Site-specific CRISPR-based mitochondrial DNA manipulation is limited by gRNA import von Schmiderer, Ludwig, Yudovich, David, Oburoglu, Leal, Hjort, Martin, Larsson, Jonas

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Activation of neuronal genes via LINE-1 elements upon global DNA demethylation in human neural progenitors von Jönsson, Marie E, Ludvik Brattås, Per, Gustafsson, Charlotte, Petri, Rebecca, Yudovich, David, Pircs, Karolina, Verschuere, Shana, Madsen, Sofia, Hansson, Jenny, Larsson, Jonas, Månsson, Robert, Meissner, Alexander, Jakobsson, Johan

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Lysine-specific demethylase 1A restricts ex vivo propagation of human HSCs and is a target of UM171 von Subramaniam, Agatheeswaran, Žemaitis, Kristijonas, Talkhoncheh, Mehrnaz Safaee, Yudovich, David, Bäckström, Alexandra, Debnath, Shubhranshu, Chen, Jun, Jain, Mayur Vilas, Galeev, Roman, Gaetani, Massimiliano, Zubarev, Roman A., Larsson, Jonas

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Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia von Tothova, Zuzana, Krill-Burger, John M., Popova, Katerina D., Landers, Catherine C., Sievers, Quinlan L., Yudovich, David, Belizaire, Roger, Aster, Jon C., Morgan, Elizabeth A., Tsherniak, Aviad, Ebert, Benjamin L.

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Combined lentiviral- and RNA-mediated CRISPR/Cas9 delivery for efficient and traceable gene editing in human hematopoietic stem and progenitor cells von Yudovich, David, Bäckström, Alexandra, Schmiderer, Ludwig, Žemaitis, Kristijonas, Subramaniam, Agatheeswaran, Larsson, Jonas

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Combinatorial gene targeting in primary human hematopoietic stem and progenitor cells von Bäckström, Alexandra, Yudovich, David, Žemaitis, Kristijonas, Nilsén Falck, Ludvig, Subramaniam, Agatheeswaran, Larsson, Jonas

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CXCR4 Signaling Has a CXCL12-Independent Essential Role in Murine MLL-AF9-Driven Acute Myeloid Leukemia von Ramakrishnan, Ramprasad, Peña-Martínez, Pablo, Agarwal, Puneet, Rodriguez-Zabala, Maria, Chapellier, Marion, Högberg, Carl, Eriksson, Mia, Yudovich, David, Shah, Mansi, Ehinger, Mats, Nilsson, Björn, Larsson, Jonas, Hagström-Andersson, Anna, Ebert, Benjamin L., Bhatia, Ravi, Järås, Marcus

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Technical considerations for the use of CRISPR/Cas9 in hematology research von Gundry, Michael C., Dever, Daniel P., Yudovich, David, Bauer, Daniel E., Haas, Simon, Wilkinson, Adam C., Singbrant, Sofie

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Efficient and nontoxic biomolecule delivery to primary human hematopoietic stem cells using nanostraws von Schmiderer, Ludwig, Subramaniam, Agatheeswaran, Žemaitis, Kristijonas, Bäckström, Alexandra, Yudovich, David, Soboleva, Svetlana, Galeev, Roman, Prinz, Christelle N., Larsson, Jonas, Hjort, Martin

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Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing von Heckl, Dirk, Kowalczyk, Monika S, Yudovich, David, Belizaire, Roger, Puram, Rishi V, McConkey, Marie E, Thielke, Anne, Aster, Jon C, Regev, Aviv, Ebert, Benjamin L

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3029 – COMBINATORIAL GENE TARGETING IN PRIMARY HUMAN HEMATOPOIETIC STEM AND PROGENITOR CELLS von Bäckström, Alexandra, Yudovich, David, Žemaitis, Kristijonas, Falck, Ludvig Nilsén, Subramaniam, Agatheeswaran, Larsson, Jonas

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Activation of endogenous retroviruses during brain development causes an inflammatory response von Jönsson, Marie E, Garza, Raquel, Sharma, Yogita, Petri, Rebecca, Södersten, Erik, Johansson, Jenny G, Johansson, Pia A, Atacho, Diahann AM, Pircs, Karolina, Madsen, Sofia, Yudovich, David, Ramakrishnan, Ramprasad, Holmberg, Johan, Larsson, Jonas, Jern, Patric, Jakobsson, Johan

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Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia von Tothova, Zuzana, Krill-Burger, John M., Popova, Katerina D., Landers, Catherine C., Sievers, Quinlan L., Yudovich, David, Belizaire, Roger, Aster, Jon C., Morgan, Elizabeth A., Tsherniak, Aviad, Ebert, Benjamin L.

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COMBINED LENTIVIRAL- AND RNA-MEDIATED CRISPR/CAS9 DELIVERY FOR EFFICIENT AND TRACEABLE GENE EDITING IN HUMAN HEMATOPOIETIC STEM AND PROGENITOR CELLS von Bäckström, Alexandra, Yudovich, David, Schmiderer, Ludwig, Žemaitis, Kristijonas, Subramaniam, Agatheeswaran, Larsson, Jonas

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3038 – UM171 PROMOTES EX VIVO EXPANSION OF HUMAN HSCS BY TARGETING THE EPIGENETIC MODULATOR COREST FOR DEGRADATION von Subramaniam, Agatheeswaran, Zemaitis, Kristijonas, Talkhoncheh, Mehrnaz Safaee, Bäckström, Alexandra, Yudovich, david, Gaetani, Massimiliano, Zubarev, Roman, Larsson, Jonas

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EFFICIENT AND NON-TOXIC MRNA DELIVERY AND GENE EDITING IN HUMAN HEMATOPOIETIC STEM AND PROGENITOR CELLS USING NANOSTRAWS von Schmiderer, Ludwig, Subramaniam, Agatheeswaran, Žemaitis, Kristijonas, Bäckström, Alexandra, Yudovich, David, Soboleva, Svetlana, Galeev, Roman, Prinz, Christelle, Hjort, Martin, Larsson, Jonas

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Generation of Models of Human Hematologic Malignancies Using CRISPR Genome Engineering von Tothova, Zuzana, Krill-Burger, John M, Popova, Katerina D, Sievers, Quinlan, Yudovich, David, Belizaire, Roger, Aster, Jon C., Morgan, Elizabeth A., Tsherniak, Aviad, Ebert, Benjamin L

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Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing von Heckl, Dirk, Kowalczyk, Monika S, Yudovich, David, Belizaire, Roger, Puram, Rishi V, McConkey, Marie E, Thielke, Anne, Aster, Jon C, Regev, Aviv, Ebert, Benjamin L

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DETERMINATION OF FREQUENCY DISTRIBUTION OF NUCLEOTIDE SEQUENCE VARIANTS von YUDOVICH, DAVID, LARSSON, JONAS

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Determination of frequency distribution of nucleotide sequence variants von Larsson, Jonas, Yudovich, David

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