Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice von McKay, Paul F., Hu, Kai, Blakney, Anna K., Samnuan, Karnyart, Brown, Jonathan C., Penn, Rebecca, Zhou, Jie, Bouton, Clément R., Rogers, Paul, Polra, Krunal, Lin, Paulo J. C., Barbosa, Christopher, Tam, Ying K., Barclay, Wendy S., Shattock, Robin J.

Volltext

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs von Akinc, Akin, Maier, Martin A., Manoharan, Muthiah, Fitzgerald, Kevin, Jayaraman, Muthusamy, Barros, Scott, Ansell, Steven, Du, Xinyao, Hope, Michael J., Madden, Thomas D., Mui, Barbara L., Semple, Sean C., Tam, Ying K., Ciufolini, Marco, Witzigmann, Dominik, Kulkarni, Jayesh A., van der Meel, Roy, Cullis, Pieter R.

Volltext

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes von Pardi, Norbert, Tuyishime, Steven, Muramatsu, Hiromi, Kariko, Katalin, Mui, Barbara L., Tam, Ying K., Madden, Thomas D., Hope, Michael J., Weissman, Drew

Volltext

Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA von Chen, Sam, Tam, Yuen Yi C., Lin, Paulo J.C., Sung, Molly M.H., Tam, Ying K., Cullis, Pieter R.

Volltext

Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies von Pardi, Norbert, Parkhouse, Kaela, Kirkpatrick, Ericka, McMahon, Meagan, Zost, Seth J., Mui, Barbara L., Tam, Ying K., Karikó, Katalin, Barbosa, Christopher J., Madden, Thomas D., Hope, Michael J., Krammer, Florian, Hensley, Scott E., Weissman, Drew

Volltext

Molecular fate-mapping of serum antibody responses to repeat immunization von Schiepers, Ariën, van ’t Wout, Marije F. L., Greaney, Allison J., Zang, Trinity, Muramatsu, Hiromi, Lin, Paulo J. C., Tam, Ying K., Mesin, Luka, Starr, Tyler N., Bieniasz, Paul D., Pardi, Norbert, Bloom, Jesse D., Victora, Gabriel D.

Volltext

Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge von Pardi, Norbert, Secreto, Anthony J., Shan, Xiaochuan, Debonera, Fotini, Glover, Joshua, Yi, Yanjie, Muramatsu, Hiromi, Ni, Houping, Mui, Barbara L., Tam, Ying K., Shaheen, Farida, Collman, Ronald G., Karikó, Katalin, Danet-Desnoyers, Gwenn A., Madden, Thomas D., Hope, Michael J., Weissman, Drew

Volltext

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo von Jayaraman, Muthusamy, Ansell, Steven M., Mui, Barbara L., Tam, Ying K., Chen, Jianxin, Du, Xinyao, Butler, David, Eltepu, Laxman, Matsuda, Shigeo, Narayanannair, Jayaprakash K., Rajeev, Kallanthottathil G., Hafez, Ismail M., Akinc, Akin, Maier, Martin A., Tracy, Mark A., Cullis, Pieter R., Madden, Thomas D., Manoharan, Muthiah, Hope, Michael J.

Volltext

CAR T cells produced in vivo to treat cardiac injury von Rurik, Joel G, Tombácz, István, Yadegari, Amir, Méndez Fernández, Pedro O, Shewale, Swapnil V, Li, Li, Kimura, Toru, Soliman, Ousamah Younoss, Papp, Tyler E, Tam, Ying K, Mui, Barbara L, Albelda, Steven M, Puré, Ellen, June, Carl H, Aghajanian, Haig, Weissman, Drew, Parhiz, Hamideh, Epstein, Jonathan A

Volltext

Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function von Hocker, Harrison J, Cho, Kwang-Jin, Chen, Chung-Ying K, Rambahal, Nandini, Sagineedu, Sreenivasa Rao, Shaari, Khozirah, Stanslas, Johnson, Hancock, John F, Gorfe, Alemayehu A

Volltext

PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated... von Parhiz, Hamideh, Shuvaev, Vladimir V., Pardi, Norbert, Khoshnejad, Makan, Kiseleva, Raisa Yu, Brenner, Jacob S., Uhler, Thomas, Tuyishime, Steven, Mui, Barbara L., Tam, Ying K., Madden, Thomas D., Hope, Michael J., Weissman, Drew, Muzykantov, Vladimir R.

Volltext

Development of a pentavalent broadly protective nucleoside-modified mRNA vaccine against influenza B viruses von Pardi, Norbert, Carreño, Juan Manuel, O’Dell, George, Tan, Jessica, Bajusz, Csaba, Muramatsu, Hiromi, Rijnink, Willemijn, Strohmeier, Shirin, Loganathan, Madhumathi, Bielak, Dominika, Sung, Molly M. H., Tam, Ying K., Krammer, Florian, McMahon, Meagan

Volltext

Plant metabolism of nematode pheromones mediates plant-nematode interactions von Manohar, Murli, Tenjo-Castano, Francisco, Chen, Shiyan, Zhang, Ying K., Kumari, Anshu, Williamson, Valerie M., Wang, Xiaohong, Klessig, Daniel F., Schroeder, Frank C.

Volltext

In vivo hematopoietic stem cell modification by mRNA delivery von Breda, Laura, Papp, Tyler E, Triebwasser, Michael P, Yadegari, Amir, Fedorky, Megan T, Tanaka, Naoto, Abdulmalik, Osheiza, Pavani, Giulia, Wang, Yongping, Grupp, Stephan A, Chou, Stella T, Ni, Houping, Mui, Barbara L, Tam, Ying K, Weissman, Drew, Rivella, Stefano, Parhiz, Hamideh

Volltext

Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood–brain barrier von Marcos-Contreras, Oscar A., Greineder, Colin F., Kiseleva, Raisa Yu, Parhiz, Hamideh, Walsh, Landis R., Zuluaga-Ramirez, Viviana, Myerson, Jacob W., Hood, Elizabeth D., Villa, Carlos H., Tombacz, Istvan, Pardi, Norbert, Seliga, Alecia, Mui, Barbara L., Tam, Ying K., Glassman, Patrick M., Shuvaev, Vladimir V., Nong, Jia, Brenner, Jacob S., Khoshnejad, Makan, Madden, Tom, Weissmann, Drew, Persidsky, Yuri, Muzykantov, Vladimir R.

Volltext

MGD011, A CD19 x CD3 Dual-Affinity Retargeting Bi-specific Molecule Incorporating Extended Circulating Half-life for the Treatment of B-Cell Malignancies von Liu, Liqin, Lam, Chia-Ying K, Long, Vatana, Widjaja, Lusiana, Yang, Yinhua, Li, Hua, Jin, Linda, Burke, Steve, Gorlatov, Sergey, Brown, Jennifer, Alderson, Ralph, Lewis, Margaret D, Nordstrom, Jeffrey L, Koenig, Scott, Moore, Paul A, Johnson, Syd, Bonvini, Ezio

Volltext

Fear of Crime: The Influence of General Fear, Risk, and Time Perspective von Chadee, Derek, Ng Ying, Nikita K., Chadee, Mary, Heath, Linda

Volltext

Lipid Nanoparticles Delivering Constitutively Active STING mRNA to Stimulate Antitumor Immunity von Liu, Wei, Alameh, Mohamad-Gabriel, Yang, June F, Xu, Jonathan R, Lin, Paulo J C, Tam, Ying K, Weissman, Drew, You, Jianxin

Volltext

Development of lipid nanoparticle formulations of siRNA for hepatocyte gene silencing following subcutaneous administration von Chen, Sam, Tam, Yuen Yi C., Lin, Paulo J.C., Leung, Alex K.K., Tam, Ying K., Cullis, Pieter R.

Volltext

Comparative metabolomics with Metaboseek reveals functions of a conserved fat metabolism pathway in C. elegans von Helf, Maximilian J., Fox, Bennett W., Artyukhin, Alexander B., Zhang, Ying K., Schroeder, Frank C.

Volltext