Structures of Three Classes of Anticancer Agents Bound to the Human Topoisomerase I−DNA Covalent Complex von Staker, Bart L, Feese, Michael D, Cushman, Mark, Pommier, Yves, Zembower, David, Stewart, Lance, Burgin, Alex B

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Discovery of 4-[(2S)-2-{[4-(4-Chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic Acid (DG-051) as a Novel Leukotriene A4 Hydrolase Inhibitor of Leukotriene B4 Biosynthesis von Sandanayaka, Vincent, Mamat, Bjorn, Mishra, Rama K, Winger, Jennifer, Krohn, Michael, Zhou, Li-Ming, Keyvan, Monica, Enache, Livia, Sullins, David, Onua, Emmanuel, Zhang, Jun, Halldorsdottir, Gudrun, Sigthorsdottir, Heida, Thorlaksdottir, Audur, Sigthorsson, Gudmundur, Thorsteinnsdottir, Margret, Davies, Douglas R, Stewart, Lance J, Zembower, David E, Andresson, Thorkell, Kiselyov, Alex S, Singh, Jasbir, Gurney, Mark E

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Structure−Activity Relationship Studies Leading to the Identification of (2E)-3-[l-[(2,4-Dichlorophenyl)methyl]-5-fluoro-3-methyl-lH-indol-7-yl]-N-[(4,5-dichloro-2-thienyl)sulfonyl... von Singh, Jasbir, Zeller, Wayne, Zhou, Nian, Hategan, Georgeta, Mishra, Rama K, Polozov, Alex, Yu, Peng, Onua, Emmanuel, Zhang, Jun, Ramírez, José L, Sigthorsson, Gudmundur, Thorsteinnsdottir, Margret, Kiselyov, Alex. S, Zembower, David E, Andrésson, Thorkell, Gurney, Mark E

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Structure―Activity Relationship Studies Leading to the Identification of (2E)-3-[1-[(2,4-Dichlorophenyl)methyl]-5-fluoro-3-methyl-1H-indol-7-yl]-N-[(4,5-dichloro-2-thienyl)sulfonyl... von SINGH, Jasbir, ZELLER, Wayne, SIGTHORSSON, Gudmundur, THORSTEINNSDOTTIR, Margret, KISELYOV, Alex S, ZEMBOWER, David E, ANDRESSON, Thorkell, GURNEY, Mark E, NIAN ZHOU, HATEGAN, Georgeta, MISHRA, Rama K, POLOZOV, Alex, PENG YU, ONUA, Emmanuel, JUN ZHANG, RAMIREZ, José L

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Development of a Scalable Process for DG-041, a Potent EP3 Receptor Antagonist, via Tandem Heck Reactions von Zegar, Siead, Tokar, Christopher, Enache, Livia A, Rajagopol, Venkat, Zeller, Wayne, O'Connell, Matthew, Singh, Jasbir, Muellner, Frank W, Zembower, David E

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Total Synthesis of Robustaflavone, a Potential Anti-Hepatitis B Agent von Zembower, David E, Zhang, Heping

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Development of a Scalable Synthetic Process for DG-051B, A First-in-Class Inhibitior of LTA4H von Enache, Livia A, Kennedy, Isaac, Sullins, David W, Chen, Wei, Ristic, Dragan, Stahl, Glenn L, Dzekhtser, Sergey, Erickson, Robert A, Yan, Changren, Muellner, Frank W, Krohn, Michael D, Winger, Jennifer, Sandanayaka, Vincent, Singh, Jasbir, Zembower, David E, Kiselyov, Alex S

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Synthesis and structural assignment of two major metabolites of the LTA4H inhibitor DG-051 von Enache, Livia A., Zhang, Jun, Sullins, David W., Kennedy, Isaac, Onua, Emmanuel, Zembower, David E., Muellner, Frank W., Singh, Jasbir, Kiselyov, Alex S.

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Structural Analogues of the Calanolide Anti-HIV Agents. Modification of the trans-10,11-Dimethyldihydropyran-12-ol Ring (Ring C) von Zembower, David E, Liao, Shuyuan, Flavin, Michael T, Xu, Ze-Qi, Stup, Tracy L, Buckheit, Robert W, Khilevich, Albert, Mar, Aye Aye, Sheinkman, Abram K

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Robustaflavone, a potential non-nucleoside anti-hepatitis B agent von Zembower, David E, Lin, Yuh-Meei, Flavin, Michael T, Fa-Ching Chen, Korba, Brent E

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Discovery of Leukotriene A4 Hydrolase Inhibitors Using Metabolomics Biased Fragment Crystallography von Davies, Douglas R, Mamat, Bjorn, Magnusson, Olafur T, Christensen, Jeff, Haraldsson, Magnus H, Mishra, Rama, Pease, Brian, Hansen, Erik, Singh, Jasbir, Zembower, David, Kim, Hidong, Kiselyov, Alex S, Burgin, Alex B, Gurney, Mark E, Stewart, Lance J

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Structural analogues of the michellamine anti-HIV agents. Importance of the tetrahydroisoquinoline rings for biological activity von Zhang, Heping, Zembower, David E, Chen, Zhidong

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Efficient reversed-phase purification of a hydrophobic reaction product following Mitsunobu-mediated glycosylation von Iyer, Mani S, Palomo, Martin, Schilling, Kevin M, Xie, Yongping, Formanski, Leo, Zembower, David E

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Antagonists of the EP3 Receptor for Prostaglandin E2 Are Novel Antiplatelet Agents That Do Not Prolong Bleeding von Singh, Jasbir, Zeller, Wayne, Zhou, Nian, Hategen, Georgeta, Mishra, Rama, Polozov, Alex, Yu, Peng, Onua, Emmanuel, Zhang, Jun, Zembower, David, Kiselyov, Alex, Ramírez, José L, Sigthorsson, Gudmundur, Bjornsson, Jon Mar, Thorsteinsdottir, Margret, Andrésson, Thorkell, Bjarnadottir, Maria, Magnusson, Olafur, Fabre, Jean-Etienne, Stefansson, Kari, Gurney, Mark E

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Automated Process Research. An Example of Accelerated Optimization of the Friedel−Crafts Acylation Reaction, a Key Step for the Synthesis of Anti-HIV (+)-Calanolide A von Zhang, Jintao, Kirchhoff, Eric W, Zembower, David E, Jimenez, Nancy, Sen, Prabir, Xu, Ze-Qi, Flavin, Michael T

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Robustaflavone, a naturally occurring biflavanoid, is a potent non-nucleoside inhibitor of hepatitis B virus replication in vitro von Lin, Yuh-Meei, Zembower, David E, Flavin, Michael T, Schure, Ralph M, Anderson, Herbert M, Korba, Brent E, Chen, Fa-Ching

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Synthesis of 5,8-dimethoxy-3-hydroxy-4-quinolone, a reported inhibitor of HIV RT, and evidence the original proposed structure was incorrect von Zembower, David E, Aytes, Shelley A

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Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G von Zembower, David E, Kam, Chih Min, Powers, James C, Zalkow, Leon H

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Enantiospecific syntheses of .alpha.-(fluoromethyl)tryptophan analogs: interactions with tryptophan hydroxylase and aromatic L-amino acid decarboxylase von Zembower, David E, Gilbert, Judith A, Ames, Matthew M

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Structure−Activity Relationship Studies Leading to the Identification of (2 E )-3-[l-[(2,4-Dichlorophenyl)methyl]-5-fluoro-3-methyl-l H -indol-7-yl]- N -[(4,5-dichloro-2-thienyl)su... von Singh, Jasbir, Zeller, Wayne, Zhou, Nian, Hategan, Georgeta, Mishra, Rama K., Polozov, Alex, Yu, Peng, Onua, Emmanuel, Zhang, Jun, Ramírez, José L., Sigthorsson, Gudmundur, Thorsteinnsdottir, Margret, Kiselyov, Alex. S., Zembower, David E., Andrésson, Thorkell, Gurney, Mark E.

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