Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein von Wang, Mingliang, Lu, Jianfeng, Wang, Mi, Yang, Chao-Yie, Wang, Shaomeng

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Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer von Han, Xin, Wang, Chao, Qin, Chong, Xiang, Weiguo, Fernandez-Salas, Ester, Yang, Chao-Yie, Wang, Mi, Zhao, Lijie, Xu, Tianfeng, Chinnaswamy, Krishnapriya, Delproposto, James, Stuckey, Jeanne, Wang, Shaomeng

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MCL-1 inhibition in cancer treatment von Xiang, Weiguo, Yang, Chao-Yie, Bai, Longchuan

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Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumo... von Li, Yangbing, Yang, Jiuling, Aguilar, Angelo, McEachern, Donna, Przybranowski, Sally, Liu, Liu, Yang, Chao-Yie, Wang, Mi, Han, Xin, Wang, Shaomeng

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Comparative Analyses of the Conformational Dynamics Between the Soluble and Membrane-Bound Cytokine Receptors von Yang, Chao-Yie

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Selective inhibition of cullin 3 neddylation through covalent targeting DCN1 protects mice from acetaminophen-induced liver toxicity von Zhou, Haibin, Lu, Jianfeng, Chinnaswamy, Krishnapriya, Stuckey, Jeanne A., Liu, Liu, McEachern, Donna, Yang, Chao-Yie, Bernard, Denzil, Shen, Hong, Rui, Liangyou, Sun, Yi, Wang, Shaomeng

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Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Induc... von Qin, Chong, Hu, Yang, Zhou, Bing, Fernandez-Salas, Ester, Yang, Chao-Yie, Liu, Liu, McEachern, Donna, Przybranowski, Sally, Wang, Mi, Stuckey, Jeanne, Meagher, Jennifer, Bai, Longchuan, Chen, Zhuo, Lin, Mei, Yang, Jiuling, Ziazadeh, Danya N, Xu, Fuming, Hu, Jiantao, Xiang, Weiguo, Huang, Liyue, Li, Siwei, Wen, Bo, Sun, Duxin, Wang, Shaomeng

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Identification of potential small molecule allosteric modulator sites on IL-1R1 ectodomain using accelerated conformational sampling method von Yang, Chao-Yie

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Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein von Zhou, Haibin, Bai, Longchuan, Xu, Renqi, Zhao, Yujun, Chen, Jianyong, McEachern, Donna, Chinnaswamy, Krishnapriya, Wen, Bo, Dai, Lipeng, Kumar, Praveen, Yang, Chao-Yie, Liu, Zhaomin, Wang, Mi, Liu, Liu, Meagher, Jennifer L, Yi, Han, Sun, Duxin, Stuckey, Jeanne A, Wang, Shaomeng

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Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer von Bai, Longchuan, Zhou, Bing, Yang, Chao-Yie, Ji, Jiao, McEachern, Donna, Przybranowski, Sally, Jiang, Hui, Hu, Jiantao, Xu, Fuming, Zhao, Yujun, Liu, Liu, Fernandez-Salas, Ester, Xu, Jing, Dou, Yali, Wen, Bo, Sun, Duxin, Meagher, Jennifer, Stuckey, Jeanne, Hayes, Daniel F, Li, Shunqiang, Ellis, Matthew J, Wang, Shaomeng

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The Making of I‑BET762, a BET Bromodomain Inhibitor Now in Clinical Development von Zhao, Yujun, Yang, Chao-Yie, Wang, Shaomeng

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A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation von Zhou, Haibin, Lu, Jianfeng, Liu, Liu, Bernard, Denzil, Yang, Chao-Yie, Fernandez-Salas, Ester, Chinnaswamy, Krishnapriya, Layton, Stephanie, Stuckey, Jeanne, Yu, Qing, Zhou, Weihua, Pan, Zhenqiang, Sun, Yi, Wang, Shaomeng

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The FHA and BRCT domains recognize ADP-ribosylation during DNA damage response von Li, Mo, Lu, Lin-Yu, Yang, Chao-Yie, Wang, Shaomeng, Yu, Xiaochun

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Recent Advances of SHP2 Inhibitors in Cancer Therapy: Current Development and Clinical Application von Yuan, Xinrui, Bu, Hong, Zhou, Jinpei, Yang, Chao-Yie, Zhang, Huibin

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High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein–Protein Interaction von Zhou, Haibin, Zhou, Weihua, Zhou, Bing, Liu, Liu, Chern, Ting-Rong, Chinnaswamy, Krishnapriya, Lu, Jianfeng, Bernard, Denzil, Yang, Chao-Yie, Li, Shasha, Wang, Mi, Stuckey, Jeanne, Sun, Yi, Wang, Shaomeng

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Allosteric Inactivation of Polycomb Repressive Complex 2 (PRC2) by Inhibiting Its Adapter Protein: Embryonic Ectodomain Development (EED) von Yang, Chao-Yie, Wang, Shaomeng

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A Potent and Orally Active Antagonist (SM-406/AT-406) of Multiple Inhibitor of Apoptosis Proteins (IAPs) in Clinical Development for Cancer Treatment von Cai, Qian, Sun, Haiying, Peng, Yuefeng, Lu, Jianfeng, Nikolovska-Coleska, Zaneta, McEachern, Donna, Liu, Liu, Qiu, Su, Yang, Chao-Yie, Miller, Rebecca, Yi, Han, Zhang, Tao, Sun, Duxin, Kang, Sanmao, Guo, Ming, Leopold, Lance, Yang, Dajun, Wang, Shaomeng

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The similarity of class II HLA genotypes defines patterns of autoreactivity in idiopathic bone marrow failure disorders von Pagliuca, Simona, Gurnari, Carmelo, Awada, Hassan, Kishtagari, Ashwin, Kongkiatkamon, Sunisa, Terkawi, Laila, Zawit, Misam, Guan, Yihong, LaFramboise, Thomas, Jha, Babal K., Patel, Bhumika J., Hamilton, Betty K., Majhail, Navneet S., Lundgren, Sofie, Mustjoki, Satu, Saunthararajah, Yogen, Visconte, Valeria, Chan, Timothy A., Yang, Chao-Yie, Lenz, Tobias L., Maciejewski, Jaroslaw P.

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Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders von Yang, Jiuling, Li, Yangbing, Aguilar, Angelo, Liu, Zhaomin, Yang, Chao-Yie, Wang, Shaomeng

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The PDBbind Database:  Methodologies and Updates von Wang, Renxiao, Fang, Xueliang, Lu, Yipin, Yang, Chao-Yie, Wang, Shaomeng

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