AlphaScreen-Based Assays: Ultra-High-Throughput Screening for Small-Molecule Inhibitors of Challenging Enzymes and Protein-Protein Interactions von Yasgar, Adam, Jadhav, Ajit, Simeonov, Anton, Coussens, Nathan P.

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Quantitative High-Throughput Screening: A Titration-Based Approach That Efficiently Identifies Biological Activities in Large Chemical Libraries von Inglese, James, Auld, Douglas S., Jadhav, Ajit, Johnson, Ronald L., Simeonov, Anton, Yasgar, Adam, Zheng, Wei, Austin, Christopher P.

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Potent and Selective Inhibitors of Human Reticulocyte 12/15-Lipoxygenase as Anti-Stroke Therapies von Rai, Ganesha, Joshi, Netra, Jung, Joo Eun, Liu, Yu, Schultz, Lena, Yasgar, Adam, Perry, Steve, Diaz, Giovanni, Zhang, Qiangli, Kenyon, Victor, Jadhav, Ajit, Simeonov, Anton, Lo, Eng H, van Leyen, Klaus, Maloney, David J, Holman, Theodore R

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A platform of assays for the discovery of anti-Zika small-molecules with activity in a 3D-bioprinted outer-blood-retina model von Dorjsuren, Dorjbal, Eastman, Richard T, Song, Min Jae, Yasgar, Adam, Chen, Yuchi, Bharti, Kapil, Zakharov, Alexey V, Jadhav, Ajit, Ferrer, Marc, Shi, Pei-Yong, Simeonov, Anton

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A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity von Yasgar, Adam, Titus, Steven A, Wang, Yuhong, Danchik, Carina, Yang, Shyh-Ming, Vasiliou, Vasilis, Jadhav, Ajit, Maloney, David J, Simeonov, Anton, Martinez, Natalia J

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Biochemical and Cellular Characterization and Inhibitor Discovery of Pseudomonas aeruginosa 15-Lipoxygenase von Deschamps, Joshua D, Ogunsola, Abiola F, Jameson, J. Brian, Yasgar, Adam, Flitter, Becca A, Freedman, Cody J, Melvin, Jeffrey A, Nguyen, Jason V. M. H, Maloney, David J, Jadhav, Ajit, Simeonov, Anton, Bomberger, Jennifer M, Holman, Theodore R

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Correction: A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity von Yasgar, Adam, Titus, Steven A, Wang, Yuhong, Danchik, Carina, Yang, Shyh-Ming, Vasiliou, Vasilis, Jadhav, Ajit, Maloney, David J, Simeonov, Anton, Martinez, Natalia J

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A fluorescence-based high throughput assay for the determination of small molecule−human serum albumin protein binding von McCallum, Megan M., Pawlak, Alan J., Shadrick, William R., Simeonov, Anton, Jadhav, Ajit, Yasgar, Adam, Maloney, David J., Arnold, Leggy A.

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High-throughput 1,536-well fluorescence polarization assays for α(1)-acid glycoprotein and human serum albumin binding von Yasgar, Adam, Furdas, Silviya D, Maloney, David J, Jadhav, Ajit, Jung, Manfred, Simeonov, Anton

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A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models von Martinez, Natalia J, Rai, Ganesha, Yasgar, Adam, Lea, Wendy A, Sun, Hongmao, Wang, Yuhong, Luci, Diane K, Yang, Shyh-Ming, Nishihara, Kana, Takeda, Shunichi, Sagor, Mohiuddin, Earnshaw, Irina, Okada, Tetsuya, Mori, Kazutoshi, Wilson, Kelli, Riggins, Gregory J, Xia, Menghang, Grimaldi, Maurizio, Jadhav, Ajit, Maloney, David J, Simeonov, Anton

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Cross-Platform Bayesian Optimization System for Autonomous Biological Assay Development von Elder, Sam, Klumpp-Thomas, Carleen, Yasgar, Adam, Travers, Jameson, Frebert, Shayne, Wilson, Kelli M., Zakharov, Alexey V., Dahlin, Jayme L., Kreisbeck, Christoph, Sheberla, Dennis, Sittampalam, Gurusingham S., Godfrey, Alexander G., Simeonov, Anton, Michael, Sam

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Correction: A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Mode... von Martinez, Natalia J, Rai, Ganesha, Yasgar, Adam, Lea, Wendy A, Sun, Hongmao, Wang, Yuhong, Luci, Diane K, Yang, Shyh-Ming, Nishihara, Kana, Takeda, Shunichi, Mohiuddin, Earnshaw, Irina, Okada, Tetsuya, Mori, Kazutoshi, Wilson, Kelli, Riggins, Gregory J, Xia, Menghang, Grimaldi, Maurizio, Jadhav, Ajit, Maloney, David J, Simeonov, Anton

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Preparation of FRET reporters to support chemical probe development von Foley, Timothy L, Yasgar, Adam, Garcia, Christopher J, Jadhav, Ajit, Simeonov, Anton, Burkart, Michael D

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Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT–phosphoprotein interaction von Simeonov, Anton, Yasgar, Adam, Jadhav, Ajit, Lokesh, G.L., Klumpp, Carleen, Michael, Sam, Austin, Christopher P., Natarajan, Amarnath, Inglese, James

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A strategy to discover inhibitors of Bacillus subtilis surfactin-type phosphopantetheinyl transferase von Yasgar, Adam, Foley, Timothy L, Jadhav, Ajit, Inglese, James, Burkart, Michael D, Simeonov, Anton

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Applications of Differential Scanning Fluorometry and Related Technologies in Characterization of Protein–Ligand Interactions von Baljinnyam, Bolormaa, Ronzetti, Michael, Yasgar, Adam, Simeonov, Anton

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The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology von Richard, Ann M, Huang, Ruili, Waidyanatha, Suramya, Shinn, Paul, Collins, Bradley J, Thillainadarajah, Inthirany, Grulke, Christopher M, Williams, Antony J, Lougee, Ryan R, Judson, Richard S, Houck, Keith A, Shobair, Mahmoud, Yang, Chihae, Rathman, James F, Yasgar, Adam, Fitzpatrick, Suzanne C, Simeonov, Anton, Thomas, Russell S, Crofton, Kevin M, Paules, Richard S, Bucher, John R, Austin, Christopher P, Kavlock, Robert J, Tice, Raymond R

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A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate von Pacold, Michael E, Brimacombe, Kyle R, Chan, Sze Ham, Rohde, Jason M, Lewis, Caroline A, Swier, Lotteke J Y M, Possemato, Richard, Chen, Walter W, Sullivan, Lucas B, Fiske, Brian P, Cho, Steve, Freinkman, Elizaveta, Birsoy, Kıvanç, Abu-Remaileh, Monther, Shaul, Yoav D, Liu, Chieh Min, Zhou, Minerva, Koh, Min Jung, Chung, Haeyoon, Davidson, Shawn M, Luengo, Alba, Wang, Amy Q, Xu, Xin, Yasgar, Adam, Liu, Li, Rai, Ganesha, Westover, Kenneth D, Vander Heiden, Matthew G, Shen, Min, Gray, Nathanael S, Boxer, Matthew B, Sabatini, David M

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Venglustat Inhibits Protein N‑Terminal Methyltransferase 1 in a Substrate-Competitive Manner von Dong, Guangping, Deng, Youchao, Yasgar, Adam, Yadav, Ravi, Talley, Daniel, Zakharov, Alexey V., Jain, Sankalp, Rai, Ganesha, Noinaj, Nicholas, Simeonov, Anton, Huang, Rong

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Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity von Yang, Shyh-Ming, Martinez, Natalia J, Yasgar, Adam, Danchik, Carina, Johansson, Catrine, Wang, Yuhong, Baljinnyam, Bolormaa, Wang, Amy Q, Xu, Xin, Shah, Pranav, Cheff, Dorian, Wang, Xinran S, Roth, Jacob, Lal-Nag, Madhu, Dunford, James E, Oppermann, Udo, Vasiliou, Vasilis, Simeonov, Anton, Jadhav, Ajit, Maloney, David J

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