Unraveling the therapeutic potential of the Hedgehog pathway in cancer von Amakye, Dereck, Jagani, Zainab, Dorsch, Marion

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Hedgehog pathway activation in chronic myeloid leukemia: A promise for a novel combination therapeutic approach? von Jagani, Zainab, Dorsch, Marion, Warmuth, Markus

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ARID1B is a specific vulnerability in ARID1A-mutant cancers von Helming, Katherine C, Wang, Xiaofeng, Wilson, Boris G, Vazquez, Francisca, Haswell, Jeffrey R, Manchester, Haley E, Kim, Youngha, Kryukov, Gregory V, Ghandi, Mahmoud, Aguirre, Andrew J, Jagani, Zainab, Wang, Zhong, Garraway, Levi A, Hahn, William C, Roberts, Charles W M

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Residual Complexes Containing SMARCA2 (BRM) Underlie the Oncogenic Drive of SMARCA4 (BRG1) Mutation von Wilson, Boris G., Helming, Katherine C., Wang, Xiaofeng, Kim, Youngha, Vazquez, Francisca, Jagani, Zainab, Hahn, William C., Roberts, Charles W. M.

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Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers von Hoffman, Gregory R., Rahal, Rami, Buxton, Frank, Xiang, Kay, McAllister, Gregory, Frias, Elizabeth, Bagdasarian, Linda, Huber, Janina, Lindeman, Alicia, Chen, Dongshu, Romero, Rodrigo, Ramadan, Nadire, Phadke, Tanushree, Haas, Kristy, Jaskelioff, Mariela, Wilson, Boris G., Meyer, Matthew J., Saenz-Vash, Veronica, Zhai, Huili, Myer, Vic E., Porter, Jeffrey A., Keen, Nicholas, McLaughlin, Margaret E., Mickanin, Craig, Roberts, Charles W. M., Stegmeier, Frank, Jagani, Zainab

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PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers von Wee, Susan, Jagani, Zainab, Xiang, Kay Xiaoqin, Loo, Alice, Dorsch, Marion, Yao, Yung-Mae, Sellers, William R, Lengauer, Christoph, Stegmeier, Frank

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Degron mediated BRM/SMARCA2 depletion uncovers novel combination partners for treatment of BRG1/SMARCA4-mutant cancers von Rago, Florencia, DiMare, Matthew T., Elliott, GiNell, Ruddy, David A., Sovath, Sosathya, Kerr, Grainne, Bhang, Hyo-eun C., Jagani, Zainab

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Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway von Jagani, Zainab, Mora-Blanco, E Lorena, Sansam, Courtney G, McKenna, Elizabeth S, Wilson, Boris, Chen, Dongshu, Klekota, Justin, Tamayo, Pablo, Nguyen, Phuong T L, Tolstorukov, Michael, Park, Peter J, Cho, Yoon-Jae, Hsiao, Kathy, Buonamici, Silvia, Pomeroy, Scott L, Mesirov, Jill P, Ruffner, Heinz, Bouwmeester, Tewis, Luchansky, Sarah J, Murtie, Joshua, Kelleher, Joseph F, Warmuth, Markus, Sellers, William R, Roberts, Charles W M, Dorsch, Marion

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FoxO tumor suppressors and BCR–ABL-induced leukemia: A matter of evasion of apoptosis von Jagani, Zainab, Singh, Amrik, Khosravi-Far, Roya

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Fibroblast growth factor receptors as novel therapeutic targets in SNF5-deleted malignant rhabdoid tumors von Wöhrle, Simon, Weiss, Andreas, Ito, Moriko, Kauffmann, Audrey, Murakami, Masato, Jagani, Zainab, Thuery, Anne, Bauer-Probst, Beatrice, Reimann, Flavia, Stamm, Christelle, Pornon, Astrid, Romanet, Vincent, Guagnano, Vito, Brümmendorf, Thomas, Sellers, William R, Hofmann, Francesco, Roberts, Charles W M, Graus Porta, Diana

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The Polycomb Group Protein Bmi-1 Is Essential for the Growth of Multiple Myeloma Cells von JAGANI, Zainab, WIEDERSCHAIN, Dmitri, WARMUTH, Markus, SELLERS, William R, DORSCH, Marion, LOO, Alice, DAN HE, MOSHER, Rebecca, FORDJOUR, Paul, MONAHAN, John, MORRISSEY, Michael, YAO, Yung-Mae, LENGAUER, Christoph

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Cytokines and BCR-ABL Mediate Suppression of TRAIL-Induced Apoptosis through Inhibition of Forkhead FOXO3a Transcription Factor von Ghaffari, Saghi, Jagani, Zainab, Kitidis, Claire, Lodish, Harvey F., Khosravi-Far, Roya

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Proteasome Inhibition Causes Regression of Leukemia and Abrogates BCR-ABL―Induced Evasion of Apoptosis in Part through Regulation of Forkhead Tumor Suppressors von JAGANI, Zainab, KELI SONG, YECKES RODIN, Heather, MILLER, Kenneth, KHOSRAVI-FAR, Roya, KUTOK, Jeffery L, RAJAN DEWAR, M, MELET, Armelle, SANTOS, Tanya, GRASSIAN, Alexandra, GHAFFARI, Saghi, WU, Catherine, RUIBAO REN

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Mammalian SWI/SNF continuously restores local accessibility to chromatin von Iurlaro, Mario, Stadler, Michael B., Masoni, Francesca, Jagani, Zainab, Galli, Giorgio G., Schübeler, Dirk

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Abstract 361: Identification of a novel dependence on the SWI/SNF chromatin remodeling complex in uveal melanoma von Rago, Florencia, Xiang, Xiaoqin, Desplat, Aurore, Niemezyk, Emilie, Ruddy, David, Kerr, Grainne, Robles, Eusebio Manchado, Castelletti, Deborah, Jagani, Zainab

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Abstract 1025: Controlled and endogenous depletion of a synthetic lethal target in human cancer cell lines via SMASh degron engineering von Rago, Florencia, Dimare, Matthew T., Bushold, Geoffrey, Kapoor, Avnish, Bhang, Hyo-eun C., Jagani, Zainab

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Intercellular Trafficking of a KNOTTED1 Green Fluorescent Protein Fusion in the Leaf and Shoot Meristem of Arabidopsis von Kim, Jae Yean, Yuan, Zhuang, Cilia, Michelle, Khalfan-Jagani, Zainab, Jackson, David

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Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening von McDonald, E. Robert, de Weck, Antoine, Schlabach, Michael R., Billy, Eric, Mavrakis, Konstantinos J., Hoffman, Gregory R., Belur, Dhiren, Castelletti, Deborah, Frias, Elizabeth, Gampa, Kalyani, Golji, Javad, Kao, Iris, Li, Li, Megel, Philippe, Perkins, Thomas A., Ramadan, Nadire, Ruddy, David A., Silver, Serena J., Sovath, Sosathya, Stump, Mark, Weber, Odile, Widmer, Roland, Yu, Jianjun, Yu, Kristine, Yue, Yingzi, Abramowski, Dorothee, Ackley, Elizabeth, Barrett, Rosemary, Berger, Joel, Bernard, Julie L., Billig, Rebecca, Brachmann, Saskia M., Buxton, Frank, Caothien, Roger, Caushi, Justina X., Chung, Franklin S., Cortés-Cros, Marta, deBeaumont, Rosalie S., Delaunay, Clara, Desplat, Aurore, Duong, William, Dwoske, Donald A., Eldridge, Richard S., Farsidjani, Ali, Feng, Fei, Feng, JiaJia, Flemming, Daisy, Forrester, William, Galli, Giorgio G., Gao, Zhenhai, Gauter, François, Gibaja, Veronica, Haas, Kristy, Hattenberger, Marc, Hood, Tami, Hurov, Kristen E., Jagani, Zainab, Jenal, Mathias, Johnson, Jennifer A., Jones, Michael D., Kapoor, Avnish, Korn, Joshua, Liu, Jilin, Liu, Qiumei, Liu, Shumei, Liu, Yue, Loo, Alice T., Macchi, Kaitlin J., Martin, Typhaine, McAllister, Gregory, Meyer, Amandine, Mollé, Sandra, Pagliarini, Raymond A., Phadke, Tanushree, Repko, Brian, Schouwey, Tanja, Shanahan, Frances, Shen, Qiong, Stamm, Christelle, Stephan, Christine, Stucke, Volker M., Tiedt, Ralph, Varadarajan, Malini, Venkatesan, Kavitha, Vitari, Alberto C., Wallroth, Marco, Weiler, Jan, Zhang, Jing, Mickanin, Craig, Myer, Vic E., Porter, Jeffery A., Lai, Albert, Bitter, Hans, Lees, Emma, Keen, Nicholas, Kauffmann, Audrey, Stegmeier, Frank, Hofmann, Francesco, Schmelzle, Tobias, Sellers, William R.

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Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers von Papillon, Julien P. N, Nakajima, Katsumasa, Adair, Christopher D, Hempel, Jonathan, Jouk, Andriana O, Karki, Rajeshri G, Mathieu, Simon, Möbitz, Henrik, Ntaganda, Rukundo, Smith, Troy, Visser, Michael, Hill, Susan E, Hurtado, Felipe Kellermann, Chenail, Gregg, Bhang, Hyo-Eun C, Bric, Anka, Xiang, Kay, Bushold, Geoffrey, Gilbert, Tamara, Vattay, Anthony, Dooley, Julie, Costa, Emily A, Park, Isabel, Li, Ailing, Farley, David, Lounkine, Eugen, Yue, Q. Kimberley, Xie, Xiaoling, Zhu, Xiaoping, Kulathila, Raviraj, King, Daniel, Hu, Tiancen, Vulic, Katarina, Cantwell, John, Luu, Catherine, Jagani, Zainab

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Exquisite Sensitivity to Dual BRG1/BRM ATPase Inhibitors Reveals Broad SWI/SNF Dependencies in Acute Myeloid Leukemia von Rago, Florencia, Rodrigues, Lindsey Ulkus, Bonney, Megan, Sprouffske, Kathleen, Kurth, Esther, Elliott, GiNell, Ambrose, Jessi, Aspesi, Peter, Oborski, Justin, Chen, Julie T, McDonald, E Robert, Mapa, Felipa A, Ruddy, David A, Kauffmann, Audrey, Abrams, Tinya, Bhang, Hyo-Eun C, Jagani, Zainab

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