Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation von Johnston, Robert J, Poholek, Amanda C, DiToro, Daniel, Yusuf, Isharat, Eto, Danelle, Barnett, Burton, Dent, Alexander L, Craft, Joe, Crotty, Shane

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IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation von Eto, Danelle, Lao, Christopher, DiToro, Daniel, Barnett, Burton, Escobar, Tania C, Kageyama, Robin, Yusuf, Isharat, Crotty, Shane

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KLF4 is a FOXO target gene that suppresses B cell proliferation von Yusuf, Isharat, Kharas, Michael G., Chen, Jing, Peralta, Raechel Q., Maruniak, Autumn, Sareen, Pratibha, Yang, Vincent W., Kaestner, Klaus H., Fruman, David A.

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Bruton's tyrosine kinase inhibition reduces disease severity in a model of secondary progressive autoimmune demyelination von Evonuk, Kirsten Scarlett, Wang, Sen, Mattie, Josh, Cracchiolo, C J, Mager, Reine, Ferenčić, Željko, Sprague, Ethan, Carrier, Brandon, Schofield, Kai, Martinez, Evelyn, Stewart, Zachary, Petrosino, Tara, Johnson, Gregory Andrew, Yusuf, Isharat, Plaisted, Warren, Naiman, Zachary, Delp, Timothy, Carter, Laura, Marušić, Suzana

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Germinal center B cell depletion diminishes CD4+ follicular T helper cells in autoimmune mice von Yusuf, Isharat, Stern, Jessica, McCaughtry, Tom M, Gallagher, Sandra, Sun, Hong, Gao, Changshou, Tedder, Thomas, Carlesso, Gianluca, Carter, Laura, Herbst, Ronald, Wang, Yue

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Optimal B-cell proliferation requires phosphoinositide 3-kinase–dependent inactivation of FOXO transcription factors von Yusuf, Isharat, Zhu, Xiaocui, Kharas, Michael G., Chen, Jing, Fruman, David A.

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KLF4 suppresses transformation of pre-B cells by ABL oncogenes von Kharas, Michael G., Yusuf, Isharat, Scarfone, Vanessa M., Yang, Vincent W., Segre, Julia A., Huettner, Claudia S., Fruman, David A.

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Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150) von Yusuf, Isharat, Kageyama, Robin, Monticelli, Laurel, Johnston, Robert J, Ditoro, Daniel, Hansen, Kyle, Barnett, Burton, Crotty, Shane

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Bcl6 expressing follicular helper CD4 T cells are fate committed early and have the capacity to form memory von Choi, Youn Soo, Yang, Jessica A, Yusuf, Isharat, Johnston, Robert J, Greenbaum, Jason, Peters, Bjoern, Crotty, Shane

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GB5121, a Brain-Penetrant, Irreversible BTK Inhibitor, Demonstrates Potent Anti-Tumor Activity in a Novel Mouse Model of Intracranial Lymphoma von Yusuf, Isharat, Steinberg, Marcos W, Gozo, Maricel, Clemons, Bryan, Hou, Kay, Guimond, David, Rose, Mark J, Taylor Meadows, Kristen, Carter, Laura

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The Receptor Ly108 Functions as a SAP Adaptor-Dependent On-Off Switch for T Cell Help to B Cells and NKT Cell Development von Kageyama, Robin, Cannons, Jennifer L., Zhao, Fang, Yusuf, Isharat, Lao, Christopher, Locci, Michela, Schwartzberg, Pamela L., Crotty, Shane

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MEDI‐551 Treatment Effectively Depletes B Cells and Reduces Serum Titers of Autoantibodies in Mice Transgenic for Sle1 and Human CD19 von Gallagher, Sandra, Yusuf, Isharat, McCaughtry, Tom M., Turman, Sean, Sun, Hong, Kolbeck, Roland, Herbst, Ronald, Wang, Yue

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Trial in Progress: A Phase 1b/2 Study of GB5121, a Brain-Penetrant, Potent, Highly Selective, and Irreversible BTK Inhibitor for Relapsed/Refractory Primary/Secondary CNS Lymphoma... von Soussain, Carole, Issa, Samar, Lewis, Katharine L, Grommes, Christian, Fox, Judith, Ward, Renee, Peterson, Caryn, Cravets, Matt, Mathias, Anita, Sosa, Judith, Kirby, Brian J, Ding, Zhaoqing, Yusuf, Isharat, Rose, Mark J, Steinberg, Marcos W, Tun, Han W.

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Safety, Tolerability, and Pharmacokinetic Profile of Single and Multiple Ascending Doses of GB5121, a CNS-Penetrant BTK Inhibitor, in Healthy Subjects von Kirby, Brian J, Aranda, Richard, Ward, Renee, Steinberg, Marcos W, Hernandez, Maria, Sosa, Judith, Cravets, Matt, Rose, Mark J, Osterhout, Robin, Ding, Zhaoqing, Yusuf, Isharat, Fox, Judith, Mathias, Anita

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DDDR-37. GB5121 IS A NOVEL, IRREVERSIBLE, COVALENT BTK INHIBITOR WITH HIGH SELECTIVITY AND CNS-PENETRANCE FOR TREATMENT OF CNS MALIGNANCIES von Yusuf, Isharat, Guimond, David, Naiman, Zachary, Schiff, Theodore, Clemons, Bryan, Paulson, Bryanna, Hou, Kay, Meadows, Kristen Taylor, Rose, Mark, Carter, Laura

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Regulation of quiescence in lymphocytes von Yusuf, Isharat, Fruman, David A.

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SAP Regulation of Follicular Helper CD4 T Cell Development and Humoral Immunity Is Independent of SLAM and Fyn Kinase von McCausland, Megan M, Yusuf, Isharat, Tran, Hung, Ono, Nobuyuki, Yanagi, Yusuke, Crotty, Shane

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Pharmacological profile of MEDI-551, a novel anti-CD19 antibody, in human CD19 transgenic mice von Gallagher, Sandra, Turman, Sean, Yusuf, Isharat, Akhgar, Ahmad, Wu, Yuling, Roskos, Lorin K., Herbst, Ronald, Wang, Yue

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FOXO transcription factors cooperate with delta EF1 to activate growth suppressive genes in B lymphocytes von Chen, Jing, Yusuf, Isharat, Andersen, Hilde-Marie, Fruman, David A

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BSCI-11 GB5121 IS A NOVEL, IRREVERSIBLE, COVALENT BTK INHIBITOR WITH HIGH SELECTIVITY AND CNS-PENETRANCE FOR TREATMENT OF CNS MALIGNANCIES von Yusuf, Isharat, Guimond, David, Naiman, Zachary, Schiff, Theodore, Clemons, Bryan, Paulson, Bryanna, Hou, Kay, Meadows, Kristen Taylor, Rose, Mark, Carter, Laura

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