The entire nogalamycin biosynthetic gene cluster of Streptomyces nogalater: characterization of a 20-kb DNA region and generation of hybrid structures von Torkkell, S, Kunnari, T, Palmu, K, Mäntsälä, P, Hakala, J, Ylihonko, K

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Molecular Evolution of Aromatic Polyketides and Comparative Sequence Analysis of Polyketide Ketosynthase and 16S Ribosomal DNA Genes from Various Streptomyces Species von Metsä-Ketelä, Mikko, Halo, Laura, Munukka, Eveliina, Hakala, Juha, Mäntsälä, Pekka, Ylihonko, Kristiina

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Hybrid anthracycline antibiotics: production of new anthracyclines by cloned genes from Streptomyces purpurascens in Streptomyces galilaeus von Niemi, Jarmo, Ylihonko, Kristiina, Hakala, Juha, Parssinen, Raimo, Kopio, Anja, Mantsala, Pekka

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Production of hybrid anthracycline antibiotics by heterologous expression of Streptomyces nogalater nogalamycin biosynthesis genes von Ylihonko, Kristiina, Hakala, Juha, Kunnari, Tero, Mantsalala, Pekka

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Isolation and characterization of aclacinomycin A-non-producing Streptomyces galilaeus (ATCC 31615) mutants von Ylihonko, Kristiina, Hakala, Juha, Niemi, Jarmo, Lundell, Juhani, Mantsala, Pekka

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Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster von Räty, Kaj, Kantola, Jaana, Hautala, Anne, Hakala, Juha, Ylihonko, Kristiina, Mäntsälä, Pekka

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Engineering Anthracycline Biosynthesis toward Angucyclines von Metsä-Ketelä, Mikko, Palmu, Kaisa, Kunnari, Tero, Ylihonko, Kristiina, Mäntsälä, Pekka

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An efficient approach for screening minimal PKS genes from Streptomyces von Metsä-Ketelä, Mikko, Salo, Virpi, Halo, Laura, Hautala, Anne, Hakala, Juha, Mäntsälä, Pekka, Ylihonko, Kristiina

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An efficient approach for screening minimal PKS genes from Streptomyces von Metsä-Ketelä, Mikko, Salo, Virpi, Halo, Laura, Hautala, Anne, Hakala, Juha, Mäntsälä, Pekka, Ylihonko, Kristiina

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Partial Activation of a Silent Angucycline-type Gene Cluster from a Rubromycin β Producing Streptomyces sp. PGA64 von METSÄ-KETELÄ, MIKKO, YLIHONKO, KRISTIINA, MÄNTSÄLÄ, PEKKA

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Identification of a Cyclase Gene Dictating the C-9 Stereochemistry of Anthracyclines from Streptomyces nogalater von Torkkell, S, Kunnari, T, Palmu, K, Hakala, J, Mäntsälä, P, Ylihonko, K

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Elucidation of anthracyclinone biosynthesis by stepwise cloning of genes for anthracyclines from three different Streptomyces spp von Kantola, Jaana, Kunnari, Tero, Hautala, Anne, Hakala, Juha, Ylihonko, Kristiina, Mantsala, Pekka

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Characterization of mutations in aclacinomycin A-non-producing Streptomyces galilaeus strains with altered glycosylation patterns von Raty, Kaj, Hautala, Anne, Torkkell, Sirke, Kantola, Jaana, Mantsala, Pekka, Hakala, Juha, Ylihonko, Kristiina

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Studies on a Second and Third Ring Cyclization in Anthracycline Biosynthesis von HAUTALA, ANNE, TORKKELL, SIRKE, RÄTY, KAJ, KUNNARI, TERO, KANTOLA, JAANA, MÄNTSÄLÄ, PEKKA, HAKALA, JUHA, YLIHONKO, KRISTIINA

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Hybrid Anthracyclines from a Genetically Engineered Streptomyces galilaeus Mutant von KUNNARI, Tero J., YLIHONKO, Kristiina P. J., KLIKA, Karel D., MäNTSäLä, Pekka I., HAKALA, Juha M. L.

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Engineering Anthracycline Biosynthesis toward Angucyclines von Metsä-Ketelä, Mikko, Palmu, Kaisa, Kunnari, Tero, Ylihonko, Kristiina, Mäntsälä, Pekka

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Incorrectly folded aromatic polyketides from polyketide reductase deficient mutants von Kunnari, Tero, Ylihonko, Kristiina, Hautala, Anne, Klika, Karel D., Mäntsälä, Pekka, Hakala, Juha

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Isolation and characterization of 8-demethoxy steffimycins and generation of 2,8-demethoxy steffimycins in Streptomyces steffisburgensis by the nogalamycin biosynthesis genes von KUNNARI, T, TUIKKANEN, J, HAUTALA, A, HAKALA, J, YLIHONKO, K, MÄNTSÄLÄ, P

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Hybrid anthracyclines by a genetically engineered Streptomyces galilaeus mutant von Kunnari, Tero, Niemi, Jarmo, Ylihonko, Kristiina, Mäntsälä, Pekka, Hakala, Juha

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Hybrid compounds generated by the introduction of a nogalamycin-producing plasmid into Streptomyces argillaceus von Kunnari, Tero, Klika, Karel D., Blanco, Gloria, Méndez, Carmen, Mäntsälä, Pekka, Hakala, Juha, Sillanpää, Reijo, Tähtinen, Petri, Salas, Jose, Ylihonko, Kristiina

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