Phosphatidylinositol 3‐kinase inhibitors: promising drug candidates for cancer therapy von Kong, Dexin, Yamori, Takao

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ZSTK474 is an ATP‐competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms von Kong, Dexin, Yamori, Takao

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Discovery of Inhibitors of Membrane Traffic from a Panel of Clinically Effective Anticancer Drugs von Kamata, Hiroko, Sadahiro, Sotaro, Yamori, Takao

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JFCR39, a panel of 39 human cancer cell lines, and its application in the discovery and development of anticancer drugs von Kong, Dexin, Yamori, Takao

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Reforms of regulatory pathways for approval of new antineoplastic drugs in Japan from 2004 to 2019 and accompanying changes in pivotal clinical trial designs von Hirai, Takehiro, Suzuki, Asuka, Yamori, Takao, Matsuura, Masaaki

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Efficacy of RG7787, a next-generation mesothelin-targeted immunotoxin, against triple-negative breast and gastric cancers von Alewine, Christine, Xiang, Laiman, Yamori, Takao, Niederfellner, Gerhard, Bosslet, Klaus, Pastan, Ira

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Lamellarin 14, a derivative of marine alkaloids, inhibits the T790M/C797S mutant epidermal growth factor receptor von Nishiya, Naoyuki, Oku, Yusuke, Ishikawa, Chie, Fukuda, Tsutomu, Dan, Shingo, Mashima, Tetsuo, Ushijima, Masaru, Furukawa, Yoko, Sasaki, Yuka, Otsu, Keishi, Sakyo, Tomoko, Abe, Masanori, Yonezawa, Honami, Ishibashi, Fumito, Matsuura, Masaaki, Tomida, Akihiro, Seimiya, Hiroyuki, Yamori, Takao, Iwao, Masatomo, Uehara, Yoshimasa

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Antitumor Activity of ZSTK474, a New Phosphatidylinositol 3-Kinase Inhibitor von Yaguchi, Shin-ichi, Fukui, Yasuhisa, Koshimizu, Ichiro, Yoshimi, Hisashi, Matsuno, Toshiyuki, Gouda, Hiroaki, Hirono, Shuichi, Yamazaki, Kanami, Yamori, Takao

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Panel of human cancer cell lines provides valuable database for drug discovery and bioinformatics von YAMORI, Takao

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Inhibition profiles of phosphatidylinositol 3-kinase inhibitors against PI3K superfamily and human cancer cell line panel JFCR39 von Kong, Dexin, Dan, Shingo, Yamazaki, Kanami, Yamori, Takao

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Telomestatin Impairs Glioma Stem Cell Survival and Growth through the Disruption of Telomeric G-Quadruplex and Inhibition of the Proto-oncogene, c-Myb von MIYAZAKI, Takeshi, YANG PAN, SHIN-YA, Kazuo, SEIMIYA, Hiroyuki, NAKANO, Ichiro, JOSHI, Kaushal, PUROHIT, Deepti, BIN HU, DEMIR, Habibe, MAZUMDER, Sarmistha, OKABE, Sachiko, YAMORI, Takao, VIAPIANO, Mariano

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Effect of ZSTK474, a Novel Phosphatidylinositol 3-Kinase Inhibitor, on DNA-Dependent Protein Kinase von Kong, Dexin, Yaguchi, Shin-ichi, Yamori, Takao

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Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells von Fujiwara, Chiaki, Muramatsu, Yukiko, Nishii, Megumi, Tokunaka, Kazuhiro, Tahara, Hidetoshi, Ueno, Masaru, Yamori, Takao, Sugimoto, Yoshikazu, Seimiya, Hiroyuki

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Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocyclic hexaoxazole von Nakamura, Takahiro, Okabe, Sachiko, Yoshida, Haruka, Iida, Keisuke, Ma, Yue, Sasaki, Shogo, Yamori, Takao, Shin-ya, Kazuo, Nakano, Ichiro, Nagasawa, Kazuo, Seimiya, Hiroyuki

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Pyrrocidine A, a metabolite of endophytic fungi, has a potent apoptosis-inducing activity against HL60 cells through caspase activation via the Michael addition von Uesugi, Shota, Fujisawa, Nozomi, Yoshida, Jun, Watanabe, Mitsuru, Dan, Shingo, Yamori, Takao, Shiono, Yoshihito, Kimura, Ken-ichi

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Autotaxin Is Overexpressed in Glioblastoma Multiforme and Contributes to Cell Motility of Glioblastoma by Converting Lysophosphatidylcholine TO Lysophosphatidic Acid von Kishi, Yasuhiro, Okudaira, Shinichi, Tanaka, Masayuki, Hama, Kotaro, Shida, Dai, Kitayama, Joji, Yamori, Takao, Aoki, Junken, Fujimaki, Takamitsu, Arai, Hiroyuki

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ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor identified using the JFCR39 drug discovery system von Kong, De-xin, Yamori, Takao

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Autotaxin Has Lysophospholipase D Activity Leading to Tumor Cell Growth and Motility by Lysophosphatidic Acid Production von Umezu-Goto, Makiko, Kishi, Yasuhiro, Taira, Akitsu, Hama, Kotaro, Dohmae, Naoshi, Takio, Koji, Yamori, Takao, Mills, Gordon B., Inoue, Keizo, Aoki, Junken, Arai, Hiroyuki

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Yaku’amides A and B, Cytotoxic Linear Peptides Rich in Dehydroamino Acids from the Marine Sponge Ceratopsion sp von Ueoka, Reiko, Ise, Yuji, Ohtsuka, Susumu, Okada, Shigeru, Yamori, Takao, Matsunaga, Shigeki

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M-COPA, a Golgi Disruptor, Inhibits Cell Surface Expression of MET Protein and Exhibits Antitumor Activity against MET-Addicted Gastric Cancers von Ohashi, Yoshimi, Okamura, Mutsumi, Hirosawa, Asaka, Tamaki, Naomi, Akatsuka, Akinobu, Wu, Kuo-Ming, Choi, Hyeong-Wook, Yoshimatsu, Kentaro, Shiina, Isamu, Yamori, Takao, Dan, Shingo

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