Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas von Bender, Sebastian, Tang, Yujie, Lindroth, Anders M., Hovestadt, Volker, Jones, David T.W., Kool, Marcel, Zapatka, Marc, Northcott, Paul A., Sturm, Dominik, Wang, Wei, Radlwimmer, Bernhard, Højfeldt, Jonas W., Truffaux, Nathalène, Castel, David, Schubert, Simone, Ryzhova, Marina, Şeker-Cin, Huriye, Gronych, Jan, Johann, Pascal David, Stark, Sebastian, Meyer, Jochen, Milde, Till, Schuhmann, Martin, Ebinger, Martin, Monoranu, Camelia-Maria, Ponnuswami, Anitha, Chen, Spenser, Jones, Chris, Witt, Olaf, Collins, V. Peter, von Deimling, Andreas, Jabado, Nada, Puget, Stephanie, Grill, Jacques, Helin, Kristian, Korshunov, Andrey, Lichter, Peter, Monje, Michelle, Plass, Christoph, Cho, Yoon-Jae, Pfister, Stefan M.

Volltext

Combined BET bromodomain and CDK2 inhibition in MYC-driven medulloblastoma von Bolin, Sara, Borgenvik, Anna, Persson, Camilla U., Sundström, Anders, Qi, Jun, Bradner, James E., Weiss, William A., Cho, Yoon-Jae, Weishaupt, Holger, Swartling, Fredrik J.

Volltext

HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC-Driven Medulloblastoma von Pei, Yanxin, Liu, Kun-Wei, Wang, Jun, Garancher, Alexandra, Tao, Ran, Esparza, Lourdes A., Maier, Donna L., Udaka, Yoko T., Murad, Najiba, Morrissy, Sorana, Seker-Cin, Huriye, Brabetz, Sebastian, Qi, Lin, Kogiso, Mari, Schubert, Simone, Olson, James M., Cho, Yoon-Jae, Li, Xiao-Nan, Crawford, John R., Levy, Michael L., Kool, Marcel, Pfister, Stefan M., Taylor, Michael D., Wechsler-Reya, Robert J.

Volltext

Pediatric high-grade glioma: biologically and clinically in need of new thinking von Jones, Chris, Karajannis, Matthias A, Jones, David T W, Kieran, Mark W, Monje, Michelle, Baker, Suzanne J, Becher, Oren J, Cho, Yoon-Jae, Gupta, Nalin, Hawkins, Cynthia, Hargrave, Darren, Haas-Kogan, Daphne A, Jabado, Nada, Li, Xiao-Nan, Mueller, Sabine, Nicolaides, Theo, Packer, Roger J, Persson, Anders I, Phillips, Joanna J, Simonds, Erin F, Stafford, James M, Tang, Yujie, Pfister, Stefan M, Weiss, William A

Volltext

The landscape of somatic copy-number alteration across human cancers von Yecies, Derek, Gabriel, Stacey, Porter, Dale, Nucera, Carmelo, Antonescu, Cristina R, Chiang, Derek Y, Janne, Pasi A, Greulich, Heidi, Loo, Alice, Prensner, John, Maher, Elizabeth, Rustgi, Anil K, Ligon, Azra H, Tanaka, Kumiko E, Kaye, Frederic J, Ebert, Benjamin L, Pomeroy, Scott L, Lander, Eric S, Fletcher, Jonathan A, Okamoto, Aikou, Signoretti, Sabina, Haery, Leila, Reich, Michael, Dobson, Jennifer, Raychaudhuri, Soumya, Wei, Guo, Baselga, José, Tsao, Ming-Sound, Letai, Anthony, Getz, Gad, Liefeld, Ted, Donovan, Jerry, Levine, Ross L, Beer, David G, Daly, Mark J, Sasaki, Hidefumi, Pinchback, Reid M, Bass, Adam J, Hoffman, Carter, Ladanyi, Marc, True, Lawrence D, Cho, Yoon-Jae, Sellers, William R, Tabernero, Josep, Demichelis, Francesca, Tepper, Joel E, Golub, Todd R, Meyerson, Matthew, Boehm, Jesse S, Mermel, Craig H, Loda, Massimo, Weir, Barbara A, Beroukhim, Rameen, Singer, Samuel, Urashima, Mitsuyoshi, Gao, Qing, Lawrence, Michael S, Rubin, Mark A, Barretina, Jordi, Garraway, Levi A, Winckler, Wendy, Mc Henry, Kevin T

Volltext

Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas von Kool, Marcel, Korshunov, Andrey, Remke, Marc, Jones, David T. W., Schlanstein, Maria, Northcott, Paul A., Cho, Yoon-Jae, Koster, Jan, Schouten-van Meeteren, Antoinette, van Vuurden, Dannis, Clifford, Steven C., Pietsch, Torsten, von Bueren, Andre O., Rutkowski, Stefan, McCabe, Martin, Collins, V. Peter, Bäcklund, Magnus L., Haberler, Christine, Bourdeaut, Franck, Delattre, Olivier, Doz, Francois, Ellison, David W., Gilbertson, Richard J., Pomeroy, Scott L., Taylor, Michael D., Lichter, Peter, Pfister, Stefan M.

Volltext

Casein kinase 2 inhibition sensitizes medulloblastoma to temozolomide von Nitta, Ryan T., Bolin, Sara, Luo, Emily, Solow-Codero, David E., Samghabadi, Peyman, Purzner, Teresa, Aujla, Parvir S., Nwagbo, Ginikachi, Cho, Yoon-Jae, Li, Gordon

Volltext

Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis von Ramaswamy, Vijay, MD, Remke, Marc, MD, Bouffet, Eric, Prof, Faria, Claudia C, MD, Perreault, Sebastien, MD, Cho, Yoon-Jae, MD, Shih, David J, MSc, Luu, Betty, BSc, Dubuc, Adrian M, PhD, Northcott, Paul A, PhD, Schüller, Ulrich, MD, Gururangan, Sridharan, Prof, McLendon, Roger, Prof, Bigner, Darell, Prof, Fouladi, Maryam, Prof, Ligon, Keith L, MD, Pomeroy, Scott L, Prof, Dunn, Sandra, PhD, Triscott, Joanna, BSc, Jabado, Nada, MD, Fontebasso, Adam, BSc, Jones, David T W, PhD, Kool, Marcel, PhD, Karajannis, Matthias A, MD, Gardner, Sharon L, MD, Zagzag, David, Prof, Nunes, Sofia, MD, Pimentel, José, MD, Mora, Jaume, MD, Lipp, Eric, MD, Walter, Andrew W, MD, Ryzhova, Marina, MD, Zheludkova, Olga, MD, Kumirova, Ella, MD, Alshami, Jad, BSc, Croul, Sidney E, Prof, Rutka, James T, Prof, Hawkins, Cynthia, Prof, Tabori, Uri, MD, Codispoti, Kari-Elise T, MD, Packer, Roger J, Prof, Pfister, Stefan M, Prof, Korshunov, Andrey, Prof, Taylor, Michael D, Prof

Volltext

Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma von Kahn, Suzana A., Wang, Xin, Nitta, Ryan T., Gholamin, Sharareh, Theruvath, Johanna, Hutter, Gregor, Azad, Tej D., Wadi, Lina, Bolin, Sara, Ramaswamy, Vijay, Esparza, Rogelio, Liu, Kun-Wei, Edwards, Michael, Swartling, Fredrik J., Sahoo, Debashis, Li, Gordon, Wechsler-Reya, Robert J., Reimand, Jüri, Cho, Yoon-Jae, Taylor, Michael D., Weissman, Irving L., Mitra, Siddhartha S., Cheshier, Samuel H.

Volltext

A First-in-Class TWIST1 Inhibitor with Activity in Oncogene-Driven Lung Cancer von Yochum, Zachary A, Cades, Jessica, Mazzacurati, Lucia, Neumann, Neil M, Khetarpal, Susheel K, Chatterjee, Suman, Wang, Hailun, Attar, Myriam A, Huang, Eric H-B, Chatley, Sarah N, Nugent, Katriana, Somasundaram, Ashwin, Engh, Johnathan A, Ewald, Andrew J, Cho, Yoon-Jae, Rudin, Charles M, Tran, Phuoc T, Burns, Timothy F

Volltext

Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1 von Ramkissoon, Lori A., Horowitz, Peleg M., Craig, Justin M., Ramkissoon, Shakti H., Rich, Benjamin E., Schumacher, Steven E., McKenna, Aaron, Lawrence, Michael S., Bergthold, Guillaume, Brastianos, Priscilla K., Tabak, Barbara, Ducar, Matthew D., Van Hummelen, Paul, MacConaill, Laura E., Pouissant-Young, Tina, Cho, Yoon-Jae, Taha, Hala, Mahmoud, Madeha, Bowers, Daniel C., Margraf, Linda, Tabori, Uri, Hawkins, Cynthia, Packer, Roger J., Hill, D. Ashley, Pomeroy, Scott L., Eberhart, Charles G., Dunn, Ian F., Goumnerova, Liliana, Getz, Gad, Chan, Jennifer A., Santagata, Sandro, Hahn, William C., Stiles, Charles D., Ligon, Azra H., Kieran, Mark W., Beroukhim, Rameen, Ligon, Keith L.

Volltext

Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway von Roberts, Charles W M, Dorsch, Marion, Jagani, Zainab, Mora-Blanco, E Lorena, Sansam, Courtney G, McKenna, Elizabeth S, Wilson, Boris, Chen, Dongshu, Klekota, Justin, Tamayo, Pablo, Nguyen, Phuong T L, Tolstorukov, Michael, Park, Peter J, Cho, Yoon-Jae, Hsiao, Kathy, Buonamici, Silvia, Pomeroy, Scott L, Mesirov, Jill P, Ruffner, Heinz, Bouwmeester, Tewis, Luchansky, Sarah J, Murtie, Joshua, Kelleher, Joseph F, Warmuth, Markus, Sellers, William R

Volltext

Pleiotropic effects of miR-183~96~182 converge to regulate cell survival, proliferation and migration in medulloblastoma von Weeraratne, Shyamal Dilhan, Amani, Vladimir, Teider, Natalia, Pierre-Francois, Jessica, Winter, Dominic, Kye, Min Jeong, Sengupta, Soma, Archer, Tenley, Remke, Marc, Bai, Alfa H. C., Warren, Peter, Pfister, Stefan M., Steen, Judith A. J., Pomeroy, Scott L., Cho, Yoon-Jae

Volltext

miR-34a confers chemosensitivity through modulation of MAGE-A and p53 in medulloblastoma von Weeraratne, Shyamal D., Amani, Vladimir, Neiss, Adrianne, Teider, Natalia, Scott, Deborah K., Pomeroy, Scott L., Cho, Yoon-Jae

Volltext

Expression of FoxM1 Is Required for the Proliferation of Medulloblastoma Cells and Indicates Worse Survival of Patients von PRILLER, Markus, PÖSCHL, Julia, ABRAO, Leticia, VON BUEREN, André O, CHO, Yoon-Jae, RUTKOWSKI, Stefan, KRETZSCHMAR, Hans A, SCHÜLLER, Ulrich

Volltext

Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group von Gottardo, Nicholas G., Hansford, Jordan R., McGlade, Jacqueline P., Alvaro, Frank, Ashley, David M., Bailey, Simon, Baker, David L., Bourdeaut, Franck, Cho, Yoon-Jae, Clay, Moira, Clifford, Steven C., Cohn, Richard J., Cole, Catherine H., Dallas, Peter B., Downie, Peter, Doz, François, Ellison, David W., Endersby, Raelene, Fisher, Paul G., Hassall, Timothy, Heath, John A., Hii, Hilary L., Jones, David T. W., Junckerstorff, Reimar, Kellie, Stewart, Kool, Marcel, Kotecha, Rishi S., Lichter, Peter, Laughton, Stephen J., Lee, Sharon, McCowage, Geoff, Northcott, Paul A., Olson, James M., Packer, Roger J., Pfister, Stefan M., Pietsch, Torsten, Pizer, Barry, Pomeroy, Scott L., Remke, Marc, Robinson, Giles W., Rutkowski, Stefan, Schoep, Tobias, Shelat, Anang A., Stewart, Clinton F., Sullivan, Michael, Taylor, Michael D., Wainwright, Brandon, Walwyn, Thomas, Weiss, William A., Williamson, Dan, Gajjar, Amar

Volltext

Twist1 suppresses senescence programs and thereby accelerates and maintains mutant Kras-induced lung tumorigenesis von Tran, Phuoc T, Shroff, Emelyn H, Burns, Timothy F, Thiyagarajan, Saravanan, Das, Sandhya T, Zabuawala, Tahera, Chen, Joy, Cho, Yoon-Jae, Luong, Richard, Tamayo, Pablo, Salih, Tarek, Aziz, Khaled, Adam, Stacey J, Vicent, Silvestre, Nielsen, Carsten H, Withofs, Nadia, Sweet-Cordero, Alejandro, Gambhir, Sanjiv S, Rudin, Charles M, Felsher, Dean W

Volltext

Local Sparse Principal Component Analysis for Exploring the Spatial Distribution of Social Infrastructure von Hong, Seong-Yun, Moon, Seonggook, Chi, Sang-Hyun, Cho, Yoon-Jae, Kang, Jeon-Young

Volltext

Neurologic features of Hutchinson-Gilford progeria syndrome after lonafarnib treatment von Ullrich, Nicole J, Kieran, Mark W, Miller, David T, Gordon, Leslie B, Cho, Yoon-Jae, Silvera, V Michelle, Giobbie-Hurder, Anita, Neuberg, Donna, Kleinman, Monica E

Volltext

Predicting Relapse in Patients With Medulloblastoma by Integrating Evidence From Clinical and Genomic Features von TAMAYO, Pablo, CHO, Yoon-Jae, POMEROY, Scott L, MESIROV, Jill P, TSHERNIAK, Aviad, GREULICH, Heidi, AMBROGIO, Lauren, SCHOUTEN-VAN MEETEREN, Netteke, TIANNI ZHOU, BUXTON, Allen, KOOL, Marcel, MEYERSON, Matthew

Volltext