T cell stemness and dysfunction in tumors are triggered by a common mechanism von Vodnala, Suman Kumar, Eil, Robert, Kishton, Rigel J, Sukumar, Madhusudhanan, Yamamoto, Tori N, Ha, Ngoc-Han, Lee, Ping-Hsien, Shin, MinHwa, Patel, Shashank J, Yu, Zhiya, Palmer, Douglas C, Kruhlak, Michael J, Liu, Xiaojing, Locasale, Jason W, Huang, Jing, Roychoudhuri, Rahul, Finkel, Toren, Klebanoff, Christopher A, Restifo, Nicholas P

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Preclinical Evaluation of Chimeric Antigen Receptors Targeting CD70-Expressing Cancers von Wang, Qiong J, Yu, Zhiya, Hanada, Ken-Ichi, Patel, Krishna, Kleiner, David, Restifo, Nicholas P, Yang, James C

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Antiangiogenic Agents Can Increase Lymphocyte Infiltration into Tumor and Enhance the Effectiveness of Adoptive Immunotherapy of Cancer von SHRIMALI, Rajeev K, ZHIYA YU, THEORET, Marc R, CHINNASAMY, Dhanalakshmi, RESTIFO, Nicholas P, ROSENBERG, Steven A

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Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia von Tran, Eric, Chinnasamy, Dhanalakshmi, Yu, Zhiya, Morgan, Richard A, Lee, Chyi-Chia Richard, Restifo, Nicholas P, Rosenberg, Steven A

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Local Delivery of Interleukin-12 Using T Cells Targeting VEGF Receptor-2 Eradicates Multiple Vascularized Tumors in Mice von CHINNASAMY, Dhanalakshmi, ZHIYA YU, KERKAR, Sid P, LING ZHANG, MORGAN, Richard A, RESTIFO, Nicholas P, ROSENBERG, Steven A

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The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity von Gautam, Sanjivan, Fioravanti, Jessica, Zhu, Wei, Le Gall, John B., Brohawn, Philip, Lacey, Neal E., Hu, Jinhui, Hocker, James D., Hawk, Nga Voong, Kapoor, Veena, Telford, William G., Gurusamy, Devikala, Yu, Zhiya, Bhandoola, Avinash, Xue, Hai-Hui, Roychoudhuri, Rahul, Higgs, Brandon W., Restifo, Nicholas P., Bender, Timothy P., Ji, Yun, Gattinoni, Luca

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Adoptively transferred effector cells derived from naïve rather than central memory CD8⁺ T cells mediate superior antitumor immunity von Hinrichs, Christian S, Borman, Zachary A, Cassard, Lydie, Gattinoni, Luca, Spolski, Rosanne, Yu, Zhiya, Sanchez-Perez, Luis, Muranski, Pawel, Kern, Steven J, Logun, Carol, Palmer, Douglas C, Ji, Yun, Reger, Robert N, Leonard, Warren J, Danner, Robert L, Rosenberg, Steven A, Restifo, Nicholas P

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Simultaneous Targeting of Tumor Antigens and the Tumor Vasculature Using T Lymphocyte Transfer Synergize to Induce Regression of Established Tumors in Mice von CHINNASAMY, Dhanalakshmi, TRAN, Eric, ZHIYA YU, MORGAN, Richard A, RESTIFO, Nicholas P, ROSENBERG, Steven A

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Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting von Slaney, Clare Y, von Scheidt, Bianca, Davenport, Alexander J, Beavis, Paul A, Westwood, Jennifer A, Mardiana, Sherly, Tscharke, David C, Ellis, Sarah, Prince, H Miles, Trapani, Joseph A, Johnstone, Ricky W, Smyth, Mark J, Teng, Michele W, Ali, Aesha, Yu, Zhiya, Rosenberg, Steven A, Restifo, Nicholas P, Neeson, Paul, Darcy, Phillip K, Kershaw, Michael H

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IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors von Kerkar, Sid P, Goldszmid, Romina S, Muranski, Pawel, Chinnasamy, Dhanalakshmi, Yu, Zhiya, Reger, Robert N, Leonardi, Anthony J, Morgan, Richard A, Wang, Ena, Marincola, Francesco M, Trinchieri, Giorgio, Rosenberg, Steven A, Restifo, Nicholas P

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Tumor-Specific CD8+ T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts von KERKAR, Sid P, MURANSKI, Pawel, MORGAN, Richard A, GATTINONI, Luca, ROSENBERG, Steven A, TRINCHIERI, Giorgio, RESTIFO, Nicholas P, KAISER, Andrew, BONI, Andrea, SANCHEZ-PEREZ, Luis, ZHIYA YU, PALMER, Douglas C, REGER, Robert N, BORMAN, Zachary A, LING ZHANG

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T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy von Zhong, Shi, Malecek, Karolina, Johnson, Laura A., Yu, Zhiya, de Miera, Eleazar Vega-Saenz, Darvishian, Farbod, McGary, Katelyn, Huang, Kevin, Boyer, Josh, Corse, Emily, Shao, Yongzhao, Rosenberg, Steven A., Restifo, Nicholas P., Osman, Iman, Krogsgaard, Michelle

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Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy von Hinrichs, Christian S., Borman, Zachary A., Gattinoni, Luca, Yu, Zhiya, Burns, William R., Huang, Jianping, Klebanoff, Christopher A., Johnson, Laura A., Kerkar, Sid P., Yang, Shicheng, Muranski, Pawel, Palmer, Douglas C., Scott, Christopher D., Morgan, Richard A., Robbins, Paul F., Rosenberg, Steven A., Restifo, Nicholas P.

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Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice von Chinnasamy, Dhanalakshmi, Yu, Zhiya, Theoret, Marc R, Zhao, Yangbing, Shrimali, Rajeev K, Morgan, Richard A, Feldman, Steven A, Restifo, Nicholas P, Rosenberg, Steven A

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miR-155 augments CD8⁺ T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic γc cytokines von Ji, Yun, Wrzesinski, Claudia, Yu, Zhiya, Hu, Jinhui, Gautam, Sanjivan, Hawk, Nga V, Telford, William G, Palmer, Douglas C, Franco, Zulmarie, Sukumar, Madhusudhanan, Roychoudhuri, Rahul, Clever, David, Klebanoff, Christopher A, Surh, Charles D, Waldmann, Thomas A, Restifo, Nicholas P, Gattinoni, Luca

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Increased Intensity Lymphodepletion Enhances Tumor Treatment Efficacy of Adoptively Transferred Tumor-specific T Cells von WRZESINSKI, Claudia, PAULOS, Chrystal M, KAISER, Andrew, MURANSKI, Pawel, PALMER, Douglas C, GATTINONI, Luca, ZHIYA YU, ROSENBERG, Steven A, RESTIFO, Nicholas P

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A TCR targeting the HLA-A0201-restricted epitope of MAGE-A3 recognizes multiple epitopes of the MAGE-A antigen superfamily in several types of cancer von Chinnasamy, Nachimuthu, Wargo, Jennifer A, Yu, Zhiya, Rao, Mahadev, Frankel, Timothy L, Riley, John P, Hong, Jenny J, Parkhurst, Maria R, Feldman, Steven A, Schrump, David S, Restifo, Nicholas P, Robbins, Paul F, Rosenberg, Steven A, Morgan, Richard A

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369 Concurrent neoantigen vaccination enhances the antitumor effect of dysfunctional T cells during cell therapy von Krishna, Sri, Yu, Zhiya, Lowery, Frank, Dulemba, Victoria, Hanada, Kenichi, Rosenberg, Steven A

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The transcription factor BACH2 promotes tumor immunosuppression von Roychoudhuri, Rahul, Eil, Robert L, Clever, David, Klebanoff, Christopher A, Sukumar, Madhusudhanan, Grant, Francis M, Yu, Zhiya, Mehta, Gautam, Liu, Hui, Jin, Ping, Ji, Yun, Palmer, Douglas C, Pan, Jenny H, Chichura, Anna, Crompton, Joseph G, Patel, Shashank J, Stroncek, David, Wang, Ena, Marincola, Francesco M, Okkenhaug, Klaus, Gattinoni, Luca, Restifo, Nicholas P

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ASXL3 Is a Novel Pluripotency Factor in Human Respiratory Epithelial Cells and a Potential Therapeutic Target in Small Cell Lung Cancer von Shukla, Vivek, Rao, Mahadev, Zhang, Hongen, Beers, Jeanette, Wangsa, Darawalee, Wangsa, Danny, Buishand, Floryne O, Wang, Yonghong, Yu, Zhiya, Stevenson, Holly S, Reardon, Emily S, McLoughlin, Kaitlin C, Kaufman, Andrew S, Payabyab, Eden C, Hong, Julie A, Zhang, Mary, Davis, Sean, Edelman, Daniel, Chen, Guokai, Miettinen, Markku M, Restifo, Nicholas P, Ried, Thomas, Meltzer, Paul A, Schrump, David S

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