FGF21 Analogs of Sustained Action Enabled by Orthogonal Biosynthesis Demonstrate Enhanced Antidiabetic Pharmacology in Rodents von MU, James, PINKSTAFF, Jason, WU, Margaret, NORMAN, Thea C, RODRIGUEZ, Carlos G, KIMMEL, Bruce, METZGER, Joseph M, MANIBUSAN, Anthony, LEE, Darin, ZALLER, Dennis M, ZHANG, Bei B, DIMARCHI, Richard D, ZHIHUA LI, BERGER, Joel P, AXELROD, Douglas W, SKIDMORE, Lillian, NINA LI, MYLER, Heather, DALLAS-YANG, Qing, PUTNAM, Anna-Maria, JUN YAO, BUSSELL, Stuart

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Structures, functions and adaptations of the human LINE-1 ORF2 protein von Baldwin, Eric T., van Eeuwen, Trevor, Hoyos, David, Zalevsky, Arthur, Tchesnokov, Egor P., Sánchez, Roberto, Miller, Bryant D., Di Stefano, Luciano H., Ruiz, Francesc Xavier, Hancock, Matthew, Işik, Esin, Mendez-Dorantes, Carlos, Walpole, Thomas, Nichols, Charles, Wan, Paul, Riento, Kirsi, Halls-Kass, Rowan, Augustin, Martin, Lammens, Alfred, Jestel, Anja, Upla, Paula, Xibinaku, Kera, Congreve, Samantha, Hennink, Maximiliaan, Rogala, Kacper B., Schneider, Anna M., Fairman, Jennifer E., Christensen, Shawn M., Desrosiers, Brian, Bisacchi, Gregory S., Saunders, Oliver L., Hafeez, Nafeeza, Miao, Wenyan, Kapeller, Rosana, Zaller, Dennis M., Sali, Andrej, Weichenrieder, Oliver, Burns, Kathleen H., Götte, Matthias, Rout, Michael P., Arnold, Eddy, Greenbaum, Benjamin D., Romero, Donna L., LaCava, John, Taylor, Martin S.

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Subcellular location of L1 retrotransposon-encoded ORF1p, reverse transcription products, and DNA sensors in lupus granulocytes von Moadab, Fatemeh, Sohrabi, Sepideh, Wang, Xiaoxing, Najjar, Rayan, Wolters, Justina C, Jiang, Hua, Miao, Wenyan, Romero, Donna, Zaller, Dennis M, Tran, Megan, Bays, Alison, Taylor, Martin S, Kapeller, Rosana, LaCava, John, Mustelin, Tomas

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A human tissue-based functional assay platform to evaluate the immune function impact of small molecule inhibitors that target the immune system von St Pierre, Cristina, Guo, Jane, Shin, John D, Engstrom, Laura W, Lee, Hyun-Hee, Herbert, Alan, Surdi, Laura, Baker, James, Salmon, Michael, Shah, Sanjiv, Ellis, J Michael, Houshyar, Hani, Crackower, Michael A, Kleinschek, Melanie A, Jones, Dallas C, Hicks, Alexandra, Zaller, Dennis M, Alves, Stephen E, Ramadas, Ravisankar A

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TLR7 Protein Expression in Mild and Severe Lupus-Prone Models Is Regulated in a Leukocyte, Genetic, and IRAK4 Dependent Manner von Celhar, Teja, Lu, Hao Kim, Benso, Lia, Rakhilina, Larissa, Lee, Hui Yin, Tripathi, Shubhita, Zharkova, Olga, Ong, Wei Yee, Yasuga, Hiroko, Au, Bijin, Marlier, Damien, Lim, Lina Hsiu Kim, Thamboo, Thomas Paulraj, Mudgett, John S, Mackey, Matthew F, Zaller, Dennis M, Connolly, John E, Fairhurst, Anna-Marie

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Pharmacological Inhibition of O-GlcNAcase Does Not Increase Sensitivity of Glucocorticoid Receptor-Mediated Transrepression von Stivers, Peter J, Harmonay, Lauren, Hicks, Alexandra, Mehmet, Huseyin, Morris, Melody, Robinson, Gain M, Strack, Peter R, Savage, Mary J, Zaller, Dennis M, Zwierzynski, Izabela, Brandish, Philip E

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Staging and resetting T cell activation in SMACs von Kupfer, Abraham, Freiberg, Benjamin A, Kupfer, Hannah, Maslanik, William, Delli, Joe, Kappler, John, Zaller, Dennis M

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Inhibition of RORγT Skews TCRα Gene Rearrangement and Limits T Cell Repertoire Diversity von Guo, Yanxia, MacIsaac, Kenzie D., Chen, Yi, Miller, Richard J., Jain, Renu, Joyce-Shaikh, Barbara, Ferguson, Heidi, Wang, I-Ming, Cristescu, Razvan, Mudgett, John, Engstrom, Laura, Piers, Kyle J., Baltus, Gretchen A., Barr, Kenneth, Zhang, Hongjun, Mehmet, Huseyin, Hegde, Laxminarayan G., Hu, Xiao, Carter, Laura L., Aicher, Thomas D., Glick, Gary, Zaller, Dennis, Hawwari, Abbas, Correll, Craig C., Jones, Dallas C., Cua, Daniel J.

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Inhibition of spleen tyrosine kinase attenuates IgE‐mediated airway contraction and mediator release in human precision cut lung slices von Koziol‐White, Cynthia J, Jia, Yanlin, Baltus, Gretchen A, Cooper, Philip R, Zaller, Dennis M, Crackower, Michael A, Sirkowski, Erich E, Smock, Steven, Northrup, Alan B, Himes, Blanca E, Alves, Stephen E, Panettieri, Reynold A

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Evidence for cyclic diguanylate as a vaccine adjuvant with novel immunostimulatory activities von Gray, Peter M., Forrest, Gail, Wisniewski, Thomas, Porter, Gene, Freed, Daniel C., DeMartino, Julie A., Zaller, Dennis M., Guo, Zhiqiang, Leone, Joseph, Fu, Tong-Ming, Vora, Kalpit A.

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Mediation by HLA-DM of dissociation of peptides from HLA-DR von Sloan, Victor S, Cameron, Patricia, Porter, Gene, Gammon, Maureen, Amaya, Miguel, Mellins, Elizabeth, Zaller, Dennis M

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Genetic ablation or pharmacological blockade of dipeptidyl peptidase IV does not impact T cell-dependent immune responses von Vora, Kalpit A, Porter, Gene, Peng, Roche, Cui, Yan, Pryor, Kellyann, Eiermann, George, Zaller, Dennis M

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Chemical Genetics Define the Roles of p38α and p38β in Acute and Chronic Inflammation von O'Keefe, Stephen J., Mudgett, John S., Cupo, Susan, Parsons, Janey N., Chartrain, Nicole A., Fitzgerald, Catherine, Chen, Shiow-Ling, Lowitz, Karen, Rasa, Cordelia, Visco, Denise, Luell, Silvi, Carballo-Jane, Ester, Owens, Karen, Zaller, Dennis M.

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Production of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor α1 von Redpath, Nicholas T, Xu, Yibin, Wilson, Nicholas J, Fabri, Louis J, Baca, Manuel, Andrews, Arna E, Braley, Hal, Lu, Ping, Ireland, Cheryl, Ernst, Robin E, Woods, Andrea, Forrest, Gail, An, Zhiqiang, Zaller, Dennis M, Strohl, William R, Luo, Cindy S, Czabotar, Peter E, Garrett, Thomas P J, Hilton, Douglas J, Nash, Andrew D, Zhang, Jian-Guo, Nicola, Nicos A

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IgG2m4, an engineered antibody isotype with reduced Fc function von An, Zhiqiang, Forrest, Gail, Moore, Renee, Cukan, Michael, Haytko, Peter, Huang, Lingyi, Vitelli, Salvatore, Zhao, Jing Zhang, Lu, Ping, Hua, Jin, Gibson, Christopher R., Harvey, Barrett R., Montgomery, Donna, Zaller, Dennis, Wang, Fubao, Strohl, William

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HLA-DR1 (DRB10101) and DR4 (DRB10401) Use the Same Anchor Residues for Binding an Immunodominant Peptide Derived from Human Type II Collagen von Rosloniec, Edward F, Whittington, Karen B, Zaller, Dennis M, Kang, Andrew H

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Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase von Stelmach, John E., Liu, Luping, Patel, Sangita B., Pivnichny, James V., Scapin, Giovanna, Singh, Suresh, Hop, Cornelis E.C.A., Wang, Zhen, Strauss, John R., Cameron, Patricia M., Nichols, Elizabeth A., O'Keefe, Stephen J., O'Neill, Edward A., Schmatz, Dennis M., Schwartz, Cheryl D., Thompson, Chris M., Zaller, Dennis M., Doherty, James B.

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Synthesis and biological activity of quinolinone and dihydroquinolinone p38 MAP kinase inhibitors von Chen, Meng-Hsin, Fitzgerald, Patricia, Singh, Suresh B., O’Neill, Edward A., Schwartz, Cheryl D., Thompson, Chris M., O’Keefe, Stephen J., Zaller, Dennis M., Doherty, James B.

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Sphingosine 1-phosphate receptor agonist FTY720-phosphate causes marginal zone B cell displacement von Vora, Kalpit A., Nichols, Elizabeth, Porter, Gene, Cui, Yan, Keohane, Carol Ann, Hajdu, Richard, Hale, Jeffery, Neway, William, Zaller, Dennis, Mandala, Suzanne

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The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection von Xiong, Yusheng, Wiltsie, Judyann, Woods, Andrea, Guo, Jian, Pivnichny, James V., Tang, Wei, Bansal, Alka, Cummings, Richard T., Cunningham, Barry R., Friedlander, Arthur M., Douglas, Cameron M., Salowe, Scott P., Zaller, Dennis M., Scolnick, Edward M., Schmatz, Dennis M., Bartizal, Kenneth, Hermes, Jeffrey D., MacCoss, Malcolm, Chapman, Kevin T.

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