Defects in the Proteome and Metabolome in Human Hypertrophic Cardiomyopathy von Previs, Michael J., O’Leary, Thomas S., Morley, Michael P., Palmer, Bradley M., LeWinter, Martin, Yob, Jaime M., Pagani, Francis D., Petucci, Christopher, Kim, Min-Soo, Margulies, Kenneth B., Arany, Zoltan, Kelly, Daniel P., Day, Sharlene M.

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Genotype-Dependent and -Independent Calcium Signaling Dysregulation in Human Hypertrophic Cardiomyopathy von Helms, Adam S, Alvarado, Francisco J, Yob, Jaime, Tang, Vi T, Pagani, Francis, Russell, Mark W, Valdivia, Héctor H, Day, Sharlene M

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Sarcomere mutation-specific expression patterns in human hypertrophic cardiomyopathy von Helms, Adam S, Davis, Frank M, Coleman, David, Bartolone, Sarah N, Glazier, Amelia A, Pagani, Francis, Yob, Jaime M, Sadayappan, Sakthivel, Pedersen, Ellen, Lyons, Robert, Westfall, Margaret V, Jones, Richard, Russell, Mark W, Day, Sharlene M

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Computational prediction of protein subdomain stability in MYBPC3 enables clinical risk stratification in hypertrophic cardiomyopathy and enhances variant interpretation von Thompson, Andrea D., Helms, Adam S., Kannan, Anamika, Yob, Jaime, Lakdawala, Neal K., Wittekind, Samuel G., Pereira, Alexandre C., Jacoby, Daniel L., Colan, Steven D., Ashley, Euan A., Saberi, Sara, Ware, James S., Ingles, Jodie, Semsarian, Christopher, Michels, Michelle, Mazzarotto, Francesco, Olivotto, Iacopo, Ho, Carolyn Y., Day, Sharlene M.

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Spatial and Functional Distribution of MYBPC3 Pathogenic Variants and Clinical Outcomes in Patients With Hypertrophic Cardiomyopathy von Helms, Adam S., Thompson, Andrea D., Glazier, Amelia A., Hafeez, Neha, Kabani, Samat, Rodriguez, Juliani, Yob, Jaime M., Woolcock, Helen, Mazzarotto, Francesco, Lakdawala, Neal K., Wittekind, Samuel G., Pereira, Alexandre C., Jacoby, Daniel L., Colan, Steven D., Ashley, Euan A., Saberi, Sara, Ware, James S., Ingles, Jodie, Semsarian, Christopher, Michels, Michelle, Olivotto, Iacopo, Ho, Carolyn Y., Day, Sharlene M.

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HSC70 is a chaperone for wild-type and mutant cardiac myosin binding protein C von Glazier, Amelia A, Hafeez, Neha, Mellacheruvu, Dattatreya, Basrur, Venkatesha, Nesvizhskii, Alexey I, Lee, Lap Man, Shao, Hao, Tang, Vi, Yob, Jaime M, Gestwicki, Jason E, Helms, Adam S, Day, Sharlene M

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An Unbiased Screen Identified the Hsp70-BAG3 Complex as a Regulator of Myosin-Binding Protein C3 von Thompson, Andrea D., Wagner, Marcus J., Rodriguez, Juliani, Malhotra, Alok, Vander Roest, Steve, Lilienthal, Ulla, Shao, Hao, Vignesh, Mathav, Weber, Keely, Yob, Jaime M., Prosser, Benjamin L., Helms, Adam S., Gestwicki, Jason E., Ginsburg, David, Day, Sharlene M.

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Targeting co-chaperones of HSP70 to modulate Myosin Binding Protein C turnover in hypertrophic cardiomyopathy von Wagner, Marcus, Branscom, Graham, Alcaro, Liana, Yob, Jaime, Day, Sharlene

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Abstract P1025: Hsp70 Co-chaperones Regulate Sarcomeric Proteostasis In Hypertrophic Cardiomyopathy von Wagner, Marcus J, Branscom, Graham A, Alcaro, Liana T, Yob, Jaime M, Day, Sharlene M

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High Intensity Exercise Improves Cardiorespiratory Capacity in a Mouse Model of Hypertrophic Cardiomyopathy von Herrera, Jonathan, Szczesniak, Danielle, Szczesniak, Kate, Goddard, Rose‐Carmel, Yob, Jaime, Day, Sharlene

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High Intensity Exercise Training Alters Cardiac Morphology In A Hypertrophic Cardiomyopathy Mouse Model: 232 von Herrera, Jonathan J., Szczesniak, Danielle L., Szczesniak, Kate, Gaur, Pranjal, Manzo, Miranda, Goddard, Rose-Carmel, Yob, Jaime, Day, Sharlene

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High Intensity Exercise Training Alters Cardiac Morphology In A Hypertrophic Cardiomyopathy Mouse Model: 232 von Herrera, Jonathan J., Szczesniak, Danielle L., Szczesniak, Kate, Gaur, Pranjal, Manzo, Miranda, Goddard, Rose-Carmel, Yob, Jaime, Day, Sharlene

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Abstract 14346: High Intensity Exercise Increases Cardiorespiratory Capacity in a Preclinical Hypertrophic Cardiomyopathy Mouse Model von Herrera, Jonathan J, Szczesniak, Danielle, Szczesniak, Kate, Gaur, Pranjal, Manzo, Miranda, Goddard, Rose-Carmel, Yob, Jaime, Tardiff, Jil C, Day, Sharlene

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Translationally Designed HIIT Protocol Improves Peak VO2 In A Preclinical HCM Model Without Adverse Events: 2405 Board #69 May 31 9:30 AM - 11:00 AM von Herrera, Jonathan J., Szczesniak, Kate, Szczesniak, Danielle L., Yob, Jaime, Tardiff, Jil C., Day, Sharlene

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Sex-Specific Effects of MTSS1 Downregulation on Dilated Cardiomyopathy von Choe, Dongwook, Burke, Megan, Brandimarto, Jeffrey A., Marti-Pamies, Ingrid, Yob, Jaime, Yang, Yifan, Morley, Michael P., Drivas, Theodore G., Day, Sharlene, Levin, Michael, Damrauer, Scott, Wang, Xiao, Cappola, Thomas P.

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Cardiac Remodeling Following High Intensity Exercise Training In A Preclinical HCM Mouse Model: 597 Board #2 May 27 1:00 PM - 3:00 PM von Herrera, Jonathan J., Szczesniak, Kate, Szczesniak, Danielle L., Goddard, Rose-Carmel, Yob, Jaime, Tardiff, Jil C., Day, Sharlene

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Impaired Exercise Capacity In cTnT-delta160E Mice Validates Pre-clinical Model To Assess Exercise Interventions For HCM: 3402 Board # 271 June 2 9 30 AM - 11 00 AM von Herrera, Jonathan J., Szczesniak, Kate, Louzon, Sean, Yob, Jaime, Tardiff, Jil C., Day, Sharlene

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Abstract 385: Cardiac Myosin Binding Protein-C Mutants Disrupt Ubiquitin Proteasome System and Hsc70 Functions von Glazier, Amelia A, Helms, Adam, Hafeez, Neha, Kotlo, Srisha, Yob, Jaime, Tang, Vi, Day, Sharlene

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Defects in the Proteome and Metabolome in Human Hypertrophic Cardiomyopathy von Previs, Michael J., O’Leary, Thomas S., Morley, Michael P., Palmer, Bradley M., LeWinter, Martin, Yob, Jaime M., Pagani, Francis D., Petucci, Christopher, Kim, Min-Soo, Margulies, Kenneth B., Arany, Zoltan, Kelly, Daniel P., Day, Sharlene M.

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Cardiac myosin binding protein C mutants interact with Hsp70‐family chaperones and disrupt protein quality control von Glazier, Amelia Ann, Helms, Adam, Kotlo, Srisha, Hafeez, Neha, Yob, Jaime, Tang, Vi, Mellacheruvu, Dattatreya, Nesvizhskii, Alexey, Day, Sharlene

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