Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase von Jankowsky, Joanna L., Fadale, Daniel J., Anderson, Jeffrey, Xu, Guilian M., Gonzales, Victoria, Jenkins, Nancy A., Copeland, Neal G., Lee, Michael K., Younkin, Linda H., Wagner, Steven L., Younkin, Steven G., Borchelt, David R.

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Environmental Enrichment Mitigates Cognitive Deficits in a Mouse Model of Alzheimer's Disease von Jankowsky, Joanna L, Melnikova, Tatiana, Fadale, Daniel J, Xu, Guilian M, Slunt, Hilda H, Gonzales, Victoria, Younkin, Linda H, Younkin, Steven G, Borchelt, David R, Savonenko, Alena V

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BACE1 Deficiency Rescues Memory Deficits and Cholinergic Dysfunction in a Mouse Model of Alzheimer's Disease von Ohno, Masuo, Sametsky, Evgeny A, Younkin, Linda H, Oakley, Holly, Younkin, Steven G, Citron, Martin, Vassar, Robert, Disterhoft, John F

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Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease von Kawarabayashi, Takeshi, Shoji, Mikio, Younkin, Linda H, Wen-Lang, Lin, Dickson, Dennis W, Murakami, Tetsuro, Matsubara, Etsuro, Abe, Koji, Ashe, Karen Hsiao, Younkin, Steven G

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The Relationship between Aβ and Memory in the Tg2576 Mouse Model of Alzheimer's Disease von Westerman, Marcus A., Cooper-Blacketer, Deirdre, Mariash, Ami, Kotilinek, Linda, Kawarabayashi, Takeshi, Younkin, Linda H., Carlson, George A., Younkin, Steven G., Ashe, Karen H.

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Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease von Kawarabayashi, Takeshi, Younkin, Linda H., Saido, Takaomi C., Shoji, Mikio, Ashe, Karen Hsiao, Younkin, Steven G.

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Cholesterol-Dependent γ-Secretase Activity in Buoyant Cholesterol-Rich Membrane Microdomains von Wahrle, Suzanne, Das, Pritam, Nyborg, Andrew C., McLendon, Chris, Shoji, Mikio, Kawarabayashi, Takeshi, Younkin, Linda H., Younkin, Steven G., Golde, Todd E.

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Persistent Amyloidosis following Suppression of Aβ Production in a Transgenic Model of Alzheimer Disease von Jankowsky, Joanna L, Slunt, Hilda H, Gonzales, Victoria, Savonenko, Alena V, Wen, Jason C, Jenkins, Nancy A, Copeland, Neal G, Younkin, Linda H, Lester, Henry A, Younkin, Steven G, Borchelt, David R

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The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice von Wen, Paul H., Hof, Patrick R., Chen, Xiaoping, Gluck, Karen, Austin, Gregory, Younkin, Steven G., Younkin, Linda H., DeGasperi, Rita, Gama Sosa, Miguel A., Robakis, Nikolaos K., Haroutunian, Vahram, Elder, Gregory A.

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Linkage of plasma A beta 42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees von Ertekin-Taner, N, Graff-Radford, N, Younkin, L H, Eckman, C, Baker, M, Adamson, J, Ronald, J, Blangero, J, Hutton, M, Younkin, S G

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Reduced effectiveness of A beta 1-42 immunization in APP transgenic mice with significant amyloid deposition von Das, P, Murphy, M P, Younkin, L H, Younkin, S G, Golde, TE

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Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives von Golde, Todd E., Estus, Steven, Younkin, Linda H., Selkoe, Dennis J., Younkin, Steven G.

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Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43) von Gravina, S A, Ho, L, Eckman, C B, Long, K E, Otvos, Jr, L, Younkin, L H, Suzuki, N, Younkin, S G

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Serum creatinine levels correlate with plasma amyloid β protein von ARVANITAKIS, Zoe, LUCAS, John A, YOUNKIN, Linda H, YOUNKIN, Steven G, GRAFF-RADFORD, Neill R

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Plasmin deficiency does not alter endogenous murine amyloid beta levels in mice von Tucker, H. Michael, Simpson, James, Kihiko-Ehmann, Muthoni, Younkin, Linda H., McGillis, Joseph P., Younkin, Steven G., Degen, Jay L., Estus, Steven

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Heritability of plasma amyloid β in typical late-onset Alzheimer's disease pedigrees von Ertekin-Taner, Nilufer, Graff-Radford, Neill, Younkin, Linda H., Eckman, Christopher, Adamson, Jennifer, Schaid, Daniel J., Blangero, John, Hutton, Michael, Younkin, Steven G.

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The β -amyloid Protein Precursor of Alzheimer Disease has Soluble Derivatives Found in Human Brain and Cerebrospinal Fluid von Palmert, Mark R., Podlisny, Marcia Berman, Witker, Dennis S., Oltersdorf, Tilman, Younkin, Linda H., Selkoe, Dennis J., Younkin, Steven G.

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Amyloid β protein levels in cerebrospinal fluid are elevated in early-onset Alzheimer's disease von Nakamura, Tamiko, Shoji, Mikio, Harigaya, Yasuo, Watanabe, Mitsunori, Hosoda, Kenji, Cheung, Tobun T., Shaffer, Lillian M., Golde, Todd E., Younkin, Linda H., Younkin, Steven G., Hirai, Shunsaku

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Amyloid Protein Precursor Messenger RNAs: Differential Expression in Alzheimer's Disease von Palmert, M. R., Golde, T. E., Cohen, M. L., Kovacs, D. M., Tanzi, R. E., Gusella, J. F., Usiak, M. F., Younkin, L. H., Younkin, S. G.

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Plasma beta-amyloid peptide, transforming growth factor-beta 1, and risk for cerebral amyloid angiopathy von Greenberg, S M, Cho, H S, O'Donnell, H C, Rosand, J, Segal, A Z, Younkin, L H, Younkin, S G, Rebeck, G W

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