Mutations in the Phosphatidylinositol-3-Kinase Pathway Predict for Antitumor Activity of the Inhibitor PX-866 whereas Oncogenic Ras Is a Dominant Predictor for Resistance von IHLE, Nathan T, LEMOS, Robert, WIPF, Peter, YACOUB, Adly, MITCHELL, Clint, SIWAK, Doris, MILLS, Gordon B, DENT, Paul, KIRKPATRICK, D. Lynn, POWIS, Garth

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MAPK pathways in radiation responses von Dent, Paul, Yacoub, Adly, Fisher, Paul B, Hagan, Michael P, Grant, Steven

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Radiation-induced cell signaling: inside-out and outside-in von Valerie, Kristoffer, Yacoub, Adly, Hagan, Michael P, Curiel, David T, Fisher, Paul B, Grant, Steven, Dent, Paul

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Sorafenib activates CD95 and promotes autophagy and cell death via Src family kinases in gastrointestinal tumor cells von Park, Margaret A, Reinehr, Roland, Häussinger, Dieter, Voelkel-Johnson, Christina, Ogretmen, Besim, Yacoub, Adly, Grant, Steven, Dent, Paul

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Sorafenib Enhances Pemetrexed Cytotoxicity through an Autophagy-Dependent Mechanism in Cancer Cells von DANIELLE BAREFORD, M, PARK, Margaret A, FISHER, Paul B, MORAN, Richard G, NEPHEW, Kenneth P, GRANT, Steven, DENT, Paul, YACOUB, Adly, HAMED, Hossein A, YONG TANG, CRUICKSHANKS, Nichola, EULITT, Patrick, HUBBARD, Nisan, TYE, Gary, BUROW, Matthew E

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Astrocyte Elevated Gene-1: A Novel Target for Human Glioma Therapy von Emdad, Luni, Sarkar, Devanand, Lee, Seok-Geun, Su, Zhao Zhong, Yoo, Byoung Kwon, Dash, Rupesh, Yacoub, Adly, Fuller, Christine E, Shah, Khalid, Dent, Paul, Bruce, Jeffrey N, Fisher, Paul B

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Melanoma differentiation associated gene-7, mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner von SU, Zao-Zhong, LEBEDEVA, Irina V, SARKAR, Devanand, GOPALKRISHNAN, Rahul V, SAUANE, Moira, SIGMON, Carter, YACOUB, Adly, VALERIE, Kristoffer, DENT, Paul, FISHER, Paul B

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Sorafenib and Vorinostat Kill Colon Cancer Cells by CD95-Dependent and -Independent Mechanisms von Walker, Teneille, Mitchell, Clint, Park, Margaret A, Yacoub, Adly, Graf, Martin, Rahmani, Mohamed, Houghton, Peter J, Voelkel-Johnson, Christina, Grant, Steven, Dent, Paul

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mda- 7/IL-24: A unique member of the IL-10 gene family promoting cancer-targeted toxicity von Dash, Rupesh, Bhutia, Sujit K, Azab, Belal, Su, Zhao-zhong, Quinn, Bridget A, Kegelmen, Timothy P, Das, Swadesh K, Kim, Keetae, Lee, Seok-Geun, Park, Margaret A, Yacoub, Adly, Rahmani, Mohammed, Emdad, Luni, Dmitriev, Igor P, Wang, Xiang-Yang, Sarkar, Devanand, Grant, Steven, Dent, Paul, Curiel, David T, Fisher, Paul B

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Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in carcinoma cells von Mitchell, Clint, Park, Margaret, Eulitt, Patrick, Yang, Chen, Yacoub, Adly, Dent, Paul

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Vorinostat and Sorafenib Synergistically Kill Tumor Cells via FLIP Suppression and CD95 Activation von GUO ZHANG, PARK, Margaret A, ROBERTS, John D, FISHER, Paul B, GRANT, Steven, DENTS, Paul, MITCHELL, Clint, HAMED, Hossein, RAHMANI, Mohamed, PANDYA MARTIN, Aditi, CURIEL, David T, YACOUB, Adly, GRAF, Martin, LEE, Ray

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Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo von Mitchell, Clint, Yacoub, Adly, Hossein, Hamed, Pandya Martin, Aditi, Bareford, M. Danielle, Eulitt, Patrick J., Yang, Chen, Nephew, Kenneth P., Dent, Paul

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Inhibition of vimentin or β1 integrin reverts morphology of prostate tumor cells grown in laminin-rich extracellular matrix gels and reduces tumor growth in vivo von Zhang, Xueping, Fournier, Marcia V., Ware, Joy L., Bissell, Mina J., Yacoub, Adly, Zehner, Zendra E.

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OSU-03012 suppresses GRP78/BiP expression that causes PERK-dependent increases in tumor cell killing von Booth, Laurence, Cazanave, Sophie C., Hamed, Hossein A., Yacoub, Adly, Ogretmen, Besim, Chen, Ching-Shih, Grant, Steven, Dent, Paul

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Sorafenib and HDAC inhibitors synergize to kill CNS tumor cells von Tang, Yong, Yacoub, Adly, Hamed, Hossein A., Poklepovic, Andrew, Tye, Gary W., Grant, Steven, Dent, Paul

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Ionizing Radiation Causes a Dose-Dependent Release of Transforming Growth Factor α In vitro from Irradiated Xenografts and during Palliative Treatment of Hormone-Refractory Prostat... von HAGAN, Michael, YACOUB, Adly, DENT, Paul

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Lapatinib Resistance in HCT116 Cells Is Mediated by Elevated MCL-1 Expression and Decreased BAK Activation and Not by ERBB Receptor Kinase Mutation von Martin, Aditi Pandya, Miller, Anna, Emad, Luni, Rahmani, Mohammed, Walker, Teneille, Mitchell, Clint, Hagan, Michael P, Park, Margaret A, Yacoub, Adly, Fisher, Paul B, Grant, Steven, Dent, Paul

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OSU-03012 Stimulates PKR-Like Endoplasmic Reticulum-Dependent Increases in 70-kDa Heat Shock Protein Expression, Attenuating Its Lethal Actions in Transformed Cells von Park, Margaret A, Yacoub, Adly, Rahmani, Mohammed, Zhang, Guo, Hart, Lori, Hagan, Michael P, Calderwood, Stuart K, Sherman, Michael Y, Koumenis, Costas, Spiegel, Sarah, Chen, Ching-Shih, Graf, Martin, Curiel, David T, Fisher, Paul B, Grant, Steven, Dent, Paul

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OSU-03012 Promotes Caspase-Independent but PERK-, Cathepsin B-, BID-, and AIF-Dependent Killing of Transformed Cells von Yacoub, Adly, Park, Margaret A, Hanna, David, Hong, Young, Mitchell, Clint, Pandya, Aditi P, Harada, Hisashi, Powis, Garth, Chen, Ching-Shih, Koumenis, Costas, Grant, Steven, Dent, Paul

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RLIP76 in Defense of Radiation Poisoning von Singhal, Jyotsana, M.S, Singhal, Sharad S., Ph.D, Yadav, Sushma, Ph.D, Suzuki, Sumihiro, Ph.D, Warnke, Molly M., B.A, Yacoub, Adly, Ph.D, Dent, Paul, Ph.D, Bae, Sejong, Ph.D, Sharma, Rajendra, Ph.D, Awasthi, Yogesh C., Ph.D, Armstrong, Daniel W., Ph.D, Awasthi, Sanjay, M.D

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