PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics von Khan, Sajid, He, Yonghan, Zhang, Xuan, Yuan, Yaxia, Pu, Shaoyan, Kong, Qingpeng, Zheng, Guangrong, Zhou, Daohong

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Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity von He, Yonghan, Zhang, Xuan, Chang, Jianhui, Kim, Ha-Neui, Zhang, Peiyi, Wang, Yingying, Khan, Sajid, Liu, Xingui, Zhang, Xin, Lv, Dongwen, Song, Lin, Li, Wen, Thummuri, Dinesh, Yuan, Yaxia, Wiegand, Janet S., Ortiz, Yuma T., Budamagunta, Vivekananda, Elisseeff, Jennifer H., Campisi, Judith, Almeida, Maria, Zheng, Guangrong, Zhou, Daohong

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Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity von Lv, Dongwen, Pal, Pratik, Liu, Xingui, Jia, Yannan, Thummuri, Dinesh, Zhang, Peiyi, Hu, Wanyi, Pei, Jing, Zhang, Qi, Zhou, Shuo, Khan, Sajid, Zhang, Xuan, Hua, Nan, Yang, Qingping, Arango, Sebastian, Zhang, Weizhou, Nayak, Digant, Olsen, Shaun K., Weintraub, Susan T., Hromas, Robert, Konopleva, Marina, Yuan, Yaxia, Zheng, Guangrong, Zhou, Daohong

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Discovery of histone deacetylase 3 (HDAC3)-specific PROTACs von Xiao, Yufeng, Wang, Jia, Zhao, Lisa Y, Chen, Xinyi, Zheng, Guangrong, Zhang, Xuan, Liao, Daiqing

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Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells von Kolb, Ryan, De, Umasankar, Khan, Sajid, Luo, Yuewan, Kim, Myung-Chul, Yu, Haijun, Wu, Chaoyan, Mo, Jiao, Zhang, Xin, Zhang, Peiyi, Zhang, Xuan, Borcherding, Nicholas, Koppel, Daniel, Fu, Yang-Xin, Zheng, Song Guo, Avram, Dorina, Zheng, Guangrong, Zhou, Daohong, Zhang, Weizhou

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Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy von Prasanna, Pataje G, Citrin, Deborah E, Hildesheim, Jeffrey, Ahmed, Mansoor M, Venkatachalam, Sundar, Riscuta, Gabriela, Xi, Dan, Zheng, Guangrong, Deursen, Jan van, Goronzy, Jorg, Kron, Stephen J, Anscher, Mitchell S, Sharpless, Norman E, Campisi, Judith, Brown, Stephen L, Niedernhofer, Laura J, O’Loghlen, Ana, Georgakilas, Alexandros G, Paris, Francois, Gius, David, Gewirtz, David A, Schmitt, Clemens A, Abazeed, Mohamed E, Kirkland, James L, Richmond, Ann, Romesser, Paul B, Lowe, Scott W, Gil, Jesus, Mendonca, Marc S, Burma, Sandeep, Zhou, Daohong, Coleman, C Norman

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Discovery of piperlongumine as a potential novel lead for the development of senolytic agents von Wang, Yingying, Chang, Jianhui, Liu, Xingui, Zhang, Xuan, Zhang, Suping, Zhang, Xin, Zhou, Daohong, Zheng, Guangrong

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Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity von He, Yonghan, Li, Wen, Lv, Dongwen, Zhang, Xin, Zhang, Xuan, Ortiz, Yuma T., Budamagunta, Vivekananda, Campisi, Judith, Zheng, Guangrong, Zhou, Daohong

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Overcoming Cancer Drug Resistance Utilizing PROTAC Technology von Burke, Matthew R, Smith, Alexis R, Zheng, Guangrong

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Oxidation resistance 1 is a novel senolytic target von Zhang, Xin, Zhang, Suping, Liu, Xingui, Wang, Yingying, Chang, Jianhui, Zhang, Xuan, Mackintosh, Samuel G., Tackett, Alan J., He, Yonghan, Lv, Dongwen, Laberge, Remi‐Martin, Campisi, Judith, Wang, Jianrong, Zheng, Guangrong, Zhou, Daohong

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Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies von He, Yonghan, Khan, Sajid, Huo, Zhiguang, Lv, Dongwen, Zhang, Xuan, Liu, Xingui, Yuan, Yaxia, Hromas, Robert, Xu, Mingjiang, Zheng, Guangrong, Zhou, Daohong

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Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL von Nayak, Digant, Lv, Dongwen, Yuan, Yaxia, Zhang, Peiyi, Hu, Wanyi, Nayak, Anindita, Ruben, Eliza A., Lv, Zongyang, Sung, Patrick, Hromas, Robert, Zheng, Guangrong, Zhou, Daohong, Olsen, Shaun K.

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Co-targeting BCL-XL and BCL-2 by PROTAC 753B eliminates leukemia cells and enhances efficacy of chemotherapy by targeting senescent cells von Jia, Yannan, Han, Lina, Ramage, Cassandra L, Wang, Zhe, Weng, Connie C, Yang, Lei, Colla, Simona, Ma, Helen, Zhang, Weiguo, Andreeff, Michael, Daver, Naval, Jain, Nitin, Pemmaraju, Naveen, Bhalla, Kapil, Mustjoki, Satu, Zhang, Peiyi, Zheng, Guangrong, Zhou, Daohong, Zhang, Qi, Konopleva, Marina

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DT2216-a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas von He, Yonghan, Koch, Raphael, Budamagunta, Vivekananda, Zhang, Peiyi, Zhang, Xuan, Khan, Sajid, Thummuri, Dinesh, Ortiz, Yuma T, Zhang, Xin, Lv, Dongwen, Wiegand, Janet S, Li, Wen, Palmer, Adam C, Zheng, Guangrong, Weinstock, David M, Zhou, Daohong

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A novel regimen for pancreatic ductal adenocarcinoma targeting MEK, BCL-xL, and EGFR von Han, Song, Tushoski-Alemán, Gerik W., Zhang, Peiyi, Zheng, Guangrong, Zhou, Daohong, Huo, Zhiguang, Licht, Jonathan, George, Thomas J., Allegra, Carmen, Trevino, Jose G., Hughes, Steven J.

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Causality between migraine and cardiovascular disease: a bidirectional Mendelian randomization study von Duan, Xirui, Du, Xiaolan, Zheng, Guangrong, Zhou, Xinyan, Tan, Na, Li, Guochen, Liu, Bin, Zhu, Mei, Ke, Tengfei, Liao, Chengde

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Ultrasound-responsive nanoparticles for nitric oxide release to inhibit the growth of breast cancer von Yang, Haiyan, Zheng, Guangrong, Li, GuoChen, Chen, Jincui, Qi, Licui, Luo, Yong, Ke, Tengfei, Xiong, Jie, Ji, Xiaojuan

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A Facile Semisynthesis and Evaluation of Garcinoic Acid and Its Analogs for the Inhibition of Human DNA Polymerase β von Gujarathi, Satheesh, Zafar, Maroof Khan, Liu, Xingui, Eoff, Robert L, Zheng, Guangrong

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BCL-XL PROTAC degrader DT2216 synergizes with sotorasib in preclinical models of KRASG12C-mutated cancers von Khan, Sajid, Wiegand, Janet, Zhang, Peiyi, Hu, Wanyi, Thummuri, Dinesh, Budamagunta, Vivekananda, Hua, Nan, Jin, Lingtao, Allegra, Carmen J, Kopetz, Scott E, Zajac-Kaye, Maria, Kaye, Frederic J, Zheng, Guangrong, Zhou, Daohong

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Amberlite IR-120H as an efficient and versatile solid phase catalyst for nucleophilic substitution of propargylic alcohols von Gujarathi, Satheesh, Hendrickson, Howard P., Zheng, Guangrong

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