Development of a Scalable Process for DG-041, a Potent EP3 Receptor Antagonist, via Tandem Heck Reactions von Zegar, Siead, Tokar, Christopher, Enache, Livia A, Rajagopol, Venkat, Zeller, Wayne, O'Connell, Matthew, Singh, Jasbir, Muellner, Frank W, Zembower, David E

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Total Synthesis of Robustaflavone, a Potential Anti-Hepatitis B Agent von Zembower, David E, Zhang, Heping

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Discovery of 4-[(2S)-2-{[4-(4-Chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic Acid (DG-051) as a Novel Leukotriene A4 Hydrolase Inhibitor of Leukotriene B4 Biosynthesis von Sandanayaka, Vincent, Mamat, Bjorn, Mishra, Rama K, Winger, Jennifer, Krohn, Michael, Zhou, Li-Ming, Keyvan, Monica, Enache, Livia, Sullins, David, Onua, Emmanuel, Zhang, Jun, Halldorsdottir, Gudrun, Sigthorsdottir, Heida, Thorlaksdottir, Audur, Sigthorsson, Gudmundur, Thorsteinnsdottir, Margret, Davies, Douglas R, Stewart, Lance J, Zembower, David E, Andresson, Thorkell, Kiselyov, Alex S, Singh, Jasbir, Gurney, Mark E

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Structure−Activity Relationship Studies Leading to the Identification of (2E)-3-[l-[(2,4-Dichlorophenyl)methyl]-5-fluoro-3-methyl-lH-indol-7-yl]-N-[(4,5-dichloro-2-thienyl)sulfonyl... von Singh, Jasbir, Zeller, Wayne, Zhou, Nian, Hategan, Georgeta, Mishra, Rama K, Polozov, Alex, Yu, Peng, Onua, Emmanuel, Zhang, Jun, Ramírez, José L, Sigthorsson, Gudmundur, Thorsteinnsdottir, Margret, Kiselyov, Alex. S, Zembower, David E, Andrésson, Thorkell, Gurney, Mark E

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Structure―Activity Relationship Studies Leading to the Identification of (2E)-3-[1-[(2,4-Dichlorophenyl)methyl]-5-fluoro-3-methyl-1H-indol-7-yl]-N-[(4,5-dichloro-2-thienyl)sulfonyl... von SINGH, Jasbir, ZELLER, Wayne, SIGTHORSSON, Gudmundur, THORSTEINNSDOTTIR, Margret, KISELYOV, Alex S, ZEMBOWER, David E, ANDRESSON, Thorkell, GURNEY, Mark E, NIAN ZHOU, HATEGAN, Georgeta, MISHRA, Rama K, POLOZOV, Alex, PENG YU, ONUA, Emmanuel, JUN ZHANG, RAMIREZ, José L

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Development of a Scalable Synthetic Process for DG-051B, A First-in-Class Inhibitior of LTA4H von Enache, Livia A, Kennedy, Isaac, Sullins, David W, Chen, Wei, Ristic, Dragan, Stahl, Glenn L, Dzekhtser, Sergey, Erickson, Robert A, Yan, Changren, Muellner, Frank W, Krohn, Michael D, Winger, Jennifer, Sandanayaka, Vincent, Singh, Jasbir, Zembower, David E, Kiselyov, Alex S

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Synthesis and structural assignment of two major metabolites of the LTA4H inhibitor DG-051 von Enache, Livia A., Zhang, Jun, Sullins, David W., Kennedy, Isaac, Onua, Emmanuel, Zembower, David E., Muellner, Frank W., Singh, Jasbir, Kiselyov, Alex S.

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Structural Analogues of the Calanolide Anti-HIV Agents. Modification of the trans-10,11-Dimethyldihydropyran-12-ol Ring (Ring C) von Zembower, David E, Liao, Shuyuan, Flavin, Michael T, Xu, Ze-Qi, Stup, Tracy L, Buckheit, Robert W, Khilevich, Albert, Mar, Aye Aye, Sheinkman, Abram K

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Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G von Zembower, David E, Kam, Chih Min, Powers, James C, Zalkow, Leon H

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Robustaflavone, a potential non-nucleoside anti-hepatitis B agent von Zembower, David E, Lin, Yuh-Meei, Flavin, Michael T, Fa-Ching Chen, Korba, Brent E

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Structural analogues of the michellamine anti-HIV agents. Importance of the tetrahydroisoquinoline rings for biological activity von Zhang, Heping, Zembower, David E, Chen, Zhidong

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Efficient reversed-phase purification of a hydrophobic reaction product following Mitsunobu-mediated glycosylation von Iyer, Mani S, Palomo, Martin, Schilling, Kevin M, Xie, Yongping, Formanski, Leo, Zembower, David E

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Automated Process Research. An Example of Accelerated Optimization of the Friedel−Crafts Acylation Reaction, a Key Step for the Synthesis of Anti-HIV (+)-Calanolide A von Zhang, Jintao, Kirchhoff, Eric W, Zembower, David E, Jimenez, Nancy, Sen, Prabir, Xu, Ze-Qi, Flavin, Michael T

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Robustaflavone, a naturally occurring biflavanoid, is a potent non-nucleoside inhibitor of hepatitis B virus replication in vitro von Lin, Yuh-Meei, Zembower, David E, Flavin, Michael T, Schure, Ralph M, Anderson, Herbert M, Korba, Brent E, Chen, Fa-Ching

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Synthesis of 5,8-dimethoxy-3-hydroxy-4-quinolone, a reported inhibitor of HIV RT, and evidence the original proposed structure was incorrect von Zembower, David E, Aytes, Shelley A

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Synthesis of (+)-calanolide A, an anti-HIV agent, Via enzyme-catalyzed resolution of the aldol products von Khilevich, Albert, Mar, Aye, Flavin, Michael T., Rizzo, John D., Lin, Lin, Dzekhtser, Sergey, Brankovic, Darko, Zhang, Heping, Chen, Wei, Liao, Shuyuan, Zembower, David E., Xu, Ze-Qi

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Enantiospecific syntheses of .alpha.-(fluoromethyl)tryptophan analogs: interactions with tryptophan hydroxylase and aromatic L-amino acid decarboxylase von Zembower, David E, Gilbert, Judith A, Ames, Matthew M

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Structure−Activity Relationship Studies Leading to the Identification of (2 E )-3-[l-[(2,4-Dichlorophenyl)methyl]-5-fluoro-3-methyl-l H -indol-7-yl]- N -[(4,5-dichloro-2-thienyl)su... von Singh, Jasbir, Zeller, Wayne, Zhou, Nian, Hategan, Georgeta, Mishra, Rama K., Polozov, Alex, Yu, Peng, Onua, Emmanuel, Zhang, Jun, Ramírez, José L., Sigthorsson, Gudmundur, Thorsteinnsdottir, Margret, Kiselyov, Alex. S., Zembower, David E., Andrésson, Thorkell, Gurney, Mark E.

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In vitro anti-human immunodeficiency virus (HIV) activity of the chromanone derivative, 12-oxocalanolide A, a novel NNRTI von Ze-Qi Xu, Buckheit, Robert W., Stup, Tracy L., Flavin, Michael T., Khilevich, Albert, Rizzo, John D., Lin, Lin, Zembower, David E.

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COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING ATRIAL FIBRILLATION von Zembower, David E, Arora, Rishi

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