Proteolysis targeting chimera (PROTAC) in drug discovery paradigm: Recent progress and future challenges von Zeng, Shenxin, Huang, Wenhai, Zheng, Xiaoliang, Liyan cheng, Zhang, Zhimin, Wang, Jian, Shen, Zhengrong

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The progress of molecules and strategies for the treatment of HBV infection von Pan, Youlu, Xia, Heye, He, Yanwen, Zeng, Shenxin, Shen, Zhengrong, Huang, Wenhai

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Photopharmacology of Proteolysis-Targeting Chimeras: A New Frontier for Drug Discovery von Zeng, Shenxin, Zhang, Hongjie, Shen, Zhengrong, Huang, Wenhai

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Identification of probe-quality degraders for Poly(ADP-ribose) polymerase-1 (PARP-1) von Zhang, Zhimin, Chang, Xinyue, Zhang, Chixiao, Zeng, Shenxin, Liang, Meihao, Ma, Zhen, Wang, Zunyuan, Huang, Wenhai, Shen, Zhengrong

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Investigation of the mechanism of USP28-mediated IFITM3 elevation in BCR-ABL-dependent imatinib resistance in CML von Li, Zilin, Xi, Yiling, Tu, Linglan, Zhang, Xu, Huang, Yue, Nie, Huizong, Peng, Cheng, Chai, Haohuan, Zeng, Shenxin, Zheng, Xiaoliang, Cheng, Liyan

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Discovery of orally available 1H-pyrazolo [3, 4-d] pyrimidin-4-amine derivative as a novel BTK inhibitor von ZunyuanWang, ShuWang, Chai, Jiazhe, Chi, Xinglong, Ying, Jiaxun, Kang, Youkun, Pan, Youlu, Zeng, Shenxin, Ma, Zhen, Wang, Wenyong, Huang, Wenhai

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Discovery of novel coumarin derivatives as potent and orally bioavailable BRD4 inhibitors based on scaffold hopping von Zhang, Zhimin, Gu, Lili, Wang, Beibei, Huang, Wenhai, Zhang, Yanmin, Ma, Zhen, Zeng, Shenxin, Shen, Zhengrong

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Current advances and development strategies of orally bioavailable PROTACs von Zeng, Shenxin, Ye, Yingqiao, Xia, Heye, Min, Jingli, Xu, Jiamei, Wang, Zunyuan, Pan, Youlu, Zhou, Xinglu, Huang, Wenhai

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Discovery of new non-covalent reversible BTK inhibitors: Synthesis, in silico studies, and in vitro evaluations von Wang, Zunyuan, Wang, Shu, Kang, Youkun, Chi, Xinglong, Pan, Youlu, Zeng, Shenxin, Zhang, Chixiao, Xu, Xiangwei, Wang, Wenyong, Huang, Wenhai

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Structural Feature Analyzation Strategies toward Discovery of Orally Bioavailable PROTACs of Bruton’s Tyrosine Kinase for the Treatment of Lymphoma von Zhang, Jingyu, Che, Jinxin, Luo, Xiaomin, Wu, Mingfei, Kan, Weijuan, Jin, Yuheng, Wang, Hanlin, Pang, Ao, Li, Cong, Huang, Wenhai, Zeng, Shenxin, Zhuang, Weihao, Wu, Yizhe, Xu, Yongjin, Zhou, Yubo, Li, Jia, Dong, Xiaowu

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Discovery of novel pyrrolo [2,3-d] pyrimidine derivatives as potent FAK inhibitors based on cyclization strategy von Zeng, Shenxin, Yuan, Shuai, Zhang, Yu, Du, Jinbei, Wu, Yuhao, Chen, Yinqiao, Zhu, Peizhen, Huang, Wenhai

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Discovery of highly efficient CRBN-recruiting HPK1-PROTAC as a potential chemical tool for investigation of scaffolding roles in TCR signaling von Zeng, Shenxin, Jin, Yuyuan, Xia, Heye, Shang, Yanwei, Li, Yingzhou, Wang, Zunyuan, Huang, Wenhai

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Opportunities and challenges for targeting HPK1 in cancer immunotherapy von Xu, Jiamei, Li, Yingzhou, Chen, Xinyi, Yang, Junyi, Xia, Heye, Huang, Wenhai, Zeng, Shenxin

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Discovery of novel, potent, selective and orally bioavailable HPK1 inhibitor for enhancing the efficacy of anti-PD-L1 antibody von Zeng, Shenxin, Wu, Mingfei, Jin, Yuyuan, Ye, Yingqiao, Xia, Heye, Chen, Xinyi, Che, Jinxin, Wang, Zunyuan, Wu, Ying, Dong, Xiaowu, Chen, Yinqiao, Huang, Wenhai

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Discovery of an Exceptionally Orally Bioavailable and Potent HPK1 PROTAC with Enhancement of Antitumor Efficacy of Anti-PD-L1 Therapy von Wu, Mingfei, Wu, Yiquan, Jin, Yuyuan, Mao, Xinfei, Zeng, Shenxin, Yu, Hengyuan, Zhang, Jingyu, Jin, Yuheng, Wu, Yizhe, Xu, Tengfei, Chen, Yong, Wang, Yuwei, Yao, Xiaojun, Che, Jinxin, Huang, Wenhai, Dong, Xiaowu

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Structure-based identification of new orally bioavailable BRD9-PROTACs for treating acute myelocytic leukemia von Zhang, Jingyu, Duan, Haiting, Gui, Renzhao, Wu, Mingfei, Shen, Liteng, Jin, Yuheng, Pang, Ao, Yu, Xiaoli, Zeng, Shenxin, Zhang, Bo, Lin, Nengming, Huang, Wenhai, Wang, Yuwei, Yao, Xiaojun, Li, Jia, Dong, Xiaowu, Zhou, Yubo, Che, Jinxin

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Cytarabine and EIP co-administration synergistically reduces viability of acute lymphoblastic leukemia cells with high ERG expression von Cheng, Liyan, Zeng, Shenxin, Yan, Dongmei, Tu, Linglan, Yang, Yadong, Wang, Xiaoju, Zheng, Xiaoliang

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Discovery of a potent CDKs/FLT3 PROTAC with enhanced differentiation and proliferation inhibition for AML von Wu, Mingfei, Wang, Wei, Mao, Xinfei, Wu, Yiquan, Jin, Yuyuan, Liu, Tao, Lu, Yan, Dai, Haibin, Zeng, Shenxin, Huang, Wenhai, Wang, Yuwei, Yao, Xiaojun, Che, Jinxin, Ying, Meidan, Dong, Xiaowu

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The Activity of Novel BCR-ABL Small-Molecule Degraders Containing Pyrimidine Rings and Their Role in Overcoming Drug Resistance von Zhang, Xu, Tu, Linglan, Chai, Haohuan, Li, Zilin, Fu, Yuhan, Zheng, Xiaoliang, Zeng, Shenxin, Cheng, Liyan

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Discovery of potent and selective HPK1 inhibitors based on the 2,4-disubstituted pyrimidine scaffold with immune modulatory properties for ameliorating T cell exhaustion von Zeng, Shenxin, Zeng, Ming, Yuan, Shuai, He, Liuxun, Jin, Yuyuan, Huang, Jiandong, Zhang, Manxuan, yang, Menghan, Pan, Youlu, Wang, Zunyuan, chen, Yinqiao, Xu, Xiangwei, Huang, Wenhai

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