NRAS mutant E132K identified in young-onset sporadic colorectal cancer and the canonical mutants G12D and Q61K affect distinct oncogenic phenotypes von Yu, Ryan Timothy D., Garcia, Reynaldo L.

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Phenotypic characterization of the novel, non-hotspot oncogenic KRAS mutants E31D and E63K von Angeles, Arlou Kristina J, Yu, Ryan Timothy D, Cutiongco-De La Paz, Eva Maria, Garcia, Reynaldo L

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Non-Redundant and Overlapping Oncogenic Readouts of Non-Canonical and Novel Colorectal Cancer KRAS and NRAS Mutants von Alcantara, Krizelle Mae M, Malapit, Joshua Reginald P, Yu, Ryan Timothy D, Garrido, Jose Antonio Ma G, Rigor, John Paul T, Angeles, Arlou Kristina J, Cutiongco-de la Paz, Eva Maria, Garcia, Reynaldo L

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Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity von Hildreth, Andrew D., Ma, Feiyang, Wong, Yung Yu, Sun, Ryan, Pellegrini, Matteo, O’Sullivan, Timothy E.

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Recessive gene disruptions in autism spectrum disorder von Doan, Ryan N., Lim, Elaine T., De Rubeis, Silvia, Betancur, Catalina, Cutler, David J., Chiocchetti, Andreas G., Overman, Lynne M., Soucy, Aubrie, Goetze, Susanne, Freitag, Christine M., Daly, Mark J., Walsh, Christopher A., Buxbaum, Joseph D., Yu, Timothy W.

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Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants von Smith, Bryan D., Kaufman, Michael D., Lu, Wei-Ping, Gupta, Anu, Leary, Cynthia B., Wise, Scott C., Rutkoski, Thomas J., Ahn, Yu Mi, Al-Ani, Gada, Bulfer, Stacie L., Caldwell, Timothy M., Chun, Lawrence, Ensinger, Carol L., Hood, Molly M., McKinley, Arin, Patt, William C., Ruiz-Soto, Rodrigo, Su, Ying, Telikepalli, Hanumaiah, Town, Ajia, Turner, Benjamin A., Vogeti, Lakshminarayana, Vogeti, Subha, Yates, Karen, Janku, Filip, Abdul Razak, Albiruni Ryan, Rosen, Oliver, Heinrich, Michael C., Flynn, Daniel L.

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Genetic drivers of oncogenic pathways in molecular subgroups of peripheral T-cell lymphoma von Heavican, Tayla B., Bouska, Alyssa, Yu, Jiayu, Lone, Waseem, Amador, Catalina, Gong, Qiang, Zhang, Weiwei, Li, Yuping, Dave, Bhavana J., Nairismägi, Maarja-Liisa, Greiner, Timothy C., Vose, Julie, Weisenburger, Dennis D., Lachel, Cynthia, Wang, Chao, Fu, Kai, Stevens, Jadd M., Lim, Soon Thye, Ong, Choon Kiat, Gascoyne, Randy D., Missiaglia, Edoardo, Lemonnier, Francois, Haioun, Corinne, Hartmann, Sylvia, Pedersen, Martin Bjerregård, Laginestra, Maria Antonella, Wilcox, Ryan A., Teh, Bin Tean, Yoshida, Noriaki, Ohshima, Koichi, Seto, Masao, Rosenwald, Andreas, Ott, German, Campo, Elias, Rimsza, Lisa M., Jaffe, Elaine S., Braziel, Rita M., d'Amore, Francesco, Inghirami, Giorgio, Bertoni, Francesco, de Leval, Laurence, Gaulard, Philippe, Staudt, Louis M., McKeithan, Timothy W., Pileri, Stefano, Chan, Wing C., Iqbal, Javeed

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Metabolomic and transcriptomic analysis reveals endogenous substrates and metabolic adaptation in rats lacking Abcg2 and Abcb1a transporters von Ganguly, Samit, Finkelstein, David, Shaw, Timothy I, Michalek, Ryan D, Zorn, Kimberly M, Ekins, Sean, Yasuda, Kazuto, Fukuda, Yu, Schuetz, John D, Mukherjee, Kamalika, Schuetz, Erin G

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Subspecific origin and haplotype diversity in the laboratory mouse von Yang, Hyuna, Wang, Jeremy R, Didion, John P, Buus, Ryan J, Bell, Timothy A, Welsh, Catherine E, Bonhomme, François, Yu, Alex Hon-Tsen, Nachman, Michael W, Pialek, Jaroslav, Tucker, Priscilla, Boursot, Pierre, McMillan, Leonard, Churchill, Gary A, de Villena, Fernando Pardo-Manuel

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CRISPR-Cas9 Ribonucleoprotein-Mediated Genomic Editing in Mature Primary Innate Immune Cells von Riggan, Luke, Hildreth, Andrew D., Rolot, Marion, Wong, Yung-Yu, Satyadi, William, Sun, Ryan, Huerta, Christopher, O’Sullivan, Timothy E.

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Individual-specific functional connectivity of the amygdala: A substrate for precision psychiatry von Sylvester, Chad M., Yu, Qiongru, Srivastava, A. Benjamin, Marek, Scott, Zheng, Annie, Alexopoulos, Dimitrios, Smyser, Christopher D., Shimony, Joshua S., Ortega, Mario, Dierker, Donna L., Patel, Gaurav H., Nelson, Steven M., Gilmore, Adrian W., McDermott, Kathleen B., Berg, Jeffrey J., Drysdale, Andrew T., Perino, Michael T., Snyder, Abraham Z., Raut, Ryan V., Laumann, Timothy O., Gordon, Evan M., Barch, Deanna M., Rogers, Cynthia E., Greene, Deanna J., Raichle, Marcus E., Dosenbach, Nico U. F.

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HIV-1 persistence in CD4+ T cells with stem cell–like properties von Buzon, Maria J, Sun, Hong, Li, Chun, Shaw, Amy, Seiss, Katherine, Ouyang, Zhengyu, Martin-Gayo, Enrique, Leng, Jin, Henrich, Timothy J, Li, Jonathan Z, Pereyra, Florencia, Zurakowski, Ryan, Walker, Bruce D, Rosenberg, Eric S, Yu, Xu G, Lichterfeld, Mathias

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Efficacy of Aerosolized Rifaximin versus Tobramycin for Treatment of Pseudomonas aeruginosa Pneumonia in Mice von Kirby, Brandon D, Al Ahmar, Roy, Withers, T Ryan, Valentine, Meagan E, Valentovic, Monica, Long, Timothy E, Gaskins, James R, Yu, Hongwei D

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Genetic analyses of diverse populations improves discovery for complex traits von Wojcik, Genevieve L., Graff, Mariaelisa, Nishimura, Katherine K., Tao, Ran, Haessler, Jeffrey, Gignoux, Christopher R., Highland, Heather M., Patel, Yesha M., Sorokin, Elena P., Avery, Christy L., Belbin, Gillian M., Bien, Stephanie A., Cheng, Iona, Cullina, Sinead, Hodonsky, Chani J., Hu, Yao, Huckins, Laura M., Jeff, Janina, Justice, Anne E., Kocarnik, Jonathan M., Lim, Unhee, Lin, Bridget M., Lu, Yingchang, Nelson, Sarah C., Park, Sung-Shim L., Poisner, Hannah, Preuss, Michael H., Richard, Melissa A., Schurmann, Claudia, Setiawan, Veronica W., Sockell, Alexandra, Vahi, Karan, Verbanck, Marie, Vishnu, Abhishek, Walker, Ryan W., Young, Kristin L., Zubair, Niha, Acuña-Alonso, Victor, Ambite, Jose Luis, Barnes, Kathleen C., Boerwinkle, Eric, Bottinger, Erwin P., Bustamante, Carlos D., Caberto, Christian, Canizales-Quinteros, Samuel, Conomos, Matthew P., Deelman, Ewa, Do, Ron, Doheny, Kimberly, Fernández-Rhodes, Lindsay, Fornage, Myriam, Hailu, Benyam, Heiss, Gerardo, Henn, Brenna M., Hindorff, Lucia A., Jackson, Rebecca D., Laurie, Cecelia A., Laurie, Cathy C., Li, Yuqing, Lin, Dan-Yu, Moreno-Estrada, Andres, Nadkarni, Girish, Norman, Paul J., Pooler, Loreall C., Reiner, Alexander P., Romm, Jane, Sabatti, Chiara, Sandoval, Karla, Sheng, Xin, Stahl, Eli A., Stram, Daniel O., Thornton, Timothy A., Wassel, Christina L., Wilkens, Lynne R., Winkler, Cheryl A., Yoneyama, Sachi, Buyske, Steven, Haiman, Christopher A., Kooperberg, Charles, Le Marchand, Loic, Loos, Ruth J. F., Matise, Tara C., North, Kari E., Peters, Ulrike, Kenny, Eimear E., Carlson, Christopher S.

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Implementation of Germline Testing for Prostate Cancer: Philadelphia Prostate Cancer Consensus Conference 2019 von Giri, Veda N, Knudsen, Karen E, Kelly, William K, Cheng, Heather H, Cooney, Kathleen A, Cookson, Michael S, Dahut, William, Weissman, Scott, Soule, Howard R, Petrylak, Daniel P, Dicker, Adam P, AlDubayan, Saud H, Toland, Amanda E, Pritchard, Colin C, Pettaway, Curtis A, Daly, Mary B, Mohler, James L, Parsons, J Kellogg, Carroll, Peter R, Pilarski, Robert, Blanco, Amie, Woodson, Ashley, Rahm, Alanna, Taplin, Mary-Ellen, Polascik, Thomas J, Helfand, Brian T, Hyatt, Colette, Morgans, Alicia K, Feng, Felix, Mullane, Michael, Powers, Jacqueline, Concepcion, Raoul, Lin, Daniel W, Wender, Richard, Mark, James Ryan, Costello, Anthony, Burnett, Arthur L, Sartor, Oliver, Isaacs, William B, Xu, Jianfeng, Weitzel, Jeffrey, Andriole, Gerald L, Beltran, Himisha, Briganti, Alberto, Byrne, Lindsey, Calvaresi, Anne, Chandrasekar, Thenappan, Chen, David Y T, Den, Robert B, Dobi, Albert, Crawford, E David, Eastham, James, Eggener, Scott, Freedman, Matthew L, Garnick, Marc, Gomella, Patrick T, Handley, Nathan, Hurwitz, Mark D, Izes, Joseph, Karnes, R Jeffrey, Lallas, Costas, Languino, Lucia, Loeb, Stacy, Lopez, Ana Maria, Loughlin, Kevin R, Lu-Yao, Grace, Malkowicz, S Bruce, Mann, Mark, Mille, Patrick, Miner, Martin M, Morgan, Todd, Moreno, Jose, Mucci, Lorelei, Myers, Ronald E, Nielsen, Sarah M, O'Neil, Brock, Pinover, Wayne, Pinto, Peter, Poage, Wendy, Raj, Ganesh V, Rebbeck, Timothy R, Ryan, Charles, Sandler, Howard, Schiewer, Matthew, Scott, E Michael D, Szymaniak, Brittany, Tester, William, Trabulsi, Edouard J, Vapiwala, Neha, Yu, Evan Y, Zeigler-Johnson, Charnita, Gomella, Leonard G

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Whole-genome analysis informs breast cancer response to aromatase inhibition von Ellis, Matthew J., Ding, Li, Shen, Dong, Luo, Jingqin, Suman, Vera J., Wallis, John W., Van Tine, Brian A., Hoog, Jeremy, Goiffon, Reece J., Goldstein, Theodore C., Ng, Sam, Lin, Li, Crowder, Robert, Snider, Jacqueline, Ballman, Karla, Weber, Jason, Chen, Ken, Koboldt, Daniel C., Kandoth, Cyriac, Schierding, William S., McMichael, Joshua F., Miller, Christopher A., Lu, Charles, Harris, Christopher C., McLellan, Michael D., Wendl, Michael C., DeSchryver, Katherine, Allred, D. Craig, Esserman, Laura, Unzeitig, Gary, Margenthaler, Julie, Babiera, G. V., Marcom, P. Kelly, Guenther, J. M., Leitch, Marilyn, Hunt, Kelly, Olson, John, Tao, Yu, Maher, Christopher A., Fulton, Lucinda L., Fulton, Robert S., Harrison, Michelle, Oberkfell, Ben, Du, Feiyu, Demeter, Ryan, Vickery, Tammi L., Elhammali, Adnan, Piwnica-Worms, Helen, McDonald, Sandra, Watson, Mark, Dooling, David J., Ota, David, Chang, Li-Wei, Bose, Ron, Ley, Timothy J., Piwnica-Worms, David, Stuart, Joshua M., Wilson, Richard K., Mardis, Elaine R.

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Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism von Satterstrom, F. Kyle, Breen, Michael S., Grove, Jakob, Klei, Lambertus, Xu, Xinyi, Norman, Utku, Brand, Harrison, Schwartz, Grace, Barbosa, Mafalda, Bybjerg-Grauholm, Jonas, Carracedo, Angel, Chiocchetti, Andreas G., Chung, Brian H.Y., Coon, Hilary, Cuccaro, Michael L., Dalla Bernardina, Bernardo, Domenici, Enrico, Dong, Shan, Freitag, Christine M., González-Peñas, Javier, Guter, Stephen, He, Xin, Herman, Gail E., Hertz-Picciotto, Irva, Hougaard, David M., Ionita-Laza, Iuliana, Jacob, Suma, Jamison, Jesslyn, Jugessur, Astanand, Kolevzon, Alexander, Kushima, Itaru, Lee, So Lun, Lehtimäki, Terho, Lim, Elaine T., Lipkin, W. Ian, Lopergolo, Diego, Lopes, Fátima, Ludena, Yunin, Maciel, Patricia, Meiri, Gal, Menashe, Idan, Miller, Judith, Montenegro, Eduarda M.S., Muglia, Pierandrea, Nordentoft, Merete, Ozaki, Norio, Palotie, Aarno, Parellada, Mara, Passos-Bueno, Maria Rita, Persico, Antonio M., Pessah, Isaac, Puura, Kaija, Renieri, Alessandra, Riberi, Evelise, Robinson, Elise B., Samocha, Kaitlin E., Sandin, Sven, Santangelo, Susan L., Schellenberg, Gerry, Scherer, Stephen W., Schmitt, Lauren, Silva, Isabela M.W., Singh, Tarjinder, Siper, Paige M., Soares, Gabriela, Susser, Ezra, Szatmari, Peter, Tang, Lara, Tassone, Flora, Teufel, Karoline, Trelles, Maria del Pilar, Werge, Thomas, Werling, Donna M., Wigdor, Emilie M., Yu, Mullin H.C., Zachi, Elaine, Agerbo, Esben, Als, Thomas Damm, Bækvad-Hansen, Marie, Belliveau, Rich, Cerrato, Felecia, Chambert, Kimberly, Churchhouse, Claire, Dumont, Ashley, Hansen, Christine S., Hauberg, Mads Engel, Hollegaard, Mads V., Howrigan, Daniel P., Maller, Julian, Mattheisen, Manuel, Moran, Jennifer, Pallesen, Jonatan, Poulsen, Jesper Buchhave, Ripke, Stephan, Gallagher, Louise, Gill, Michael, Zwick, Michael E., State, Matthew W., Daly, Mark J., Buxbaum, Joseph D.

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Trapping‐Enrichment Multi‐dimensional Liquid Chromatography with On‐Line Deuterated Solvent Exchange for Streamlined Structure Elucidation at the Microgram Scale von Ahmad, Imad A. Haidar, Losacco, Gioacchino Luca, Shchurik, Vladimir, Wang, Xiao, Cohen, Ryan D., Herron, Alastair N., Aiken, Sheenagh, Fiorito, Daniele, Wang, Heather, Reibarkh, Mikhail, Nowak, Timothy, Makarov, Alexey A., Stoll, Dwight R., Guillarme, Davy, Mangion, Ian, Aggarwal, Varinder K., Yu, Jin‐Quan, Regalado, Erik L.

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Integrative analysis of 111 reference human epigenomes von Kundaje, Anshul, Meuleman, Wouter, Ernst, Jason, Bilenky, Misha, Yen, Angela, Heravi-Moussavi, Alireza, Kheradpour, Pouya, Zhang, Zhizhuo, Wang, Jianrong, Ziller, Michael J., Amin, Viren, Whitaker, John W., Schultz, Matthew D., Ward, Lucas D., Sarkar, Abhishek, Quon, Gerald, Sandstrom, Richard S., Eaton, Matthew L., Wu, Yi-Chieh, Pfenning, Andreas R., Wang, Xinchen, Claussnitzer, Melina, Liu, Yaping, Coarfa, Cristian, Harris, R. Alan, Shoresh, Noam, Epstein, Charles B., Gjoneska, Elizabeta, Leung, Danny, Xie, Wei, Hawkins, R. David, Lister, Ryan, Hong, Chibo, Gascard, Philippe, Mungall, Andrew J., Moore, Richard, Chuah, Eric, Tam, Angela, Canfield, Theresa K., Hansen, R. Scott, Kaul, Rajinder, Sabo, Peter J., Bansal, Mukul S., Carles, Annaick, Dixon, Jesse R., Farh, Kai-How, Feizi, Soheil, Karlic, Rosa, Kim, Ah-Ram, Kulkarni, Ashwinikumar, Li, Daofeng, Lowdon, Rebecca, Elliott, GiNell, Mercer, Tim R., Neph, Shane J., Onuchic, Vitor, Polak, Paz, Rajagopal, Nisha, Ray, Pradipta, Sallari, Richard C., Siebenthall, Kyle T., Sinnott-Armstrong, Nicholas A., Stevens, Michael, Thurman, Robert E., Wu, Jie, Zhang, Bo, Zhou, Xin, Beaudet, Arthur E., Boyer, Laurie A., De Jager, Philip L., Farnham, Peggy J., Fisher, Susan J., Haussler, David, Jones, Steven J. M., Li, Wei, Marra, Marco A., McManus, Michael T., Sunyaev, Shamil, Thomson, James A., Tlsty, Thea D., Tsai, Li-Huei, Wang, Wei, Waterland, Robert A., Zhang, Michael Q., Chadwick, Lisa H., Bernstein, Bradley E., Costello, Joseph F., Ecker, Joseph R., Hirst, Martin, Meissner, Alexander, Milosavljevic, Aleksandar, Ren, Bing, Stamatoyannopoulos, John A., Wang, Ting, Kellis, Manolis

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Altered network and rescue of human neurons derived from individuals with early-onset genetic epilepsy von Negraes, Priscilla D., Trujillo, Cleber A., Yu, Nam-Kyung, Wu, Wei, Yao, Hang, Liang, Nicholas, Lautz, Jonathan D., Kwok, Ellius, McClatchy, Daniel, Diedrich, Jolene, de Bartolome, Salvador Martinez, Truong, Justin, Szeto, Ryan, Tran, Timothy, Herai, Roberto H., Smith, Stephen E. P., Haddad, Gabriel G., Yates, John R., Muotri, Alysson R.

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