Conclusions of the SIGNAL study in Huntington and implications for treatment of other slowly progressive neurodegenerative diseases von Zauderer, Maurice, Evans, Elizabeth Erin

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A Vaccinia-based system for directed evolution of GPCRs in mammalian cells von Klenk, Christoph, Scrivens, Maria, Niederer, Anina, Shi, Shuying, Mueller, Loretta, Gersz, Elaine, Zauderer, Maurice, Smith, Ernest S., Strohner, Ralf, Plückthun, Andreas

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Semaphorin 4D is upregulated in neurons of diseased brains and triggers astrocyte reactivity von Evans, Elizabeth E, Mishra, Vikas, Mallow, Crystal, Gersz, Elaine M, Balch, Leslie, Howell, Alan, Reilly, Christine, Smith, Ernest S, Fisher, Terrence L, Zauderer, Maurice

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SEMA4D compromises blood–brain barrier, activates microglia, and inhibits remyelination in neurodegenerative disease von Smith, Ernest S, Jonason, Alan, Reilly, Christine, Veeraraghavan, Janaki, Fisher, Terrence, Doherty, Michael, Klimatcheva, Ekaterina, Mallow, Crystal, Cornelius, Chad, Leonard, John E, Marchi, Nicola, Janigro, Damir, Argaw, Azeb Tadesse, Pham, Trinh, Seils, Jennifer, Bussler, Holm, Torno, Sebold, Kirk, Renee, Howell, Alan, Evans, Elizabeth E, Paris, Mark, Bowers, William J, John, Gareth, Zauderer, Maurice

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Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease von Southwell, Amber L, Franciosi, Sonia, Villanueva, Erika B, Xie, Yuanyun, Winter, Laurie A, Veeraraghavan, Janaki, Jonason, Alan, Felczak, Boguslaw, Zhang, Weining, Kovalik, Vlad, Waltl, Sabine, Hall, George, Pouladi, Mahmoud A, Smith, Ernest S, Bowers, William J, Zauderer, Maurice, Hayden, Michael R

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CXCL13 antibody for the treatment of autoimmune disorders von Klimatcheva, Ekaterina, Pandina, Tracy, Reilly, Christine, Torno, Sebold, Bussler, Holm, Scrivens, Maria, Jonason, Alan, Mallow, Crystal, Doherty, Michael, Paris, Mark, Smith, Ernest S, Zauderer, Maurice

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Anti-Semaphorin 4D Rescues Motor, Cognitive, and Respiratory Phenotypes in a Rett Syndrome Mouse Model von Mao, Yilin, Evans, Elizabeth, Mishra, Vikas, Balch, Leslie, Eberhardt, Allison, Zauderer, Maurice, Gold, Wendy

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Semaphorin4D Inhibition Improves Response to Immune-Checkpoint Blockade via Attenuation of MDSC Recruitment and Function von Clavijo, Paul E, Friedman, Jay, Robbins, Yvette, Moore, Ellen C, Smith, Ernest, Zauderer, Maurice, Evans, Elizabeth E, Allen, Clint T

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Nonclinical Safety Evaluation of VX15/2503, a Humanized IgG4 Anti-SEMA4D Antibody von Leonard, John E, Fisher, Terrence L, Winter, Laurie A, Cornelius, Chad A, Reilly, Christine, Smith, Ernest S, Zauderer, Maurice

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Use of poxvirus display to select antibodies specific for complex membrane antigens von Smith, Ernest S., Balch, Leslie A., Scrivens, Maria, Shi, Shuying, Wang, Wei, Harvey, Caroline D., Cornelison, Angelica A., Gil-Moore, Malgorzata, Kirk, Renee A., Mueller, Loretta L., Hall, Richard L., Howell, Alan P., Reilly, Christine A., Mayer, Jessica M., Murante, Francis G., Viggiani, Kari A, Gersz, Elaine M., Bussler, Holm, Keefe, Madeleine R., Evans, Elizabeth E., Paris, Mark J., Zauderer, Maurice

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Generation and preclinical characterization of an antibody specific for SEMA4D von Fisher, Terrence L, Reilly, Christine A, Winter, Laurie A, Pandina, Tracy, Jonason, Alan, Scrivens, Maria, Balch, Leslie, Bussler, Holm, Torno, Sebold, Seils, Jennifer, Mueller, Loretta, Huang, He, Klimatcheva, Ekaterina, Howell, Alan, Kirk, Renee, Evans, Elizabeth, Paris, Mark, Leonard, John E, Smith, Ernest S, Zauderer, Maurice

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Safety/tolerability of the anti-semaphorin 4D antibody VX15/2503 in a randomized phase 1 trial von LaGanke, Christopher, Samkoff, Lawrence, Edwards, Keith, Jung Henson, Lily, Repovic, Pavle, Lynch, Sharon, Stone, Lael, Mattson, David, Galluzzi, Aaron, Fisher, Terrence L, Reilly, Christine, Winter, Laurie A, Leonard, John E, Zauderer, Maurice

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676 Pepinemab, a semaphorin 4D inhibitor, in combination with pembrolizumab induced formation of organized lymphoid aggregates in phase 1b/2 study for first-line treatment of R/M H... von Fisher, Terrence, Evans, Elizabeth, Mallow, Crystal, Foster, Amber, Leonard, John, Chaney, Marya, Mekhail, Tarek, Seetharamu, Nagashree, Steuer, Conor, Saba, Nabil F, Adkins, Douglas, Thaddeus Beck, J, Algazi, Alain, Burtness, Barbara, Baumgart, Megan, Hager, Steven, Chay, Christopher, Spira, Alexander, Zauderer, Maurice

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Immunomodulation of the tumor microenvironment by neutralization of Semaphorin 4D von Evans, Elizabeth E, Paris, Mark, Smith, Ernest S, Zauderer, Maurice

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434 Phase 1/2 study to evaluate pepinemab in combination with pembrolizumab in advanced, recurrent or metastatic head and neck cancer (KEYNOTE B84) von Evans, Elizabeth, Fisher, Terrence, Mallow, Crystal, Foster, Amber, Smith, Ernest, Leonard, John, Chaney, Marya, Zauderer, Maurice

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629 Neoadjuvant SEMA4D inhibitor pepinemab combination with nivolumab increases crosstalk between B cell and CD26hi T cell in patients with resectable stage III melanoma von Ruffin, Ayana T, Olson, Brian, Mallow, Crystal, Reilly, Christine, Hammons, Jacklyn, Kim, Jayden, Burns, Brian, Harutyunyan, Agnes, Evans, Elizabeth, Fisher, Terrence, Zauderer, Maurice, Delman, Keith A, Yushak, Melinda, Mokhtari, Ali, Parker, Douglas, Kudchadkar, Ragini, Paulos, Chrystal M, Lesinski, Gregory B, Lowe, Michael C

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A biological classification of Huntington's disease: the Integrated Staging System von Tabrizi, Sarah J, Schobel, Scott, Gantman, Emily C, Mansbach, Alexandra, Borowsky, Beth, Konstantinova, Pavlina, Mestre, Tiago A, Panagoulias, Jennifer, Ross, Christopher A, Zauderer, Maurice, Mullin, Ariana P, Romero, Klaus, Sivakumaran, Sudhir, Turner, Emily C, Long, Jeffrey D, Sampaio, Cristina

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C35 (C17orf37) is a novel tumor biomarker abundantly expressed in breast cancer von Evans, Elizabeth E, Henn, Alicia D, Jonason, Alan, Paris, Mark J, Schiffhauer, Linda M, Borrello, Melinda A, Smith, Ernest S, Sahasrabudhe, Deepak M, Zauderer, Maurice

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Clinical evidence that treatment with pepinemab, a novel regulator of neuroinflammation, provides cognitive benefit to patients with Huntington’s and potentially other neurodegener... von Evans, Elizabeth, Fisher, Terrence, Mishra, Vikas, Boise, Megan, Foster, Amber, Smith, Ernest, Leonard, John, Feigin, Andrew, Siemers, Eric, Zauderer, Maurice

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A Vaccinia-based system for directed evolution of GPCRs in mammalian cells von Klenk, Christoph, Scrivens, Maria, Niederer, Anina, Shi, Shuying, Mueller, Loretta, Gersz, Elaine, Zauderer, Maurice, Smith, Ernest S, Strohner, Ralf, Plückthun, Andreas

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