PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting von Thorpe, Lauren M., Yuzugullu, Haluk, Zhao, Jean J.

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Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells von Yuzugullu, Haluk, Benhaj, Khemais, Ozturk, Nuri, Senturk, Serif, Celik, Emine, Toylu, Asli, Tasdemir, Nilgun, Yilmaz, Mustafa, Erdal, Esra, Akcali, Kamil Can, Atabey, Nese, Ozturk, Mehmet

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Cell-Cycle-Targeting MicroRNAs as Therapeutic Tools against Refractory Cancers von Hydbring, Per, Wang, Yinan, Fassl, Anne, Li, Xiaoting, Matia, Veronica, Otto, Tobias, Choi, Yoon Jong, Sweeney, Katharine E., Suski, Jan M., Yin, Hao, Bogorad, Roman L., Goel, Shom, Yuzugullu, Haluk, Kauffman, Kevin J., Yang, Junghoon, Jin, Chong, Li, Yingxiang, Floris, Davide, Swanson, Richard, Ng, Kimmie, Sicinska, Ewa, Anders, Lars, Zhao, Jean J., Polyak, Kornelia, Anderson, Daniel G., Li, Cheng, Sicinski, Piotr

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Genome-wide transcriptional reorganization associated with senescence-to-immortality switch during human hepatocellular carcinogenesis von Yildiz, Gokhan, Arslan-Ergul, Ayca, Bagislar, Sevgi, Konu, Ozlen, Yuzugullu, Haluk, Gursoy-Yuzugullu, Ozge, Ozturk, Nuri, Ozen, Cigdem, Ozdag, Hilal, Erdal, Esra, Karademir, Sedat, Sagol, Ozgul, Mizrak, Dilsa, Bozkaya, Hakan, Ilk, Hakki Gokhan, Ilk, Ozlem, Bilen, Biter, Cetin-Atalay, Rengul, Akar, Nejat, Ozturk, Mehmet

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The ability to generate senescent progeny as a mechanism underlying breast cancer cell heterogeneity von Mumcuoglu, Mine, Bagislar, Sevgi, Yuzugullu, Haluk, Alotaibi, Hani, Senturk, Serif, Telkoparan, Pelin, Gur-Dedeoglu, Bala, Cingoz, Burcu, Bozkurt, Betul, Tazebay, Uygar H, Yulug, Isik G, Akcali, K Can, Ozturk, Mehmet

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Overcoming Therapeutic Resistance in HER2-Positive Breast Cancers with CDK4/6 Inhibitors von Goel, Shom, Wang, Qi, Watt, April C., Tolaney, Sara M., Dillon, Deborah A., Li, Wei, Ramm, Susanne, Palmer, Adam C., Yuzugullu, Haluk, Varadan, Vinay, Tuck, David, Harris, Lyndsay N., Wong, Kwok-Kin, Liu, X. Shirley, Sicinski, Piotr, Winer, Eric P., Krop, Ian E., Zhao, Jean J.

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CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer von Wang, Yubao, Zhang, Tinghu, Kwiatkowski, Nicholas, Abraham, Brian J., Lee, Tong Ihn, Xie, Shaozhen, Yuzugullu, Haluk, Von, Thanh, Li, Heyuan, Lin, Ziao, Stover, Daniel G., Lim, Elgene, Wang, Zhigang C., Iglehart, J. Dirk, Young, Richard A., Gray, Nathanael S., Zhao, Jean J.

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Aflatoxin genotoxicity is associated with a defective DNA damage response bypassing p53 activation von Gursoy-Yuzugullu, Ozge, Yuzugullu, Haluk, Yilmaz, Mustafa, Ozturk, Mehmet

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A PI3K p110β–Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis von Yuzugullu, Haluk, Baitsch, Lukas, Von, Thanh, Steiner, Allison, Tong, Haoxuan, Ni, Jing, Clayton, Linda K., Bronson, Roderick, Roberts, Thomas M., Gritsman, Kira, Zhao, Jean J.

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Senescence and immortality in hepatocellular carcinoma von Ozturk, Mehmet, Arslan-Ergul, Ayca, Bagislar, Sevgi, Senturk, Serif, Yuzugullu, Haluk

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PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting von Thorpe, Lauren M, Yuzugullu, Haluk, Zhao, Jean J

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Evaluation of ATAD2 as a Potential Target in Hepatocellular Carcinoma von Ekin, Umut, Yuzugullu, Haluk, Ozen, Cigdem, Korhan, Peyda, Bagirsakci, Ezgi, Yilmaz, Funda, Yuzugullu, Ozge Gursoy, Uzuner, Hamdiye, Alotaibi, Hani, Kirmizibayrak, Petek Ballar, Atabey, Nese, Karakülah, Gökhan, Ozturk, Mehmet

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Abstract 700: Development of a second-generation TRAIL agonist and predictive biomarker profile for colorectal cancer von Ghassemifar, Sara, Hashambhoy-Ramsay, Yasmin, Yuzugullu, Haluk, Utermark, Tamara, Paragas, Violette, Maiwald, Tim, Luus, Lia, Razlog, Maja, Hudson, Hannah, Chai, Diane, Schoeberl, Birgit, Reynolds, C. Patrick, Sorger, Peter, Sawyer, Andrew J., Drummond, Daryl C., Tam, Eric

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Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110α von Gritsman, Kira, Yuzugullu, Haluk, Von, Thanh, Yan, Howard, Clayton, Linda, Fritsch, Christine, Maira, Sauveur-Michel, Hollingworth, Gregory, Choi, Christine, Khandan, Tulasi, Paktinat, Mahnaz, Okabe, Rachel O, Roberts, Thomas M, Zhao, Jean J

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Abstract 22: MM-161, a first-in-class pan-FGFR antibody von Dake, Tamara, Finn, Greg, Geddie, Melissa, Kohli, Neeraj, Razlog, Maja, Xu, Lihui, Paragas, Violette, Yuzugullu, Haluk, Ghassemifar, Sara, Hashambhoy-Ramsay, Yasmin, McDonagh, Charlotte, Muda, Marco, Schoeberl, Birgit

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Abstract 3220: Doxorubicin-induced senescence in hepatocellular carcinoma cells von Gursoy-Yuzugullu, Ozge, Yuzugullu, Haluk, Ozturk, Mehmet

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Abstract 4775: PI3K-p110β is required for leukemic transformation and HSC depletion in the absence of Pten von Yuzugullu, Haluk, Baitsch, Lukas, Steiner, Allison, Clayton, Linda K., Gritsman, Kira, Zhao, Jean J.

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Aflatoxin genotoxicity is associated with a defective DNA damage response bypassing p53 activation: DNA damage response to aflatoxin B1 von Gursoy-Yuzugullu, Ozge, Yuzugullu, Haluk, Yilmaz, Mustafa, Ozturk, Mehmet

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A PI3K p110β–Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis von Yuzugullu, Haluk, Baitsch, Lukas, Von, Thanh, Steiner, Allison, Tong, Haoxuan, Ni, Jing, Clayton, Linda K, Bronson, Roderick, Roberts, Thomas M, Gritsman, Kira, Zhao, Jean J

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Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110[alpha] von Gritsman, Kira, Yuzugullu, Haluk, Von, Thanh, Yan, Howard, Clayton, Linda, Fritsch, Christine, Maira, Sauveur-Michel, Hollingworth, Gregory, Choi, Christine, Khandan, Tulasi, Paktinat, Mahnaz, Okabe, Rachel O, Roberts, Thomas M, Zhao, Jean J

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