Critically Appraised Topic (CAT): Building a Library of Validated Practices von Moghadam, Jahan, Yates, Samuel W., Baskerville, Richard L

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Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer’s Disease-like Pathology von Savas, Jeffrey N., Wang, Yi-Zhi, DeNardo, Laura A., Martinez-Bartolome, Salvador, McClatchy, Daniel B., Hark, Timothy J., Shanks, Natalie F., Cozzolino, Kira A., Lavallée-Adam, Mathieu, Smukowski, Samuel N., Park, Sung Kyu, Kelly, Jeffery W., Koo, Edward H., Nakagawa, Terunaga, Masliah, Eliezer, Ghosh, Anirvan, Yates, John R.

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Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins under Native Solution Conditions von Arosio, Paolo, Müller, Thomas, Rajah, Luke, Yates, Emma V, Aprile, Francesco A, Zhang, Yingbo, Cohen, Samuel I. A, White, Duncan A, Herling, Therese W, De Genst, Erwin J, Linse, Sara, Vendruscolo, Michele, Dobson, Christopher M, Knowles, Tuomas P. J

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In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer von Dubrot, Juan, Du, Peter P., Lane-Reticker, Sarah Kate, Kessler, Emily A., Muscato, Audrey J., Mehta, Arnav, Freeman, Samuel S., Allen, Peter M., Olander, Kira E., Ockerman, Kyle M., Wolfe, Clara H., Wiesmann, Fabius, Knudsen, Nelson H., Tsao, Hsiao-Wei, Iracheta-Vellve, Arvin, Schneider, Emily M., Rivera-Rosario, Andrea N., Kohnle, Ian C., Pope, Hans W., Ayer, Austin, Mishra, Gargi, Zimmer, Margaret D., Kim, Sarah Y., Mahapatra, Animesh, Ebrahimi-Nik, Hakimeh, Frederick, Dennie T., Boland, Genevieve M., Haining, W. Nicholas, Root, David E., Doench, John G., Hacohen, Nir, Yates, Kathleen B., Manguso, Robert T.

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Macrophages disseminate pathogen associated molecular patterns through the direct extracellular release of the soluble content of their phagolysosomes von Greene, Catherine J., Nguyen, Jenny A., Cheung, Samuel M., Arnold, Corey R., Balce, Dale R., Wang, Ya Ting, Soderholm, Adrian, McKenna, Neil, Aggarwal, Devin, Campden, Rhiannon I., Ewanchuk, Benjamin W., Virgin, Herbert W., Yates, Robin M.

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Utility of Body Weight, Urine Color, and Thirst Perception (WUT) in Determining Hydration in Young Adults von Adams, William M, Anderson, Travis, Zaplatosch, Mitchell E, Cheuvront, Samuel N, Kenefick, Robert W, Yates, Brandon A, Morrissey-Basler, Margaret C, Casa, Douglas J, Wideman, Laurie

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Targeted reconstruction of T cell receptor sequence from single cell RNA-seq links CDR3 length to T cell differentiation state von Afik, Shaked, Yates, Kathleen B, Bi, Kevin, Darko, Samuel, Godec, Jernej, Gerdemann, Ulrike, Swadling, Leo, Douek, Daniel C, Klenerman, Paul, Barnes, Eleanor J, Sharpe, Arlene H, Haining, W Nicholas, Yosef, Nir

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Blinatumomab Nonresponse and High-Disease Burden Are Associated With Inferior Outcomes After CD19-CAR for B-ALL von Myers, Regina M, Taraseviciute, Agne, Steinberg, Seth M, Lamble, Adam J, Sheppard, Jennifer, Yates, Bonnie, Kovach, Alexandra E, Wood, Brent, Borowitz, Michael J, Stetler-Stevenson, Maryalice, Yuan, Constance M, Pillai, Vinodh, Foley, Toni, Chung, Perry, Chen, Lee, Lee, Daniel W, Annesley, Colleen, DiNofia, Amanda, Grupp, Stephan A, John, Samuel, Bhojwani, Deepa, Brown, Patrick A, Laetsch, Theodore W, Gore, Lia, Gardner, Rebecca A, Rheingold, Susan R, Pulsipher, Michael A, Shah, Nirali N

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Inhibition of WEE1 Is Effective in TP53 - and RAS -Mutant Metastatic Colorectal Cancer: A Randomized Trial (FOCUS4-C) Comparing Adavosertib (AZD1775) With Active Monitoring von Seligmann, Jenny F, Fisher, David J, Brown, Louise C, Adams, Richard A, Graham, Janet, Quirke, Philip, Richman, Susan D, Butler, Rachel, Domingo, Enric, Blake, Andrew, Yates, Emma, Braun, Michael, Collinson, Fiona, Jones, Rob, Brown, Ewan, de Winton, Emma, Humphrey, Timothy C, Parmar, Mahesh, Kaplan, Richard, Wilson, Richard H, Seymour, Matthew, Maughan, Timothy S

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Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study von Halpin, Sophie, Donohue, Chloe, Ladhani, Shamez, Horby, Peter W, Docherty, Annemarie B, Semple, Malcolm G, Openshaw, Peter J M, Bach, Benjamin, Chand, Meera, Harrison, Ewen M, Hiscox, Julian A, Horby, Peter W, Klenerman, Paul, Law, Andrew, Moore, Shona C, Palmarini, Massimo, Russell, Clark D, Solomon, Tom, Sriskandan, Shiranee, Stuart, David, Thomson, Emma C, Oosthuyzen, Wilna, Norman, Lisa, Pius, Riinu, Mclean, Kenneth A, Saviciute, Egle, Leeming, Gary, Hendry, Ross, Greenhalf, William, Ahmed, Katie A, Asiimwe, Innocent G, Brennan, Benjamin, Catterall, Benjamin WA, Clark, Jordan J, Cole, Sarah, Cox, Helen, Elliott, Angela, Foster, Terry, Greenhalf, Willliam, Jones, Trevor R, Murphy, Ellen G, Small, Benjamin, Subramaniam, Krishanthi S, Tanianis, Jolanta, Trochu, Erwan, van Tonder, Libby, Wilcock, Eve, Agranoff, Daniel, Angus, Brian, Atkinson, Dougal, Barlow, Gavin, Barrett, Nicholas, Bassford, Christopher, Beadsworth, Michael, Best, Nicola, Burden, Tom, Chukkambotla, Srikanth, Cupitt, Jason, Dark, Paul, Dushianthan, Ahilanadan, Dyer, Tristan, Evans, Cariad, Fegan, Christopher, Finn, Adam, Fullerton, Duncan, Goldsmith, Arthur, Hardy, Elaine, Havalda, Peter, Holme, Anita, Kendall, Jason, Kerrison, Caroline, Larkin, Susan, Leiner, Tamas, Lillie, Patrick, MacNaughton, Emily, McCullough, Katherine, Moore, Elinoor, Morgan, Patrick, Morris, Craig, Nelson, Mark, Panchatsharam, Selva, Pintus, Stefania, Prout, Rachel, Rousseau, Guy, Ryan, Brendan, Saluja, Taranprit, Shanmuga, Prad, Sharma, Anil, Sizer, Jeremy, Smith, Richard, Snelson, Catherine, Spittle, Nick, Stambach, Tom, Tridente, Ascanio, Ustianowski, Andrew, Waddy, Sam, Whittaker, Paul, Williams, Martin, Wiselka, Martin, Young, Peter

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Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity von Wu, Meng-Ju, Kondo, Hiroshi, Kammula, Ashwin V, Shi, Lei, Xiao, Yi, Dhiab, Sofiene, Xu, Qin, Slater, Chloe J, Avila, Omar I, Merritt, Joshua, Kato, Hiroyuki, Kattel, Prabhat, Sussman, Jonathan, Gritti, Ilaria, Eccleston, Jason, Sun, Yi, Cho, Hyo Min, Olander, Kira, Katsuda, Takeshi, Shi, Diana D, Savani, Milan R, Smith, Bailey C, Cleary, James M, Mostoslavsky, Raul, Vijay, Vindhya, Kitagawa, Yosuke, Wakimoto, Hiroaki, Jenkins, Russell W, Yates, Kathleen B, Paik, Jihye, Tassinari, Ania, Saatcioglu, Duygu Hatice, Tron, Adriana E, Haas, Wilhelm, Cahill, Daniel, McBrayer, Samuel K, Manguso, Robert T, Bardeesy, Nabeel

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Trajectory of Mortality and Health-Related Quality of Life Morbidity Following Community-Acquired Pediatric Septic Shock von Zimmerman, Jerry J, Banks, Russell, Berg, Robert A, Zuppa, Athena, Newth, Christopher J, Wessel, David, Pollack, Murray M, Meert, Kathleen L, Hall, Mark W, Quasney, Michael, Sapru, Anil, Carcillo, Joseph A, McQuillen, Patrick S, Mourani, Peter M, Wong, Hector, Chima, Ranjit S, Holubkov, Richard, Coleman, Whitney, Sorenson, Samuel, Varni, James W, McGalliard, Julie, Haaland, Wren, Whitlock, Kathryn, Dean, J Michael, Reeder, Ron W

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Prognostic and therapeutic potential of senescent stromal fibroblasts in prostate cancer von Mori, Joakin O., Elhussin, Isra, Brennen, W. Nathaniel, Graham, Mindy K., Lotan, Tamara L., Yates, Clayton C., De Marzo, Angelo M., Denmeade, Samuel R., Yegnasubramanian, Srinivasan, Nelson, William G., Denis, Gerald V., Platz, Elizabeth A., Meeker, Alan K., Heaphy, Christopher M.

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Functional Dyspepsia and Gastroparesis in Tertiary Care are Interchangeable Syndromes With Common Clinical and Pathologic Features von Pasricha, Pankaj J., Grover, Madhusudan, Yates, Katherine P., Abell, Thomas L., Bernard, Cheryl E., Koch, Kenneth L., McCallum, Richard W., Sarosiek, Irene, Kuo, Braden, Bulat, Robert, Chen, Jiande, Shulman, Robert J., Lee, Linda, Tonascia, James, Miriel, Laura A., Hamilton, Frank, Farrugia, Gianrico, Parkman, Henry P., Pasricha, Pankaj Jay, Bulat, Robert, Burns, Robert, Hernandez, Guillermo Barahona, McKnight, Megan, Kuo, Braden, Mendez, April, Staller, Kyle, Thurler, Andrea, Velez, Christopher, Silvernale, Casey, Parkman, Henry P., Malik, Zubair, Maurer, Alan, Palit, Amiya, McCallum, Richard W., Sarosiek, Irene, Vega, Natalia, Vasquez, Denise, Connery, Sean, Espino, Karina, Friedman, Marvin, Abell, Thomas, Stocker, Abigail, Cannon, Bridget, McElmurray, Lindsay, Cooper, Kelly, McBride, Catherine, Koch, Kenneth, Baxter, Lynn, Brown, Anya, Stuart, Paula, Abdullah, Amirah, Snape, William, DeVole, Nata, Earle, Karen, Kirkeby, Kjersti, Lee, Candice, Lin, Mimi, Troyer, Doug, von Bakonyi, Anna, Shulman, Robert, Chumpitazi, Bruno, Febo-Rodriguez, Liz, Hollier, John, Bouette, Cynthia, Charron, Heather, Nurko, Samuel, Wall, Stephanie, Kane, Madeline, Williams, Kent, Yossef-Salameh, Lina, Woodley, Frederick, Farrugia, Gianrico, Grover, Madhusudan, Bernard, Cheryl, Serrano, Jose, Hamilton, Frank, Hall, Sherry, James, Stephen, Torrance, Rebecca, Tonascia, James, Adamo, Margaret, Belt, Patricia, Dodge, John, Donithan, Michele, Isaacson, Milana, Lee, Linda, Meinert, Jill, Miriel, Laura, Sharkey, Emily, Smith, Jacqueline, Smith, Michael, Sternberg, Alice, Van Natta, Mark, Wagoner, Annette, Wilson, Laura, Yamada, Goro, Yates, Katherine

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Critical Illness Factors Associated With Long-Term Mortality and Health-Related Quality of Life Morbidity Following Community-Acquired Pediatric Septic Shock von Zimmerman, Jerry J, Banks, Russell, Berg, Robert A, Zuppa, Athena, Newth, Christopher J, Wessel, David, Pollack, Murray M, Meert, Kathleen L, Hall, Mark W, Quasney, Michael, Sapru, Anil, Carcillo, Joseph A, McQuillen, Patrick S, Mourani, Peter M, Wong, Hector, Chima, Ranjit S, Holubkov, Richard, Coleman, Whitney, Sorenson, Samuel, Varni, James W, McGalliard, Julie, Haaland, Wren, Whitlock, Kathryn, Dean, J Michael, Reeder, Ron W

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Targeting TBK1 to overcome resistance to cancer immunotherapy von Sun, Yi, Revach, Or-yam, Anderson, Seth, Kessler, Emily A., Wolfe, Clara H., Jenney, Anne, Mills, Caitlin E., Robitschek, Emily J., Davis, Thomas G. R., Kim, Sarah, Fu, Amina, Ma, Xiang, Gwee, Jia, Tiwari, Payal, Du, Peter P., Sindurakar, Princy, Tian, Jun, Mehta, Arnav, Schneider, Alexis M., Yizhak, Keren, Sade-Feldman, Moshe, LaSalle, Thomas, Sharova, Tatyana, Xie, Hongyan, Liu, Shuming, Michaud, William A., Saad-Beretta, Rodrigo, Yates, Kathleen B., Iracheta-Vellve, Arvin, Spetz, Johan K. E., Qin, Xingping, Sarosiek, Kristopher A., Zhang, Gao, Kim, Jong Wook, Su, Mack Y., Cicerchia, Angelina M., Rasmussen, Martin Q., Klempner, Samuel J., Juric, Dejan, Pai, Sara I., Miller, David M., Giobbie-Hurder, Anita, Chen, Jonathan H., Pelka, Karin, Frederick, Dennie T., Stinson, Susanna, Ivanova, Elena, Aref, Amir R., Paweletz, Cloud P., Barbie, David A., Sen, Debattama R., Fisher, David E., Corcoran, Ryan B., Hacohen, Nir, Sorger, Peter K., Flaherty, Keith T., Boland, Genevieve M., Manguso, Robert T., Jenkins, Russell W.

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Capecitabine Versus Active Monitoring in Stable or Responding Metastatic Colorectal Cancer After 16 Weeks of First-Line Therapy: Results of the Randomized FOCUS4-N Trial von Adams, Richard A, Fisher, David J, Graham, Janet, Seligmann, Jenny F, Seymour, Matthew, Kaplan, Richard, Yates, Emma, Parmar, Mahesh, Richman, Susan D, Quirke, Philip, Butler, Rachel, Brown, Ewan, Collinson, Fiona, Falk, Stephen, Wasan, Harpreet, Shiu, Kai-Keen, Middleton, Gary, Samuel, Leslie, Wilson, Richard H, Brown, Louise C, Maughan, Timothy S

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Signatures of mutational processes in human cancer von Alexandrov, Ludmil B., Nik-Zainal, Serena, Wedge, David C., Aparicio, Samuel A. J. R., Behjati, Sam, Biankin, Andrew V., Bignell, Graham R., Bolli, Niccolò, Borg, Ake, Børresen-Dale, Anne-Lise, Boyault, Sandrine, Burkhardt, Birgit, Butler, Adam P., Caldas, Carlos, Davies, Helen R., Desmedt, Christine, Eils, Roland, Eyfjörd, Jórunn Erla, Foekens, John A., Greaves, Mel, Hosoda, Fumie, Hutter, Barbara, Ilicic, Tomislav, Imbeaud, Sandrine, Imielinski, Marcin, Jäger, Natalie, Jones, David T. W., Jones, David, Knappskog, Stian, Kool, Marcel, Lakhani, Sunil R., López-Otín, Carlos, Martin, Sancha, Munshi, Nikhil C., Nakamura, Hiromi, Northcott, Paul A., Pajic, Marina, Papaemmanuil, Elli, Paradiso, Angelo, Pearson, John V., Puente, Xose S., Raine, Keiran, Ramakrishna, Manasa, Richardson, Andrea L., Richter, Julia, Rosenstiel, Philip, Schlesner, Matthias, Schumacher, Ton N., Span, Paul N., Teague, Jon W., Totoki, Yasushi, Tutt, Andrew N. J., Valdés-Mas, Rafael, van Buuren, Marit M., van ’t Veer, Laura, Vincent-Salomon, Anne, Waddell, Nicola, Yates, Lucy R., Zucman-Rossi, Jessica, Andrew Futreal, P., McDermott, Ultan, Lichter, Peter, Meyerson, Matthew, Grimmond, Sean M., Siebert, Reiner, Campo, Elías, Shibata, Tatsuhiro, Pfister, Stefan M., Campbell, Peter J., Stratton, Michael R.

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AR42, a novel histone deacetylase inhibitor, as a potential therapy for vestibular schwannomas and meningiomas von Bush, Matthew L., Oblinger, Janet, Brendel, Victoria, Santarelli, Griffin, Huang, Jie, Akhmametyeva, Elena M., Burns, Sarah S., Wheeler, Justin, Davis, Jeremy, Yates, Charles W., Chaudhury, Abhik R., Kulp, Samuel, Chen, Ching-Shih, Chang, Long-Sheng, Welling, D. Bradley, Jacob, Abraham

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Thermal conductance across harmonic-matched epitaxial Al-sapphire heterointerfaces von Cheng, Zhe, Koh, Yee Rui, Ahmad, Habib, Hu, Renjiu, Shi, Jingjing, Liao, Michael E., Wang, Yekan, Bai, Tingyu, Li, Ruiyang, Lee, Eungkyu, Clinton, Evan A., Matthews, Christopher M., Engel, Zachary, Yates, Luke, Luo, Tengfei, Goorsky, Mark S., Doolittle, W. Alan, Tian, Zhiting, Hopkins, Patrick E., Graham, Samuel

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