Comprehensive analysis of kinase inhibitor selectivity von Davis, Mindy I, Hunt, Jeremy P, Herrgard, Sanna, Ciceri, Pietro, Wodicka, Lisa M, Pallares, Gabriel, Hocker, Michael, Treiber, Daniel K, Zarrinkar, Patrick P

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AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML) von Zarrinkar, Patrick P., Gunawardane, Ruwanthi N., Cramer, Merryl D., Gardner, Michael F., Brigham, Daniel, Belli, Barbara, Karaman, Mazen W., Pratz, Keith W., Pallares, Gabriel, Chao, Qi, Sprankle, Kelly G., Patel, Hitesh K., Levis, Mark, Armstrong, Robert C., James, Joyce, Bhagwat, Shripad S.

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A quantitative analysis of kinase inhibitor selectivity von Zarrinkar, Patrick P, Karaman, Mazen W, Herrgard, Sanna, Treiber, Daniel K, Gallant, Paul, Atteridge, Corey E, Campbell, Brian T, Chan, Katrina W, Ciceri, Pietro, Davis, Mindy I, Edeen, Philip T, Faraoni, Raffaella, Floyd, Mark, Hunt, Jeremy P, Lockhart, Daniel J, Milanov, Zdravko V, Morrison, Michael J, Pallares, Gabriel, Patel, Hitesh K, Pritchard, Stephanie, Wodicka, Lisa M

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High-throughput kinase profiling as a platform for drug discovery von Zarrinkar, Patrick P, Goldstein, David M, Gray, Nathanael S

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Inhibition of Drug-Resistant Mutants of ABL, KIT, and EGF Receptor Kinases von Carter, Todd A., Wodicka, Lisa M., Shah, Neil P., Velasco, Anne Marie, Fabian, Miles A., Treiber, Daniel K., Milanov, Zdravko V., Atteridge, Corey E., Biggs, William H., Edeen, Philip T., Floyd, Mark, Ford, Julia M., Grotzfeld, Robert M., Herrgard, Sanna, Insko, Darren E., Mehta, Shamal A., Patel, Hitesh K., Pao, William, Sawyers, Charles L., Varmus, Harold, Zarrinkar, Patrick P., Lockhart, David J.

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Analysis of Gene Expression Profiles in Normal and Neoplastic Ovarian Tissue Samples Identifies Candidate Molecular Markers of Epithelial Ovarian Cancer von Welsh, John B., Zarrinkar, Patrick P., Sapinoso, Lisa M., Kern, Suzanne G., Behling, Cynthia A., Monk, Bradley J., Lockhart, David J., Burger, Robert A., Hampton, Garret M.

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Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor von Janes, Matthew R., Zhang, Jingchuan, Li, Lian-Sheng, Hansen, Rasmus, Peters, Ulf, Guo, Xin, Chen, Yuching, Babbar, Anjali, Firdaus, Sarah J., Darjania, Levan, Feng, Jun, Chen, Jeffrey H., Li, Shuangwei, Li, Shisheng, Long, Yun O., Thach, Carol, Liu, Yuan, Zarieh, Ata, Ely, Tess, Kucharski, Jeff M., Kessler, Linda V., Wu, Tao, Yu, Ke, Wang, Yi, Yao, Yvonne, Deng, Xiaohu, Zarrinkar, Patrick P., Brehmer, Dirk, Dhanak, Dashyant, Lorenzi, Matthew V., Hu-Lowe, Dana, Patricelli, Matthew P., Ren, Pingda, Liu, Yi

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Outlier analysis of functional genomic profiles enriches for oncology targets and enables precision medicine von Zhu, Zhou, Ihle, Nathan T, Rejto, Paul A, Zarrinkar, Patrick P

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KRAS G12C NSCLC Models Are Sensitive to Direct Targeting of KRAS in Combination with PI3K Inhibition von Misale, Sandra, Fatherree, Jackson P, Cortez, Eliane, Li, Chendi, Bilton, Samantha, Timonina, Daria, Myers, David T, Lee, Dana, Gomez-Caraballo, Maria, Greenberg, Max, Nangia, Varuna, Greninger, Patricia, Egan, Regina K, McClanaghan, Joseph, Stein, Giovanna T, Murchie, Ellen, Zarrinkar, Patrick P, Janes, Matthew R, Li, Lian-Sheng, Liu, Yi, Hata, Aaron N, Benes, Cyril H

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Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia von Smith, Catherine C., Wang, Qi, Chin, Chen-Shan, Salerno, Sara, Damon, Lauren E., Levis, Mark J., Perl, Alexander E., Travers, Kevin J., Wang, Susana, Hunt, Jeremy P., Zarrinkar, Patrick P., Schadt, Eric E., Kasarskis, Andrew, Kuriyan, John, Shah, Neil P.

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Kinetic Intermediates Trapped by Native Interactions in RNA Folding von Treiber, Daniel K., Rook, Martha S., Zarrinkar, Patrick P., Williamson, James R.

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Identification of N-(5-tert-Butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea Dihydrochloride (AC220), a Uniquely Potent, Sele... von Chao, Qi, Sprankle, Kelly G, Grotzfeld, Robert M, Lai, Andiliy G, Carter, Todd A, Velasco, Anne Marie, Gunawardane, Ruwanthi N, Cramer, Merryl D, Gardner, Michael F, James, Joyce, Zarrinkar, Patrick P, Patel, Hitesh K, Bhagwat, Shripad S

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An Internally Controlled Quantitative Target Occupancy Assay for Covalent Inhibitors von Hansen, Rasmus, Firdaus, Sarah J., Li, Shuangwei, Janes, Matthew R., Zhang, Jingchuan, Liu, Yi, Zarrinkar, Patrick P.

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A small molecule-kinase interaction map for clinical kinase inhibitors von Zarrinkar, Patrick P, Floyd, Mark, Lai, Andiliy G, Atteridge, Corey E, Carter, Todd A, Galvin, Margaret, Mehta, Shamal A, Lélias, Jean-Michel, Wodicka, Lisa M, Benedetti, Michael G, Azimioara, Mihai D, Treiber, Daniel K, Insko, Darren E, Insko, Michael A, Edeen, Philip T, Gerlach, Jay L, Fabian, Miles A, Grotzfeld, Robert M, Lockhart, David J, Patel, Hitesh K, Milanov, Zdravko V, Ciceri, Pietro, Biggs, William H, Herrgard, Sanna, Velasco, Anne Marie, Ford, Julia M

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Structure of the kinase domain of an imatinib-resistant abl mutant in complex with the aurora kinase inhibitor VX-680 von YOUNG, Matthew A, SHAH, Neil P, SAWYERS, Charles L, KURIYAN, John, CHAO, Luke H, SEELIGER, Markus, MILANOV, Zdravko V, BIGGS, William H, TREIBER, Daniel K, PATEL, Hitesh K, ZARRINKAR, Patrick P, LOCKHART, David J

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The reactivity-driven biochemical mechanism of covalent KRASG12C inhibitors von Hansen, Rasmus, Peters, Ulf, Babbar, Anjali, Chen, Yuching, Feng, Jun, Janes, Matthew R., Li, Lian-Sheng, Ren, Pingda, Liu, Yi, Zarrinkar, Patrick P.

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Discovery and optimization of a highly efficacious class of 5-aryl-2-aminopyridines as FMS-like tyrosine kinase 3 (FLT3) inhibitors von Liu, Gang, Abraham, Sunny, Liu, Xing, Xu, Shimin, Rooks, Allison M., Nepomuceno, Ron, Dao, Alan, Brigham, Daniel, Gitnick, Dana, Insko, Darren E., Gardner, Michael F., Zarrinkar, Patrick P., Christopher, Ron, Belli, Barbara, Armstrong, Robert C., Holladay, Mark W.

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Tuning a Three-Component Reaction For Trapping Kinase Substrate Complexes von Statsuk, Alexander V, Maly, Dustin J, Seeliger, Markus A, Fabian, Miles A, Biggs, William H, Lockhart, David J, Zarrinkar, Patrick P, Kuriyan, John, Shokat, Kevan M

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Kinetic Intermediates in RNA Folding von Zarrinkar, Patrick P., Williamson, James R.

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Arylcarboxyamino-substituted diaryl ureas as potent and selective FLT3 inhibitors von Patel, Hitesh K., Grotzfeld, Robert M., Lai, Andiliy G., Mehta, Shamal A., Milanov, Zdravko V., Chao, Qi, Sprankle, Kelly G., Carter, Todd A., Velasco, Anne Marie, Fabian, Miles A., James, Joyce, Treiber, Daniel K., Lockhart, David J., Zarrinkar, Patrick P., Bhagwat, Shripad S.

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