From micrograms to grams: scale-up synthesis of eribulin mesylate von Yu, Melvin J, Zheng, Wanjun, Seletsky, Boris M

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Induction of morphological and biochemical apoptosis following prolonged mitotic blockage by halichondrin B macrocyclic ketone analog E7389 von KUZNETSOV, Galina, TOWLE, Murray J, HONGSHENG CHENG, KAWAMURA, Takanori, TENDYKE, Karen, LIU, Diana, KISHI, Yoshito, YU, Melvin J, LITTLEFIELD, Bruce A

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Eribulin Induces Irreversible Mitotic Blockade: Implications of Cell-Based Pharmacodynamics for In vivo Efficacy under Intermittent Dosing Conditions von TOWLE, Murray J, SALVATO, Kathleen A, LITTLEFIELD, Bruce A, WELS, Bruce F, AALFS, Kimberley K, WANJUN ZHENG, SELETSKY, Boris M, XIAOJIE ZHU, LEWIS, Bryan M, KISHI, Yoshito, YU, Melvin J

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Simulating the drug discovery pipeline: a Monte Carlo approach von Yu, Melvin J

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Natural Product-Like Virtual Libraries: Recursive Atom-Based Enumeration von Yu, Melvin J

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Novel second generation analogs of eribulin. Part III: Blood–brain barrier permeability and in vivo activity in a brain tumor model von Narayan, Sridhar, Carlson, Eric M., Cheng, Hongsheng, Condon, Krista, Du, Hong, Eckley, Sean, Hu, Yongbo, Jiang, Yimin, Kumar, Vipul, Lewis, Bryan M., Saxton, Philip, Schuck, Edgar, Seletsky, Boris M., Tendyke, Karen, Zhang, Huiming, Zheng, Wanjun, Littlefield, Bruce A., Towle, Murray J., Yu, Melvin J.

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Novel second generation analogs of eribulin. Part I: Compounds containing a lipophilic C32 side chain overcome P-glycoprotein susceptibility von Narayan, Sridhar, Carlson, Eric M., Cheng, Hongsheng, Du, Hong, Hu, Yongbo, Jiang, Yimin, Lewis, Bryan M., Seletsky, Boris M., Tendyke, Karen, Zhang, Huiming, Zheng, Wanjun, Littlefield, Bruce A., Towle, Murray J., Yu, Melvin J.

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Predicting Total Clearance in Humans from Chemical Structure von Yu, Melvin J

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Broad Spectrum Preclinical Antitumor Activity of Eribulin (Halaven®): Optimal Effectiveness under Intermittent Dosing Conditions von TOWLE, Murray J, NOMOTO, Kenichi, ASANO, Makoto, KISHI, Yoshito, YU, Melvin J, LITTLEFIELD, Bruce A

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Druggable chemical space and enumerative combinatorics von Yu, Melvin J

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Atom-based enumeration: New eribulin analogues with low susceptibility to P-glycoprotein-mediated drug efflux von Yu, Melvin J., Zheng, Wanjun, Tendyke, Karen

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In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B von TOWLE, Murray J, SALVATO, Kathleen A, HABGOOD, Gregory J, SINGER, Lori A, DIPIETRO, Lucian V, YUAN WANG, CHEN, Jack J, QUINCY, David A, DAVIS, Ashley, YOSHIMATSU, Kentaro, KISHI, Yoshito, YU, Melvin J, BUDROW, Jacqueline, LITTLEFIELD, Bruce A, WELS, Bruce F, KUZNETSOV, Galina, AALFS, Kimberley K, WELSH, Susan, WANJUN ZHENG, SELETSKY, Boris M, PALME, Monica H

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Macrocyclic ketone analogues of halichondrin B von Zheng, Wanjun, Seletsky, Boris M., Palme, Monica H., Lydon, Paul J., Singer, Lori A., Chase, Charles E., Lemelin, Charles A., Shen, Yongchun, Davis, Heather, Tremblay, Lynda, Towle, Murray J., Salvato, Kathleen A., Wels, Bruce F., Aalfs, Kimberley K., Kishi, Yoshito, Littlefield, Bruce A., Yu, Melvin J.

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Novel second generation analogs of eribulin. Part II: Orally available and active against resistant tumors in vivo von Narayan, Sridhar, Carlson, Eric M., Cheng, Hongsheng, Condon, Krista, Du, Hong, Eckley, Sean, Hu, Yongbo, Jiang, Yimin, Kumar, Vipul, Lewis, Bryan M., Saxton, Philip, Schuck, Edgar, Seletsky, Boris M., Tendyke, Karen, Zhang, Huiming, Zheng, Wanjun, Littlefield, Bruce A., Towle, Murray J., Yu, Melvin J.

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Structurally simplified macrolactone analogues of halichondrin B von Seletsky, Boris M., Wang, Yuan, Hawkins, Lynn D., Palme, Monica H., Habgood, Gregory J., DiPietro, Lucian V., Towle, Murray J., Salvato, Kathleen A., Wels, Bruce F., Aalfs, Kimberley K., Kishi, Yoshito, Littlefield, Bruce A., Yu, Melvin J.

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Synthesis and x-ray crystallographic analysis of quinazolinone cholecystokinin/gastrin receptor ligands von Yu, Melvin J, McCowan, Jefferson R, Mason, Norman R, Deeter, Jack B, Mendelsohn, Laurane G

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Benzylamine antioxidants: relationship between structure, peroxyl radical scavenging, lipid peroxidation inhibition and cytoprotection von Yu, Melvin J, McCowan, Jefferson R, Phebus, Lee A, Towner, Richard D, Ho, Peter P. K, Keith, Priscilla T, Luttman, Charlotte A, Saunders, Royal D, Ruterbories, Kenneth J

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ChemInform Abstract: From Micrograms to Grams. Scale-up Synthesis of Eribulin Mesylate von Yu, Melvin J., Zheng, Wanjun, Seletsky, Boris M.

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Atrial natriuretic peptide receptor modulators: effects of disubstituted quinazolines on receptor binding and in vitro biological activity von Yu, Melvin J, McCowan, Jefferson R, Steinberg, Mitchell I, Wiest, Sally A, Wyss, Virginia L, Horng, Jong Sin

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Quinazolinone cholecystokinin-B receptor ligands von Yu, Melvin J, Thrasher, K. Jeff, McCowan, Jefferson R, Mason, Norma R, Mendelsohn, Laurane G

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