Cancer associated fibroblast FAK regulates malignant cell metabolism von Demircioglu, Fevzi, Wang, Jun, Candido, Juliana, Costa, Ana S. H., Casado, Pedro, de Luxan Delgado, Beatriz, Reynolds, Louise E., Gomez-Escudero, Jesus, Newport, Emma, Rajeeve, Vinothini, Baker, Ann-Marie, Roy-Luzarraga, Marina, Graham, Trevor A., Foster, Julie, Wang, Yu, Campbell, James J., Singh, Rajinder, Zhang, Penglie, Schall, Thomas J., Balkwill, Frances R., Sosabowski, Jane, Cutillas, Pedro R., Frezza, Christian, Sancho, Patricia, Hodivala-Dilke, Kairbaan

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Structural basis of ligand interaction with atypical chemokine receptor 3 von Gustavsson, Martin, Wang, Liwen, van Gils, Noortje, Stephens, Bryan S., Zhang, Penglie, Schall, Thomas J., Yang, Sichun, Abagyan, Ruben, Chance, Mark R., Kufareva, Irina, Handel, Tracy M.

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Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evalua... von Bekker, Pirow, Dairaghi, Daniel, Seitz, Lisa, Leleti, Manmohan, Wang, Yu, Ertl, Linda, Baumgart, Trageen, Shugarts, Sarah, Lohr, Lisa, Dang, Ton, Miao, Shichang, Zeng, Yibin, Fan, Pingchen, Zhang, Penglie, Johnson, Daniel, Powers, Jay, Jaen, Juan, Charo, Israel, Schall, Thomas J

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CXCR7 prevents excessive CXCL12-mediated downregulation of CXCR4 in migrating cortical interneurons von Abe, Philipp, Mueller, Wiebke, Schütz, Dagmar, MacKay, Fabienne, Thelen, Marcus, Zhang, Penglie, Stumm, Ralf

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IL-17-Secreting γδ T Cells Are Completely Dependent upon CCR6 for Homing to Inflamed Skin von Campbell, James J, Ebsworth, Karen, Ertl, Linda S, McMahon, Jeffrey P, Newland, Dale, Wang, Yu, Liu, Shirley, Miao, Zhenhua, Dang, Ton, Zhang, Penglie, Charo, Israel F, Singh, Rajinder, Schall, Thomas J

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Elucidation of CXCR7-Mediated Signaling Events and Inhibition of CXCR4-Mediated Tumor Cell Transendothelial Migration by CXCR7 Ligands von Zabel, Brian A, Wang, Yu, Lewen, Susanna, Berahovich, Robert D, Penfold, Mark E. T, Zhang, Penglie, Powers, Jay, Summers, Bretton C, Miao, Zhenhua, Zhao, Bin, Jalili, Ali, Janowska-Wieczorek, Anna, Jaen, Juan C, Schall, Thomas J

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CCX559 is a potent, orally-administered small molecule PD-L1 inhibitor that induces anti-tumor immunity von Sullivan, Kathleen M C, Vilalta, Marta, Ertl, Linda S, Wang, Yu, Dunlap, Carolyn, Ebsworth, Karen, Zhao, Bin N, Li, Shijie, Zeng, Yibin, Miao, Zhenhua, Fan, Pingchen, Mali, Venkat, Lange, Christopher, McMurtrie, Darren, Yang, Ju, Lui, Rebecca, Scamp, Ryan, Chhina, Vicky, Kumamoto, Alice, Yau, Simon, Dang, Ton, Easterday, Ashton, Liu, Shirley, Miao, Shichang, Charo, Israel, Schall, Thomas J, Zhang, Penglie

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CCR1 blockade reduces tumor burden and osteolysis in vivo in a mouse model of myeloma bone disease von Dairaghi, Daniel J., Oyajobi, Babatunde O., Gupta, Anjana, McCluskey, Brandon, Miao, Shichang, Powers, Jay P., Seitz, Lisa C., Wang, Yu, Zeng, Yibin, Zhang, Penglie, Schall, Thomas J., Jaen, Juan C.

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CCR2 antagonism leads to marked reduction in proteinuria and glomerular injury in murine models of focal segmental glomerulosclerosis (FSGS) von Miao, Zhenhua, Ertl, Linda S, Newland, Dale, Zhao, Bin, Wang, Yu, Zang, Xiaoping, Campbell, James J, Liu, Xiaoli, Dang, Ton, Miao, Shichang, Krasinski, Antoni, Punna, Sreenivas, Zeng, Yibin, McMahon, Jeffrey, Zhang, Penglie, Charo, Israel F, Schall, Thomas J, Singh, Rajinder

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Correction: Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Precli... von Bekker, Pirow, Dairaghi, Daniel, Seitz, Lisa, Leleti, Manmohan, Wang, Yu, Ertl, Linda, Baumgart, Trageen, Shugarts, Sarah, Lohr, Lisa, Dang, Ton, Miao, Shichang, Zeng, Yibin, Fan, Pingchen, Zhang, Penglie, Johnson, Daniel, Powers, Jay, Jaen, Juan, Charo, Israel, Schall, Thomas J

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Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-( N, N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious fa... von Zhang, Penglie, Huang, Wenrong, Wang, Lingyan, Bao, Liang, Jia, Zhaozhong J., Bauer, Shawn M., Goldman, Erick A., Probst, Gary D., Song, Yonghong, Su, Ting, Fan, Jingmei, Wu, Yanhong, Li, Wenhao, Woolfrey, John, Sinha, Uma, Wong, Paul W., Edwards, Susan T., Arfsten, Ann E., Clizbe, Lane A., Kanter, James, Pandey, Anjali, Park, Gary, Hutchaleelaha, Athiwat, Lambing, Joseph L., Hollenbach, Stanley J., Scarborough, Robert M., Zhu, Bing-Yan

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Inhibitory effect of carboxylic acid group on hERG binding von Zhu, Bing-Yan, Jia, Zhaozhong J., Zhang, Penglie, Su, Ting, Huang, Wenrong, Goldman, Erick, Tumas, Daniel, Kadambi, Vic, Eddy, Priya, Sinha, Uma, Scarborough, Robert M., Song, Yonghong

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Design, Synthesis and Discovery of 1-(2-(6-Chloro-3-methylsulfonyl)-naphthyl)-1H-pyrazole-5-carboxylamides as Highly Potent Factor Xa Inhibitors von Jia, Zhaozhong Jon, Scarborough, Robert Murry, Zhang, Penglie, Halfon, Sherin, Arfsten, Ann Elizabeth, Sinha, Uma, Zhu, Bing-Yan

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Anthranilamide-based N, N-dialkylbenzamidines as potent and orally bioavailable factor Xa inhibitors: P4 SAR von Zhang, Penglie, Bao, Liang, Fan, Jingmei, Jia, Zhaozhong J., Sinha, Uma, Wong, Paul W., Park, Gary, Hutchaleelaha, Athiwat, Scarborough, Robert M., Zhu, Bing-Yan

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1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor xa inhibitors. Part 3: Design, synthesis and sar of orally bioavailable benzamidine-P4 inhibitors von JIA, Zhaozhong J, YANHONG WU, HOLLENNBACH, Stanley J, LAMBING, Joseph L, SCARBOROUGH, Robert M, ZHU, Bing-Yan, WENRONG HUANG, PENGLIE ZHANG, YONGHONG SONG, WOOLFREY, John, SINHA, Uma, ARFSTEN, Ann E, EDWARDS, Susan T, HUTCHALEELAHA, Athiwat

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Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells von Wong, Ping-Pui, Muñoz-Félix, José M., Hijazi, Maruan, Kim, Hyojin, Robinson, Stephen D., De Luxán-Delgado, Beatriz, Rodríguez-Hernández, Irene, Maiques, Oscar, Meng, Ya-Ming, Meng, Qiong, Bodrug, Natalia, Dukinfield, Matthew Scott, Reynolds, Louise E., Elia, George, Clear, Andrew, Harwood, Catherine, Wang, Yu, Campbell, James J., Singh, Rajinder, Zhang, Penglie, Schall, Thomas J., Matchett, Kylie P., Henderson, Neil C., Szlosarek, Peter W., Dreger, Sally A., Smith, Sally, Jones, J. Louise, Gribben, John G., Cutillas, Pedro R., Meier, Pascal, Sanz-Moreno, Victoria, Hodivala-Dilke, Kairbaan M.

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CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity von Cruz-Orengo, Lillian, Holman, David W, Dorsey, Denise, Zhou, Liang, Zhang, Penglie, Wright, Melissa, McCandless, Erin E, Patel, Jigisha R, Luker, Gary D, Littman, Dan R, Russell, John H, Klein, Robyn S

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Preliminary data from an ongoing phase 1 dose-escalation study of CCX559, an orally administered small molecule PD-L1 inhibitor, in patients with advanced solid tumors von Tapia, Gonzalo, Lundy, Joanne, Richardson, Gary Edward, Zhao, Niky, Ebsworth, Karen, Yue, Huibin, Miao, Shichang, deGoma, Emil, Jain, Rita, Schall, Thomas J., Sullivan, Kathleen, Zhang, Penglie, de Souza, Paul L.

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CC chemokine receptor 2 promotes recruitment of myeloid cells associated with insulin resistance in nonalcoholic fatty liver disease von Parker, Richard, Weston, Christopher J, Miao, Zhenhua, Corbett, Christopher, Armstrong, Matthew J, Ertl, Linda, Ebsworth, Karen, Walters, Matthew J, Baumart, Trageen, Newland, Dale, McMahon, Jeff, Zhang, Penglie, Singh, Rajinder, Campbell, James, Newsome, Philip N, Charo, Israel, Schall, Thomas J, Adams, David H

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Enzalutamide and CXCR7 inhibitor combination treatment suppresses cell growth and angiogenic signaling in castration‐resistant prostate cancer models von Luo, Yong, Azad, Abul Kalam, Karanika, Styliani, Basourakos, Spyridon P., Zuo, Xuemei, Wang, Jianxiang, Yang, Luan, Yang, Guang, Korentzelos, Dimitrios, Yin, Jianhua, Park, Sanghee, Zhang, Penglie, Campbell, James J., Schall, Thomas J., Cao, Guangwen, Li, Likun, Thompson, Timothy C.

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