Therapeutic Activity of Agonistic, Human Anti-CD40 Monoclonal Antibodies Requires Selective FcγR Engagement von Dahan, Rony, Barnhart, Bryan C., Li, Fubin, Yamniuk, Aaron P., Korman, Alan J., Ravetch, Jeffrey V.

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IL-2/CD25: A Long-Acting Fusion Protein That Promotes Immune Tolerance by Selectively Targeting the IL-2 Receptor on Regulatory T Cells von Ward, Natasha C, Yu, Aixin, Moro, Alejandro, Ban, Yuguang, Chen, Xi, Hsiung, Sunnie, Keegan, James, Arbanas, Jaren M, Loubeau, Martine, Thankappan, Anil, Yamniuk, Aaron P, Davis, Jonathan H, Struthers, Mary, Malek, Thomas R

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Solution structures of the SH3 domains from Shank scaffold proteins and their interactions with Cav1.3 calcium channels von Ishida, Hiroaki, Skorobogatov, Anton, Yamniuk, Aaron P., Vogel, Hans J.

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Engineering of a novel anti-CD40L domain antibody for treatment of autoimmune diseases von Xie, Jenny H, Yamniuk, Aaron P, Borowski, Virna, Kuhn, Robert, Susulic, Vojkan, Rex-Rabe, Sandra, Yang, Xiaoxia, Zhou, Xiadi, Zhang, Yifan, Gillooly, Kathleen, Brosius, Ruth, Ravishankar, Rathna, Waggie, Kimberly, Mink, Kathy, Price, Laura, Rehfuss, Robert, Tamura, James, An, Yongmi, Cheng, Lin, Abramczyk, Bozena, Ignatovich, Olga, Drew, Philip, Grant, Steven, Bryson, James W, Suchard, Suzanne, Salter-Cid, Luisa, Nadler, Steven, Suri, Anish

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Developability considerations for bispecific and multispecific antibodies von Amash, Alaa, Volkers, Gesa, Farber, Patrick, Griffin, Daniel, Davison, K Shawn, Goodman, Allison, Tonikian, Raffi, Yamniuk, Aaron, Barnhart, Bryan, Jacobs, Tim

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Characterization and quantification of histidine degradation in therapeutic protein formulations by size exclusion-hydrophilic interaction two dimensional-liquid chromatography wit... von Wang, Chunlei, Chen, Sike, Brailsford, John A., Yamniuk, Aaron P., Tymiak, Adrienne A., Zhang, Yingru

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Calmodulin's flexibility allows for promiscuity in its interactions with target proteins and peptides von YAMNIUK, Aaron P, VOGEL, Hans H

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Investigation of anomalous charge variant profile reveals discrete pH-dependent conformations and conformation-dependent charge states within the CDR3 loop of a therapeutic mAb von Lan, Wenkui, Valente, Joseph J, Ilott, Andrew, Chennamsetty, Naresh, Liu, Zhihua, Rizzo, Joseph M, Yamniuk, Aaron P, Qiu, Difei, Shackman, Holly M, Bolgar, Mark S

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Detection of drug specific circulating immune complexes from in vivo cynomolgus monkey serum samples von Pierog, Piotr, Krishna, Murli, Yamniuk, Aaron, Chauhan, Anil, DeSilva, Binodh

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Functional Antagonism of Human CD40 Achieved by Targeting a Unique Species-Specific Epitope von Yamniuk, Aaron P., Suri, Anish, Krystek, Stanley R., Tamura, James, Ramamurthy, Vidhyashankar, Kuhn, Robert, Carroll, Karen, Fleener, Catherine, Ryseck, Rolf, Cheng, Lin, An, Yongmi, Drew, Philip, Grant, Steven, Suchard, Suzanne J., Nadler, Steven G., Bryson, James W., Sheriff, Steven

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Bioavailability of protein therapeutics in rats following inhalation exposure: Relevance to occupational exposure limit calculations von Gould, Janet C., Carvajal, Irvith, Davidson, Todd, Graham, Jessica, Hillegass, Jedd, Julien, Susan, Kozhich, Alex, Wang, Bonnie, Wei, Hui, Yamniuk, Aaron P., Mathias, Neil, Haggerty, Helen G., Graziano, Michael

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Thermodynamic characterization of the interactions between the immunoregulatory proteins osteopontin and lactoferrin von Yamniuk, Aaron P., Burling, Hans, Vogel, Hans J.

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Application of a Kosmotrope-Based Solubility Assay to Multiple Protein Therapeutic Classes Indicates Broad Use as a High-Throughput Screen for Protein Therapeutic Aggregation Prope... von Yamniuk, Aaron P., Ditto, Noah, Patel, Mehul, Dai, Jun, Sejwal, Preeti, Stetsko, Paul, Doyle, Michael L.

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Characterization of Mauritian Cynomolgus Macaque FcγR Alleles Using Long-Read Sequencing von Haj, Amelia K, Arbanas, Jaren M, Yamniuk, Aaron P, Karl, Julie A, Bussan, Hailey E, Drinkwater, Kenneth Y, Graham, Michael E, Ericsen, Adam J, Prall, Trent M, Moore, Kristina, Cheng, Lin, Gao, Mian, Graziano, Robert F, Loffredo, John T, Wiseman, Roger W, O'Connor, David H

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The structure of the death receptor 4-TNF-related apoptosis-inducing ligand (DR4-TRAIL) complex von Ramamurthy, Vidhyashankar, Yamniuk, Aaron P., Lawrence, Eric J., Yong, Wei, Schneeweis, Lumelle A., Cheng, Lin, Murdock, Melissa, Corbett, Martin J., Doyle, Michael L., Sheriff, Steven

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Thermodynamic Effects of Noncoded and Coded Methionine Substitutions in Calmodulin von Yamniuk, Aaron P., Ishida, Hiroaki, Lippert, Dustin, Vogel, Hans J.

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Role of Self-Association and Supersaturation in Oral Absorption of a Poorly Soluble Weakly Basic Drug von Narang, Ajit S., Badawy, Sherif, Ye, Qingmei, Patel, Dhaval, Vincent, Maria, Raghavan, Krishnaswamy, Huang, Yande, Yamniuk, Aaron, Vig, Balvinder, Crison, John, Derbin, George, Xu, Yan, Ramirez, Antonio, Galella, Michael, Rinaldi, Frank A.

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Comparison of Ensemble and Single Molecule Methods for Particle Characterization and Binding Analysis of a PEGylated Single-Domain Antibody von Schneeweis, Lumelle A., Obenauer-Kutner, Linda, Kaur, Parminder, Yamniuk, Aaron P., Tamura, James, Jaffe, Neil, O’Mara, Brian W., Lindsay, Stuart, Doyle, Michael, Bryson, James

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A fibronectin scaffold approach to bispecific inhibitors of epidermal growth factor receptor and insulin-like growth factor-I receptor von Emanuel, Stuart L., Engle, Linda J., Chao, Ginger, Zhu, Rong-Rong, Cao, Carolyn, Lin, Zheng, Yamniuk, Aaron P., Hosbach, Jennifer, Brown, Jennifer, Fitzpatrick, Elizabeth, Gokemeijer, Jochem, Morin, Paul, Morse, Brent A., Carvajal, Irvith M., Fabrizio, David, Wright, Martin C., Das Gupta, Ruchira, Gosselin, Michael, Cataldo, Daniel, Ryseck, Rolf P., Doyle, Michael L., Wong, Tai W., Camphausen, Raymond T., Cload, Sharon T., Marsh, H. Nicholas, Gottardis, Marco M., Furfine, Eric S.

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1367 A rational approach to selecting CD3-binding antibodies for T-cell engager development von Mai, Juntao (Matt), Puyraimond, Valentine de, Pouliot, Philippe, Caldwell, Kate, Clifford, Lauren, Goodman, Allison, Farber, Patrick, Rowe, Patrick, Dhupar, Harveer, Reimer, Janice, Herve, Karine, Li, Vivian, Yu, Irene, Marwick, John, Blamey, Nathalie, Cid, Melissa, Crichlow, Cindy-Lee, Bolten, Lena M, Pinsky, Tova, Volkers, Gesa, Bodhankar, Girija, Jong, Caitlyn De, Cullen, Sophie, Xiang, Ping, Lee, Ahn, Conaghan, Gabrielle, Samiotakis, Antonios, Hannie, Stefan, Chappell, Rhys, Lathouwers, Emma, Chong, Lauren, Gibson, Kate, Masterman, Stephanie K, Brown, Kirstin, Fogg, Mark, Tonikian, Raffi, Jacobs, Tim, Yamniuk, Aaron, Barnhart, Bryan C

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