An Efficient Scale-Up Synthesis of BMS-520, a Potent and Selective Isoxazole-Containing S1P1 Receptor Agonist von Hou, Xiaoping, Zhu, Juliang, Chen, Bang-Chi, Watterson, Scott H, Pitts, William J, Dyckman, Alaric J, Carter, Percy H, Mathur, Arvind, Zhang, Huiping

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An Effective Procedure for the Acylation of Azaindoles at C-3 von Zhang, Zhongxing, Yang, Zhong, Wong, Henry, Zhu, Juliang, Meanwell, Nicholas A, Kadow, John F, Wang, Tao

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Design, Synthesis, and SAR of C‑3 Benzoic Acid, C‑17 Triterpenoid Derivatives. Identification of the HIV‑1 Maturation Inhibitor 4‑((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)‑3a-((2-(... von Regueiro-Ren, Alicia, Swidorski, Jacob J., Liu, Zheng, Chen, Yan, Sin, Ny, Sit, Sing-Yuen, Chen, Jie, Venables, Brian L., Zhu, Juliang, Nowicka-Sans, Beata, Protack, Tricia, Lin, Zeyu, Terry, Brian, Samanta, Himadri, Zhang, Sharon, Li, Zhufang, Easter, John, Beno, Brett R., Arora, Vinod, Huang, Xiaohua S., Rahematpura, Sandhya, Parker, Dawn D., Haskell, Roy, Santone, Kenneth S., Cockett, Mark I., Krystal, Mark, Meanwell, Nicholas A., Jenkins, Susan, Hanumegowda, Umesh, Dicker, Ira B.

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Hepatitis C Virus NS5A Replication Complex Inhibitors: The Discovery of Daclatasvir von Belema, Makonen, Nguyen, Van N., Bachand, Carol, Deon, Dan H., Goodrich, Jason T., James, Clint A., Lavoie, Rico, Lopez, Omar D., Martel, Alain, Romine, Jeffrey L., Ruediger, Edward H., Snyder, Lawrence B., Laurent, Denis R. St, Yang, Fukang, Zhu, Juliang, Wong, Henry S., Langley, David R., Adams, Stephen P., Cantor, Glenn H., Chimalakonda, Anjaneya, Fura, Aberra, Johnson, Benjamin M., Knipe, Jay O., Parker, Dawn D., Santone, Kenneth S., Fridell, Robert A., Lemm, Julie A., O’Boyle, Donald R., Colonno, Richard J., Gao, Min, Meanwell, Nicholas A., Hamann, Lawrence G.

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Inhibitors of Human Immunodeficiency Virus Type 1 (HIV-1) Attachment 6. Preclinical and Human Pharmacokinetic Profiling of BMS-663749, a Phosphonooxymethyl Prodrug of the HIV-1 Att... von Kadow, John F, Ueda, Yasutsugu, Meanwell, Nicholas A, Connolly, Timothy P, Wang, Tao, Chen, Chung-Pin, Yeung, Kap-Sun, Zhu, Juliang, Bender, John A, Yang, Zhong, Parker, Dawn, Lin, Pin-Fang, Colonno, Richard J, Mathew, Marina, Morgan, Daniel, Zheng, Ming, Chien, Caly, Grasela, Dennis

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Discovery of BMS-955176, a Second Generation HIV‑1 Maturation Inhibitor with Broad Spectrum Antiviral Activity von Regueiro-Ren, Alicia, Liu, Zheng, Chen, Yan, Sin, Ny, Sit, Sing-Yuen, Swidorski, Jacob J, Chen, Jie, Venables, Brian L, Zhu, Juliang, Nowicka-Sans, Beata, Protack, Tricia, Lin, Zeyu, Terry, Brian, Samanta, Himadri, Zhang, Sharon, Li, Zhufang, Beno, Brett R, Huang, Xiaohua S, Rahematpura, Sandhya, Parker, Dawn D, Haskell, Roy, Jenkins, Susan, Santone, Kenneth S, Cockett, Mark I, Krystal, Mark, Meanwell, Nicholas A, Hanumegowda, Umesh, Dicker, Ira B

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Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)... von Regueiro-Ren, Alicia, Swidorski, Jacob J, Liu, Zheng, Chen, Yan, Sin, Ny, Sit, Sing-Yuen, Chen, Jie, Venables, Brian L, Zhu, Juliang, Nowicka-Sans, Beata, Protack, Tricia, Lin, Zeyu, Terry, Brian, Samanta, Himadri, Zhang, Sharon, Li, Zhufang, Easter, John, Beno, Brett R, Arora, Vinod, Huang, Xiaohua S, Rahematpura, Sandhya, Parker, Dawn D, Haskell, Roy, Santone, Kenneth S, Cockett, Mark I, Krystal, Mark, Meanwell, Nicholas A, Jenkins, Susan, Hanumegowda, Umesh, Dicker, Ira B

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(+)-Dinapsoline:  An Efficient Synthesis and Pharmacological Profile of a Novel Dopamine Agonist von Sit, Sing-Yuen, Xie, Kai, Jacutin-Porte, Swanee, Taber, Matthew T, Gulwadi, Amit G, Korpinen, Carolyn D, Burris, Kevin D, Molski, Thaddeus F, Ryan, Elaine, Xu, Cen, Wong, Henry, Zhu, Juliang, Krishnananthan, Subramaniam, Gao, Qi, Verdoorn, Todd, Johnson, Graham

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Improving Metabolic Stability with Deuterium: The Discovery of BMT-052, a Pan-genotypic HCV NS5B Polymerase Inhibitor von Parcella, Kyle, Eastman, Kyle, Yeung, Kap-Sun, Grant-Young, Katharine A, Zhu, Juliang, Wang, Tao, Zhang, Zhongxing, Yin, Zhiwei, Parker, Dawn, Mosure, Kathy, Fang, Hua, Wang, Ying-Kai, Lemm, Julie, Zhuo, Xiaoliang, Hanumegowda, Umesh, Liu, Mengping, Rigat, Karen, Donoso, Maria, Tuttle, Maria, Zvyaga, Tatyana, Haarhoff, Zuzana, Meanwell, Nicholas A, Soars, Matthew G, Roberts, Susan B, Kadow, John F

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An Efficient Scale-Up Synthesis of BMS-520, a Potent and Selective Isoxazole-Containing S1P 1 Receptor Agonist von Hou, Xiaoping, Zhu, Juliang, Chen, Bang-Chi, Watterson, Scott H., Pitts, William J., Dyckman, Alaric J., Carter, Percy H., Mathur, Arvind, Zhang, Huiping

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The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase von Eastman, Kyle J, Parcella, Kyle, Yeung, Kap-Sun, Grant-Young, Katharine A, Zhu, Juliang, Wang, Tao, Zhang, Zhongxing, Yin, Zhiwei, Beno, Brett R, Sheriff, Steven, Kish, Kevin, Tredup, Jeffrey, Jardel, Adam G, Halan, Vivek, Ghosh, Kaushik, Parker, Dawn, Mosure, Kathy, Fang, Hua, Wang, Ying-Kai, Lemm, Julie, Zhuo, Xiaoliang, Hanumegowda, Umesh, Rigat, Karen, Donoso, Maria, Tuttle, Maria, Zvyaga, Tatyana, Haarhoff, Zuzana, Meanwell, Nicholas A, Soars, Matthew G, Roberts, Susan B, Kadow, John F

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Structure–Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition in HCV NS5B Inhibitors von Yeung, Kap-Sun, Beno, Brett R, Mosure, Kathy, Zhu, Juliang, Grant-Young, Katherine A, Parcella, Kyle, Anjanappa, Prakash, Bora, Rajesh Onkardas, Selvakumar, Kumaravel, Wang, Ying-Kai, Fang, Hua, Krause, Rudolph, Rigat, Karen, Liu, Mengping, Lemm, Julie, Sheriff, Steven, Witmer, Mark, Tredup, Jeffrey, Jardel, Adam, Kish, Kevin, Parker, Dawn, Haskell, Roy, Santone, Kenneth, Meanwell, Nicholas A, Soars, Matthew G, Roberts, Susan B, Kadow, John F

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Identification of 1-{2-[4-chloro-1′-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4′-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent... von Jeon, Yoon T., Yang, Wu, Qiao, Jennifer X., Li, Ling, Ruel, Rejean, Thibeault, Carl, Hiebert, Sheldon, Wang, Tammy C., Wang, Yufeng, Liu, Yajun, Clark, Charles G., Wong, Henry S., Zhu, Juliang, Wu, Dauh-Rurng, Sun, Dawn, Chen, Bang-Chi, Mathur, Arvind, Chacko, Silvi A., Malley, Mary, Chen, Xue-Qing, Shen, Hong, Huang, Christine S., Schumacher, William A., Bostwick, Jeffrey S., Stewart, Anne B., Price, Laura A., Hua, Ji, Li, Danshi, Levesque, Paul C., Seiffert, Dietmar A., Rehfuss, Robert, Wexler, Ruth R., Lam, Patrick Y.S.

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Identification of 1-{2-[4-chloro-1'-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent... von Jeon, Yoon T, Yang, Wu, Qiao, Jennifer X, Li, Ling, Ruel, Rejean, Thibeault, Carl, Hiebert, Sheldon, Wang, Tammy C, Wang, Yufeng, Liu, Yajun, Clark, Charles G, Wong, Henry S, Zhu, Juliang, Wu, Dauh-Rurng, Sun, Dawn, Chen, Bang-Chi, Mathur, Arvind, Chacko, Silvi A, Malley, Mary, Chen, Xue-Qing, Shen, Hong, Huang, Christine S, Schumacher, William A, Bostwick, Jeffrey S, Stewart, Anne B, Price, Laura A, Hua, Ji, Li, Danshi, Levesque, Paul C, Seiffert, Dietmar A, Rehfuss, Robert, Wexler, Ruth R, Lam, Patrick Y S

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Anti-HIV-1 activity and cellular pharmacology of various analogs of gossypol von Tai-Shun, Lin, Schinazi, Raymond F., Zhu, Juliang, Birks, Evelyn, Carbone, Rocco, Yikang, Si, Kemei, Wu, Liang, Huang, Prusoff, William H.

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An effective procedure for the preparation of 3-substituted-4- or 6-azaindoles from ortho-methyl nitro pyridines von Zhu, Juliang, Wong, Henry, Zhang, Zhongxing, Yin, Zhiwei, Meanwell, Nicholas A., Kadow, John F., Wang, Tao

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The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymeraseThe authors declare no competing interests.Electronic supplementary information (ESI) available. See D... von Eastman, Kyle J, Parcella, Kyle, Yeung, Kap-Sun, Grant-Young, Katharine A, Zhu, Juliang, Wang, Tao, Zhang, Zhongxing, Yin, Zhiwei, Beno, Brett R, Sheriff, Steven, Kish, Kevin, Tredup, Jeffrey, Jardel, Adam G, Halan, Vivek, Ghosh, Kaushik, Parker, Dawn, Mosure, Kathy, Fang, Hua, Wang, Ying-Kai, Lemm, Julie, Zhuo, Xiaoliang, Hanumegowda, Umesh, Rigat, Karen, Donoso, Maria, Tuttle, Maria, Zvyaga, Tatyana, Haarhoff, Zuzana, Meanwell, Nicholas A, Soars, Matthew G, Roberts, Susan B, Kadow, John F

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The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase† †The authors declare no competing interests. ‡ ‡Electronic supplementary information (ESI) available... von Eastman, Kyle J., Parcella, Kyle, Yeung, Kap-Sun, Grant-Young, Katharine A., Zhu, Juliang, Wang, Tao, Zhang, Zhongxing, Yin, Zhiwei, Beno, Brett R., Sheriff, Steven, Kish, Kevin, Tredup, Jeffrey, Jardel, Adam G., Halan, Vivek, Ghosh, Kaushik, Parker, Dawn, Mosure, Kathy, Fang, Hua, Wang, Ying-Kai, Lemm, Julie, Zhuo, Xiaoliang, Hanumegowda, Umesh, Rigat, Karen, Donoso, Maria, Tuttle, Maria, Zvyaga, Tatyana, Haarhoff, Zuzana, Meanwell, Nicholas A., Soars, Matthew G., Roberts, Susan B., Kadow, John F.

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Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist von Shi, Yan, Li, Jun, Kennedy, Lawrence J, Tao, Shiwei, Hernández, Andrés S, Lai, Zhi, Chen, Sean, Wong, Henry, Zhu, Juliang, Trehan, Ashok, Lim, Ngiap-Kie, Zhang, Huiping, Chen, Bang-Chi, Locke, Kenneth T, O’Malley, Kevin M, Zhang, Litao, Srivastava, Rai Ajit, Miao, Bowman, Meyers, Daniel S, Monshizadegan, Hossain, Search, Debra, Grimm, Denise, Zhang, Rongan, Harrity, Thomas, Kunselman, Lori K, Cap, Michael, Muckelbauer, Jodi, Chang, Chiehying, Krystek, Stanley R, Li, Yi-Xin, Hosagrahara, Vinayak, Zhang, Lisa, Kadiyala, Pathanjali, Xu, Carrie, Blanar, Michael A, Zahler, Robert, Mukherjee, Ranjan, Cheng, Peter T. W, Tino, Joseph A

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2,8-DIACYL-2,8-DIAZASPIRO[5.5]UNDECANE COMPOUNDS USEFUL AS IMMUNOMODULATORS von ZHU, Juliang, SCOLA, Paul Michael, YEUNG, Kap-Sun

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