Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques von Waldmann, Thomas A., Lugli, Enrico, Roederer, Mario, Perera, Liyanage P., Smedley, Jeremy V., Macallister, Rhonda P., Goldman, Carolyn K., Bryant, Bonita R., Decker, Jean M., Fleisher, Thomas A., Lane, H. Clifford, Sneller, Michael C., Kurlander, Roger J., Kleiner, David E., Pletcher, John M., Figg, William D., Yovandich, Jason L., Creekmore, Stephen P.

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Transient and persistent effects of IL-15 on lymphocyte homeostasis in nonhuman primates von Lugli, Enrico, Goldman, Carolyn K., Perera, Liyanage P., Smedley, Jeremy, Pung, Rhonda, Yovandich, Jason L., Creekmore, Stephen P., Waldmann, Thomas A., Roederer, Mario

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Novel Human Interleukin-15 Agonists von Zhu, Xiaoyun, Marcus, Warren D, Xu, Wenxin, Lee, Hyung-il, Han, Kaiping, Egan, Jack O, Yovandich, Jason L, Rhode, Peter R, Wong, Hing C

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Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleuki... von Conlon, Kevin C, Lugli, Enrico, Welles, Hugh C, Rosenberg, Steven A, Fojo, Antonio Tito, Morris, John C, Fleisher, Thomas A, Dubois, Sigrid P, Perera, Liyanage P, Stewart, Donn M, Goldman, Carolyn K, Bryant, Bonita R, Decker, Jean M, Chen, Jing, Worthy, Tat'Yana A, Figg, Sr, William D, Peer, Cody J, Sneller, Michael C, Lane, H Clifford, Yovandich, Jason L, Creekmore, Stephen P, Roederer, Mario, Waldmann, Thomas A

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IL15 by Continuous Intravenous Infusion to Adult Patients with Solid Tumors in a Phase I Trial Induced Dramatic NK-Cell Subset Expansion von Conlon, Kevin C, Potter, E Lake, Pittaluga, Stefania, Lee, Chyi-Chia Richard, Miljkovic, Milos D, Fleisher, Thomas A, Dubois, Sigrid, Bryant, Bonita R, Petrus, Michael, Perera, Liyanage P, Hsu, Jennifer, Figg, William D, Peer, Cody J, Shih, Joanna H, Yovandich, Jason L, Creekmore, Stephen P, Roederer, Mario, Waldmann, Thomas A

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IL-15:IL-15 receptor alpha superagonist complex: High-level co-expression in recombinant mammalian cells, purification and characterization von Han, Kai-ping, Zhu, Xiaoyun, Liu, Bai, Jeng, Emily, Kong, Lin, Yovandich, Jason L., Vyas, Vinay V., Marcus, Warren D., Chavaillaz, Pierre-Andre, Romero, Christian A., Rhode, Peter R., Wong, Hing C.

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Characterization of Recombinant Human IL-15 Deamidation and Its Practical Elimination through Substitution of Asparagine 77 von Nellis, David F., Michiel, Dennis F., Jiang, Man-Shiow, Esposito, Dominic, Davis, Richard, Jiang, Hengguang, Korrell, Angela, Knapp, George C., Lucernoni, Lauren E., Nelson, Roy E., Pritt, Emily M., Procter, Lauren V., Rogers, Mark, Sumpter, Terry L., Vyas, Vinay V., Waybright, Timothy J., Yang, Xiaoyi, Zheng, Amy M., Yovandich, Jason L., Gilly, John A., Mitra, George, Zhu, Jianwei

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IL-15 administered by continuous infusion to rhesus macaques induces massive expansion of CD8+ T effector memory population in peripheral blood von Sneller, Michael C., Kopp, William C., Engelke, Kory J., Yovandich, Jason L., Creekmore, Stephen P., Waldmann, Thomas A., Lane, H. Clifford

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Clinical manufacturing of recombinant human interleukin 15. I. Production cell line development and protein expression in E. coli with stop codon optimization von Vyas, Vinay V., Esposito, Dominic, Sumpter, Terry L., Broadt, Trevor L., Hartley, James, Knapp IV, George C., Cheng, Wei, Jiang, Man-Shiow, Roach, John M., Yang, Xiaoyi, Giardina, Steven L., Mitra, George, Yovandich, Jason L., Creekmore, Stephen P., Waldmann, Thomas A., Zhu, Jianwei

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Protection of Macaca nemestrina from Disease following Pathogenic Simian Immunodeficiency Virus (SIV) Challenge: Utilization of SIV Nucleocapsid Mutant DNA Vaccines with and withou... von Gorelick, R J, Benveniste, R E, Lifson, J D, Yovandich, J L, Morton, W R, Kuller, L, Flynn, B M, Fisher, B A, Rossio, J L, Piatak, Jr, M, Bess, Jr, J W, Henderson, L E, Arthur, L O

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IL-15 by continuous i.v. infusion to adult patients with solid tumors in a Phase I trial induced dramatic NK cell subset expansion von Conlon, Kevin C., Potter, E. Lake, Pittaluga, Stefania, Lee, Chyi-Chia Richard, Miljkovic, Milos D., Fleisher, Thomas A., Dubois, Sigrid, Bryant, Bonita R., Petrus, Michael N., Perera, Liyanage P., Hsu, Jennifer, Figg, William D., Peer, Cody J., Shih, Joanna H., Yovandich, Jason L., Creekmore, Stephen P., Roederer, Mario, Waldmann, Thomas A.

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Alteration of Zinc-Binding Residues of Simian Immunodeficiency Virus p8NC Results in Subtle Differences in Gag Processing and Virion Maturation Associated with Degradative Loss of... von Yovandich, Jason L., Chertova, Elena N., Kane, Brad P., Gagliardi, Tracy D., Bess, Julian W., Sowder, Raymond C., Henderson, Louis E., Gorelick, Robert J.

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15:IL-15 receptor alpha superagonist complex: High-level co-expression in recombinant mammalian cells, purification and characterization von Han, Kai-ping, Zhu, Xiaoyun, Liu, Bai, Jeng, Emily, Kong, Lin, Yovandich, Jason L, Vyas, Vinay V, Marcus, Warren D, Chavaillaz, Pierre-Andre, Romero, Christian A, Rhode, Peter R, Wong, Hing C

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Alteration of Zinc-Binding Residues of Simian Immunodeficiency Virus p8 NC Results in Subtle Differences in Gag Processing and Virion Maturation Associated with Degradative Loss of... von Yovandich, Jason L., Chertova, Elena N., Kane, Brad P., Gagliardi, Tracy D., Bess, Julian W., Sowder, Raymond C., Henderson, Louis E., Gorelick, Robert J.

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Mucosal challenge of Macaca nemestrina with simian immunodeficiency virus (SIV) following SIV nucleocapsid mutant DNA vaccination von Gorelick, Robert J., Lifson, Jeffrey D., Yovandich, Jason L., Rossio, Jeffrey L., Piatak Jr, Michael, Scarzello, Anthony J., Knott, Walter B., Bess Jr, Julian W., Fisher, Bradley A., Flynn, Bernard M., Henderson, Louis E., Arthur, Larry O., Benveniste, Raoul E.

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Challenges and next steps in the advancement of immunotherapy: summary of the 2018 and 2020 National Cancer Institute workshops on cell-based immunotherapy for solid tumors von Fogli, Laura K, Aurigemma, Rosemarie, Sommers, Connie L, Singh, Anju, Bourcier, Kasia, Ernstoff, Marc S

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