Developing neoantigen-targeted T cell–based treatments for solid tumors von Yamamoto, Tori N., Kishton, Rigel J., Restifo, Nicholas P.

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Ionic immune suppression within the tumour microenvironment limits T cell effector function von Eil, Robert, Vodnala, Suman K., Clever, David, Klebanoff, Christopher A., Sukumar, Madhusudhanan, Pan, Jenny H., Palmer, Douglas C., Gros, Alena, Yamamoto, Tori N., Patel, Shashank J., Guittard, Geoffrey C., Yu, Zhiya, Carbonaro, Valentina, Okkenhaug, Klaus, Schrump, David S., Linehan, W. Marston, Roychoudhuri, Rahul, Restifo, Nicholas P.

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Identification of essential genes for cancer immunotherapy von Patel, Shashank J., Sanjana, Neville E., Kishton, Rigel J., Eidizadeh, Arash, Vodnala, Suman K., Cam, Maggie, Gartner, Jared J., Jia, Li, Steinberg, Seth M., Yamamoto, Tori N., Merchant, Anand S., Mehta, Gautam U., Chichura, Anna, Shalem, Ophir, Tran, Eric, Eil, Robert, Sukumar, Madhusudhanan, Guijarro, Eva Perez, Day, Chi-Ping, Robbins, Paul, Feldman, Steve, Merlino, Glenn, Zhang, Feng, Restifo, Nicholas P.

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T cell stemness and dysfunction in tumors are triggered by a common mechanism von Vodnala, Suman Kumar, Eil, Robert, Kishton, Rigel J, Sukumar, Madhusudhanan, Yamamoto, Tori N, Ha, Ngoc-Han, Lee, Ping-Hsien, Shin, MinHwa, Patel, Shashank J, Yu, Zhiya, Palmer, Douglas C, Kruhlak, Michael J, Liu, Xiaojing, Locasale, Jason W, Huang, Jing, Roychoudhuri, Rahul, Finkel, Toren, Klebanoff, Christopher A, Restifo, Nicholas P

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An engineered IL-2 partial agonist promotes CD8+ T cell stemness von Mo, Fei, Yu, Zhiya, Li, Peng, Oh, Jangsuk, Spolski, Rosanne, Zhao, Liang, Glassman, Caleb R., Yamamoto, Tori N., Chen, Yun, Golebiowski, Filip M., Hermans, Dalton, Majri-Morrison, Sonia, Picton, Lora K., Liao, Wei, Ren, Min, Zhuang, Xiaoxuan, Mitra, Suman, Lin, Jian-Xin, Gattinoni, Luca, Powell, Jonathan D., Restifo, Nicholas P., Garcia, K. Christopher, Leonard, Warren J.

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Evaluation of SARS-CoV-2 serology assays reveals a range of test performance von Whitman, Jeffrey D., Hiatt, Joseph, Mowery, Cody T., Shy, Brian R., Yu, Ruby, Yamamoto, Tori N., Rathore, Ujjwal, Goldgof, Gregory M., Whitty, Caroline, Woo, Jonathan M., Gallman, Antonia E., Miller, Tyler E., Levine, Andrew G., Nguyen, David N., Bapat, Sagar P., Balcerek, Joanna, Bylsma, Sophia A., Lyons, Ana M., Li, Stacy, Wong, Allison Wai-yi, Gillis-Buck, Eva Mae, Steinhart, Zachary B., Lee, Youjin, Apathy, Ryan, Lipke, Mitchell J., Smith, Jennifer Anne, Zheng, Tina, Boothby, Ian C., Isaza, Erin, Chan, Jackie, Acenas, Dante D., Lee, Jinwoo, Macrae, Trisha A., Kyaw, Than S., Wu, David, Ng, Dianna L., Gu, Wei, York, Vanessa A., Eskandarian, Haig Alexander, Callaway, Perri C., Warrier, Lakshmi, Moreno, Mary E., Levan, Justine, Torres, Leonel, Farrington, Lila A., Loudermilk, Rita P., Koshal, Kanishka, Zorn, Kelsey C., Garcia-Beltran, Wilfredo F., Yang, Diane, Astudillo, Michael G., Bernstein, Bradley E., Gelfand, Jeffrey A., Ryan, Edward T., Charles, Richelle C., Iafrate, A. John, Lennerz, Jochen K., Miller, Steve, Chiu, Charles Y., Stramer, Susan L., Wilson, Michael R., Manglik, Aashish, Ye, Chun Jimmie, Krogan, Nevan J., Anderson, Mark S., Cyster, Jason G., Ernst, Joel D., Wu, Alan H. B., Lynch, Kara L., Bern, Caryn, Hsu, Patrick D., Marson, Alexander

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T cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy von Yamamoto, Tori N, Lee, Ping-Hsien, Vodnala, Suman K, Gurusamy, Devikala, Kishton, Rigel J, Yu, Zhiya, Eidizadeh, Arash, Eil, Robert, Fioravanti, Jessica, Gattinoni, Luca, Kochenderfer, James N, Fry, Terry J, Aksoy, Bulent Arman, Hammerbacher, Jeffrey E, Cruz, Anthony C, Siegel, Richard M, Restifo, Nicholas P, Klebanoff, Christopher A

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Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy von Klebanoff, Christopher A, Scott, Christopher D, Leonardi, Anthony J, Yamamoto, Tori N, Cruz, Anthony C, Ouyang, Claudia, Ramaswamy, Madhu, Roychoudhuri, Rahul, Ji, Yun, Eil, Robert L, Sukumar, Madhusudhanan, Crompton, Joseph G, Palmer, Douglas C, Borman, Zachary A, Clever, David, Thomas, Stacy K, Patel, Shashankkumar, Yu, Zhiya, Muranski, Pawel, Liu, Hui, Wang, Ena, Marincola, Francesco M, Gros, Alena, Gattinoni, Luca, Rosenberg, Steven A, Siegel, Richard M, Restifo, Nicholas P

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Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells von Lee, Ping-Hsien, Yamamoto, Tori N, Gurusamy, Devikala, Sukumar, Madhusudhanan, Yu, Zhiya, Hu-Li, Jane, Kawabe, Takeshi, Gangaplara, Arunakumar, Kishton, Rigel J, Henning, Amanda N, Vodnala, Suman K, Germain, Ronald N, Paul, William E, Restifo, Nicholas P

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Novel serial positive enrichment technology enables clinical multiparameter cell sorting von Stemberger, Christian, Dreher, Stefan, Tschulik, Claudia, Piossek, Christine, Bet, Jeannette, Yamamoto, Tori N, Schiemann, Matthias, Neuenhahn, Michael, Martin, Klaus, Schlapschy, Martin, Skerra, Arne, Schmidt, Thomas, Edinger, Matthias, Riddell, Stanley R, Germeroth, Lothar, Busch, Dirk H

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Generation of CD19-chimeric antigen receptor modified CD8+ T cells derived from virus-specific central memory T cells von Terakura, Seitaro, Yamamoto, Tori N., Gardner, Rebecca A., Turtle, Cameron J., Jensen, Michael C., Riddell, Stanley R.

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Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction von Cruz, Anthony C., Ramaswamy, Madhu, Ouyang, Claudia, Klebanoff, Christopher A., Sengupta, Prabuddha, Yamamoto, Tori N., Meylan, Françoise, Thomas, Stacy K., Richoz, Nathan, Eil, Robert, Price, Susan, Casellas, Rafael, Rao, V. Koneti, Lippincott-Schwartz, Jennifer, Restifo, Nicholas P., Siegel, Richard M.

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The B-cell tumor–associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor von Hudecek, Michael, Schmitt, Thomas M., Baskar, Sivasubramanian, Lupo-Stanghellini, Maria Teresa, Nishida, Tetsuya, Yamamoto, Tori N., Bleakley, Marie, Turtle, Cameron J., Chang, Wen-Chung, Greisman, Harvey A., Wood, Brent, Maloney, David G., Jensen, Michael C., Rader, Christoph, Riddell, Stanley R.

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Mg2+ regulation of kinase signaling and immune function von Kanellopoulou, Chryssa, George, Alex B., Masutani, Evan, Cannons, Jennifer L., Ravell, Juan C., Yamamoto, Tori N., Smelkinson, Margery G., Jiang, Ping Du, Matsuda-Lennikov, Mami, Reilley, Julie, Handon, Robin, Lee, Ping-Hsien, Miller, J. Richard, Restifo, Nicholas P., Zheng, Lixin, Schwartzberg, Pamela L., Young, Matthew, Lenardo, Michael J.

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Modular pooled discovery of synthetic knockin sequences to program durable cell therapies von Blaeschke, Franziska, Chen, Yan Yi, Apathy, Ryan, Daniel, Bence, Chen, Andy Y., Chen, Peixin Amy, Sandor, Katalin, Zhang, Wenxi, Li, Zhongmei, Mowery, Cody T., Yamamoto, Tori N., Nyberg, William A., To, Angela, Yu, Ruby, Bueno, Raymund, Kim, Min Cheol, Schmidt, Ralf, Goodman, Daniel B., Feuchtinger, Tobias, Eyquem, Justin, Jimmie Ye, Chun, Carnevale, Julia, Satpathy, Ansuman T., Shifrut, Eric, Roth, Theodore L., Marson, Alexander

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Inhibition of AKT signaling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy von Klebanoff, Christopher A, Crompton, Joseph G, Leonardi, Anthony J, Yamamoto, Tori N, Chandran, Smita S, Eil, Robert L, Sukumar, Madhusudhanan, Vodnala, Suman K, Hu, Jinhui, Ji, Yun, Clever, David, Black, Mary A, Gurusamy, Devikala, Kruhlak, Michael J, Jin, Ping, Stroncek, David F, Gattinoni, Luca, Feldman, Steven A, Restifo, Nicholas P

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Cross-presentation and genome-wide screening reveal candidate T cells antigens for a herpes simplex virus type 1 vaccine von Jing, Lichen, Haas, Jürgen, Chong, Tiana M, Bruckner, Joseph J, Dann, Greg C, Dong, Lichun, Marshak, Joshua O, McClurkan, Christopher L, Yamamoto, Tori N, Bailer, Susanne M, Laing, Kerry J, Wald, Anna, Verjans, Georges M G M, Koelle, David M

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Multi-phenotype CRISPR-Cas9 Screen Identifies p38 Kinase as a Target for Adoptive Immunotherapies von Gurusamy, Devikala, Henning, Amanda N., Yamamoto, Tori N., Yu, Zhiya, Zacharakis, Nikolaos, Krishna, Sri, Kishton, Rigel J., Vodnala, Suman K., Eidizadeh, Arash, Jia, Li, Kariya, Christine M., Black, Mary A., Eil, Robert, Palmer, Douglas C., Pan, Jenny H., Sukumar, Madhusudhanan, Patel, Shashank J., Restifo, Nicholas P.

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Cancer genes disfavoring T cell immunity identified via integrated systems approach von Kishton, Rigel J., Patel, Shashank J., Decker, Amy E., Vodnala, Suman K., Cam, Maggie, Yamamoto, Tori N., Patel, Yogin, Sukumar, Madhusudhanan, Yu, Zhiya, Ji, Michelle, Henning, Amanda N., Gurusamy, Devikala, Palmer, Douglas C., Stefanescu, Roxana A., Girvin, Andrew T., Lo, Winifred, Pasetto, Anna, Malekzadeh, Parisa, Deniger, Drew C., Wood, Kris C., Sanjana, Neville E., Restifo, Nicholas P.

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Cytomegalovirus-specific T cells are primed early after cord blood transplant but fail to control virus in vivo von McGoldrick, Suzanne M., Bleakley, Marie E., Guerrero, Abraham, Turtle, Cameron J., Yamamoto, Tori N., Pereira, Shalini E., Delaney, Colleen S., Riddell, Stanley R.

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