PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting von Thorpe, Lauren M., Yuzugullu, Haluk, Zhao, Jean J.

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CDK4/6 Inhibition in Cancer: Beyond Cell Cycle Arrest von Goel, Shom, DeCristo, Molly J., McAllister, Sandra S., Zhao, Jean J.

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Targeting the phosphoinositide 3-kinase pathway in cancer von Zhao, Jean J, Liu, Pixu, Cheng, Hailing, Roberts, Thomas M

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CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer von Wang, Yubao, Zhang, Tinghu, Kwiatkowski, Nicholas, Abraham, Brian J., Lee, Tong Ihn, Xie, Shaozhen, Yuzugullu, Haluk, Von, Thanh, Li, Heyuan, Lin, Ziao, Stover, Daniel G., Lim, Elgene, Wang, Zhigang C., Iglehart, J. Dirk, Young, Richard A., Gray, Nathanael S., Zhao, Jean J.

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PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer von Ding, Liya, Kim, Hye-Jung, Wang, Qiwei, Kearns, Michael, Jiang, Tao, Ohlson, Carolynn E., Li, Ben B., Xie, Shaozhen, Liu, Joyce F., Stover, Elizabeth H., Howitt, Brooke E., Bronson, Roderick T., Lazo, Suzan, Roberts, Thomas M., Freeman, Gordon J., Konstantinopoulos, Panagiotis A., Matulonis, Ursula A., Zhao, Jean J.

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STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer von Wang, Qiwei, Bergholz, Johann S., Ding, Liya, Lin, Ziying, Kabraji, Sheheryar K., Hughes, Melissa E., He, Xiadi, Xie, Shaozhen, Jiang, Tao, Wang, Weihua, Zoeller, Jason J., Kim, Hye-Jung, Roberts, Thomas M., Konstantinopoulos, Panagiotis A., Matulonis, Ursula A., Dillon, Deborah A., Winer, Eric P., Lin, Nancy U., Zhao, Jean J.

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Oncogenic Kinase-Induced PKM2 Tyrosine 105 Phosphorylation Converts Nononcogenic PKM2 to a Tumor Promoter and Induces Cancer Stem-like Cells von Zhou, Zhifen, Li, Min, Zhang, Lin, Zhao, Hong, Şahin, Özgür, Chen, Jing, Zhao, Jean J, Songyang, Zhou, Yu, Dihua

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Targeting tumor-associated macrophages with STING agonism improves the antitumor efficacy of osimertinib in a mouse model of EGFR- mutant lung cancer von Lin, Ziying, Wang, Qiwei, Jiang, Tao, Wang, Weihua, Zhao, Jean J

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PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer von Spangle, Jennifer M., Dreijerink, Koen M., Groner, Anna C., Cheng, Hailing, Ohlson, Carolynn E., Reyes, Jaime, Lin, Charles Y., Bradner, James, Zhao, Jean J., Roberts, Thomas M., Brown, Myles

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Targeting CDK4 and CDK6 in cancer von Goel, Shom, Bergholz, Johann S., Zhao, Jean J.

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Central GLP-2 Enhances Hepatic Insulin Sensitivity via Activating PI3K Signaling in POMC Neurons von Shi, Xuemei, Zhou, Fuguo, Li, Xiaojie, Chang, Benny, Li, Depei, Wang, Yi, Tong, Qingchun, Xu, Yong, Fukuda, Makoto, Zhao, Jean J., Li, Defa, Burrin, Douglas G., Chan, Lawrence, Guan, Xinfu

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Cell-Cycle-Targeting MicroRNAs as Therapeutic Tools against Refractory Cancers von Hydbring, Per, Wang, Yinan, Fassl, Anne, Li, Xiaoting, Matia, Veronica, Otto, Tobias, Choi, Yoon Jong, Sweeney, Katharine E., Suski, Jan M., Yin, Hao, Bogorad, Roman L., Goel, Shom, Yuzugullu, Haluk, Kauffman, Kevin J., Yang, Junghoon, Jin, Chong, Li, Yingxiang, Floris, Davide, Swanson, Richard, Ng, Kimmie, Sicinska, Ewa, Anders, Lars, Zhao, Jean J., Polyak, Kornelia, Anderson, Daniel G., Li, Cheng, Sicinski, Piotr

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Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival von Wang, Yubao, Begley, Michael, Li, Qing, Huang, Hai-Tsang, Lako, Ana, Eck, Michael J., Gray, Nathanael S., Mitchison, Timothy J., Cantley, Lewis C., Zhao, Jean J.

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Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapies von Hanker, Ariella B., Pfefferle, Adam D., Balko, Justin M., Kuba, María Gabriela, Young, Christian D., Sánchez, Violeta, Sutton, Cammie R., Cheng, Hailing, Perou, Charles M., Zhao, Jean J., Cook, Rebecca S., Arteaga, Carlos L.

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PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context von Schmit, Fabienne, Utermark, Tamara, Zheng, Sen, Wang, Qi, Von, Thanh, Roberts, Thomas M., Zhao, Jean J.

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Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases von Ni, Jing, Ramkissoon, Shakti H, Xie, Shaozhen, Goel, Shom, Stover, Daniel G, Guo, Hanbing, Luu, Victor, Marco, Eugenio, Ramkissoon, Lori A, Kang, Yun Jee, Hayashi, Marika, Nguyen, Quang-De, Ligon, Azra H, Du, Rose, Claus, Elizabeth B, Alexander, Brian M, Yuan, Guo-Cheng, Wang, Zhigang C, Iglehart, J Dirk, Krop, Ian E, Roberts, Thomas M, Winer, Eric P, Lin, Nancy U, Ligon, Keith L, Zhao, Jean J

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An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer von Li, Ji, Choi, Peter S, Chaffer, Christine L, Labella, Katherine, Hwang, Justin H, Giacomelli, Andrew O, Kim, Jong Wook, Ilic, Nina, Doench, John G, Ly, Seav Huong, Dai, Chao, Hagel, Kimberly, Hong, Andrew L, Gjoerup, Ole, Goel, Shom, Ge, Jennifer Y, Root, David E, Zhao, Jean J, Brooks, Angela N, Weinberg, Robert A, Hahn, William C

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p16INK4A-deficiency predicts response to combined HER2 and CDK4/6 inhibition in HER2+ breast cancer brain metastases von Ni, Jing, Kabraji, Sheheryar, Xie, Shaozhen, Wang, Yanzhi, Pan, Peichen, He, Xiaofang, Liu, Zongming, Leone, Jose Palbo, Long, Henry W., Brown, Myles A., Winer, Eric P., Dillon, Deborah A. R., Lin, Nancy U., Zhao, Jean J.

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Bioprinting for cancer research von Knowlton, Stephanie, Onal, Sevgi, Yu, Chu Hsiang, Zhao, Jean J, Tasoglu, Savas

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MELK is not necessary for the proliferation of basal-like breast cancer cells von Huang, Hai-Tsang, Seo, Hyuk-Soo, Zhang, Tinghu, Wang, Yubao, Jiang, Baishan, Li, Qing, Buckley, Dennis L, Nabet, Behnam, Roberts, Justin M, Paulk, Joshiawa, Dastjerdi, Shiva, Winter, Georg E, McLauchlan, Hilary, Moran, Jennifer, Bradner, James E, Eck, Michael J, Dhe-Paganon, Sirano, Zhao, Jean J, Gray, Nathanael S

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