The RASopathies: from pathogenetics to therapeutics von Hebron, Katie E, Hernandez, Edjay Ralph, Yohe, Marielle E

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Chemical genomics reveals histone deacetylases are required for core regulatory transcription von Gryder, Berkley E., Wu, Lei, Woldemichael, Girma M., Pomella, Silvia, Quinn, Taylor R., Park, Paul M. C., Cleveland, Abigail, Stanton, Benjamin Z., Song, Young, Rota, Rossella, Wiest, Olaf, Yohe, Marielle E., Shern, Jack F., Qi, Jun, Khan, Javed

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PAX3-FOXO1 Establishes Myogenic Super Enhancers and Confers BET Bromodomain Vulnerability von Gryder, Berkley E, Yohe, Marielle E, Chou, Hsien-Chao, Zhang, Xiaohu, Marques, Joana, Wachtel, Marco, Schaefer, Beat, Sen, Nirmalya, Song, Young, Gualtieri, Alberto, Pomella, Silvia, Rota, Rossella, Cleveland, Abigail, Wen, Xinyu, Sindiri, Sivasish, Wei, Jun S, Barr, Frederic G, Das, Sudipto, Andresson, Thorkell, Guha, Rajarshi, Lal-Nag, Madhu, Ferrer, Marc, Shern, Jack F, Zhao, Keji, Thomas, Craig J, Khan, Javed

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Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma von Yeung, Choh, Gibson, Anna E, Issaq, Sameer H, Oshima, Nobu, Baumgart, Joshua T, Edessa, Leah D, Rai, Ganesha, Urban, Daniel J, Johnson, Michelle S, Benavides, Gloria A, Squadrito, Giuseppe L, Yohe, Marielle E, Lei, Haiyan, Eldridge, Sandy, Hamre, 3rd, John, Dowdy, Tyrone, Ruiz-Rodado, Victor, Lita, Adrian, Mendoza, Arnulfo, Shern, Jack F, Larion, Mioara, Helman, Lee J, Stott, Gordon M, Krishna, Murali C, Hall, Matthew D, Darley-Usmar, Victor, Neckers, Leonard M, Heske, Christine M

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CASZ1 induces skeletal muscle and rhabdomyosarcoma differentiation through a feed-forward loop with MYOD and MYOG von Liu, Zhihui, Zhang, Xiyuan, Lei, Haiyan, Lam, Norris, Carter, Sakereh, Yockey, Oliver, Xu, Max, Mendoza, Arnulfo, Hernandez, Edjay R., Wei, Jun S., Khan, Javed, Yohe, Marielle E., Shern, Jack F., Thiele, Carol J.

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Clonality and evolutionary history of rhabdomyosarcoma von Chen, Li, Shern, Jack F, Wei, Jun S, Yohe, Marielle E, Song, Young K, Hurd, Laura, Liao, Hongling, Catchpoole, Daniel, Skapek, Stephen X, Barr, Frederic G, Hawkins, Douglas S, Khan, Javed

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Molecular Basis for Cooperative Binding of Anionic Phospholipids to the PH Domain of the Arf GAP ASAP1 von Jian, Xiaoying, Tang, Wai-Kwan, Zhai, Peng, Roy, Neeladri Sekhar, Luo, Ruibai, Gruschus, James M., Yohe, Marielle E., Chen, Pei-Wen, Li, Yifei, Byrd, R. Andrew, Xia, Di, Randazzo, Paul A.

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Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma von Pomella, Silvia, Sreenivas, Prethish, Gryder, Berkley E., Wang, Long, Milewski, David, Cassandri, Matteo, Baxi, Kunal, Hensch, Nicole R., Carcarino, Elena, Song, Young, Chou, Hsien-Chao, Yohe, Marielle E., Stanton, Benjamin Z., Amadio, Bruno, Caruana, Ignazio, De Stefanis, Cristiano, De Vito, Rita, Locatelli, Franco, Chen, Yidong, Chen, Eleanor Y., Houghton, Peter, Khan, Javed, Rota, Rossella, Ignatius, Myron S.

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Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression von Mitin, Natalia, Betts, Laurie, Yohe, Marielle E, Der, Channing J, Sondek, John, Rossman, Kent L

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ARF GTPases and their GEFs and GAPs: concepts and challenges von Sztul, Elizabeth, Chen, Pei-Wen, Casanova, James E, Cherfils, Jacqueline, Dacks, Joel B, Lambright, David G, Lee, Fang-Jen S, Randazzo, Paul A, Santy, Lorraine C, Schürmann, Annette, Wilhelmi, Ilka, Yohe, Marielle E, Kahn, Richard A

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Aurora B kinase is a potent and selective target in MYCN-driven neuroblastoma von Bogen, Dominik, Wei, Jun S, Azorsa, David O, Ormanoglu, Pinar, Buehler, Eugen, Guha, Rajarshi, Keller, Jonathan M, Mathews Griner, Lesley A, Ferrer, Marc, Song, Young K, Liao, Hongling, Mendoza, Arnulfo, Gryder, Berkley E, Sindri, Sivasish, He, Jianbin, Wen, Xinyu, Zhang, Shile, Shern, John F, Yohe, Marielle E, Taschner-Mandl, Sabine, Shohet, Jason M, Thomas, Craig J, Martin, Scott E, Ambros, Peter F, Khan, Javed

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Genomic Classification and Clinical Outcome in Rhabdomyosarcoma: A Report From an International Consortium von Shern, Jack F, Selfe, Joanna, Izquierdo, Elisa, Patidar, Rajesh, Chou, Hsien-Chao, Song, Young K, Yohe, Marielle E, Sindiri, Sivasish, Wei, Jun, Wen, Xinyu, Rudzinski, Erin R, Barkauskas, Donald A, Lo, Tammy, Hall, David, Linardic, Corinne M, Hughes, Debbie, Jamal, Sabri, Jenney, Meriel, Chisholm, Julia, Brown, Rebecca, Jones, Kristine, Hicks, Belynda, Angelini, Paola, George, Sally, Chesler, Louis, Hubank, Michael, Kelsey, Anna, Gatz, Susanne A, Skapek, Stephen X, Hawkins, Douglas S, Shipley, Janet M, Khan, Javed

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Role of the C-Terminal SH3 Domain and N-Terminal Tyrosine Phosphorylation in Regulation of Tim and Related Dbl-Family Proteins von Yohe, Marielle E, Rossman, Kent, Sondek, John

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MultiDimensional ClinOmics for Precision Therapy of Children and Adolescent Young Adults with Relapsed and Refractory Cancer: A Report from the Center for Cancer Research von Chang, Wendy, Brohl, Andrew S, Patidar, Rajesh, Sindiri, Sivasish, Shern, Jack F, Wei, Jun S, Song, Young K, Yohe, Marielle E, Gryder, Berkley, Zhang, Shile, Calzone, Kathleen A, Shivaprasad, Nityashree, Wen, Xinyu, Badgett, Thomas C, Miettinen, Markku, Hartman, Kip R, League-Pascual, James C, Trahair, Toby N, Widemann, Brigitte C, Merchant, Melinda S, Kaplan, Rosandra N, Lin, Jimmy C, Khan, Javed

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Targeting farnesylation as a novel therapeutic approach in HRAS-mutant rhabdomyosarcoma von Odeniyide, Patience, Yohe, Marielle E., Pollard, Kai, Vaseva, Angelina V., Calizo, Ana, Zhang, Lindy, Rodriguez, Fausto J., Gross, John M., Allen, Amy N., Wan, Xiaolin, Somwar, Romel, Schreck, Karisa C., Kessler, Linda, Wang, Jiawan, Pratilas, Christine A.

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MEK inhibitors for neurofibromatosis type 1 manifestations: Clinical evidence and consensus von de Blank, Peter M K, Gross, Andrea M, Akshintala, Srivandana, Blakeley, Jaishri O, Bollag, Gideon, Cannon, Ashley, Dombi, Eva, Fangusaro, Jason, Gelb, Bruce D, Hargrave, Darren, Kim, AeRang, Klesse, Laura J, Loh, Mignon, Martin, Staci, Moertel, Christopher, Packer, Roger, Payne, Jonathan M, Rauen, Katherine A, Rios, Jonathan J, Robison, Nathan, Schorry, Elizabeth K, Shannon, Kevin, Stevenson, David A, Stieglitz, Elliot, Ullrich, Nicole J, Walsh, Karin S, Weiss, Brian D, Wolters, Pamela L, Yohay, Kaleb, Yohe, Marielle E, Widemann, Brigitte C, Fisher, Michael J

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Phase I trial of Ganitumab plus Dasatinib to Cotarget the Insulin-Like Growth Factor 1 Receptor and Src Family Kinase YES in Rhabdomyosarcoma von Akshintala, Srivandana, Sundby, R Taylor, Bernstein, Donna, Glod, John W, Kaplan, Rosandra N, Yohe, Marielle E, Gross, Andrea M, Derdak, Joanne, Lei, Haiyan, Pan, Alexander, Dombi, Eva, Palacio-Yance, Isabel, Herrera, Kailey R, Miettinen, Markku M, Chen, Helen X, Steinberg, Seth M, Helman, Lee J, Mascarenhas, Leo, Widemann, Brigitte C, Navid, Fariba, Shern, Jack F, Heske, Christine M

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The small molecule inhibitor NAV-2729 has a complex target profile including multiple ADP-ribosylation factor regulatory proteins von Rosenberg, Eric M., Jian, Xiaoying, Soubias, Olivier, Yoon, Hye-Young, Yadav, Mukesh P., Hammoudeh, Sarah, Pallikkuth, Sandeep, Akpan, Itoro, Chen, Pei-Wen, Maity, Tapan K., Jenkins, Lisa M., Yohe, Marielle E., Byrd, R. Andrew, Randazzo, Paul A.

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Inhibition of NAD+-Dependent Metabolic Processes Induces Cellular Necrosis and Tumor Regression in Rhabdomyosarcoma Models von McKay-Corkum, Grace B, Collins, Victor J, Yeung, Choh, Ito, Takeshi, Issaq, Sameer H, Holland, David, Vulikh, Ksenia, Zhang, Yiping, Lee, Unsun, Lei, Haiyan, Mendoza, Arnulfo, Shern, Jack F, Yohe, Marielle E, Yamamoto, Kazutoshi, Wilson, Kelli, Ji, Jiuping, Karim, Baktiar O, Thomas, Craig J, Krishna, Murali C, Neckers, Leonard M, Heske, Christine M

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Insights into pediatric rhabdomyosarcoma research: Challenges and goals von Yohe, Marielle E., Heske, Christine M., Stewart, Elizabeth, Adamson, Peter C., Ahmed, Nabil, Antonescu, Cristina R., Chen, Eleanor, Collins, Natalie, Ehrlich, Alan, Galindo, Rene L., Gryder, Berkley E., Hahn, Heidi, Hammond, Sharon, Hatley, Mark E., Hawkins, Douglas S., Hayes, Madeline N., Hayes‐Jordan, Andrea, Helman, Lee J., Hettmer, Simone, Ignatius, Myron S., Keller, Charles, Khan, Javed, Kirsch, David G., Linardic, Corinne M., Lupo, Philip J., Rota, Rossella, Shern, Jack F., Shipley, Janet, Sindiri, Sivasish, Tapscott, Stephen J., Vakoc, Christopher R., Wexler, Leonard H., Langenau, David M.

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