sharma, Rajiv, Schmitt, Michael, Wang, Yingcai, Liu, Jiwen, Liu, Jinqian, Medina, Julio C., Reagan, Jeff D., Luo, Jian, Tonn, George, Zhang, Jane, Lu, Jenny Ying-Lin, Chen, Michael, Lopez, Edwin, Nguyen, Kathy, Yang, Li, Tang, Liang, Tian, Hui, Shuttleworth, Steven J., Lin, Daniel C.-H.

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A mild preparation of substituted indolizines and indole from simple aromatic precursors using (trimethylsilyl)diazomethane von Zhu, Liusheng, Vimolratana, Marc, Brown, Sean P., Medina, Julio C.

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Optimization of a series of quinazolinone-derived antagonists of CXCR3 von Liu, Jiwen, Fu, Zice, Li, An-Rong, Johnson, Michael, Zhu, Liusheng, Marcus, Andrew, Danao, Jay, Sullivan, Tim, Tonn, George, Collins, Tassie, Medina, Julio

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Discovery and optimization of a novel series of liver X receptor-α agonists von Li, Leping, Liu, Jiwen, Zhu, Liusheng, Cutler, Serena, Hasegawa, Hirohiko, Shan, Bei, Medina, Julio C.

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Optimization of the heterocyclic core of the quinazolinone-derived CXCR3 antagonists von Li, An-Rong, Johnson, Michael G., Liu, Jiwen, Chen, Xiaoqi, Du, Xiaohui, Mihalic, Jeffrey T., Deignan, Jeffrey, Gustin, Darin J., Duquette, Jason, Fu, Zice, Zhu, Liusheng, Marcus, Andrew P., Bergeron, Phillipe, McGee, Lawrence R., Danao, Jay, Lemon, Bryan, Carabeo, Teresa, Sullivan, Timothy, Ma, Ji, Tang, Liang, Tonn, George, Collins, Tassie L., Medina, Julio C.

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AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies von Caenepeel, Sean, Brown, Sean P, Belmontes, Brian, Moody, Gordon, Keegan, Kathleen S, Chui, Danny, Whittington, Douglas A, Huang, Xin, Poppe, Leszek, Cheng, Alan C, Cardozo, Mario, Houze, Jonathan, Li, Yunxiao, Lucas, Brian, Paras, Nick A, Wang, Xianghong, Taygerly, Joshua P, Vimolratana, Marc, Zancanella, Manuel, Zhu, Liusheng, Cajulis, Elaina, Osgood, Tao, Sun, Jan, Damon, Leah, Egan, Regina K, Greninger, Patricia, McClanaghan, Joseph D, Gong, Jianan, Moujalled, Donia, Pomilio, Giovanna, Beltran, Pedro, Benes, Cyril H, Roberts, Andrew W, Huang, David C, Wei, Andrew, Canon, Jude, Coxon, Angela, Hughes, Paul E

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Optimization of 2-aminothiazole derivatives as CCR4 antagonists von Wang, Xuemei, Xu, Feng, Xu, Qingge, Mahmud, Hossen, Houze, Jonathan, Zhu, Liusheng, Akerman, Michelle, Tonn, George, Tang, Liang, McMaster, Brian E., Dairaghi, Daniel J., Schall, Thomas J., Collins, Tassie L., Medina, Julio C.

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Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101) von Rew, Yosup, Du, Xiaohui, Eksterowicz, John, Zhou, Haiying, Jahchan, Nadine, Zhu, Liusheng, Yan, Xuelei, Kawai, Hiroyuki, McGee, Lawrence R, Medina, Julio C, Huang, Tom, Chen, Chelsea, Zavorotinskaya, Tatiana, Sutimantanapi, Dena, Waszczuk, Joanna, Jackson, Erica, Huang, Elizabeth, Ye, Qiuping, Fantin, Valeria R, Sun, Daqing

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Discovery of a Potent Steroidal Glucocorticoid Receptor Antagonist with Enhanced Selectivity against the Progesterone and Androgen Receptors (OP-3633) von Du, Xiaohui, Eksterowicz, John, Zhou, Haiying, Rew, Yosup, Zhu, Liusheng, Yan, Xuelei, Medina, Julio C, Huang, Tom, Chen, Xi, Sutimantanapi, Dena, Jahchan, Nadine, Kong, Wayne, Sun, Jessica, Zavorotinskaya, Tatiana, Ye, Qiuping, Fantin, Valeria R, Sun, Daqing

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Abstract A133: Development of murine models to evaluate the impact of glucocorticoid receptor (GR) inhibition on chemotherapy response von Jahchan, Nadine, Zhou, Haiying, Stice, James, Kong, Wayne, McWeeney, Dan, Sun, Daqing, Rew, Yosup, Du, Xiaohui, Zhu, Liusheng, Ye, Qiuping, Jackson, Erica L., Fantin, Valeria

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Abstract 4172: Activation of AR signaling by mifepristone enhances prostate cancer growth and impairs enzalutamide response von Zhou, Haiying, Jachan, Nadine, Singh, Mallika, Tran, Chris, McWeeney, Dan, Balbas, Minna, Schenkein, Emily, Zovorotinskaya, Tatiana, Jackson, Erica L., Medina, Julio, Sun, Daqing, Rew, Yosup, Du, Xiaohui, Eksterowicz, John, Yan, Xuelei, Zhu, Liusheng, Ye, Qiuping, Fantin, Valeria

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Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist von Brown, Sean P, Dransfield, Paul J, Vimolratana, Marc, Jiao, XianYun, Zhu, Liusheng, Pattaropong, Vatee, Sun, Ying, Liu, Jinqian, Luo, Jian, Zhang, Jane, Wong, Simon, Zhuang, Run, Guo, Qi, Li, Frank, Medina, Julio C, Swaminath, Gayathri, Lin, Daniel C.-H, Houze, Jonathan B

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Discovery of the imidazole-derived GPR40 agonist AM-3189 von Ma, Zhihua, Lin, Daniel C.-H., Sharma, Rajiv, Liu, Jinqian, Zhu, Liusheng, Li, An-Rong, Kohn, Todd, Wang, Yingcai, Liu, Jiwen (Jim), Bartberger, Michael D., Medina, Julio C., Zhuang, Run, Li, Frank, Zhang, Jane, Luo, Jian, Wong, Simon, Tonn, George R., Houze, Jonathan B.

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Discovery of AM-6226: A Potent and Orally Bioavailable GPR40 Full Agonist That Displays Efficacy in Nonhuman Primates von Brown, Sean P., Dransfield, Paul, Vimolratana, Marc, Zhu, Liusheng, Luo, Jian, Zhang, Jane, Jiao, XianYun, Pattaropong, Vatee, Wong, Simon, Zhuang, Run, Swaminath, Gayathri, Houze, Jonathan B., Lin, Daniel C.-H.

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Optimization of GPR40 Agonists for Type 2 Diabetes von Liu, Jiwen (Jim), Wang, Yingcai, Ma, Zhihua, Schmitt, Mike, Zhu, Liusheng, Brown, Sean P, Dransfield, Paul J, Sun, Ying, Sharma, Rajiv, Guo, Qi, Zhuang, Run, Zhang, Jane, Luo, Jian, Tonn, George R, Wong, Simon, Swaminath, Gayathri, Medina, Julio C, Lin, Daniel C.-H, Houze, Jonathan B

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Improving the Pharmacokinetics of GPR40/FFA1 Full Agonists von Du, Xiaohui, Dransfield, Paul J, Lin, Daniel C.-H, Wong, Simon, Wang, Yingcai, Wang, Zhongyu, Kohn, Todd, Yu, Ming, Brown, Sean P, Vimolratana, Marc, Zhu, Liusheng, Li, An-Rong, Su, Yongli, Jiao, Xianyun, Liu, Jiwen (Jim), Swaminath, Gayathri, Tran, Thanhvien, Luo, Jian, Zhuang, Run, Zhang, Jane, Guo, Qi, Li, Frank, Connors, Richard, Medina, Julio C, Houze, Jonathan B

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Film conveying belt for cotton picker von ZHU LIUSHENG

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Cotton picker packing belt with wear-resistant layers on side edges von ZHU LIUSHENG

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