Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice von Zhou, Haibo, Su, Jinlin, Hu, Xinde, Zhou, Changyang, Li, He, Chen, Zhaorong, Xiao, Qingquan, Wang, Bo, Wu, Wenyan, Sun, Yidi, Zhou, Yingsi, Tang, Cheng, Liu, Fei, Wang, Linhan, Feng, Canbin, Liu, Mingzhe, Li, Sanlan, Zhang, Yifeng, Xu, Huatai, Yao, Haishan, Shi, Linyu, Yang, Hui

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A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects von Zuo, Erwei, Sun, Yidi, Yuan, Tanglong, He, Bingbing, Zhou, Changyang, Ying, Wenqin, Liu, Jing, Wei, Wu, Zeng, Rong, Li, Yixue, Yang, Hui

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A Cas-embedding strategy for minimizing off-target effects of DNA base editors von Liu, Yajing, Zhou, Changyang, Huang, Shisheng, Dang, Lu, Wei, Yu, He, Jun, Zhou, Yingsi, Mao, Shaoshuai, Tao, Wanyu, Zhang, Yu, Yang, Hui, Huang, Xingxu, Chi, Tian

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In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR–dCas9-activator transgenic mice von Zhou, Haibo, Liu, Junlai, Zhou, Changyang, Gao, Ni, Rao, Zhiping, Li, He, Hu, Xinde, Li, Changlin, Yao, Xuan, Shen, Xiaowen, Sun, Yidi, Wei, Yu, Liu, Fei, Ying, Wenqin, Zhang, Junming, Tang, Cheng, Zhang, Xu, Xu, Huatai, Shi, Linyu, Cheng, Leping, Huang, Pengyu, Yang, Hui

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Adenine base editors induce off-target structure variations in mouse embryos and primary human T cells von Wu, Leilei, Jiang, Shutan, Shi, Meisong, Yuan, Tanglong, Li, Yaqin, Huang, Pinzheng, Li, Yingqi, Zuo, Erwei, Zhou, Changyang, Sun, Yidi

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One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs von Zuo, Erwei, Cai, Yi-Jun, Li, Kui, Wei, Yu, Wang, Bang-An, Sun, Yidi, Liu, Zhen, Liu, Jiwei, Hu, Xinde, Wei, Wei, Huo, Xiaona, Shi, Linyu, Tang, Cheng, Liang, Dan, Wang, Yan, Nie, Yan-Hong, Zhang, Chen-Chen, Yao, Xuan, Wang, Xing, Zhou, Changyang, Ying, Wenqin, Wang, Qifang, Chen, Ren-Chao, Shen, Qi, Xu, Guo-Liang, Li, Jinsong, Sun, Qiang, Xiong, Zhi-Qi, Yang, Hui

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Endogenous promoter-driven sgRNA for monitoring the expression of low-abundance transcripts and lncRNAs von Gao, Ni, Hu, Jing, He, Bingbing, Ji, Zhengbang, Hu, Xinde, Huang, Jia, Wei, Yu, Peng, Jianpeng, Wei, Yinghui, Zhou, Yingsi, Shen, Xiaowen, Li, He, Feng, Xue, Xiao, Qingquan, Shi, Linyu, Sun, Yidi, Zhou, Changyang, Zhou, Haibo, Yang, Hui

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Highly efficient base editing in human tripronuclear zygotes von Zhou, Changyang, Zhang, Meiling, Wei, Yu, Sun, Yidi, Sun, Yun, Pan, Hong, Yao, Ning, Zhong, Wanxia, Li, Yixue, Li, Weiping, Yang, Hui, Chen, Zi-jiang

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Indiscriminate ssDNA cleavage activity of CRISPR-Cas12a induces no detectable off-target effects in mouse embryos von Wei, Yu, Zhou, Yingsi, Liu, Yajing, Ying, Wenqin, Lv, Ruiming, Zhao, Qimeng, Zhou, Haibo, Zuo, Erwei, Sun, Yidi, Yang, Hui, Zhou, Changyang

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Human cleaving embryos enable robust homozygotic nucleotide substitutions by base editors von Zhang, Meiling, Zhou, Changyang, Wei, Yu, Xu, Chunlong, Pan, Hong, Ying, Wenqin, Sun, Yidi, Sun, Yun, Xiao, Qingquan, Yao, Ning, Zhong, Wanxia, Li, Yun, Wu, Keliang, Yuan, Gao, Mitalipov, Shoukhrat, Chen, Zi-Jiang, Yang, Hui

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Base-Editing-Mediated R17H Substitution in Histone H3 Reveals Methylation-Dependent Regulation of Yap Signaling and Early Mouse Embryo Development von Yang, Guang, Zhou, Changyang, Wang, Ran, Huang, Shisheng, Wei, Yu, Yang, Xianfa, Liu, Yajing, Li, Jianan, Lu, Zongyang, Ying, Wenqin, Li, Xiajun, Jing, Naihe, Huang, Xingxu, Yang, Hui, Qiao, Yunbo

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Structure design and performance comparison of large-scale marine sediment microbial fuel cells in lab and real sea as power source to drive monitoring instruments for long-term wo... von Zhou, Changyang, Fu, Yubin, Zhang, Haoshuang, Chen, Wei, Liu, Zhi, Liu, Zhaohui, Ying, Ming, Zai, Xuerong

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Epigenetic editing alleviates Angelman syndrome phenotype in mice by unsilencing paternal Ube3a von Liu, Yajing, Lou, Sensen, Li, Jinhui, Liu, Yuanhua, Huang, Shisheng, Wei, Yu, Liu, Jikai, Lv, Ruimin, Tang, Junjie, Shen, Zhixin, Sun, Yidi, Huang, Xingxu, Xiong, Zhiqi, Yang, Hui, Zhou, Changyang

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Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis von Zhou, Changyang, Sun, Yidi, Yan, Rui, Liu, Yajing, Zuo, Erwei, Gu, Chan, Han, Linxiao, Wei, Yu, Hu, Xinde, Zeng, Rong, Li, Yixue, Zhou, Haibo, Guo, Fan, Yang, Hui

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A high-fidelity RNA-targeting Cas13 restores paternal Ube3a expression and improves motor functions in Angelman syndrome mice von Li, Jinhui, Shen, Zhixin, Liu, Yajing, Yan, Zixiang, Liu, Yuanhua, Lin, Xiang, Tang, Junjie, Lv, Ruimin, Geng, Guannan, Xiong, Zhi-Qi, Zhou, Changyang, Yang, Hui

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OS-093 Efficient and heritable elimination of HBV viral antigens in vivo by epigenome editing von Peng, Wenbo, Zhao, Junzheng, Wu, Dai-tze, Mao, Shaoshuai, Wu, Leilei, Sun, Jing, Lv, Ruimin, Sun, Di, Zhang, Bob, Sun, YiDi, Zhou, Changyang

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Composite‐modified anode by MnO2/polypyrrole in marine benthic microbial fuel cells and its electrochemical performance von Chen, Wei, Liu, Zhaohui, Su, Ge, Fu, Yubin, Zai, Xuerong, Zhou, Changyang, Wang, Jian

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Simultaneous zygotic inactivation of multiple genes in mouse through CRISPR/Cas9-mediated base editing von Zhang, He, Pan, Hong, Zhou, Changyang, Wei, Yu, Ying, Wenqin, Li, Shuting, Wang, Guangqin, Li, Chao, Ren, Yifei, Li, Gen, Ding, Xu, Sun, Yidi, Li, Geng-Lin, Song, Lei, Li, Yixue, Yang, Hui, Liu, Zhiyong

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CasRx-mediated RNA targeting prevents choroidal neovascularization in a mouse model of age-related macular degeneration von Zhou, Changyang, Hu, Xinde, Tang, Cheng, Liu, Wenjia, Wang, Shaoran, Zhou, Yingsi, Zhao, Qimeng, Bo, Qiyu, Shi, Linyu, Sun, Xiaodong, Zhou, Haibo, Yang, Hui

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Prediction and Validation of Mouse Meiosis-Essential Genes Based on Spermatogenesis Proteome Dynamics von Fang, Kailun, Li, Qidan, Wei, Yu, Zhou, Changyang, Guo, Wenhui, Shen, Jiaqi, Wu, Ruoxi, Ying, Wenqin, Yu, Lu, Zi, Jin, Zhang, Yuxing, Yang, Hui, Liu, Siqi, Chen, Charlie Degui

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