AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast... von Youngblood, Bradford A., Brock, Emily C., Leung, John, Falahati, Rustom, Bryce, Paul J., Bright, Jessica, Williams, Jason, Shultz, Leonard D., Greiner, Dale L., Brehm, Michael A., Bebbington, Christopher, Tomasevic, Nenad

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Mast Cell and Eosinophil Activation Are Associated With COVID-19 and TLR-Mediated Viral Inflammation: Implications for an Anti-Siglec-8 Antibody von Gebremeskel, Simon, Schanin, Julia, Coyle, Krysta M., Butuci, Melina, Luu, Thuy, Brock, Emily C., Xu, Alan, Wong, Alan, Leung, John, Korver, Wouter, Morin, Ryan D., Schleimer, Robert P., Bochner, Bruce S., Youngblood, Bradford A.

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The Inhibitory Receptor Siglec-8 Interacts With FcεRI and Globally Inhibits Intracellular Signaling in Primary Mast Cells Upon Activation von Korver, Wouter, Wong, Alan, Gebremeskel, Simon, Negri, Gian Luca, Schanin, Julia, Chang, Katherine, Leung, John, Benet, Zachary, Luu, Thuy, Brock, Emily C, Luehrsen, Kenneth, Xu, Alan, Youngblood, Bradford A

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Discovery, Function, and Therapeutic Targeting of Siglec-8 von Youngblood, Bradford A., Leung, John, Falahati, Rustom, Williams, Jason, Schanin, Julia, Brock, Emily C., Singh, Bhupinder, Chang, Alan T., O'Sullivan, Jeremy A., Schleimer, Robert P., Tomasevic, Nenad, Bebbington, Christopher R., Bochner, Bruce S.

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The Number of MRGPRX2-Expressing Cells Is Increased in Skin Lesions of Patients With Indolent Systemic Mastocytosis, But Is Not Linked to Symptom Severity von Pyatilova, Polina, Ashry, Tameem, Luo, Yanyan, He, Jiajun, Bonnekoh, Hanna, Jiao, Qingqing, Moñino-Romero, Sherezade, Hu, Man, Scheffel, Jörg, Frischbutter, Stefan, Hermans, Maud A. W., Youngblood, Bradford A., Maurer, Marcus, Siebenhaar, Frank, Kolkhir, Pavel

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Discovery of an agonistic Siglec-6 antibody that inhibits and reduces human mast cells von Schanin, Julia, Korver, Wouter, Brock, Emily C., Leung, John, Benet, Zachary, Luu, Thuy, Chang, Katherine, Xu, Alan, De Freitas, Naomi, Luehrsen, Kenneth, Brehm, Michael A., Wong, Alan, Youngblood, Bradford A.

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Functional and Phenotypic Characterization of Siglec-6 on Human Mast Cells von Robida, Piper A, Rische, Clayton H, Morgenstern, Netali Ben-Baruch, Janarthanam, Rethavathi, Cao, Yun, Krier-Burris, Rebecca A, Korver, Wouter, Xu, Alan, Luu, Thuy, Schanin, Julia, Leung, John, Rothenberg, Marc E, Wechsler, Joshua B, Youngblood, Bradford A, Bochner, Bruce S, O'Sullivan, Jeremy A

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Mast cell activation is associated with post‐acute COVID‐19 syndrome von Wechsler, Joshua B., Butuci, Melina, Wong, Alan, Kamboj, Amol P., Youngblood, Bradford A.

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CstF-64 is necessary for endoderm differentiation resulting in cardiomyocyte defects von Youngblood, Bradford A., MacDonald, Clinton C.

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Siglec-8 antibody reduces eosinophils and mast cells in a transgenic mouse model of eosinophilic gastroenteritis von Youngblood, Bradford A., Brock, Emily C., Leung, John, Falahati, Rustom, Bochner, Bruce S., Rasmussen, Henrik S., Peterson, Kathryn, Bebbington, Christopher, Tomasevic, Nenad

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Mast Cell and Eosinophil Counts in Gastric and Duodenal Biopsy Specimens From Patients With and Without Eosinophilic Gastroenteritis von Reed, Craig C., Genta, Robert M., Youngblood, Bradford A., Wechsler, Joshua B., Dellon, Evan S.

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Eosinophil and mast cell Siglecs: From biology to drug target von O'Sullivan, Jeremy A., Chang, Alan T., Youngblood, Bradford A., Bochner, Bruce S.

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Mast cell silencing: A novel therapeutic approach for urticaria and other mast cell‐mediated diseases von Metz, Martin, Kolkhir, Pavel, Altrichter, Sabine, Siebenhaar, Frank, Levi‐Schaffer, Francesca, Youngblood, Bradford A., Church, Martin K., Maurer, Marcus

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Siglecs in allergy and asthma von Bochner, Bruce S., O'Sullivan, Jeremy A., Chang, Alan T., Youngblood, Bradford A.

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Siglecs as potential targets of therapy in human mast cell- and/or eosinophil-associated diseases von O’Sullivan, Jeremy A., Youngblood, Bradford A., Schleimer, Robert P., Bochner, Bruce S.

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Sialic acid–binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies von Legrand, Fanny, Cao, Yun, Wechsler, Joshua B., Zhu, Xiang, Zimmermann, Nives, Rampertaap, Shakuntala, Monsale, Joseph, Romito, Kimberly, Youngblood, Bradford A., Brock, Emily C., Makiya, Michelle A., Tomasevic, Nenad, Bebbington, Christopher, Maric, Irina, Metcalfe, Dean D., Bochner, Bruce S., Klion, Amy D.

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Regulation of mast cells by overlapping but distinct protein interactions of Siglec‐6 and Siglec‐8 von Korver, Wouter, Benet, Zachary, Wong, Alan, Negri, Gian Luca, Chang, Katherine, Sanchez, Robert, Leung, John, De Freitas, Naomi, Luu, Thuy, Schanin, Julia, Youngblood, Bradford A.

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A monoclonal antibody to Siglec-8 suppresses non-allergic airway inflammation and inhibits IgE-independent mast cell activation von Schanin, Julia, Gebremeskel, Simon, Korver, Wouter, Falahati, Rustom, Butuci, Melina, Haw, Tatt Jhong, Nair, Prema M., Liu, Gang, Hansbro, Nicole G., Hansbro, Philip M., Evensen, Erik, Brock, Emily C., Xu, Alan, Wong, Alan, Leung, John, Bebbington, Christopher, Tomasevic, Nenad, Youngblood, Bradford A.

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Detecting Changes in Mast Cell Numbers Versus Activation in Human Disease: A Roadblock for Current Biomarkers? von Akin, Cem, Siebenhaar, Frank, Wechsler, Joshua B., Youngblood, Bradford A., Maurer, Marcus

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Lirentelimab for severe and chronic forms of allergic conjunctivitis von Anesi, Stephen D, Tauber, Joseph, Nguyen, Quan Dong, Chang, Peter, Berdy, Gregg J, Lin, Charles C, Chu, David S, Levine, H Terry, Fernandez, Andrew D, Roy, Neeta, Asbell, Penny A, Kantor, Andrea M, Chang, Alan T, Singh, Bhupinder, Youngblood, Bradford A, Jeng, Bennie H, Jhanji, Vishal, Rasmussen, Henrik S, Foster, C Stephen

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