A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice von Escribano-Díaz, Cristina, Orthwein, Alexandre, Fradet-Turcotte, Amélie, Xing, Mengtan, Young, Jordan T.F., Tkáč, Ján, Cook, Michael A., Rosebrock, Adam P., Munro, Meagan, Canny, Marella D., Xu, Dongyi, Durocher, Daniel

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HELB Is a Feedback Inhibitor of DNA End Resection von Tkáč, Ján, Xu, Guotai, Adhikary, Hemanta, Young, Jordan T.F., Gallo, David, Escribano-Díaz, Cristina, Krietsch, Jana, Orthwein, Alexandre, Munro, Meagan, Sol, Wendy, Al-Hakim, Abdallah, Lin, Zhen-Yuan, Jonkers, Jos, Borst, Piet, Brown, Grant W., Gingras, Anne-Claude, Rottenberg, Sven, Masson, Jean-Yves, Durocher, Daniel

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The MMS22L-TONSL Complex Mediates Recovery from Replication Stress and Homologous Recombination von O'Donnell, Lara, Panier, Stephanie, Wildenhain, Jan, Tkach, Johnny M., Al-Hakim, Abdallah, Landry, Marie-Claude, Escribano-Diaz, Cristina, Szilard, Rachel K., Young, Jordan T.F., Munro, Meagan, Canny, Marella D., Kolas, Nadine K., Zhang, Wei, Harding, Shane M., Ylanko, Jarkko, Mendez, Megan, Mullin, Michael, Sun, Thomas, Habermann, Bianca, Datti, Alessandro, Bristow, Robert G., Gingras, Anne-Claude, Tyers, Michael D., Brown, Grant W., Durocher, Daniel

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CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition von Gallo, David, Young, Jordan T. F., Fourtounis, Jimmy, Martino, Giovanni, Álvarez-Quilón, Alejandro, Bernier, Cynthia, Duffy, Nicole M., Papp, Robert, Roulston, Anne, Stocco, Rino, Szychowski, Janek, Veloso, Artur, Alam, Hunain, Baruah, Prasamit S., Fortin, Alexanne Bonneau, Bowlan, Julian, Chaudhary, Natasha, Desjardins, Jessica, Dietrich, Evelyne, Fournier, Sara, Fugère-Desjardins, Chloe, Goullet de Rugy, Theo, Leclaire, Marie-Eve, Liu, Bingcan, Bhaskaran, Vivek, Mamane, Yael, Melo, Henrique, Nicolas, Olivier, Singhania, Akul, Szilard, Rachel K., Tkáč, Ján, Yin, Shou Yun, Morris, Stephen J., Zinda, Michael, Marshall, C. Gary, Durocher, Daniel

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Profound synthetic lethality between SMARCAL1 and FANCM von Feng, Sumin, Liu, Kaiwen, Shang, Jinfeng, Hoeg, Lisa, Pastore, Graziana, Yang, William, Roy, Sabrina, Sastre-Moreno, Guillermo, Young, Jordan T.F., Wu, Wei, Xu, Dongyi, Durocher, Daniel

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RP-3500: A Novel, Potent, and Selective ATR Inhibitor that is Effective in Preclinical Models as a Monotherapy and in Combination with PARP Inhibitors von Roulston, Anne, Zimmermann, Michal, Papp, Robert, Skeldon, Alexander, Pellerin, Charles, Dumas-Bérube, Émilie, Dumais, Valerie, Dorich, Stéphane, Fader, Lee D, Fournier, Sara, Li, Li, Leclaire, Marie-Eve, Yin, Shou Yun, Chefson, Amandine, Alam, Hunain, Yang, William, Fugère-Desjardins, Chloe, Vignini-Hammond, Sabrina, Skorey, Kathryn, Mulani, Amina, Rimkunas, Victoria, Veloso, Artur, Hamel, Martine, Stocco, Rino, Mamane, Yael, Li, Zuomei, Young, Jordan T F, Zinda, Michael, Black, W Cameron

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Guiding ATR and PARP inhibitor combinationswith chemogenomic screens von Zimmermann, Michal, Bernier, Cynthia, Kaiser, Beatrice, Fournier, Sara, Li, Li, Desjardins, Jessica, Skeldon, Alexander, Rimkunas, Victoria, Veloso, Artur, Young, Jordan T F, Roulston, Anne, Zinda, Michael

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Guiding ATR and PARP inhibitor combinations with chemogenomic screens von Zimmermann, Michal, Bernier, Cynthia, Kaiser, Beatrice, Fournier, Sara, Li, Li, Desjardins, Jessica, Skeldon, Alexander, Rimkunas, Victoria, Veloso, Artur, Young, Jordan T.F., Roulston, Anne, Zinda, Michael

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The CIP2A-TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer von Adam, Salomé, Rossi, Silvia Emma, Moatti, Nathalie, De Marco Zompit, Mara, Xue, Yibo, Ng, Timothy F, Álvarez-Quilón, Alejandro, Desjardins, Jessica, Bhaskaran, Vivek, Martino, Giovanni, Setiaputra, Dheva, Noordermeer, Sylvie M, Ohsumi, Toshiro K, Hustedt, Nicole, Szilard, Rachel K, Chaudhary, Natasha, Munro, Meagan, Veloso, Artur, Melo, Henrique, Yin, Shou Yun, Papp, Robert, Young, Jordan T F, Zinda, Michael, Stucki, Manuel, Durocher, Daniel

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LSD1 is required for euchromatic origin firing and replication timing von Wang, Yue, Huang, Yunchao, Cheng, Edith, Liu, Xinhua, Zhang, Yu, Yang, Jianguo, Young, Jordan T. F., Brown, Grant W., Yang, Xiaohan, Shang, Yongfeng

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Endogenous DNA 3′ Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease von Álvarez-Quilón, Alejandro, Wojtaszek, Jessica L., Mathieu, Marie-Claude, Patel, Tejas, Appel, C. Denise, Hustedt, Nicole, Rossi, Silvia Emma, Wallace, Bret D., Setiaputra, Dheva, Adam, Salomé, Ohashi, Yota, Melo, Henrique, Cho, Tiffany, Gervais, Christian, Muñoz, Ivan M., Grazzini, Eric, Young, Jordan T.F., Rouse, John, Zinda, Michael, Williams, R. Scott, Durocher, Daniel

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Proteasome inhibition induces hsp30 and hsp70 gene expression as well as the acquisition of thermotolerance in Xenopus laevis A6 cells von Young, Jordan T. F., Heikkila, John J.

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Simultaneous exposure of Xenopus A6 kidney epithelial cells to concurrent mild sodium arsenite and heat stress results in enhanced hsp30 and hsp70 gene expression and the acquisiti... von Young, Jordan T.F., Gauley, Julie, Heikkila, John J.

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Analysis of heat shock-, sodium arsenite- and proteasome inhibitor-induced heat shock protein gene expression in Xenopus laevis von Young, Jordan T.F

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