Engineered arylsulfatase A with increased activity, stability and brain delivery for therapy of metachromatic leukodystrophy von Yaghootfam, Claudia, Sylvester, Marc, Turk, Boris, Gieselmann, Volkmar, Matzner, Ulrich

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Deletion of fatty acid amide hydrolase reduces lyso-sulfatide levels but exacerbates metachromatic leukodystrophy in mice von Yaghootfam, Claudia, Gehrig, Bernd, Sylvester, Marc, Gieselmann, Volkmar, Matzner, Ulrich

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Evolutionary redesign of the lysosomal enzyme arylsulfatase A increases efficacy of enzyme replacement therapy for metachromatic leukodystrophy von Simonis, Heidi, Yaghootfam, Claudia, Sylvester, Marc, Gieselmann, Volkmar, Matzner, Ulrich

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Brain cell type-specific endocytosis of arylsulfatase A identifies limitations of enzyme-based therapies for metachromatic leukodystrophy von Kaminski, Debora, Yaghootfam, Claudia, Matthes, Frank, Reßing, Annika, Gieselmann, Volkmar, Matzner, Ulrich

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Potential of surfactant-coated nanoparticles to improve brain delivery of arylsulfatase A von Schuster, Tilman, Mühlstein, Astrid, Yaghootfam, Claudia, Maksimenko, Olga, Shipulo, Elena, Gelperina, Svetlana, Kreuter, Jörg, Gieselmann, Volkmar, Matzner, Ulrich

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