Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation von Zhu, Guangya, Xie, Jingjing, Kong, Wenna, Xie, Jingfei, Li, Yichen, Du, Lin, Zheng, Qiangang, Sun, Lin, Guan, Mingfeng, Li, Huan, Zhu, Tianxin, He, Hao, Liu, Zhenying, Xia, Xi, Kan, Chen, Tao, Youqi, Shen, Hong C., Li, Dan, Wang, Siying, Yu, Yongguo, Yu, Zhi-Hong, Zhang, Zhong-Yin, Liu, Cong, Zhu, Jidong

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Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1 von Zhu, Jidong, Blenis, John, Yuan, Junying

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Pharmacological inhibition of SRC-1 phase separation suppresses YAP oncogenic transcription activity von Zhu, Guangya, Xie, Jingjing, Fu, Zhenzhen, Wang, Mingliang, Zhang, Qichen, He, Hao, Chen, Zijun, Guo, Xin, Zhu, Jidong

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Decoding the genomic landscape of chromatin-associated biomolecular condensates von Yu, Zhaowei, Wang, Qi, Zhang, Qichen, Tian, Yawen, Yan, Guo, Zhu, Jidong, Zhu, Guangya, Zhang, Yong

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Targeting MLL1 H3K4 Methyltransferase Activity in Mixed-Lineage Leukemia von Cao, Fang, Townsend, Elizabeth C., Karatas, Hacer, Xu, Jing, Li, Li, Lee, Shirley, Liu, Liu, Chen, Yong, Ouillette, Peter, Zhu, Jidong, Hess, Jay L., Atadja, Peter, Lei, Ming, Qin, Zhaohui S., Malek, Sami, Wang, Shaomeng, Dou, Yali

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Radical-Induced Metal-Free Alkynylation of Aldehydes by Direct CH Activation von Liu, Xuesong, Yu, Linqian, Luo, Mupeng, Zhu, Jidong, Wei, Wanguo

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Histone methyltransferase SETDB1 regulates liver cancer cell growth through methylation of p53 von Fei, Qi, Shang, Ke, Zhang, Jianhua, Chuai, Shannon, Kong, Desheng, Zhou, Tianlun, Fu, Shijun, Liang, Ying, Li, Chong, Chen, Zhi, Zhao, Yuan, Yu, Zhengtian, Huang, Zheng, Hu, Min, Ying, Haiyan, Chen, Zhui, Zhang, Yun, Xing, Feng, Zhu, Jidong, Xu, Haiyan, Zhao, Kehao, Lu, Chris, Atadja, Peter, Xiao, Zhi-Xiong, Li, En, Shou, Jianyong

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Protein O-GlcNAcylation coupled to Hippo signaling drives vascular dysfunction in diabetic retinopathy von Lei, Yi, Liu, Qiangyun, Chen, Binggui, Wu, Fangfang, Li, Yiming, Dong, Xue, Ma, Nina, Wu, Ziru, Zhu, Yanfang, Wang, Lu, Fu, Yuxin, Liu, Yuming, Song, Yinting, Du, Mei, Zhang, Heng, Zhu, Jidong, Lyons, Timothy J., Wang, Ting, Hu, Junhao, Xu, Heping, Chen, Mei, Yan, Hua, Wang, Xiaohong

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Modeling tumor development and metastasis using paired organoids derived from patients with colorectal cancer liver metastases von Li, He, Dai, Weixing, Xia, Xi, Wang, Renjie, Zhao, Jing, Han, Lingyu, Mo, Shaobo, Xiang, Wenqiang, Du, Lin, Zhu, Guangya, Xie, Jingjing, Yu, Jun, Liu, Nan, Huang, Mingzhu, Zhu, Jidong, Cai, Guoxiang

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Targeting androgen receptor phase separation to overcome antiandrogen resistance von Xie, Jingjing, He, Hao, Kong, Wenna, Li, Ziwen, Gao, Zhenting, Xie, Daoqing, Sun, Lin, Fan, Xiaofei, Jiang, Xiangqing, Zheng, Qiangang, Li, Guo, Zhu, Jidong, Zhu, Guangya

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Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment von Xie, Jingjing, Si, Xiaojia, Gu, Shoulai, Wang, Mingliang, Shen, Jian, Li, Haoyan, Shen, Jian, Li, Dan, Fang, Yanjia, Liu, Cong, Zhu, Jidong

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Screening inhibitors for blocking UHRF1-methylated DNA interaction with capillary electrophoresis von Lou, Chunli, Ye, Xiongzhen, Chen, Ge, Zhu, Jidong, Kang, Jingwu

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Phase separation ability and phosphatase activity of the SHP1-R360E mutant von Zhang, Qichen, Kong, Wenna, Zhu, Tianxin, Zhu, Guangya, Zhu, Jidong, Kong, Xiangyu, Du, Yiqi

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Researches on the Space-Time View of the Special Relativity von Zhu, Jidong

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Radical-Induced Metal-Free Alkynylation of Aldehydes by Direct CH Activation von Liu, Xuesong, Yu, Linqian, Luo, Mupeng, Zhu, Jidong, Wei, Wanguo

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Inhibition of cIAP1 as a strategy for targeting c-MYC–driven oncogenic activity von Li, Haoyan, Fang, Yanjia, Niu, Chunyi, Cao, Hengyi, Mi, Ting, Zhu, Hong, Yuan, Junying, Zhu, Jidong

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Phase separation underlies signaling activation of oncogenic NTRK fusions von Zhu, Tianxin, Xie, Jingjing, He, Hao, Li, Huan, Tang, Xianbin, Wang, Shuyang, Li, Ziwen, Tian, Yawen, Li, Lingyu, Zhu, Jidong, Zhu, Guangya

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Discovery of new small molecule inhibitors targeting isocitrate dehydrogenase 1 (IDH1) with blood-brain barrier penetration von Cao, Hengyi, Zhu, Guangya, Sun, Lin, Chen, Ge, Ma, Xinxin, Luo, Xiao, Zhu, Jidong

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Effective approach to ureas through organocatalyzed one-pot process von Wang, Mingliang, Han, Jilai, Si, Xiaojia, Hu, Yimin, Zhu, Jidong, Sun, Xun

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Abstract 1475: Discovery of ETS-001, a highly potent allosteric SHP2 inhibitor to treat RTK/RAS-driven cancers von Xia, Xi, Du, Lin, Zhuge, Hao, Zheng, Qiangang, Cui, Wenqi, Zhu, Jidong, Li, Guo

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