Discovery and Preclinical Pharmacology of NX-2127, an Orally Bioavailable Degrader of Bruton’s Tyrosine Kinase with Immunomodulatory Activity for the Treatment of Patients with B C... von Robbins, Daniel W., Noviski, Mark A., Tan, Ying Siow, Konst, Zef A., Kelly, Aileen, Auger, Paul, Brathaban, Nivetha, Cass, Robert, Chan, Ming Liang, Cherala, Ganesh, Clifton, Matthew C., Gajewski, Stefan, Ingallinera, Timothy G., Karr, Dane, Kato, Daisuke, Ma, Jun, McKinnell, Jenny, McIntosh, Joel, Mihalic, Jeff, Murphy, Brent, Panga, Jaipal Reddy, Peng, Ge, Powers, Janine, Perez, Luz, Rountree, Ryan, Tenn-McClellan, Austin, Sands, Arthur T., Weiss, Dahlia R., Wu, Jeffrey, Ye, Jordan, Guiducci, Cristiana, Hansen, Gwenn, Cohen, Frederick

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Site-Selective Aliphatic C–H Chlorination Using N‑Chloroamides Enables a Synthesis of Chlorolissoclimide von Quinn, Ryan K, Könst, Zef A, Michalak, Sharon E, Schmidt, Yvonne, Szklarski, Anne R, Flores, Alex R, Nam, Sangkil, Horne, David A, Vanderwal, Christopher D, Alexanian, Erik J

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A practical method for regiocontrolled one-carbon ring contraction von Mitcheltree, Matthew J., Konst, Zef A., Herzon, Seth B.

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Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides von Könst, Zef A., Szklarski, Anne R., Pellegrino, Simone, Michalak, Sharon E., Meyer, Mélanie, Zanette, Camila, Cencic, Regina, Nam, Sangkil, Voora, Vamsee K., Horne, David A., Pelletier, Jerry, Mobley, David L., Yusupova, Gulnara, Yusupov, Marat, Vanderwal, Christopher D.

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Understanding the role of intermolecular interactions between lissoclimides and the eukaryotic ribosome von Pellegrino, Simone, Meyer, Mélanie, Könst, Zef A, Holm, Mikael, Voora, Vamsee K, Kashinskaya, Daniya, Zanette, Camila, Mobley, David L, Yusupova, Gulnara, Vanderwal, Chris D, Blanchard, Scott C, Yusupov, Marat

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Catalyst-Controlled Stereoselective Synthesis Secures the Structure of the Antimalarial Isocyanoterpene Pustulosaisonitrile‑1 von White, Andrew M, Dao, Kathy, Vrubliauskas, Darius, Könst, Zef A, Pierens, Gregory K, Mándi, Attila, Andrews, Katherine T, Skinner-Adams, Tina S, Clarke, Mary E, Narbutas, Patrick T, Sim, Desmond C.-M, Cheney, Karen L, Kurtán, Tibor, Garson, Mary J, Vanderwal, Christopher D

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Sgr-2921, a Potent CDC7 Inhibitor, Demonstrates Significant Anti-Leukemic Responses in Patient-Derived AML Models Representing Difficult-to-Treat Disease von Izadi, Hooman, Wang, Hui, Atsriku, Christian, Konst, Zef, Levinson, Adam, Piccotti, Joseph, Pirie-Shepherd, Steven, Tang, Lin, Weiss, Dan, Akinsanya, Karen, Wright, Hamish, Jensen, Kristian K

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Nx-5948, a Selective Degrader of BTK with Activity in Preclinical Models of Hematologic and Brain Malignancies von Robbins, Daniel W, Noviski, Mark, Rountree, Ryan, Tan, May, Brathaban, Nivetha, Ingallinera, Timothy, Karr, Dane E, Kelly, Aileen, Konst, Zef, Ma, Jun, Tenn-McClellan, Austin, McKinnell, Jenny, Perez, Luz, Guiducci, Cristiana, Hansen, Gwenn, Sands, Arthur

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Abstract 1338: Discovery of novel, potent USP7 inhibitors that upregulate p53 leading to anti-proliferative effects in cancer cells von Futran, Alan, Lu, Tao, Amberg-Johnson, Katherine, Yang, Xiaoxiao, He, Saidi, Bell, Jeffrey, Boyce, Sarah, Dahlgren, Markus, Dingley, Karen, Fang, Liping, Koldsoe, Heidi, Konst, Zef, Lin, Fang-Yu, Pelleltier, Robert, Qian, Heng, Svensson, Mats, Trzoss, Michael, Xu, Jie, Xu, Shuping, Xu, Zhaowu, Yapici, Engin, Zhang, Yan, Xing, Li, Suzuki, Takao, Huang, Xianhai, Xu, Jiayi, Wright, Hamish, Jensen, Kristian, Tang, Wayne, Guo, Tao, Akinsanya, Karen, Madge, David

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Nx-2127, a Degrader of BTK and IMiD Neosubstrates, for the Treatment of B-Cell Malignancies von Robbins, Daniel W, Kelly, Aileen, Tan, May, McIntosh, Joel, Wu, Jeffrey, Konst, Zef, Kato, Daisuke, Peng, Ge, Mihalic, Jeff, Weiss, Dahlia, Perez, Luz, Tung, Jennifer, Kolobova, Anna, Borodovsky, Sasha, Rountree, Ryan, Tenn-McClellan, Austin, Noviski, Mark, Ye, Jordan, Basham, Steve, Ingallinera, Timothy, McKinnell, Jenny, Karr, Dane E, Powers, Janine, Guiducci, Cristiana, Sands, Arthur

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Targeted Protein Degradation of BTK As a Unique Therapeutic Approach for B Cell Malignancies von Kelly, Aileen, Robbins, Daniel W, Tan, May, Tenn-McClellan, Austin, McIntosh, Joel, Wu, Jeffrey, Konst, Zef, Kato, Daisuke, Perez, Luz, Tung, Jennifer, Kolobova, Anna, Ingallinera, Timothy, McKinnell, Jenny, Weiss, Dahlia, Noviski, Mark, Ye, Jordan, Peng, Ge, Cardozo, Mario, Mihalic, Jeff, Basham, Steve, Rountree, Ryan, Karr, Dane E, Bence, Neil, Zapf, Christoph W, Sands, Arthur T

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ChemInform Abstract: A Practical Method for Regiocontrolled One-Carbon Ring Contraction von Mitcheltree, Matthew J., Konst, Zef A., Herzon, Seth B.

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Understanding the role of intermolecular interactions between lissoclimides and the eukaryotic ribosome von Pellegrino, Simone, Meyer, Mélanie, Könst, Zef, Holm, Mikael, Voora, Vamsee, Kashinskaya, Daniya, Zanette, Camila, Mobley, David, Yusupova, Gulnara, Vanderwal, Chris, Blanchard, Scott, Yusupov, Marat

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PHENYL AMIDE COMPOUNDS AND METHODS OF USE von GREENWOOD, Jeremy, HOUANG, Evelyne, RUVINSKY, Anatoly, LEVINSON, Adam, PLACZEK, Andrew, KONST, Zef, LEFFLER, Abba

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PHENYL AMIDE COMPOUNDS AND METHODS OF USE von GREENWOOD, Jeremy, HOUANG, Evelyne, RUVINSKY, Anatoly, LEVINSON, Adam, PLACZEK, Andrew, KONST, Zef, LEFFLER, Abba

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HETEROCYCLIC COMPOUNDS AND METHODS OF USE von LEFFLER, Abba Elias, HOUANG, Evelyne, FRYE, Leah, RUVINSKY, Anatoly, GREENWOOD, Jeremy Robert, PLACZEK, Andrew, KONST, Zef, LEVINSON, Adam Marc

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HETEROCYCLIC COMPOUNDS AND METHODS OF USE von Greenwood, Jeremy Robert, Houang, Evelyne, Konst, Zef, Leffler, Abba Elias, Placzek, Andrew, Levinson, Adam Marc, Ruvinsky, Anatoly, Frye, Leah

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HETEROCYCLIC COMPOUNDS AND METHODS OF USE von LEFFLER, Abba Elias, HOUANG, Evelyne, FRYE, Leah, RUVINSKY, Anatoly, GREENWOOD, Jeremy Robert, PLACZEK, Andrew, KONST, Zef, LEVINSON, Adam Marc

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HETEROCYCLIC COMPOUNDS AND METHODS OF USE von LEFFLER, Abba Elias, HOUANG, Evelyne, FRYE, Leah, RUVINSKY, Anatoly, GREENWOOD, Jeremy Robert, PLACZEK, Andrew, KONST, Zef, LEVINSON, Adam Marc

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CYCLIC COMPOUNDS AND METHODS OF USING SAME von HUANG, Xianhai, FRYE, Leah, TANG, Haifeng, BHAT, Sathesh, BOS, Pieter Harm, GREENWOOD, Jeremy Robert, MONDAL, Sayan, GHANAKOTA, Phani, KONST, Zef, LEVINSON, Adam Marc

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