Preclinical Characterization and Human Microdose Pharmacokinetics of ITMN-8187, a Nonmacrocyclic Inhibitor of the Hepatitis C Virus NS3 Protease von Rajagopalan, Ravi, Pan, Lin, Schaefer, Caralee, Nicholas, John, Lim, Sharlene, Misialek, Shawn, Stevens, Sarah, Hooi, Lisa, Aleskovski, Natalia, Ruhrmund, Donald, Kossen, Karl, Huang, Lea, Yap, Sophia, Beigelman, Leonid, Serebryany, Vladimir, Liu, Jyanwei, Sastry, Srikonda, Seiwert, Scott, Buckman, Brad

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Newly diagnosed nasopharyngeal carcinoma with intracranial extension complicated with multiple thrombotic complications von Yap, Yoon Chin, Lo, Zhen Zhen, Heng, Sophia Si Ling

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Tunable spatial heterogeneity in structure and composition within aqueous microfluidic droplets von Hui Sophia Lee, Su, Wang, Pengzhi, Kun Yap, Swee, Alan Hatton, T., Khan, Saif A.

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Acceptance and commitment therapy for hoarding disorder: A proposed treatment protocol for individuals von Eppingstall, Jan, Xenos, Sophia, Yap, Keong

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Vinculin Tension and YAP Activation are Altered in Dystrophic Muscle Cells von Ramirez, Maria Paz, Wenthe, Sophia, Ervasti, James, Gordon, Wendy

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Developing a knowledge base on the habitats and reproductive conditions of Dipterocarps through information extraction von Gabud, Roselyn, Yap, Sandra, Batista-Navarro, Riza, Ananiadou, Sophia

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Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway von Kurppa, Kari J., Liu, Yao, To, Ciric, Zhang, Tinghu, Fan, Mengyang, Vajdi, Amir, Knelson, Erik H., Xie, Yingtian, Lim, Klothilda, Cejas, Paloma, Portell, Andrew, Lizotte, Patrick H., Ficarro, Scott B., Li, Shuai, Chen, Ting, Haikala, Heidi M., Wang, Haiyun, Bahcall, Magda, Gao, Yang, Shalhout, Sophia, Boettcher, Steffen, Shin, Bo Hee, Thai, Tran, Wilkens, Margaret K., Tillgren, Michelle L., Mushajiang, Mierzhati, Xu, Man, Choi, Jihyun, Bertram, Arrien A., Ebert, Benjamin L., Beroukhim, Rameen, Bandopadhayay, Pratiti, Awad, Mark M., Gokhale, Prafulla C., Kirschmeier, Paul T., Marto, Jarrod A., Camargo, Fernando D., Haq, Rizwan, Paweletz, Cloud P., Wong, Kwok-Kin, Barbie, David A., Long, Henry W., Gray, Nathanael S., Jänne, Pasi A.

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YAP-dependent proliferation by a small molecule targeting annexin A2 von Shalhout, Sophia Z., Yang, Peng-Yu, Grzelak, Edyta M., Nutsch, Kayla, Shao, Sida, Zambaldo, Claudio, Iaconelli, Jonathan, Ibrahim, Lara, Stanton, Caroline, Chadwick, Stormi R., Chen, Emily, DeRan, Michael, Li, Sijia, Hull, Mitchell, Wu, Xu, Chatterjee, Arnab K., Shen, Weijun, Camargo, Fernando D., Schultz, Peter G., Bollong, Michael J.

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Abstract CT006: First-in-class, first-in-human phase 1 trial of VT3989, an inhibitor of yes-associated protein (YAP)/transcriptional enhancer activator domain (TEAD), in patients (pts) with advanced solid tumors enriched for malignant mesothelioma and other tumors with neurofibromatosis 2 (NF2) mutations von Yap, Timothy A., Kwiatkowski, David J., Desai, Jayesh, Dagogo-Jack, Ibiayi, Millward, Michael, Kindler, Hedy L., Tolcher, Anthony W., Frentzas, Sophia, Thurston, Archie W., Post, Len, Dorr, F Andrew

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Hippo and PI5P4K signaling intersect to control the transcriptional activation of YAP von Palamiuc, Lavinia, Johnson, Jared L, Haratipour, Zeinab, Loughran, Ryan M, Choi, Woong Jae, Arora, Gurpreet K, Tieu, Vivian, Ly, Kyanh, Llorente, Alicia, Crabtree, Sophia, Wong, Jenny C Y, Ravi, Archna, Wiederhold, Thorsten, Murad, Rabi, Blind, Raymond D, Emerling, Brooke M

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Loss of ANCO1 repression at AIB1/YAP targets drives breast cancer progression von Kushner, Max H, Ory, Virginie, Graham, Garrett T, Sharif, Ghada M, Kietzman, William B, Thevissen, Sophia, Yuan, Meng, Schmidt, Marcel O, Wellstein, Anton, Riegel, Anna T

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YAP-Dependent Proliferation by a Small Molecule Targeting Annexin A2 von Shalhout, Sophia, Yang, Peng-Yu, Grzelak, Edyta M, Nutsch, Kayla, Shao, Sida, Zambaldo, Claudio, Iaconelli, Jonathan, Ibrahim, Lara, Stanton, Caroline, Chadwick, Stormi R, Chen, Emily, DeRan, Michael, Li, Sijia, Hull, Mitchell, Wu, Xu, Chatterjee, Arnab K, Shen, Weijun, Camargo, Fernando, Schultz, Peter, Bollong, Michael J

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Abstract 3861: c-MYC mediated resistance to trametinib plus hydroxychloroquine in pancreatic cancer is overcome by CDK4/6 and lysosomal inhibition von Silvis, Mark, Silva, Dilru, Riley, Rohweder, Schuman, Sophia, Gudipaty, Swapna, Truong, Amanda, Yap, Jeffery, Affolter, Kajsa, McMahon, Martin, Kinsey, Conan

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An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair von Yan, Ruorong, Cigliola, Valentina, Oonk, Kelsey A., Petrover, Zachary, DeLuca, Sophia, Wolfson, David W., Vekstein, Andrew, Mendiola, Michelle A., Devlin, Garth, Bishawi, Muath, Gemberling, Matthew P., Sinha, Tanvi, Sargent, Michelle A., York, Allen J., Shakked, Avraham, DeBenedittis, Paige, Wendell, David C., Ou, Jianhong, Kang, Junsu, Goldman, Joseph A., Baht, Gurpreet S., Karra, Ravi, Williams, Adam R., Bowles, Dawn E., Asokan, Aravind, Tzahor, Eldad, Gersbach, Charles A., Molkentin, Jeffery D., Bursac, Nenad, Black, Brian L., Poss, Kenneth D.

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Abstract 2183: Protective autophagy elicited by RAF®MEK®ERK inhibition suggests a treatment strategy for pancreatic cancer von Kinsey, Conan G., Camolotto, Soledad A., Boespflug, Amelie M., Guillen, Katrin P., Foth, Mona, Truong, Amanda, Schuman, Sophia S., Shea, Jill E., Seipp, Michael T., Yap, Jeffrey T., Burrell, Lance D., Lum, David H., Whisenant, Jonathan R., Gilcrease, G. Weldon, Cavalieri, Courtney C., Rehbein, Kaitrin M., Cutler, Stephanie L., Affolter, Kajsa E., Welm, Alana L., Welm, Bryan E., Scaife, Courtney L., Snyder, Eric L., McMahon, Martin

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Plant-Based Scaffolds Modify Cellular Response to Drug and Radiation Exposure Compared to Standard Cell Culture Models von Lacombe, Jerome, Harris, Ashlee F, Zenhausern, Ryan, Karsunsky, Sophia, Zenhausern, Frederic

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Upregulation of mechanosensitive channel Piezo1 involved in high shear stress-induced pulmonary hypertension von Chen, Jiyuan, Miao, Jinrui, Zhou, Dansha, Liao, Jing, Wang, Ziyi, Lin, Ziying, Zhang, Chenting, Luo, Xiaoyun, Li, Yi, Li, Xiang, Liu, Shiyun, Xing, Yue, Zhang, Zizhou, Zhao, Manjia, Parmisano, Sophia, Chen, Yuqin, Yuan, Jason X.-J., Yang, Kai, Sun, Dejun, Wang, Jian

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HPV-YAP1 oncogenic alliance drives malignant transformation of fallopian tube epithelial cells von He, Chunbo, Lv, Xiangmin, Liu, Jiyuan, Ruan, Jinpeng, Chen, Peichao, Huang, Cong, Angeletti, Peter C, Hua, Guohua, Moness, Madelyn Leigh, Shi, Davie, Dhar, Anjali, Yang, Siyi, Murphy, Savannah, Montoute, Isabelle, Chen, Xingcheng, Islam, Kazi Nazrul, George, Sophia, Ince, Tan A, Drapkin, Ronny, Guda, Chittibabu, Davis, John S, Wang, Cheng

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Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers von Kinsey, Conan G., Camolotto, Soledad A., Boespflug, Amelie M., Guillen, Katrin P., Foth, Mona, Truong, Amanda, Schuman, Sophia S., Shea, Jill E., Seipp, Michael T., Yap, Jeffrey T., Burrell, Lance D., Lum, David H., Whisenant, Jonathan R., Gilcrease, G. Weldon, Cavalieri, Courtney C., Rehbein, Kaitrin M., Cutler, Stephanie L., Affolter, Kajsa E., Welm, Alana L., Welm, Bryan E., Scaife, Courtney L., Snyder, Eric L., McMahon, Martin

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YAP-TEAD INHIBITORS AND USES THEREOF von SHALHOUT, Sophia, CAMARGO, Fernando

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