Synthesis of the Oxygenated Pactamycin Core von Knapp, Spencer, Yu, Younong

Volltext

C(4)-alkyl substituted furanyl cyclobutenediones as potent, orally bioavailable CXCR2 and CXCR1 receptor antagonists von Chao, Jianhua, Taveras, Arthur G., Chao, Jianping, Aki, Cynthia, Dwyer, Michael, Yu, Younong, Purakkattle, Biju, Rindgen, Diane, Jakway, James, Hipkin, William, Fosetta, James, Fan, Xuedong, Lundell, Daniel, Fine, Jay, Minnicozzi, Michael, Phillips, Jonathan, Merritt, J. Robert

Volltext

Chemoselective Peptide Modification via Photocatalytic Tryptophan β‑Position Conjugation von Yu, Younong, Zhang, Li-Kang, Buevich, Alexei V, Li, Guoqing, Tang, Haiqun, Vachal, Petr, Colletti, Steven L, Shi, Zhi-Cai

Volltext

Substituted dibenzo[c, h]cinnolines: Topoisomerase I-targeting anticancer agents von YOUNONG YU, SINGH, Sudhir K, LIU, Angela, LI, Tsai-Kun, LIU, Leroy F, LAVOIE, Edmond J

Volltext

Discovery of 2-Hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5- methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123):  A Potent, Orally Bioavailable CXCR2/CXCR1... von Dwyer, Michael P, Yu, Younong, Chao, Jianping, Aki, Cynthia, Chao, Jianhua, Biju, Purakkattle, Girijavallabhan, Viyyoor, Rindgen, Diane, Bond, Richard, Mayer-Ezel, Rosemary, Jakway, James, Hipkin, R. William, Fossetta, James, Gonsiorek, Waldemar, Bian, Hong, Fan, Xuedong, Terminelli, Carol, Fine, Jay, Lundell, Daniel, Merritt, J. Robert, Rokosz, Laura L, Kaiser, Bernd, Li, Ge, Wang, Wei, Stauffer, Tara, Ozgur, Lynne, Baldwin, John, Taveras, Arthur G

Volltext

Diaminocyclobutenediones as potent and orally bioavailable CXCR2 receptor antagonists: SAR in the phenolic amide region von Aki, Cynthia, Chao, Jianping, Ferreira, Johan A., Dwyer, Michael P., Yu, Younong, Chao, Jianhua, Merritt, Robert J., Lai, Gaifa, Wu, Minglang, Hipkin, R. William, Fan, Xuedong, Gonsiorek, Waldemar, Fosseta, James, Rindgen, Diane, Fine, Jay, Lundell, Daniel, Taveras, Arthur G., Biju, Purakkattle

Volltext

3,4-Diamino-2,5-thiadiazole-1-oxides as potent CXCR2/CXCR1 antagonists von Biju, Purakkattle, Taveras, Arthur, Yu, Younong, Zheng, Junying, Chao, Jianhua, Rindgen, Diane, Jakway, James, Hipkin, R. William, Fossetta, James, Fan, Xuedong, Fine, Jay, Qiu, Hongchen, Merritt, J. Robert, Baldwin, John J.

Volltext

Synthesis and structure–activity relationships of heteroaryl substituted-3,4-diamino-3-cyclobut-3-ene-1,2-dione CXCR2/CXCR1 receptor antagonists von Yu, Younong, Dwyer, Michael P., Chao, Jianping, Aki, Cynthia, Chao, Jianhua, Purakkattle, Biju, Rindgen, Diane, Bond, Richard, Mayer-Ezel, Rosemary, Jakway, James, Qiu, Hongchen, Hipkin, R. William, Fossetta, James, Gonsiorek, Waldemar, Bian, Hong, Fan, Xuedong, Terminelli, Carol, Fine, Jay, Lundell, Daniel, Merritt, J. Robert, He, Zhenmin, Lai, Gaifa, Wu, Minglang, Taveras, Arthur

Volltext

Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation von Yu, Wensheng, Liu, Jian, Yu, Younong, Zhang, Vivian, Clausen, Dane, Kelly, Joseph, Wolkenberg, Scott, Beshore, Douglas, Duffy, Joseph L., Chung, Christine C., Myers, Robert W., Klein, Daniel J., Fells, James, Holloway, Kate, Wu, Jin, Wu, Guoxin, Howell, Bonnie J., Barnard, Richard J.O., Kozlowski, Joseph

Volltext

Discovery of Ethyl Ketone-Based Highly Selective HDACs 1, 2, 3 Inhibitors for HIV Latency Reactivation with Minimum Cellular Potency Serum Shift and Reduced hERG Activity von Yu, Wensheng, Liu, Jian, Clausen, Dane, Yu, Younong, Duffy, Joseph L, Wang, Ming, Xu, Shouning, Deng, Lin, Suzuki, Takao, Chung, Christine C, Myers, Robert W, Klein, Daniel J, Fells, James I, Holloway, M. Katharine, Wu, Jin, Wu, Guoxin, Howell, Bonnie J, Barnard, Richard J. O, Kozlowski, Joseph

Volltext

Discovery of Highly Selective and Potent HDAC3 Inhibitors Based on a 2‑Substituted Benzamide Zinc Binding Group von Liu, Jian, Yu, Younong, Kelly, Joseph, Sha, Deyou, Alhassan, Abdul-Basit, Yu, Wensheng, Maletic, Milana M, Duffy, Joseph L, Klein, Daniel J, Holloway, M. Katharine, Carroll, Steve, Howell, Bonnie J, Barnard, Richard J. O, Wolkenberg, Scott, Kozlowski, Joseph A

Volltext

Identification of Oxidation Products of (−)-Epigallocatechin Gallate and (−)-Epigallocatechin with H2O2 von Zhu, Nanqun, Huang, Tzou-Chi, Yu, Younong, LaVoie, Edmond J, Yang, Chung S, Ho, Chi-Tang

Volltext

Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a]pyrazine core featuring 3-position bicyclic ring substitutes von Liu, Jian, Guiadeen, Deodial, Krikorian, Arto, Gao, Xiaolei, Wang, James, Babu Boga, Sobhana, Alhassan, Abdul-Basit, Yu, Wensheng, Selyutin, Oleg, Yu, Younong, Anand, Rajan, Xu, Jiayi, Kelly, Joseph, Duffy, Joseph L., Liu, Shilan, Yang, Chundao, Wu, Hao, Cai, Jiaqiang, Bennett, Chad, Maloney, Kevin M., Tyagarajan, Sriram, Gao, Ying-Duo, Fischmann, Thierry O., Presland, Jeremy, Mansueto, My, Xu, Zangwei, Leccese, Erica, Zhang-Hoover, Jie, Knemeyer, Ian, Garlisi, Charles G., Stivers, Peter, Brandish, Philip E., Hicks, Alexandra, Kim, Ronald, Kozlowski, Joseph A.

Volltext

Rapid Affinity and Microsomal Stability Ranking of Crude Mixture Libraries of Histone Deacetylase Inhibitors von Tyagarajan, Sriram, Andrews, Christine L., Beshore, Douglas C., Buevich, Alexei V., Curran, Patrick J., Dandliker, Peter, Greshock, Thomas J., Hoar, Jason, Kim, Alex, Karnachi, Prabha, Knemeyer, Ian, Kozlowski, Joseph, Liu, Jian, Maletic, Milana, Myers, Robert, Rada, Vanessa, Sha, Deyou, Sauvagnat, Berengere, Vachal, Petr, Wolkenberg, Scott, Yu, Wensheng, Yu, Younong, Krska, Shane W.

Volltext

Selective Class I HDAC Inhibitors Based on Aryl Ketone Zinc Binding Induce HIV‑1 Protein for Clearance von Liu, Jian, Kelly, Joseph, Yu, Wensheng, Clausen, Dane, Yu, Younong, Kim, Hyunjin, Duffy, Joseph L, Chung, Christine C, Myers, Robert W, Carroll, Steve, Klein, Daniel J, Fells, James, Holloway, M. Katharine, Wu, Jin, Wu, Guoxin, Howell, Bonnie J, Barnard, Richard J. O, Kozlowski, Joseph A

Volltext

A new synthesis of 3,4-disubstituted 1,2,5-thiadiazoles von Biju, Purakkattle, Yu, Younong

Volltext

Synthesis of HDAC Inhibitor Libraries via Microscale Workflow von Dykstra, Kevin D, Streckfuss, Eric, Liu, Min, Liu, Jian, Yu, Younong, Wang, Ming, Kozlowski, Joseph A, Myers, Robert W, Buevich, Alexei V, Maletic, Milana M, Vachal, Petr, Krska, Shane W

Volltext

Discovery of novel BTK inhibitors with carboxylic acids von Gao, Xiaolei, Wang, James, Liu, Jian, Guiadeen, Deodial, Krikorian, Arto, Boga, Sobhana Babu, Alhassan, Abdul-Basit, Selyutin, Oleg, Yu, Wensheng, Yu, Younong, Anand, Rajan, Liu, Shilan, Yang, Chundao, Wu, Hao, Cai, Jiaqiang, Cooper, Alan, Zhu, Hugh, Maloney, Kevin, Gao, Ying-Duo, Fischmann, Thierry O., Presland, Jeremy, Mansueto, My, Xu, Zangwei, Leccese, Erica, Zhang-Hoover, Jie, Knemeyer, Ian, Garlisi, Charles G., Bays, Nathan, Stivers, Peter, Brandish, Philip E., Hicks, Alexandra, Kim, Ronald, Kozlowski, Joeseph A.

Volltext

Use of molecular modeling aided design to dial out hERG liability in adenosine A(2A) receptor antagonists von Deng, Qiaolin, Lim, Yeon-Hee, Anand, Rajan, Yu, Younong, Kim, Jae-hun, Zhou, Wei, Zheng, Junying, Tempest, Paul, Levorse, Dorothy, Zhang, Xiaoping, Greene, Scott, Mullins, Deborra, Culberson, Chris, Sherborne, Brad, Parker, Eric M, Stamford, Andrew, Ali, Amjad

Volltext

Discovery of 3-morpholino-imidazole[1,5-a]pyrazine BTK inhibitors for rheumatoid arthritis von Boga, Sobhana Babu, Alhassan, Abdul-Basit, Liu, Jian, Guiadeen, Deodial, Krikorian, Arto, Gao, Xiaolei, Wang, James, Yu, Younong, Anand, Rajan, Liu, Shilan, Yang, Chundao, Wu, Hao, Cai, Jiaqiang, Zhu, Hugh, Desai, Jagdish, Maloney, Kevin, Gao, Ying-Duo, Fischmann, Thierry O., Presland, Jeremy, Mansueto, My, Xu, Zangwei, Leccese, Erica, Knemeyer, Ian, Garlisi, Charles G., Bays, Nathan, Stivers, Peter, Brandish, Philip E., Hicks, Alexandra, Cooper, Alan, Kim, Ronald M., Kozlowski, Joseph A.

Volltext