p53 Nongenotoxic Activation and mTORC1 Inhibition Lead to Effective Combination for Neuroblastoma Therapy von Moreno-Smith, Myrthala, Lakoma, Anna, Chen, Zaowen, Tao, Ling, Scorsone, Kathleen A, Schild, Linda, Aviles-Padilla, Kevin, Nikzad, Rana, Zhang, Yankai, Chakraborty, Rikhia, Molenaar, Jan J, Vasudevan, Sanjeev A, Sheehan, Vivien, Kim, Eugene S, Paust, Silke, Shohet, Jason M, Barbieri, Eveline

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Histone Chaperone CHAF1A Inhibits Differentiation and Promotes Aggressive Neuroblastoma von BARBIERI, Eveline, DE PRETER, Katleen, SPELEMAN, Frank, KIM, Eugene S, SHOHET, Jason M, CAPASSO, Mario, ZAOWEN CHEN, HSU, Danielle M, TONINI, Gian Paolo, LEFEVER, Steve, HICKS, John, VERSTEEG, Rogier, PESSION, Andrea

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MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma von Agarwal, Saurabh, Milazzo, Giorgio, Rajapakshe, Kimal, Bernardi, Ronald, Chen, Zaowen, Barbieri, Eveline, Koster, Jan, Perini, Giovanni, Coarfa, Cristian, Shohet, Jason M

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A p53 drug response signature identifies prognostic genes in high-risk neuroblastoma von Barbieri, Eveline, De Preter, Katleen, Capasso, Mario, Johansson, Peter, Man, Tsz-Kwong, Chen, Zaowen, Stowers, Paris, Tonini, Gian Paolo, Speleman, Frank, Shohet, Jason M

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A Genome-Wide Search for Promoters That Respond to Increased MYCN Reveals Both New Oncogenic and Tumor Suppressor MicroRNAs Associated with Aggressive Neuroblastoma von SHOHET, Jason M, GHOSH, Rajib, MILOSAVLJEVIC, Aleksandar, KIM, Eugene S, GUNARATNE, Preethi H, COARFA, Cristian, LUDWIG, Andrew, BENHAM, Ashley L, ZAOWEN CHEN, PATTERSON, Danielle M, BARBIERI, Eveline, MESTDAGH, Pieter, SIKORSKI, Denae N

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G-CSF Receptor Positive Neuroblastoma Subpopulations Are Enriched in Chemotherapy-Resistant or Relapsed Tumors and Are Highly Tumorigenic von HSU, Danielle M, AGARWAL, Saurabh, METELITSA, Leonid S, GUNARATNE, Preethi, KIM, Eugene S, SHOHET, Jason M, BENHAM, Ashley, COARFA, Cristian, TRAHAN, Denae N, CHEN, Zaowen, STOWERS, Paris N, COURTNEY, Amy N, LAKOMA, Anna, BARBIERI, Eveline

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The p53 Regulatory Gene MDM2 Is a Direct Transcriptional Target of MYCN in Neuroblastoma von Slack, Andrew, Chen, Zaowen, Tonelli, Roberto, Pule, Martin, Hunt, Lisa, Pession, Andrea, Shohet, Jason M., Eisenman, Robert N.

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MDM2 inhibition sensitizes neuroblastoma to chemotherapy-induced apoptotic cell death von Barbieri, Eveline, Mehta, Parth, Chen, Zaowen, Zhang, Linna, Slack, Andrew, Berg, Stacey, Shohet, Jason M

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Effect of MDM2 and vascular endothelial growth factor inhibition on tumor angiogenesis and metastasis in neuroblastoma von Patterson, Danielle M., Gao, Dongbing, Trahan, Denae N., Johnson, Brett A., Ludwig, Andrew, Barbieri, Eveline, Chen, Zaowen, Diaz-Miron, Jose, Vassilev, Lyubomir, Shohet, Jason M., Kim, Eugene S.

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Mdm2 Deficiency Suppresses MYCN-Driven Neuroblastoma Tumorigenesis In Vivo von Chen, Zaowen, Lin, Yunfu, Barbieri, Eveline, Burlingame, Sue, Hicks, John, Ludwig, Andrew, Shohet, Jason M.

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MYCN-directed centrosome amplification requires MDM2-mediated suppression of p53 activity in neuroblastoma cells von SLACK, Andrew D, ZAOWEN CHEN, LUDWIG, Andrew D, HICKS, John, SHOHET, Jason M

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G-CSF Promotes Neuroblastoma Tumorigenicity and Metastasis via STAT3-Dependent Cancer Stem Cell Activation von Agarwal, Saurabh, Lakoma, Anna, Chen, Zaowen, Hicks, John, Metelitsa, Leonid S, Kim, Eugene S, Shohet, Jason M

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Divergent structures of Mammalian and gammaherpesvirus uracil DNA glycosylases confer distinct DNA binding and substrate activity von Mu, Yunxiang, Zelazowska, Monika A., Chen, Zaowen, Plummer, Joshua B., Dong, Qiwen, Krug, Laurie T., McBride, Kevin M.

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Abstract A15: Epigenetic regulators maintain neuroblastoma cancer stem cells: Model to treatment von Agarwal, Saurabh, Chen, Zaowen, Vasudevan, Sanjeev, Shohet, Jason M.

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Uracil DNA Glycosylase of Gammaherpesvirus alters somatic hypermutation through error-free DNA repair von Mu, Yunxiang, Dong, Qiwen, Zelazowska, Monika Anna, Chen, Zaowen, Plummer, Joshua, Krug, Laurie, McBride, Kevin M.

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Abstract 4781: Epigenetic regulation of neuroblastoma tumorigenicity through MLL1 and JMJD3 modulation in cancer stem cells von Agarwal, Saurabh, Chen, Zaowen, Tomolonis, Julie A., Vasudevan, Sanjeev A., Shohet, Jason M.

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Abstract A02: The epigenetic modifier CHAF1A opposes neuroblastoma differentiation via metabolic reprogramming von Barbieri, Eveline, Chen, Zaowen, Moreno-Smith, Mirthala, Shohet, Jason M.

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Abstract B44: The epigenetic modifier CHAF1A opposes neuroblastoma differentiation via metabolic reprogramming von Barbieri, Eveline, Chen, Zaowen, Lakoma, Anna, Kim, Eugene, Shohet, Jason

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Abstract A59: CHAF1A blocks neuroblastoma differentiation and promotes tumor growth via metabolic reprogramming von Moreno-Smith, Myrthala, Chen, Zaowen, Kim, Eugene S., Shohet, Jason M., Barbieri, Eveline

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Transmembrane adaptor protein PAG1 is a novel tumor suppressor in neuroblastoma von Agarwal, Saurabh, Ghosh, Rajib, Chen, Zaowen, Lakoma, Anna, Gunaratne, Preethi H, Kim, Eugene S, Shohet, Jason M

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